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1.

A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma.

Lytle, Nikki K; Ferguson, L Paige; Rajbhandari, Nirakar; Gilroy, Kathryn; Fox, Raymond G; Deshpande, Anagha; Schürch, Christian M; Hamilton, Michael; Robertson, Neil; Lin, Wei; Noel, Pawan; Wartenberg, Martin; Zlobec, Inti; Eichmann, Micha; Galván, José A; Karamitopoulou, Eva; Gilderman, Tami; Esparza, Lourdes Adriana; Shima, Yutaka; Spahn, Philipp; French, Randall; Lewis, Nathan E; Fisch, Kathleen M; Sasik, Roman; Rosenthal, Sara Brin; Kritzik, Marcie; Von Hoff, Daniel; Han, Haiyong; Ideker, Trey; Deshpande, Aniruddha J; Lowy, Andrew M; Adams, Peter D; Reya, Tannishtha.

Cell; 177(3): 572-586.e22, 2019 04 18.

Artículo en Inglés | MEDLINE | ID: mdl-30955884

2.

Hedgehog Pathway Inhibition.

Sekulic, Aleksandar; Von Hoff, Daniel.

Cell; 164(5): 831, 2016 Feb 25.

Artículo en Inglés | MEDLINE | ID: mdl-26919418

3.

A Circulating Panel of circRNA Biomarkers for the Noninvasive and Early Detection of Pancreatic Ductal Adenocarcinoma.

Xu, Caiming; Jun, Eunsung; Okugawa, Yoshinaga; Toiyama, Yuji; Borazanci, Erkut; Bolton, John; Taketomi, Akinobu; Kim, Song Cheol; Shang, Dong; Von Hoff, Daniel; Zhang, Guixin; Goel, Ajay.

Gastroenterology; 166(1): 178-190.e16, 2024 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-37839499

4.

Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring.

Shi, Yu; Gao, Weina; Lytle, Nikki K; Huang, Peiwu; Yuan, Xiao; Dann, Amanda M; Ridinger-Saison, Maya; DelGiorno, Kathleen E; Antal, Corina E; Liang, Gaoyang; Atkins, Annette R; Erikson, Galina; Sun, Huaiyu; Meisenhelder, Jill; Terenziani, Elena; Woo, Gyunghwi; Fang, Linjing; Santisakultarm, Thom P; Manor, Uri; Xu, Ruilian; Becerra, Carlos R; Borazanci, Erkut; Von Hoff, Daniel D; Grandgenett, Paul M; Hollingsworth, Michael A; Leblanc, Mathias; Umetsu, Sarah E; Collisson, Eric A; Scadeng, Miriam; Lowy, Andrew M; Donahue, Timothy R; Reya, Tannishtha; Downes, Michael; Evans, Ronald M; Wahl, Geoffrey M; Pawson, Tony; Tian, Ruijun; Hunter, Tony.

Nature; 569(7754): 131-135, 2019 05.

Artículo en Inglés | MEDLINE | ID: mdl-30996350

5.

First-in-Human Phase I Study of Minnelide in Patients With Advanced Gastrointestinal Cancers: Safety, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity.

Borazanci, Erkut; Saluja, Ashok; Gockerman, Jon; Velagapudi, Mohana; Korn, Ronald; Von Hoff, Daniel; Greeno, Ed.

Oncologist; 29(2): 132-141, 2024 Feb 02.

Artículo en Inglés | MEDLINE | ID: mdl-38169017

6.

Tumor and Peritoneum-Associated Macrophage Gene Signature as a Novel Molecular Biomarker in Gastric Cancer.

Sullivan, Kevin M; Li, Haiqing; Yang, Annie; Zhang, Zhifang; Munoz, Ruben R; Mahuron, Kelly M; Yuan, Yate-Ching; Paz, Isaac Benjamin; Von Hoff, Daniel; Han, Haiyong; Fong, Yuman; Woo, Yanghee.

Int J Mol Sci; 25(7)2024 Apr 08.

Artículo en Inglés | MEDLINE | ID: mdl-38612926

7.

Tumor Growth Rate Informs Treatment Efficacy in Metastatic Pancreatic Adenocarcinoma: Application of a Growth and Regression Model to Pivotal Trial and Real-World Data.

