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1.
Molecules ; 28(19)2023 Oct 09.
Artículo en Inglés | MEDLINE | ID: mdl-37836836

RESUMEN

Efficient and stable electrode materials are urgently required for wastewater treatment in the electrocatalytic degradation of toxic and refractory organic pollutants. Ti3+ self-doping black TiO2 nanotube arrays (Ti/B-TiO2-NTs) as an interlayer were used for preparing a novel PbO2 electrode via an electrochemical reduction technology, and a sodium dodecyl sulfate (SDS)-modified PbO2 catalytic layer was successfully achieved via an electrochemical deposition technology. The physicochemical characterization tests showed that the Ti/B-TiO2-NTs/PbO2-SDS electrodes have a denser surface and finer grain size with the introduction of Ti3+ in the interlayer of Ti/TiO2-NTs and the addition of SDS in the active layer of PbO2. The electrochemical characterization results showed that the Ti3+ self-doping black Ti/TiO2-NTs/PbO2-SDS electrode had higher oxygen evolution potential (2.11 V vs. SCE), higher electrode stability, smaller charge-transfer resistance (6.74 Ω cm-2), and higher hydroxyl radical production activity, leading to it possessing better electrocatalytic properties. The above results indicated that the physicochemical and electrochemical characterization of the PbO2 electrode were all enhanced significantly with the introduction of Ti3+ and SDS. Furthermore, the Ti/B-TiO2-NTs/PbO2-SDS electrodes displayed the best performance on the degradation of methylene blue (MB) in simulated wastewater via bulk electrolysis. The removal efficiency of MB and the chemical oxygen demand (COD) could reach about 99.7% and 80.6% under the optimal conditions after 120 min, respectively. The pseudo-first-order kinetic constant of the Ti/B-TiO2-NTs/PbO2-SDS electrode was 0.03956 min-1, which was approximately 3.18 times faster than that of the Ti/TiO2-NTs/PbO2 electrode (0.01254 min-1). In addition, the Ti/B-TiO2-NTs/PbO2-SDS electrodes showed excellent stability and reusability. The degradation mechanism of MB was explored via the experimental identification of intermediates. In summary, the Ti3+ self-doping black Ti/TiO2-NTs/PbO2-SDS electrode is a promising electrode in treating wastewater.

2.
Plant Foods Hum Nutr ; 78(2): 329-335, 2023 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-36964883

RESUMEN

Durian seeds are normally considered as agricultural waste in durian fruit processing, resulting in a huge waste of resources. The structure characterization of polysaccharide from durian seed and its neuroprotective effects against Alzheimer's disease (AD) in a transgenic Caenorhabditis elegans model were conducted in this study. A water-soluble polysaccharide was obtained using atmospheric pressure plasma treatment, and named DSPP-1. DSPP-1 was composed of rhamnose, galactose and galacturonic acid and its molecular weight was 3.765 × 105 Da. PDSP and DSPP-1 showed considerable antioxidant activity in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging compared to the positive control (vitamin C). Besides, compared with the positive group (epigallocatechin gallate), PDSP and DSPP-1 exhibited the certain Abeta1 - 42 aggregation inhibitory effectiveness (p < 0.05). In contrast, DSPP-2 exerted a poor antioxidant and anti-aggregation effect (p < 0.05). In vivo results showed that DSPP-1 could decrease abnormal Aß1-42 aggregation to delay the paralysis process of AD-nematodes. Moreover, DSPP-1 significantly improved the antioxidant enzyme activities and reduced lipid peroxidation in AD-nematodes. Taken together, these results indicated that DSPP-1 could be used as a potential natural source for the prevention and treatment of AD.


Asunto(s)
Enfermedad de Alzheimer , Bombacaceae , Animales , Enfermedad de Alzheimer/tratamiento farmacológico , Enfermedad de Alzheimer/prevención & control , Caenorhabditis elegans , Antioxidantes/farmacología , Antioxidantes/análisis , Péptidos beta-Amiloides/análisis , Semillas/química , Polisacáridos/farmacología
3.
Phys Chem Chem Phys ; 23(18): 10946-10952, 2021 May 12.
Artículo en Inglés | MEDLINE | ID: mdl-33913457

