1.
Org Lett
; 15(18): 4750-3, 2013 Sep 20.
Artículo
en Inglés
| MEDLINE
| ID: mdl-24020617
RESUMEN
The first N-heterocyclic carbene-catalyzed stereoselective aza-Michael-Michael-lactonization cascade reaction of 2'-aminophenylenones and 2-bromoenals for the construction of chiral functionalized tetrahydroquinolines with three consecutive stereogenic centers has been achieved in high yields (up to 98%) with excellent diastereo- (>25:1) and enantioselectivities (up to 98.7% ee).