Yeh, Celine; Zhou, Mengxi; Sigel, Keith; Jameson, Gayle; White, Ruth; Safyan, Rachael; Saenger, Yvonne; Hecht, Elizabeth; Chabot, John; Schreibman, Stephen; Juzyna, Béata; Ychou, Marc; Conroy, Thierry; Fojo, Tito; Manji, Gulam A; Von Hoff, Daniel; Bates, Susan E.

Oncologist; 28(2): 139-148, 2023 02 08.

Artículo en Inglés | MEDLINE | ID: mdl-36367377

8.

An Exosome-based Transcriptomic Signature for Noninvasive, Early Detection of Patients With Pancreatic Ductal Adenocarcinoma: A Multicenter Cohort Study.

Nakamura, Kota; Zhu, Zhongxu; Roy, Souvick; Jun, Eunsung; Han, Haiyong; Munoz, Ruben M; Nishiwada, Satoshi; Sharma, Geeta; Cridebring, Derek; Zenhausern, Frederic; Kim, Seungchan; Roe, Denise J; Darabi, Sourat; Han, In-Woong; Evans, Douglas B; Yamada, Suguru; Demeure, Michael J; Becerra, Carlos; Celinski, Scott A; Borazanci, Erkut; Tsai, Susan; Kodera, Yasuhiro; Park, Joon Oh; Bolton, John S; Wang, Xin; Kim, Song Cheol; Von Hoff, Daniel; Goel, Ajay.

Gastroenterology; 163(5): 1252-1266.e2, 2022 11.

Artículo en Inglés | MEDLINE | ID: mdl-35850192

9.

Non-coding RNA biomarkers in pancreatic ductal adenocarcinoma.

Sharma, Geeta G; Okada, Yasuyuki; Von Hoff, Daniel; Goel, Ajay.

Semin Cancer Biol; 75: 153-168, 2021 10.

Artículo en Inglés | MEDLINE | ID: mdl-33049362

10.

Identification of Serum miRNA Signature and Establishment of a Nomogram for Risk Stratification in Patients With Pancreatic Ductal Adenocarcinoma.

Kandimalla, Raju; Shimura, Tadanobu; Mallik, Saurav; Sonohara, Fuminori; Tsai, Susan; Evans, Douglas B; Kim, Song Cheol; Baba, Hideo; Kodera, Yasuhiro; Von Hoff, Daniel; Chen, Xi; Goel, Ajay.

Ann Surg; 275(1): e229-e237, 2022 01 01.

Artículo en Inglés | MEDLINE | ID: mdl-32398486

11.

Transcriptomic Profiling Identifies an Exosomal microRNA Signature for Predicting Recurrence Following Surgery in Patients With Pancreatic Ductal Adenocarcinoma.

Nishiwada, Satoshi; Cui, Ya; Sho, Masayuki; Jun, Eunsung; Akahori, Takahiro; Nakamura, Kota; Sonohara, Fuminori; Yamada, Suguru; Fujii, Tsutomu; Han, In Woong; Tsai, Susan; Kodera, Yasuhiro; Park, Joon Oh; Von Hoff, Daniel; Kim, Song Cheol; Li, Wei; Goel, Ajay.

Ann Surg; 276(6): e876-e885, 2022 12 01.

Artículo en Inglés | MEDLINE | ID: mdl-34132691

12.

Mechanisms of GZ17-6.02 resistance.

Booth, Laurence; West, Cameron; Von Hoff, Daniel; Dent, Paul.

Anticancer Drugs; 33(5): 415-423, 2022 06 01.

Artículo en Inglés | MEDLINE | ID: mdl-35276694

13.

A phase II trial of the super-enhancer inhibitor Minnelide™ in advanced refractory adenosquamous carcinoma of the pancreas.

Skorupan, Nebojsa; Ahmad, Mehwish I; Steinberg, Seth M; Trepel, Jane B; Cridebring, Derek; Han, Haiyong; Von Hoff, Daniel D; Alewine, Christine.

Future Oncol; 18(20): 2475-2481, 2022 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-35535581

14.

Author Correction: Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring.