RESUMEN

Due to their strong relativistic effects, Au clusters exhibit many unusual geometric structures. Among them, Au7-, Au8 and Au9+ have 18 valence electrons satisfying the magic numbers in the jellium model, respectively, but these three non-spherical clusters are not superatoms. In general, a single dopant atom can drastically change the structural and electronic properties of Au clusters. Here, we searched structures of NiAu7-, NiAu8 and NiAu9+ clusters using the genetic algorithm program (GA) combined with density functional theory (DFT). It was found that the alloy clusters are all 3D spherical structures. The molecular orbitals and density of states analysis indicate that they have completely filled superatomic shells (1S21P6), in which the electronic structure of the Ni atom is d10. Then, the electrostatic potential surfaces of the alloy clusters are analyzed, and the calculated results show that the NiAu8 superatom has remarkable σ-holes with positive potential regions. Moreover, these electron-deficient regions can be considered as interaction sites with some electron donors. After a Lewis base CO gas molecule is adsorbed on the Au-based superatom, we found that the C-O bond distance becomes slightly elongated and its stretching frequency presents a significant red-shift. This is due to the fact that 5d electrons of the Au atom of the NiAu8 transfer towards the anti-bond π orbitals of the CO molecule. Hence, this is an effective strategy for finding new types of superatoms and potential catalysts for covalent bond activation.

4.
Sensors (Basel) ; 20(6)2020 Mar 22.
Artículo en Inglés | MEDLINE | ID: mdl-32235812

RESUMEN

Forecasting vessel flows is important to the development of intelligent transportation systems in the maritime field, as real-time and accurate traffic information has favorable potential in helping a maritime authority to alleviate congestion, mitigate emission of GHG (greenhouse gases) and enhance public safety, as well as assisting individual vessel users to plan better routes and reduce additional costs due to delays. In this paper, we propose three deep learning-based solutions to forecast the inflow and outflow of vessels within a given region, including a convolutional neural network (CNN), a long short-term memory (LSTM) network, and the integration of a bidirectional LSTM network with a CNN (BDLSTM-CNN). To apply those solutions, we first divide the given maritime region into M × N grids, then we forecast the inflow and outflow for all the grids. Experimental results based on the real AIS (Automatic Identification System) data of marine vessels in Singapore demonstrate that the three deep learning-based solutions significantly outperform the conventional method in terms of mean absolute error and root mean square error, with the performance of the BDLSTM-CNN-based hybrid solution being the best.

5.
J Nat Prod ; 82(6): 1503-1509, 2019 06 28.
Artículo en Inglés | MEDLINE | ID: mdl-31117520

RESUMEN

Six new macrolides named myrothecines D-G (1-4), 16-hydroxymytoxin B (5), and 14'-dehydrovertisporin (6), including four 10,13-cyclotrichothecane derivatives, in addition to 12 known compounds (7-18), were isolated from three endophytic Myrothecium roridum, IFB-E008, IFB-E009, and IFB-E012. The isolated compounds were characterized by MS, NMR, CD, and single-crystal X-ray crystallography. The isolated macrolides exhibited an antiproliferation effect against chronic myeloid leukemia K562 and colorectal carcinoma SW1116 cell lines. Compounds 1-6 were cytotoxic, with IC50 values ranging between 56 nM and 16 µM. Since slight structural changes led to obvious activity differences, the CoMFA (comparative molecular field analysis) and CoMSIA (comparative molecular similarity indices analysis) methods were then used to explore the 3D QSAR (three-dimensional quantitative structure-activity relationship) of these macrolides. The result showed that the steric, electrostatic, hydrophobic, and H-bond acceptor factors were involved in their cytotoxicity and provided an in-depth understanding of the structure-activity relationships of these metabolites.


Asunto(s)
Antibacterianos/farmacología , Antineoplásicos/farmacología , Hypocreales/química , Macrólidos/farmacología , Hongos Mitospóricos/química , Inhibidores de la Síntesis de la Proteína/farmacología , Tricotecenos/farmacología , Antibacterianos/química , Antibacterianos/aislamiento & purificación , Antineoplásicos/química , Antineoplásicos/aislamiento & purificación , Cristalografía por Rayos X , Macrólidos/química , Macrólidos/aislamiento & purificación , Espectroscopía de Resonancia Magnética , Estructura Molecular , Inhibidores de la Síntesis de la Proteína/química , Inhibidores de la Síntesis de la Proteína/aislamiento & purificación , Relación Estructura-Actividad Cuantitativa , Tricotecenos/química , Tricotecenos/aislamiento & purificación
6.
Mar Drugs ; 16(11)2018 Oct 23.
Artículo en Inglés | MEDLINE | ID: mdl-30360544

