Dynamic analysis of a SIQR epidemic model considering the interaction of environmental differences.

Infectious diseases have a devastating impact on individual health and social development. Different external environmental factors will affect the scale and the speed of disease outbreaks, such as sanitary conditions and policy interventions. In this paper, we attempt to establish a dual-system susceptible-infectious-quarantine-recovered model with different environmental impacts to explore it. For the deterministic model, we calculate the basic reproduction number, simultaneously, and investigate the local asymptotic stability of the disease-free equilibrium and the endemic equilibrium. Numerical simulations and theoretical analyses verify the conclusion of this paper. It is a surprise that there is a great probability of finding a quarantine inflection point, which can effectively control the scale of infection outbreak when two different systems of infection rate and recovery rate are determined.

Nickel-vanadium layered double hydroxide nanosheets as the saturable absorber for a passively Q-switched 2 µm solid-state laser.

Nickel-vanadium (NiV)-layered double hydroxide (LDH) was fabricated into a novel saturable absorber (SA) by the liquid phase exfoliation method and utilized as the laser modulator for the first time, to our best knowledge. We investigated a passive Q-switched Tm:YAG ceramic laser at 2 µm with the NiV-LDH SA. Under an absorbed pump power of 7.2 W, the shortest pulse width of 398 ns was obtained with an average output power of 263 mW and a pulse repetition frequency of 101.8 kHz, corresponding to a single pulse energy at 2.30 µJ. The results indicate that the NiV-LDH SA has great research potential in the field of laser modulation.

In-band pumped polarized, narrow-linewidth Er:YAG laser at 1645 nm.

We report a polarized, narrow-linewidth Er:YAG laser operating at 1645 nm, in-band pumped by a continuous-wave (CW), narrowband 1532 nm fiber-coupled laser diode (LD). A maximum polarized continuous wave output power of 8.45 W was obtained, resulting in an optical conversion efficiency of 56% with respect to the absorbed pump power. The central wavelength was measured to be 1645.45 nm, with a full width at half-maximum of 0.13 nm. For Q-switched operation, pulse energy of 12 mJ at 100 Hz pulse repetition frequency and 95 ns pulse duration was yielded. To the best of our knowledge, this polarized pulse energy is the highest energy reported for a Q-switched Er:YAG laser pumped by a CW LD.

High efficiency, linearly polarized, directly diode-pumped Er:YAG laser at 1617 nm.

An efficient, directly diode-pumped Er:YAG laser at 1617 nm was demonstrated. A folding mirror with high reflectivity for the s-polarized light at the laser wavelength was used to achieve a linearly polarized laser. A maximum continuous-wave output power of 7.73 W was yielded under incident pump power of 50.57 W, and the optical conversion efficiency with respect to incident pump power was ∼15.28%, which was the highest optical conversion efficiency with directly diode-pumped Er:YAG lasers up to now; in Q-switched operation, the maximum pulse energy of 7.82 mJ was generated with pulse duration of about 80 ns at a pulse repetition frequency of 500 Hz.

Antioxidant and anti­inflammatory effects of esculin and esculetin (Review).

Fraxinus chinensis Roxb is a deciduous tree, which is distributed worldwide and has important medicinal value. In Asia, the bark of Fraxinus chinensis Roxb is a commonly used traditional Chinese medicine called Qinpi. Esculetin is a coumarin compound derived from the bark of Fraxinus chinensis Roxb and its glycoside form is called esculin. The aim of the present study was to systematically review relevant literature on the antioxidant and anti-inflammatory effects of esculetin and esculin. Esculetin and esculin can promote the expression of various endogenous antioxidant proteins, such as superoxide dismutase, glutathione peroxidase and glutathione reductase. This is associated with the activation of the nuclear factor erythroid-derived factor 2-related factor 2 signaling pathway. The anti-inflammatory effects of esculetin and esculin are associated with the inhibition of the nuclear factor κ-B and mitogen-activated protein kinase inflammatory signaling pathways. In various inflammatory models, esculetin and esculin can reduce the expression levels of various proinflammatory factors such as tumor necrosis factor-α, interleukin (IL)-1ß and IL-6, thereby inhibiting the development of inflammation. In summary, esculetin and esculin may be promising candidates for the treatment of numerous diseases associated with inflammation and oxidative stress, such as ulcerative colitis, acute lung and kidney injury, lung cancer, acute kidney injury.

[Association between left ventricular diastolic function and blood pressure variability in essential hypertensive patients].

