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1.
Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation.
Proc Natl Acad Sci U S A;
121(1): e2307086120, 2024 Jan 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-38147543
2.
The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity.
Nature;
575(7781): 217-223, 2019 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-31666701
3.
Industry Perspective on the Pharmacokinetic and Absorption, Distribution, Metabolism, and Excretion Characterization of Heterobifunctional Protein Degraders.
Drug Metab Dispos;
51(7): 792-803, 2023 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-37041086
4.
Characterization of JNJ-2482272 [4-(4-Methyl-2-(4-(Trifluoromethyl)Phenyl)Thiazole-5-yl) Pyrimidine-2-Amine] As a Strong Aryl Hydrocarbon Receptor Activator in Rat and Human.
Drug Metab Dispos;
50(8): 1064-1076, 2022 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35680134
5.
Intravital Multiphoton Microscopy with Fluorescent Bile Salts in Rats as an In Vivo Biomarker for Hepatobiliary Transport Inhibition.
Drug Metab Dispos;
46(5): 704-718, 2018 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29467212
6.
Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers.
Br J Clin Pharmacol;
75(2): 450-62, 2013 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-22725836
7.
Current Approaches for Predicting Human PK for Small Molecule Development Candidates: Findings from the IQ Human PK Prediction Working Group Survey.
AAPS J;
24(5): 85, 2022 07 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-35854202
8.
Systematic Study of the Glutathione Reactivity of N-Phenylacrylamides: 2. Effects of Acrylamide Substitution.
J Med Chem;
63(20): 11602-11614, 2020 10 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-32965113
9.
Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors.
J Med Chem;
63(1): 52-65, 2020 01 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31820981
10.
Discovery of N-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C.
ACS Med Chem Lett;
10(9): 1302-1308, 2019 Sep 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31531201
11.
Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor.
Drug Metab Dispos;
36(8): 1594-605, 2008 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-18480186
12.
Systematic Study of the Glutathione (GSH) Reactivity of N-Arylacrylamides: 1. Effects of Aryl Substitution.
J Med Chem;
58(23): 9171-8, 2015 Dec 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-26580091
13.
Discovery and optimization of a series of 3-(3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amines: orally bioavailable, selective, and potent ATP-independent Akt inhibitors.
J Med Chem;
55(11): 5291-310, 2012 Jun 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-22533986
14.
Zinc status influences zinc transport by porcine brain capillary endothelial cells.
J Nutr;
132(9): 2763-8, 2002 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-12221242
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