RESUMEN

The chemical investigation of the culture filtrate of endophyte Alternaria sp. W-1 associated with Laminaria japonica provided a new tricycloalternarene compound, 2H-(2E)-tricycloalternarene 12a (1), together with five known analogs: (2E)-tricycloalternarene 12a (2), tricycloalternarene 3a (3), tricycloalternarene F (4), 15-hydroxyl tricycloalternarene 5b (5), and ACTG-Toxin D (6). In vitro cytotoxicity against the human hepatocellular carcinoma cell line SMMC-7721 and the human gastric carcinoma cell line SGC-7901 was evaluated by the MTT method. Compounds 1, 3, and 4 inhibited the growth of SMMC-7721 cells with IC50 values of 49.7 ± 1.1, 45.8 ± 4.6, and 80.3 ± 3.8 µg/mL, respectively, while the IC50 value of the positive control cisplatin was 6.5 ± 0.5 µg/mL. Compounds 3 and 6 also showed moderate anti-proliferation activity against SGC-7901 cells with IC50 values of 53.2 ± 2.9 and 35.1 ± 0.8 µg/mL, respectively, while the IC50 value of cisplatin was 4.5 ± 0.6 µg/mL. Further studies revealed that the in vitro anticancer activity of compound 3 to SMMC-7721 cells was related to G1 phase cell cycle arrest and cell apoptosis, and the induced apoptosis was involved in both the mitochondrial pathway and the death receptor pathway. This is the first report on the anticancer mechanism of tricycloalternarene compounds.


Asunto(s)
Alternaria/química , Antineoplásicos/farmacología , Laminaria/microbiología , Terpenos/farmacología , Alternaria/aislamiento & purificación , Antineoplásicos/química , Apoptosis/efectos de los fármacos , Carcinoma Hepatocelular/tratamiento farmacológico , Caspasa 3/metabolismo , Caspasa 8/metabolismo , Línea Celular Tumoral , Proliferación Celular/efectos de los fármacos , Inhibidor p27 de las Quinasas Dependientes de la Ciclina/metabolismo , Endófitos/química , Puntos de Control de la Fase G1 del Ciclo Celular/efectos de los fármacos , Humanos , Neoplasias Hepáticas/tratamiento farmacológico , Proteínas Proto-Oncogénicas c-bcl-2/metabolismo , Neoplasias Gástricas/tratamiento farmacológico , Terpenos/química , Proteína X Asociada a bcl-2/metabolismo
7.
Environ Microbiol ; 19(6): 2483-2494, 2017 06.
Artículo en Inglés | MEDLINE | ID: mdl-28464383

RESUMEN

Interactions among microbes determine the prevalence of harmful algal blooms that threaten water quality. These interactions can be indirectly mediated by shared resources or consumers, or through interference by the production of allelochemicals. Allelopathic interactions and resource competition have been shown to occur among algae and associated microbes. However, little work has considered seasonal influences on ecosystem structure and function. Here, we report results of our investigations on seasonal changes in the interactions between benthic microbial assemblies and the bloom forming cyanobacterium Microcystis aeruginosa. We show that phosphorus (P) competition and allelopathy by the microbial assembly vary seasonally and inhibit growth of M. aeruginosa. The interactions per unit biomass of the microbial assembly are stronger under winter than summer conditions and inhibit the recruitment of the cyanobacteria, thereby preventing the reoccurrence of cyanobacterial blooms in the following summer. The seasonality of these interactions correlates with changes in composition, metabolic activity and functional diversity of the microbial assembly. Our findings highlight the importance of competitive and allelopathic interactions in regulating the occurrence of harmful algal blooms. Our results also imply that seasonal variation of competition and allelopathy of the microbial assembly might be beneficial to adjust aquatic ecosystem structure and function.