OBJECTIVE: To investigate the relationship between blood pressure variability (BPV) and left ventricular diastolic function in patients with essential hypertension. METHODS: Left ventricular diastolic function of 252 hypertensive patients were assessed by early (E) diastolic transmitral flows to early diastolic mitral annular velocity (Ea) (E/Ea) ratio derived from Doppler echocardiography. Patients were divided into two groups according to normal left ventricular diastolic function group (E/Ea<15, n = 168) and left ventricular diastolic dysfunction group (E/Ea ≥ 15, n = 84). All patients were monitored by ambulatory blood pressure. Standard deviation (SD) and coefficient of variation (CV) of blood pressure were calculated as the BPV. Relationship between BPV and left ventricular diastolic function were analyzed by multivariate logistic regression analysis. RESULTS: All-day average diastolic blood pressure(DBP), the day systolic blood pressure (SBP), night SBP, night DBP, SBPSD, DBPSD and DBPCV in the left ventricular diastolic dysfunction group were significantly higher than in the normal diastolic function group (all P < 0.05). Multivariate logistic regression analysis showed that left ventricular diastolic dysfunction was associated with SBPSD (OR:1.126, 95%CI:1.054-1.203, P < 0.01), SBPCV (OR:1.127, 95%CI:1.036-1.225, P < 0.01) in this patient cohort. CONCLUSION: High variability of SBP is correlated with left ventricular diastolic dysfunction in hypertensive patients.

Efficient all-solid-state mid-infrared optical parametric oscillator based on resonantly pumped 1.645 µm Er:YAG laser.

We first report an all-solid-state tunable mid-infrared singly resonant optical parametric oscillator based on a 1532 nm laser diode resonantly pumped, Q-switched 1.645 µm Er:YAG laser. An MgO-doped periodically poled lithium niobate was used as the nonlinear material. At the pulse repetition frequency of 2 KHz, a maximum overall average output power of 0.95 W with pump power of 2.8 W was achieved, corresponding to a conversion efficiency of 34% and a slope efficiency of 38%. The temperature tuning was performed giving signal and idler ranges of 2.67 to 2.71 µm and 4.18 to 4.31 µm, respectively.

High-energy directly diode-pumped Q-switched 1617 nm Er:YAG laser at room temperature.

We describe high-energy Erbium-doped yttrium aluminum garnet (Er:YAG) lasers operating at 1617 nm, resonantly pumped using 1532 nm fiber-coupled laser diodes. A maximum continuous wave output power of 4.3 W at 1617 nm was achieved with an output coupler of 20% transmission under incident pump power of 29.7 W, resulting in an optical conversion of 14% with respect to the incident pump power. In Q-switched operation, the pulse energy of 11.8 mJ at 100 Hz pulse repetition frequency and 81 ns pulse duration was obtained. This energy is the highest pulse energy reported for a directly diode-pumped Q-switched Er:YAG laser operating at 1617 nm.

Bending modulus of the rippled graphene: the role of thickness.

Bending modulus is a key parameter to characterize the stiffness of materials. Commonly, it is believed that the bending modulus is closely related to the thickness as described by the thin plate theory. However, the thin plate theory fails in multilayer van der Waals materials like multilayer graphene, suggesting a more complex relationship between the bending modulus and thickness. Here, rippled graphene structures containing non-hexagonal carbon rings with different thicknesses are constructed to study the thickness-dependent bending modulus by the first-principles calculations. It is found that the bending modulus of rippled graphene depends on several factors, such as geometry, bending curvature, and thickness. Particularly, for the egg-tray graphene structures with similar structural pattern and bending curvature, i.e., eliminating the effects of structural pattern and bending curvature, the bending modulus could show a linear relationship to the thickness. Moreover, this linear relationship is very robust even in the case of changing the thickness through heteroatom doping.

Efficient 1645 nm continuous-wave and Q-switched Er:YAG laser pumped by 1532 nm narrow-band laser diode.

Energy transfer upconversion induced thermal effects are mainly responsible for the low efficiency of laser diode pumped Er:YAG lasers. The current work adopts Er:YAG rods with 0.25% Er(3+) doping concentration, instead of the commonly used rods with 0.5% Er(3+) doping concentration. Results show that the thermal effect is greatly alleviated. A continuous-wave output of 10.2 W is obtained using 31 W incident pump power. Optical-optical efficiency is approximately 33%. Slope efficiency, with respect to the absorbed pump power, is as high as 83%, which is close to the quantum efficiency. In a Q-switched operation, 7 mJ pulses with a pulse width of ~65 ns are obtained at 100 Hz PRF.

Efficient Q-switched Tm:YAG ceramic slab laser.

Characteristics of Tm:YAG ceramic for high efficient 2-µm lasers are analyzed. Efficient diode end-pumped continuous-wave and Q-switched Tm:YAG ceramic lasers are demonstrated. At the absorbed pump power of 53.2W, the maximum continuous wave (cw) output power of 17.2 W around 2016 nm was obtained with the output transmission of 5%. The optical conversion efficiency is 32.3%, corresponding to a slope efficiency of 36.5%. For Q-switched operation, the shortest width of 69 ns was achieved with the pulse repetition frequency of 500 Hz and single pulse energy of 20.4 mJ, which indicates excellent energy storage capability of the Tm:YAG ceramic.

