Búsqueda | Portal de Búsqueda de la BVS España

1.

The Dopamine D1 Receptor Positive Allosteric Modulator Mevidalen (LY3154207) Enhances Wakefulness in the Humanized D1 Mouse and in Sleep-Deprived Healthy Male Volunteers.

McCarthy, Andrew P; Svensson, Kjell A; Shanks, Elaine; Brittain, Claire; Eastwood, Brian J; Kielbasa, William; Biglan, Kevin M; Wafford, Keith A.

J Pharmacol Exp Ther; 380(3): 143-152, 2022 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-34893551

2.

REM sleep's unique associations with corticosterone regulation, apoptotic pathways, and behavior in chronic stress in mice.

Nollet, Mathieu; Hicks, Harriet; McCarthy, Andrew P; Wu, Huihai; Möller-Levet, Carla S; Laing, Emma E; Malki, Karim; Lawless, Nathan; Wafford, Keith A; Dijk, Derk-Jan; Winsky-Sommerer, Raphaelle.

Proc Natl Acad Sci U S A; 116(7): 2733-2742, 2019 02 12.

Artículo en Inglés | MEDLINE | ID: mdl-30683720

3.

Effects of Aging on Cortical Neural Dynamics and Local Sleep Homeostasis in Mice.

McKillop, Laura E; Fisher, Simon P; Cui, Nanyi; Peirson, Stuart N; Foster, Russell G; Wafford, Keith A; Vyazovskiy, Vladyslav V.

J Neurosci; 38(16): 3911-3928, 2018 04 18.

Artículo en Inglés | MEDLINE | ID: mdl-29581380

4.

Modelling maintenance of wakefulness in rats: comparing potential non-invasive sleep-restriction methods and their effects on sleep and attentional performance.

Mccarthy, Andrew; Loomis, Sally; Eastwood, Brian; Wafford, Keith A; Winsky-Sommerer, Raphaëlle; Gilmour, Gary.

J Sleep Res; 26(2): 179-187, 2017 04.

Artículo en Inglés | MEDLINE | ID: mdl-27739157

5.

Novel bicyclo[3.1.0]hexane analogs as antagonists of metabotropic glutamate 2/3 receptors for the treatment of depression.

Dressman, Bruce A; Tromiczak, Eric G; Chappell, Mark D; Tripp, Allie E; Quimby, Steven J; Vetman, Tatiana; Fivush, Adam M; Matt, James; Jaramillo, Carlos; Li, Renhua; Khilevich, Albert; Blanco, Maria-Jesus; Smith, Stephon C; Carpintero, Mercedes; de Diego, José Eugenio; Barberis, Mario; García-Cerrada, Susana; Soriano, José F; Schkeryantz, Jeffrey M; Witkin, Jeffrey M; Wafford, Keith A; Seidel, Wesley; Britton, Thomas; Overshiner, Carl D; Li, Xia; Wang, Xu-Shan; Heinz, Beverly A; Catlow, John T; Swanson, Steven; Bedwell, David; Ornstein, Paul L; Mitch, Charles H.

Bioorg Med Chem Lett; 26(23): 5663-5668, 2016 12 01.

Artículo en Inglés | MEDLINE | ID: mdl-27836401

6.

N-(4-((2-(trifluoromethyl)-3-hydroxy-4-(isobutyryl)phenoxy)methyl)benzyl)-1-methyl-1H-imidazole-4-carboxamide (THIIC), a novel metabotropic glutamate 2 potentiator with potential anxiolytic/antidepressant properties: in vivo profiling suggests a link between behavioral and central nervous system neurochemical changes.