Asunto(s)
Alelopatía/fisiología , Floraciones de Algas Nocivas , Microcystis/crecimiento & desarrollo , Microcystis/metabolismo , Fósforo/metabolismo , Biomasa , Ecosistema , Feromonas/biosíntesis , Estaciones del Año
8.
J Mater Sci Mater Med ; 28(6): 82, 2017 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-28424946

RESUMEN

In this work, a magnesium phytic acid/hydroxyapatite composite coating was successfully prepared on AZ31 magnesium alloy substrate by chemical conversion deposition technology with the aim of improving its corrosion resistance and bioactivity. The influence of hydroxyapatite (HA) content on the microstructure and corrosion resistance of the coatings was investigated. The results showed that with the increase of HA content in phytic acid solution, the cracks on the surface of the coatings gradually reduced, which subsequently improved the corrosion resistance of these coated magnesium alloy. Electrochemical measurements in simulated body fluid (SBF) revealed that the composite coating with 45 wt.% HA addition exhibited superior surface integrity and significantly improved corrosion resistance compared with the single phytic acid conversion coating. The results of the immersion test in SBF showed that the composite coating could provide more effective protection for magnesium alloy substrate than that of the single phytic acid coating and showed good bioactivity. Magnesium phytic acid/hydroxyapatite composite, with the desired bioactivity, can be synthesized through chemical conversion deposition technology as protective coatings for surface modification of the biodegradable magnesium alloy implants. The design idea of the new type of biomaterial is belong to the concept of "third generation biomaterial". Corrosion behavior and bioactivity of coated magnesium alloy are the key issues during implantation. In this study, preparation and corrosion behavior of magnesium phytic acid/hydroxyapatite composite coatings on magnesium alloy were studied. The basic findings and significance of this paper are as follows: 1. A novel environmentally friendly, homogenous and crack-free magnesium phytic acid/hydroxyapatite composite coating was fabricated on AZ31 magnesium alloy via chemical conversion deposition technology with the aim of enhancing its corrosion resistance and bioactivity. The chemical conversion coatings, which are formed through the reaction between the substrate and the environment, have attracted increasing attention owing to the relative low treatment temperature, favorable bonding to substrate and simple implementation process. 2. With the increasing of hydroxyapatite (HA) content, the crack width in the composite coatings and the thickness of the coatings exhibit obviously decreased. The reason is probably that when adding HA into the phytic acid solution, the amount of active hydroxyl groups in the phytic acid are reduced via forming the coordination bond between P-OH groups from phytic acid and P-OH groups from the surface of HA, thus decreasing the coating thickness and hydrogen formation, as well as avoiding coating cracking. 3. By adjusting the HA content to 45 wt.%, a dense and relatively smooth composite coating with ~1.4 µm thickness is obtained on magnesium alloy, and exhibits high corrosion resistance and good bioactivity when compared with the single phytic acid conversion coating.


Asunto(s)
Implantes Absorbibles , Aleaciones/química , Durapatita/química , Compuestos de Magnesio/química , Ácido Fítico/química , Materiales Biocompatibles Revestidos/química , Corrosión , Ensayo de Materiales , Microscopía Electrónica de Rastreo , Espectroscopía Infrarroja por Transformada de Fourier , Propiedades de Superficie
9.
Zhongguo Zhong Yao Za Zhi ; 42(21): 4142-4149, 2017 Nov.
Artículo en Zh | MEDLINE | ID: mdl-29271152

RESUMEN

Isolation and purification of chemical constituents of liquid culture of symbiotic Chaetomium globosum ML-4 of oyster was performed through silica gel column chromatography, gel filtration over Sephadex LH-20, preparative TLC and HPLC. Five compounds were obtained and their structures were determined as chaetoglobosin V(1), chaetoglobosin Vb(2), tyrosol(3), 5-methyluracil(4)and uracil(5), respectively, based on HR-MS and NMR data and comparison with literatures. In vitro cytotoxicity of compounds against human hepatocellular carcinoma cell line SMMC-7721 were measured byMTT method, and results showed that compound 1 could obviously inhibit the proliferation of SMMC-7721 cells with an IC50 value of 60.5 mg•L⁻¹, while the IC50 value of positive control cisplatin was 19.96 mg•L⁻¹. Further studies discovered that compound 1 could lead to G2 phase arrest in SMMC-7721 cells and induce SMMC-7721 cells apoptosis. The ratio of Bcl-2/Bax in SMMC-7721 cells was decreased. The expression of protein Caspases-3,-8,-9 was improved and the expression and phosphorylation level of Akt were reduced. Aforementioned results revealed that in vitro antitumor activity of compound 1 against SMMC-7721 cells were related to G2 phase cell cycle arrest and induced-apoptosis. The induced-apoptosis was involved in both the mitochondrial pathway and the death receptor pathway and connected with activity decline of PI3K/Akt signaling pathway.