Continuous wave and passively Q-switched Nd:Lu xY1-x VO4 laser at 1.34 µm with V3+:YAG as the saturable absorber.

We demonstrated a diode-pumped continuous wave and passively Q-switched Nd:Lu(x)Y(1-x)VO4 laser at 1.34 µm with V3+:YAG as the saturable absorber. The crystal Nd:Lu(x)Y(1-x)VO4 with equal ionic ratio (x = 0.5) shows better laser performance. The maximum continuous wave output power of 1.45 W was obtained with the optical efficiency of 20.1% and the slope efficiency of 24.5%. For the pulsed operation, the minimum pulse width achieved was 42 ns with the pulse repetition frequency of 142 kHz, and the single pulse energy and the peak power were estimated to be 6.62 µJ and 157.6 W, respectively.

Equivalent optical model for lenslike gain medium in continuously single-end-pumped solid-state laser.

In order to conveniently and precisely estimate the spot size of laser modes in continuously single-end-pumped solid-state lasers, a ray matrix for the thermal-induced lenslike medium with exponential heat distribution along the axial direction is, for the first time to our best knowledge, derived under assumptions of only radial heat flow and uniform pump spot size. An equivalent optical model is also developed and especially modified for a lenslike gain medium in a continuously single-end-pumped solid-state laser. The result is verified by discussing how it fits the practical cases much better than the previous simplified model and by numerical simulation in a practice problem. This work is especially important in cases with a relatively long gain medium, which has been used more and more frequently in recent years.

Role of ferroptosis in neurological diseases.

Ferroptosis is a newly identified form of nonapoptotic regulated cell death (RCD) characterized by iron-dependent accumulation of lipid peroxides which leads to oxidative stress and cell death. Recent studies have indicated that ferroptosis plays an essential role in the pathology of neurological diseases, such as intracerebral hemorrhage, ischemic stroke, epilepsy, neurodegenerative diseases, traumatic brain injury and brain cancer. This review focuses on the latest researches on the relationship of ferroptosis with nervous system diseases, highlighting the ferroptosis-based mechanisms, and elaborating the new perspective therapeutic targets of neurological disorders.

Scutellarin regulates osteoarthritis in vitro by inhibiting the PI3K/AKT/mTOR signaling pathway.

Osteoarthritis (OA) is a highly prevalent disease worldwide that causes disability and diminishes the quality of life of affected individuals. The disease is characterized by cartilage destruction, increased inflammatory responses and cholesterol metabolic disorder. Scutellarin is the major active ingredient extracted from Erigeron breviscapus, and it has been demonstrated to possess various pharmacological functions in the treatment of the disease. However, its effects on OA are complex. The present study investigated whether scutellarin can mediate the release of inflammatory cytokines, the expression of collagen- and cholesterol-related proteins, and regulate the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway in a cell model of OA. Interleukin (IL)-1ß was used to stimulate OA in SW1353 cells in vitro. The primary methods used were ELISA and western blotting, which were carried out to examine the effects of scutellarin on the cell model of OA. It was found that scutellarin increased the expression of collagen II and SRY-box 9, whereas it suppressed the expression of matrix metalloproteinase 13. In addition, scutellarin downregulated the expression levels of cholesterol 25-hydroxylase and cytochrome P450 family 7 subfamily B polypeptide 1, but upregulated the expression of apolipoprotein A-1 and adenosine triphosphate-binding cassette transporter A1. The IL-1ß-induced increase in the expression of IL-6 was decreased by treatment with scutellarin; however, scutellarin did not alter the expression of C-reactive protein and tumor necrosis factor-α. The protein expression levels of AKT, phosphorylated (p)-AKT, mTOR and p-mTOR in the PI3K/AKT/mTOR signaling pathway were decreased in the IL-1ß-induced SW1353 cells following scutellarin treatment. Overall, the findings of the present study demonstrated that scutellarin regulated OA in vitro by inhibiting the PI3K/AKT/mTOR signaling pathway.

Some polycyclic aromatic hydrocarbons in vegetables from northern China.

Nine important vegetables were collected from northern Chinese wholesale markets and analyzed for polycyclic aromatic hydrocarbon (PAH) contents. Anthracene, flupranthene, benzo(a)anthracene and benzo(a)pyrene were determined. The contents of the four PAH congeners were at the same level with the mean concentrations 6.46, 4.05, 3.33, 4.51 microg kg(-1) for fresh weight for anthracene, flupranthene, benzo(a)anthracene and benzo(a)pyrene, respectively. However, leafy and stem vegetables had higher PAH content than root and fruit vegetables. Peels of the root and fruit vegetables had higher PAH concentrations than their cores. Human exposure to PAHs by consumption of these vegetables is estimated, by using typical northern Chinese intake rates, although the study was not designed to be statistically representative for the China as a whole.