Detalles de la búsqueda
1.
Design and synthesis of potent hydroxyethylamine (HEA) BACE-1 inhibitors carrying prime side 4,5,6,7-tetrahydrobenzazole and 4,5,6,7-tetrahydropyridinoazole templates.
Bioorg Med Chem Lett;
22(21): 6721-7, 2012 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23010268
2.
Discovery of 4'-azido-2'-deoxy-2'-C-methyl cytidine and prodrugs thereof: a potent inhibitor of Hepatitis C virus replication.
Bioorg Med Chem Lett;
22(9): 3265-8, 2012 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22472694
3.
Quantification of interactions between drug leads and serum proteins by use of "binding efficiency".
Anal Biochem;
409(2): 163-75, 2011 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21036137
4.
Design and synthesis of potent macrocyclic renin inhibitors.
Bioorg Med Chem Lett;
21(1): 358-62, 2011 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21112780
5.
In vitro resistance profile of the hepatitis C virus NS3/4A protease inhibitor TMC435.
Antimicrob Agents Chemother;
54(5): 1878-87, 2010 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-20176898
6.
Synthesis and SAR of potent inhibitors of the Hepatitis C virus NS3/4A protease: exploration of P2 quinazoline substituents.
Bioorg Med Chem Lett;
20(14): 4004-11, 2010 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20541405
7.
Discovery of potent BACE-1 inhibitors containing a new hydroxyethylene (HE) scaffold: exploration of P1' alkoxy residues and an aminoethylene (AE) central core.
Bioorg Med Chem;
18(4): 1711-23, 2010 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20122837
8.
In vitro activity and preclinical profile of TMC435350, a potent hepatitis C virus protease inhibitor.
Antimicrob Agents Chemother;
53(4): 1377-85, 2009 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-19171797
9.
Screening for NNRTIs with slow dissociation and high affinity for a panel of HIV-1 RT variants.
J Biomol Screen;
14(4): 395-403, 2009 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-19403922
10.
Preclinical evaluation of 1H-benzylindole derivatives as novel human immunodeficiency virus integrase strand transfer inhibitors.
Antimicrob Agents Chemother;
52(8): 2861-9, 2008 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-18541726
11.
Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350.
Bioorg Med Chem Lett;
18(17): 4853-8, 2008 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18678486
12.
Discovery of novel, potent and bioavailable proline-urea based macrocyclic HCV NS3/4A protease inhibitors.
Bioorg Med Chem Lett;
18(23): 6189-93, 2008 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18954982
13.
Design and synthesis of potent inhibitors of plasmepsin I and II: X-ray crystal structure of inhibitor in complex with plasmepsin II.
J Med Chem;
48(13): 4400-9, 2005 Jun 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-15974592
14.
Induced-fit binding of the macrocyclic noncovalent inhibitor TMC435 to its HCV NS3/NS4A protease target.
Angew Chem Int Ed Engl;
49(9): 1652-5, 2010 Feb 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-20166108
15.
Improved structure-activity relationship analysis of HIV-1 protease inhibitors using interaction kinetic data.
J Med Chem;
47(24): 5953-61, 2004 Nov 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-15537350
16.
Design and synthesis of plasmepsin I and plasmepsin II inhibitors with activity in Plasmodium falciparum-infected cultured human erythrocytes.
J Med Chem;
46(5): 734-46, 2003 Feb 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-12593654
17.
Design and synthesis of potent inhibitors of the malaria aspartyl proteases plasmepsin I and II. Use of solid-phase synthesis to explore novel statine motifs.
J Med Chem;
47(13): 3353-66, 2004 Jun 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-15189032
18.
Transient replication of a hepatitis C virus genotype 1b replicon chimera encoding NS5A-5B from genotype 3a.
J Virol Methods;
195: 156-63, 2014 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-24120570
19.
Synthesis of P1'-functionalized macrocyclic transition-state mimicking HIV-1 protease inhibitors encompassing a tertiary alcohol.
J Med Chem;
57(15): 6444-57, 2014 Aug 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-25054811
20.
Resolution of the interaction mechanisms and characteristics of non-nucleoside inhibitors of hepatitis C virus polymerase.
Antiviral Res;
97(3): 356-68, 2013 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-23305851