Asunto(s)
Carcinoma Hepatocelular/patología , Chaetomium/química , Neoplasias Hepáticas/patología , Ostreidae/microbiología , Animales , Apoptosis , Carcinoma Hepatocelular/tratamiento farmacológico , Puntos de Control del Ciclo Celular , Línea Celular Tumoral , Humanos , Neoplasias Hepáticas/tratamiento farmacológico , Fosfatidilinositol 3-Quinasas , Transducción de Señal
10.
J Asian Nat Prod Res ; 15(12): 1284-9, 2013.
Artículo en Inglés | MEDLINE | ID: mdl-24152038

RESUMEN

A new trichothecene, 12'-episatratoxin H (1), together with three known analogs: roridin A (2), 16-hydroxyroridin E (3), and roridin E (4), was isolated from the culture broth of the symbiotic fungus Myrothecium roridum QDFE005, which was isolated from Mactra chinensis. Their structures were elucidated on the basis of spectroscopic methods, including 1D and 2D NMR (COSY, HMQC, and HMBC) techniques. Compound 1 exhibited significant cytotoxicity against the human tumor cell lines KB and HepG2 with IC50 values of 1.42 and 2.27 µM, respectively.


Asunto(s)
Antineoplásicos/aislamiento & purificación , Bivalvos/microbiología , Hypocreales/química , Tricotecenos/aislamiento & purificación , Animales , Antineoplásicos/química , Antineoplásicos/farmacología , Ensayos de Selección de Medicamentos Antitumorales , Humanos , Estructura Molecular , Resonancia Magnética Nuclear Biomolecular , Tricotecenos/química , Tricotecenos/farmacología
11.
J Med Food ; 26(1): 14-26, 2023 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-36595373

RESUMEN

Previous reports revealed that peel extracts of Ficus carica (fig) have a wide range of pharmacological and biological activities. The current study aimed to determine the phytochemical components of the ethanol extracts of Peggy Red fig (PRF) and Green fig (GF) peels by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis, along with its antioxidant properties and neuroprotective effect in Caenorhabditis elegans. LC-MS/MS analysis confirmed 50 compounds in the extract, which revealed the presence of phenols, flavonoids, and anthocyanins, and exhibited in vitro antioxidant activity. PRF and GF peel had 163.25 (mg gallic acid equivalent [mg GAE]) g-1, 125.32 (mg GAE) g-1 of total phenolic content, 62.52 (mg rutin equivalent [mg RE]) g-1, and 43.36 (mg RE) g-1 flavonoids content, respectively. In all antioxidant assays, the extract of PRF peel showed higher antioxidant activity than the GF peel, and the extract of PRF peel could effectively reduce the aggregation of amyloid-beta (Aß), decrease the paralysis of the body, and increase the antioxidant enzyme activities to reduce the toxicity of Aß1-42 in Alzheimer's disease (AD) transgenic C. elegans CL4176. Therefore, PRF peel extract may have potential applications as a new source for drug development against AD.


Asunto(s)
Antioxidantes , Ficus , Animales , Antioxidantes/farmacología , Antioxidantes/análisis , Caenorhabditis elegans , Ficus/química , Antocianinas/análisis , Cromatografía Liquida , Espectrometría de Masas en Tándem , Extractos Vegetales/química , Flavonoides/farmacología , Flavonoides/análisis , Fenoles/farmacología , Fenoles/análisis , Ácido Gálico/análisis
12.
Chemosphere ; 313: 137591, 2023 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-36563722

RESUMEN

Photoelectrocatalysis (PEC) has long been regarded as an efficient and green method to eliminate various organic pollutants from wastewater. However, the lack of highly photoelectrocatalytic active and stable electrodes limits the development of the PEC technologies. Herein, a novel hierarchical photo-electrode with hollow Cu1.8S/NH2-La MOFs decorated black titanium dioxide nanotubes (Cu1.8S/NH2-La MOFs/Black TNTs) was fabricated by a two-step water-heating method. The prepared photoelectrode was used to degradation of 2, 4-dichlorophenol (2, 4-DCP). Analysis of photoelectrocatalytic degradation process of 2, 4-DCP was evaluated using UV-Vis absorption spectroscopy and the main degradation paths were analyzed by LC-MS. The results showed that 99.3% of the pollutant could be rapidly degraded within 180 min. Furthermore, the Cu1.8S/NH2-La MOFs/Black TNTs photoelectric pole exhibited excellent stability after 15 cycling experiments.