Shi, Yu; Gao, Weina; Lytle, Nikki K; Huang, Peiwu; Yuan, Xiao; Dann, Amanda M; Ridinger-Saison, Maya; DelGiorno, Kathleen E; Antal, Corina E; Liang, Gaoyang; Atkins, Annette R; Erikson, Galina; Sun, Huaiyu; Meisenhelder, Jill; Terenziani, Elena; Woo, Gyunghwi; Fang, Linjing; Santisakultarm, Thom P; Manor, Uri; Xu, Ruilian; Becerra, Carlos R; Borazanci, Erkut; Von Hoff, Daniel D; Grandgenett, Paul M; Hollingsworth, Michael A; Leblanc, Mathias; Umetsu, Sarah E; Collisson, Eric A; Scadeng, Miriam; Lowy, Andrew M; Donahue, Timothy R; Reya, Tannishtha; Downes, Michael; Evans, Ronald M; Wahl, Geoffrey M; Pawson, Tony; Tian, Ruijun; Hunter, Tony.

Nature; 600(7889): E18, 2021 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-34848876

15.

Increasing Stress to Induce Apoptosis in Pancreatic Cancer via the Unfolded Protein Response (UPR).

Botrus, Gehan; Miller, Richard M; Uson Junior, Pedro Luiz Serrano; Kannan, Geoffrey; Han, Haiyong; Von Hoff, Daniel D.

Int J Mol Sci; 24(1)2022 Dec 29.

Artículo en Inglés | MEDLINE | ID: mdl-36614019

16.

Analysis of the Role of Plasma 25-Hydroxyvitamin D Levels in Survival Outcomes in Patients from the Phase III MPACT Trial of Metastatic Pancreatic Cancer.

Von Hoff, Daniel D; Cridebring, Derek; Tian, Olivia Yu; Han, Haiyong; Bhore, Rafia; Franco, Twyla; Ondovik, Michael S; Louis, Chrystal U.

Oncologist; 26(4): e704-e709, 2021 04.

Artículo en Inglés | MEDLINE | ID: mdl-33345430

17.

SuperCT: a supervised-learning framework for enhanced characterization of single-cell transcriptomic profiles.

Xie, Peng; Gao, Mingxuan; Wang, Chunming; Zhang, Jianfei; Noel, Pawan; Yang, Chaoyong; Von Hoff, Daniel; Han, Haiyong; Zhang, Michael Q; Lin, Wei.

Nucleic Acids Res; 47(8): e48, 2019 05 07.

Artículo en Inglés | MEDLINE | ID: mdl-30799483

18.

GZ17-6.02 initiates DNA damage causing autophagosome-dependent HDAC degradation resulting in enhanced anti-PD1 checkpoint inhibitory antibody efficacy.

Booth, Laurence; Roberts, Jane L; West, Cameron; Von Hoff, Daniel; Dent, Paul.

J Cell Physiol; 235(11): 8098-8113, 2020 11.

Artículo en Inglés | MEDLINE | ID: mdl-31951027

19.

Phase 2 study of vismodegib, a hedgehog inhibitor, combined with gemcitabine and nab-paclitaxel in patients with untreated metastatic pancreatic adenocarcinoma.

De Jesus-Acosta, Ana; Sugar, Elizabeth A; O'Dwyer, Peter J; Ramanathan, Ramesh K; Von Hoff, Daniel D; Rasheed, Zeshaan; Zheng, Lei; Begum, Asma; Anders, Robert; Maitra, Anirban; McAllister, Florencia; Rajeshkumar, N V; Yabuuchi, Shinichi; de Wilde, Roeland F; Batukbhai, Bhavina; Sahin, Ismet; Laheru, Daniel A.

Br J Cancer; 122(4): 498-505, 2020 02.

Artículo en Inglés | MEDLINE | ID: mdl-31857726

20.

First-in-Human Phase I Study of MBC-11, a Novel Bone-Targeted Cytarabine-Etidronate Conjugate in Patients with Cancer-Induced Bone Disease.

Zinnen, Shawn Patrick; Karpeisky, Alexander; Von Hoff, Daniel D; Plekhova, Larisa; Alexandrov, Alexander.

Oncologist; 24(3): 303-e102, 2019 03.

Artículo en Inglés | MEDLINE | ID: mdl-30413669

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