Fell, Matthew J; Witkin, Jeffrey M; Falcone, Julie F; Katner, Jason S; Perry, Kenneth W; Hart, John; Rorick-Kehn, Linda; Overshiner, Carl D; Rasmussen, Kurt; Chaney, Stephen F; Benvenga, Mark J; Li, Xia; Marlow, Deanna L; Thompson, Linda K; Luecke, Susan K; Wafford, Keith A; Seidel, Wesley F; Edgar, Dale M; Quets, Anne T; Felder, Christian C; Wang, XuShan; Heinz, Beverly A; Nikolayev, Alexander; Kuo, Ming-Shang; Mayhugh, Daniel; Khilevich, Albert; Zhang, Deyi; Ebert, Philip J; Eckstein, James A; Ackermann, Bradley L; Swanson, Steven P; Catlow, John T; Dean, Robert A; Jackson, Kimberley; Tauscher-Wisniewski, Sitra; Marek, Gerard J; Schkeryantz, Jeffrey M; Svensson, Kjell A.

J Pharmacol Exp Ther; 336(1): 165-77, 2011 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-20947638

7.

Aberrant waste disposal in neurodegeneration: why improved sleep could be the solution.

Wafford, Keith A.

Cereb Circ Cogn Behav; 2: 100025, 2021.

Artículo en Inglés | MEDLINE | ID: mdl-36324713

8.

In vitro and in vivo properties of 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA receptor alpha5 subtype-selective inverse agonist.

Atack, John R; Maubach, Karen A; Wafford, Keith A; O'Connor, Desmond; Rodrigues, A David; Evans, David C; Tattersall, F David; Chambers, Mark S; MacLeod, Angus M; Eng, Wai-Si; Ryan, Christine; Hostetler, Eric; Sanabria, Sandra M; Gibson, Raymond E; Krause, Stephen; Burns, H Donald; Hargreaves, Richard J; Agrawal, Nancy G B; McKernan, Ruth M; Murphy, M Gail; Gingrich, Kevin; Dawson, Gerard R; Musson, Donald G; Petty, Kevin J.

J Pharmacol Exp Ther; 331(2): 470-84, 2009 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-19704033

9.

Pharmacological Modulation of Sleep Homeostasis in Rat: Novel Effects of an mGluR2/3 Antagonist.

Hanley, Nicola; Paulissen, Jerome; Eastwood, Brian J; Gilmour, Gary; Loomis, Sally; Wafford, Keith A; McCarthy, Andrew.

Sleep; 42(9)2019 09 06.

Artículo en Inglés | MEDLINE | ID: mdl-31106825

10.

The expression of GABAA beta subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells.

Herd, Murray B; Haythornthwaite, Alison R; Rosahl, Thomas W; Wafford, Keith A; Homanics, Gregg E; Lambert, Jeremy J; Belelli, Delia.

J Physiol; 586(4): 989-1004, 2008 Feb 15.

Artículo en Inglés | MEDLINE | ID: mdl-18079158

11.

Investigating the role of mGluR2 versus mGluR3 in antipsychotic-like effects, sleep-wake architecture and network oscillatory activity using novel Han Wistar rats lacking mGluR2 expression.

Wood, Christian M; Wafford, Keith A; McCarthy, Andrew P; Hewes, Nicola; Shanks, Elaine; Lodge, David; Robinson, Emma S J.

Neuropharmacology; 140: 246-259, 2018 09 15.

Artículo en Inglés | MEDLINE | ID: mdl-30005976

12.

Preclinical profile of a dopamine D1 potentiator suggests therapeutic utility in neurological and psychiatric disorders.

Bruns, Robert F; Mitchell, Stephen N; Wafford, Keith A; Harper, Alex J; Shanks, Elaine A; Carter, Guy; O'Neill, Michael J; Murray, Tracey K; Eastwood, Brian J; Schaus, John M; Beck, James P; Hao, Junliang; Witkin, Jeffrey M; Li, Xia; Chernet, Eyassu; Katner, Jason S; Wang, Hong; Ryder, John W; Masquelin, Meghane E; Thompson, Linda K; Love, Patrick L; Maren, Deanna L; Falcone, Julie F; Menezes, Michelle M; Zhang, Linli; Yang, Charles R; Svensson, Kjell A.