Asunto(s)
Contaminantes Ambientales , Nanotubos , Nanotubos/química , Contaminantes Ambientales/química , Fenoles , Electrodos , Titanio/química , Catálisis
13.
Chemosphere ; 312(Pt 1): 137237, 2023 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-36400199

RESUMEN

Photoelectrocatalysis (PEC) can effectively degrade organic pollutants by using photoelectrodes without secondary pollution. However, significant mass transport resistance and decreased catalytic activity caused by the shedding of active components remain a barrier to achieving the photocatalytic system with a high degradation rate and long-term durability. Here, an in situ recombination concept is presented to overcome this challenge. The bionic coral-like electrode, obtained by in situ assembly of UIO-66 around TiO2 nanoflowers (TNF) on Ti-foam substrate, is employed as the photoanode in PEC. Ex situ evaluation of photoelectrochemical activity demonstrates that the UIO-66@TNF/Ti-foam (U@T/T) design significantly improves the light-propagation, light-absorption and charge transfer. In Situ degradation evaluations also shows that the interesting design promotes rapid and stable degradation of organic dye (e.g. Rhodamine B (RhB)). At 2.0 V of bias potential and pH 7.0 in 5 mg L-1 RhB, under the action of active species such as ·O2- and ·OH (proved by the degradation mechanism experiments), the removal rate of RhB can reach 96.1% at 120 min and almost complete removal at 200 min (99.1%).


Asunto(s)
Ácidos Ftálicos , Aguas Residuales , Titanio , Colorantes , Catálisis , Recombinación Genética
14.
J Med Food ; 25(7): 751-759, 2022 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-35730991

RESUMEN

Alcoholic liver disease (ALD) has become a global health problem. The hepatoprotective effects of bioactive ingredients extracted from Rumex hanus by. on chronic alcoholic liver injury was investigated for the first time. The extract from R. hanus by. (ERHB) was obtained by 70% ethanol extraction, and the endotoxin antagonism rate of ERHB was 88.94 ± 1.24% in vitro. The animal experiments demonstrated that ERHB promoted hepatic function by significantly enhancing the activities of alcohol dehydrogenase and acetaldehyde dehydrogenase, and by reducing the activities of cytochrome P450 proteins, alkaline phosphatase, aspartate aminotransferase, and alanine aminotransferase. Furthermore, ERHB improved alcohol-induced dyslipidemia by regulating lipid metabolism. In addition, ERHB ameliorated the alcohol-induced liver injury by inhibiting endotoxin-caused inflammation. Seven compounds with antagonistic activity on endotoxin were identified in ERHB. These results demonstrated that ERHB had protective effects on ALD and if the results can be confirmed in humans, it might be useful as a functional food supplement for ALD treatment.


Asunto(s)
Enfermedad Hepática Crónica Inducida por Sustancias y Drogas , Hepatopatías Alcohólicas , Rumex , Animales , Endotoxinas , Etanol/efectos adversos , Etanol/metabolismo , Humanos , Hígado/metabolismo , Hepatopatías Alcohólicas/tratamiento farmacológico , Hepatopatías Alcohólicas/prevención & control , Ratones , Extractos Vegetales/metabolismo , Extractos Vegetales/farmacología , Extractos Vegetales/uso terapéutico
15.
Sci Rep ; 12(1): 11441, 2022 07 06.
Artículo en Inglés | MEDLINE | ID: mdl-35794199

RESUMEN

With the serious shortage of water resources and the development of water-saving agriculture, the application of drip irrigation has been paid more and more attention. But there was lack of oat planting methods suitable for drip irrigation, currently. In order to establish an efficient oat planting method for drip irrigation, a study was conducted at Agriculture and Forestry Sciences of Ulanqab, Inner Mongolia during the season (2019-2020) to evaluate the effect of strip cropping with reducing row spacing and super absorbent polymer on the yield and water use efficiency of oat. To conduct the field trials, a split plot system in three replications was established. Three planting patterns were in the main plots, including conventional cropping with 20 cm equal row spacing (PA), strip cropping with the 15 cm row spacing (PB) and strip cropping with the 10 cm row spacing (PC), and two super absorbent polymer levels were in the subplots, including 22.5 kg ha-2 (Y) and 0 (N). The results showed that, compared with PA, PB and PC both decreased the irrigation volumes by 4.5-18.4 mm, and the irrigation volumes of PB was lower than that of PC. When super absorbent polymers were applied, compared with PA, PB significantly increased grain yield and above-ground biomass, but PC had the opposite effects. The grain yield and above-ground biomass of PB significantly increased by 16.65% and 7.31% on average in two years, respectively. And the increasing of grain yield was attributed by the significant increasing of pike number and kernel number per spike. But when super absorbent polymers were not applied, PB had no significant effects on grain yield and above-ground biomass. PB also had the significant effects on regulating water use of oats weather or not super absorbent polymers were applied, it significantly increased the precipitation ratio by 2.64% (PBY) and 2.13% (PBN) and decreased irrigation ration by 3.32% (PBY) and 5.28% (PBN) on average in two years. Although PB and PC both decreased the total evapotranspiration, but PB increased WUE and PC deceased WUE. The WUE of PB increased by 19.70% (PBY) and 9.87% (PBN) on average in two years. Also PB had the highest economic benefits in all treatments. In conclusion, a drip irrigation oat planting pattern was proposed, which the row spacing is 15 cm, adjusted the equal row spacing planting to 8-row strip planting, with a belt spacing of 30 cm, combined with the application of 22.5 kg ha-2 applying super absorbent polymers. And this oat planting pattern is a viable strategy to improve oat productivity.


Asunto(s)
Avena , Agua , Agricultura/métodos , Grano Comestible , Polímeros
16.
Acta Crystallogr Sect E Struct Rep Online ; 67(Pt 2): m245, 2011 Jan 22.
Artículo en Inglés | MEDLINE | ID: mdl-21522900

RESUMEN

In the title compound, [Co(C(12)H(13)N(2)O(3))(2)], the Co(II) ion is situated on a twofold rotation axis and is coordinated by two N and two O atoms from two symmetry-related Schiff base 2-(cyclo-pentyl-imino-meth-yl)-4-nitro-phenolate ligands (L) in a distorted tetra-hedral geometry. The cyclo-pentyl ring in L is disordered over two conformations in a 0.640 (19):0.360 (19) ratio.

17.
Nat Prod Res ; 35(23): 5323-5328, 2021 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-32292060

RESUMEN

Accumulating evidences have shown the beneficial effects of natural products for Alzheimer's disease (AD) treatment. The present study was designed to investigate the neuroprotective effects of secondary metabolites of Galactomyces geotrichum (SMGG) on D-galactose induced AD mice. SMGG was extracted and its toxicological evaluation was conducted. To explore the neuroprotective mechanism responsible for anti-AD activity of SMGG, spatial learning and memory behavioral, oxidative stress levels, acetylcholinesterase and choline acetyltransferase activity assays were employed. The AD mice received SMGG treatment exhibited significant improvement in cognitive performance, enhanced antioxidant capacity, decreased acetylcholinesterase activity and increased choline acetyltransferase activity. Meanwhile, SMGG had no toxicity and seven compounds were separated from it: 7,8-dimethyl-iso-alloxazine, 1-methyl-3-benzyl-6-(4-hydroxybenzyl)-2,5-piperzainedione, cyclo-(Phe-Pro), cyclo-(Leu-Pro), cyclo-(Pro-Gly), cyclo-(Gly-Leu) and uracil, respectively. Overall, these data suggested that SMGG protects the brain against D-galactose induced cognitive impairment, oxidative damages and acetylcholine content decrease in AD mice.


Asunto(s)
Enfermedad de Alzheimer , Disfunción Cognitiva , Laminaria , Fármacos Neuroprotectores , Acetilcolinesterasa/metabolismo , Enfermedad de Alzheimer/inducido químicamente , Enfermedad de Alzheimer/tratamiento farmacológico , Animales , Encéfalo/metabolismo , Cognición , Disfunción Cognitiva/tratamiento farmacológico , Modelos Animales de Enfermedad , Galactosa/farmacología , Geotrichum , Laminaria/metabolismo , Aprendizaje por Laberinto , Ratones , Fármacos Neuroprotectores/farmacología , Fármacos Neuroprotectores/uso terapéutico , Estrés Oxidativo
18.
Food Chem ; 334: 127520, 2021 Jan 01.
Artículo en Inglés | MEDLINE | ID: mdl-32693332

RESUMEN

CaCl2, Ca2+ chelator (EGTA) and Ca2+ channel blocker (verapamil) were used to investigate mechanism of glucoraphanin metabolism in broccoli sprouts under ZnSO4 stress. CaCl2 treatment promoted sprout growth, reduced MDA (malonaldehyde) content and electrolyte leakage in sprouts under ZnSO4 stress. The highest MDA content and electrolyte leakage were obtained in ZnSO4 plus verapamil-treated sprouts. In addition, ZnSO4 plus CaCl2 treatment significantly enhanced glucoraphanin content and sulforaphane formation, while an opposite result was observed after ZnSO4 plus EGTA treatment; which were further supported by expression of glucoraphanin biosynthetic and hydrolytic genes as well as myrosinase (MYR) and epithiospecifier protein (ESP) activities. These results indicated that exogenous and endogenous calcium promoted glucoraphanin biosynthesis and the conversion rate of glucoraphanin into sulforaphane. Verapamil treatment also stimulated glucoraphanin biosynthesis, but exerted an adverse influence on sulforaphane formation from the hydrolysis of glucoraphanin because of much higher ESP expression and ESP activity than ZnSO4 treatment.


Asunto(s)
Brassica/efectos de los fármacos , Cloruro de Calcio/farmacología , Glucosinolatos/metabolismo , Imidoésteres/metabolismo , Sulfato de Zinc/farmacología , Brassica/crecimiento & desarrollo , Brassica/metabolismo , Ácido Egtácico/farmacología , Glicósido Hidrolasas/metabolismo , Hidrólisis , Isotiocianatos/metabolismo , Malondialdehído/metabolismo , Oximas , Proteínas de Plantas/metabolismo , Plantones/efectos de los fármacos , Plantones/metabolismo , Estrés Fisiológico , Sulfóxidos
19.
Chem Biodivers ; 7(1): 216-20, 2010 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-20087992

RESUMEN

The first natural S-containing benzophenone dimer, named guignasulfide (3), was isolated from the culture of Guignardia sp. IFB-E028, an endophytic fungus residing in healthy leaves of Hopea hainanensis. Its structure was determined through correlative analyses of its MS, 1D- and 2D-NMR spectroscopic data. Two other known benzophenone derivatives, monomethylsulochrin and rhizoctonic acid (1 and 2, resp.) were also isolated. Guignasulfide (3) was more active against the human liver cancer cell line HepG2 (IC(50) value: 5.2+/-0.4 microM) than metabolites 1 and 2 (IC(50) values: 63.5+/-0.6 and 60.2+/-0.5 microM); compounds 1-3 showed also moderately inhibitory effects on the human bacterial pathogen Helicobacter pylori with MIC values of 28.9+/-0.1, 60.2+/-0.4, and 42.9+/-0.5 microM, respectively.


Asunto(s)
Antibacterianos/química , Ascomicetos/química , Benzofenonas/química , Dipterocarpaceae/microbiología , Sulfuros/química , Antibacterianos/aislamiento & purificación , Antibacterianos/farmacología , Ascomicetos/metabolismo , Benzofenonas/aislamiento & purificación , Benzofenonas/toxicidad , Helicobacter pylori/efectos de los fármacos , Células Hep G2 , Humanos , Sulfuros/aislamiento & purificación , Sulfuros/toxicidad
20.
Int J Biol Macromol ; 155: 1194-1201, 2020 Jul 15.
Artículo en Inglés | MEDLINE | ID: mdl-31726167

RESUMEN

The occurrence of Maillard reaction in protein - polysaccharide coacervated microcapsules and its effects on microcapsule properties were investigated. Vitamin E microcapsules were prepared by soybean protein isolate - chitosan coacervation at 50 °C, 70 °C, or 90 °C for 12 h in the presence of maltose. Chromatic and furosine measurements revealed that Maillard reaction occurred in the microcapsules and was favored by high incubation temperatures. The three coacervation temperatures did not destroy the microcapsule structure, but improved the microencapsulation efficiency and microencapsulation yield instead. The microcapsules exhibited decreased aggregation and the increased absolute zeta potential and particle size were believed contribute to this improvement. Stability analysis demonstrated that the microcapsules possessed enhanced resistance to dissolution in water and improved storage stability than control microcapsules. It is concluded that coacervation at a temperature high enough to initiate Maillard reaction is a promising way to improve the physiochemical properties of protein - polysaccharide coacervated microcapsules.


Asunto(s)
Cápsulas/química , Quitosano/química , Composición de Medicamentos , Reacción de Maillard , Polisacáridos/química , Proteínas de Soja/química , Fenómenos Químicos , Coloides/química , Estabilidad de Medicamentos , Tamaño de la Partícula , Temperatura , Vitamina E/química
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