Neuropharmacology; 128: 351-365, 2018 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-29102759

13.

Alpha5GABAA receptors mediate the amnestic but not sedative-hypnotic effects of the general anesthetic etomidate.

Cheng, Victor Y; Martin, Loren J; Elliott, Erin M; Kim, John H; Mount, Howard T J; Taverna, Franco A; Roder, John C; Macdonald, John F; Bhambri, Amit; Collinson, Neil; Wafford, Keith A; Orser, Beverley A.

J Neurosci; 26(14): 3713-20, 2006 Apr 05.

Artículo en Inglés | MEDLINE | ID: mdl-16597725

14.

Treating insomnia: Current and investigational pharmacological approaches.

Ebert, Bjarke; Wafford, Keith A; Deacon, Stephen.

Pharmacol Ther; 112(3): 612-29, 2006 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-16876255

15.

Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands.

Fradley, Rosa L; Guscott, Martin R; Bull, Sharlene; Hallett, David J; Goodacre, Simon C; Wafford, Keith A; Garrett, Elizabeth M; Newman, Richard J; O'Meara, Gillian F; Whiting, Paul J; Rosahl, Thomas W; Dawson, Gerard R; Reynolds, David S; Atack, John R.

J Psychopharmacol; 21(4): 384-91, 2007 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-17092983

16.

Gaboxadol--a new awakening in sleep.

Wafford, Keith A; Ebert, Bjarke.

Curr Opin Pharmacol; 6(1): 30-6, 2006 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-16368265

17.

Polypharmacological in Silico Bioactivity Profiling and Experimental Validation Uncovers Sedative-Hypnotic Effects of Approved and Experimental Drugs in Rat.

Drakakis, Georgios; Wafford, Keith A; Brewerton, Suzanne C; Bodkin, Michael J; Evans, David A; Bender, Andreas.

ACS Chem Biol; 12(6): 1593-1602, 2017 06 16.

Artículo en Inglés | MEDLINE | ID: mdl-28414209

18.

Phase-amplitude coupled persistent theta and gamma oscillations in rat primary motor cortex in vitro.

Johnson, Nicholas W; Özkan, Mazhar; Burgess, Adrian P; Prokic, Emma J; Wafford, Keith A; O'Neill, Michael J; Greenhill, Stuart D; Stanford, Ian M; Woodhall, Gavin L.

Neuropharmacology; 119: 141-156, 2017 06.

Artículo en Inglés | MEDLINE | ID: mdl-28400257

19.

Electroencephalographic, cognitive, and neurochemical effects of LY3130481 (CERC-611), a selective antagonist of TARP-Î³8-associated AMPA receptors.

Witkin, Jeffrey M; Li, Jennifer; Gilmour, Gary; Mitchell, Stephen N; Carter, Guy; Gleason, Scott D; Seidel, Wesley F; Eastwood, Brian J; McCarthy, Andrew; Porter, Warren J; Reel, Jon; Gardinier, Kevin M; Kato, Akihiko S; Wafford, Keith A.

Neuropharmacology; 126: 257-270, 2017 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-28757050

20.

TaiNi: Maximizing research output whilst improving animals' welfare in neurophysiology experiments.

Jiang, Zhou; Huxter, John R; Bowyer, Stuart A; Blockeel, Anthony J; Butler, James; Imtiaz, Syed A; Wafford, Keith A; Phillips, Keith G; Tricklebank, Mark D; Marston, Hugh M; Rodriguez-Villegas, Esther.

Sci Rep; 7(1): 8086, 2017 08 14.

Artículo en Inglés | MEDLINE | ID: mdl-28808347

Portal de Búsqueda de la BVS España

Información y Conocimiento para la Salud

Configurar filtros

Su selección (0)

Formato de exportación:

Exportar: