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1.
Zhonghua Yu Fang Yi Xue Za Zhi ; 57(7): 1059-1062, 2023 Jul 06.
Artículo en Zh | MEDLINE | ID: mdl-37482741

RESUMEN

To discuss the effect of varicella vaccination on the clinical characteristics of herpes zoster (shingles) cases aged 20 years and under, and analyze its clinical features. Based on the Yichang Health Big Data Platform, a descriptive study was conducted to collect the information of cases aged 20 years and under in three medical institutions of Yichang Central People's Hospital, Yichang First People's Hospital and Yichang Second People's Hospital from March 2019 to September 2020. According to the history of varicella vaccine, cases were divided into vaccination group and non-vaccination group, and their clinical features and outcomes were compared. The results showed that 46 shingles cases, aged from 7 to 20 years old, were included in this study. 26 males (56.5%), 20 females (43.5%), 15 cases in vaccination group (32.6%) and 31 cases in non-vaccination group (67.4%). 28 cases had thoracic involvement, followed by lumbar (n=8), cranial (n=7) involvements and extremities (n=7). The spread of herpes skin area: 2 cases involved too large area, 21 cases of 10 cm×10 cm, 14 cases of 5 cm×5 cm, 9 cases of 1 cm×1 cm. Herpes number: 26 cases had 10-49 herpes, followed by <10 herpes (n=9), uncountable herpes (n=7) and 50-99 herpes (n=4). The clinical course[M(Q1,Q3)] lasted 20.5 (13.5,24.8) d averagely, 5 cases had postherpetic neuralgia (PHN) and 1 case had respiratory complications. Shingles decrustation time was significantly shorter in vaccination group (Z=-2.01, P<0.05), and there was no significant difference in other characteristics by vaccination. In conclusion, the number and spread of shingles in most children and adolescents are less, and the complications such as PHN are less. Varicella vaccination can reduce the decrustation time and relieve shingles cases with some clinical symptoms.


Asunto(s)
Varicela , Vacuna contra el Herpes Zóster , Herpes Zóster , Neuralgia Posherpética , Adolescente , Niño , Femenino , Humanos , Masculino , Adulto Joven , Varicela/epidemiología , Varicela/prevención & control , Herpes Zóster/epidemiología , Herpes Zóster/prevención & control , Vacuna contra el Herpes Zóster/uso terapéutico , Herpesvirus Humano 3 , Neuralgia Posherpética/prevención & control
2.
Zhonghua Yu Fang Yi Xue Za Zhi ; 57(9): 1380-1384, 2023 Sep 06.
Artículo en Zh | MEDLINE | ID: mdl-37743298

RESUMEN

To explore the characteristics of big data of patients with allergic rhinitis, including the time, population and spatial distribution of allergic rhinitis in Beijing from 2016 to 2021, so as to provide reference for the prevention and treatment of this disease. Descriptive epidemiological methods were used to analyze the distribution (including gender, age and location)and trend of allergic rhinitis patients in 30 pilot hospitals from January 2016 to December 2021, T test and Kruskal-Wallis rank sum test were used to test the statistical differences. The results showed that the number of patients with allergic rhinitis in 30 hospitals increased year by year from 2016 to 2019, with an increase of 97.9%. In 2020, the number of patients decreased. In 2021, the number of visits returned to the pre-epidemic level (461 332); The number of patients with allergic rhinitis was the highest in September, with a seasonal index of 177.6%, while the lowest number was in February, accounting for only 47.2%; a significant difference was observed in the number of patients in different age groups(H=45 319.48, P<0.05), and patients under 15 years old accounted for the highest proportion(819 284 visits); There were significant differences between patients of different genders in the 45-59 year old group (t=-4.26, P<0.05).There were relatively more patients with allergic rhinitis in Dongcheng District(31.1%) than in Huairou District and Miyun District (0.4%). In conclusion, since 2016, the number of patients increased significantly, with a varied trend in different seasons. Most patients were children. There were more patients in the central urban area than in the outer suburbs.


Asunto(s)
Epidemias , Rinitis Alérgica , Niño , Humanos , Femenino , Masculino , Adolescente , Persona de Mediana Edad , Beijing/epidemiología , Macrodatos , Hospitales , Rinitis Alérgica/epidemiología
3.
Fa Yi Xue Za Zhi ; 37(1): 11-14, 2021 Feb.
Artículo en Inglés, Zh | MEDLINE | ID: mdl-33780178

RESUMEN

ABSTRACT: Objective To investigate the stability of IgE in postmortem plasma and hemolyzed samples under different storage conditions and freezing-thawing. Methods Thirty nine cardiac blood samples were collected from non-frozen corpses with the postmortem interval of less than 48 hours, including 20 plasma samples and 19 hemolyzed samples taken from whole blood. The samples were stored at -20 ℃, 4 ℃ and 25 ℃ for 28 d and at -80 ℃ for 1 year to evaluate the stability of IgE under different storage conditions. Repeated freezing-thawing treatment was conducted for 5 times to explore the stability of IgE in postmortem plasma and hemolyzed samples. IgE concentration in plasma and hemolyzed samples was detected by electroluminescence before and after treatment. Results The degradation rates of IgE in plasma samples under the three storage conditions, -20 ℃, 4 ℃ and 25 ℃ were close. After 28 d, the mean value was about 15%, the degradation speed of IgE in hemolyzed samples was faster than that of plasma under the same condition (P<0.05) and the degradation rate was faster than other two conditions under 25 ℃ (P<0.05). The differences in the concentration of plasma samples after freezing at -80 ℃ for 1 year and that before freezing had no statistical significance ( P>0.05), while the concentration of hemolyzed samples was degraded after freezing at -80 ℃ for 1 year (P<0.05). The differences between the detection results of plasma and hemolyzed samples after repeated freezing-thawing for 5 times and that before freezing-thawing showed no statistical significance ( P>0.05). Conclusion IgE has good freezing-thawing stability in postmortem plasma and hemolyzed samples. Stability of IgE is better in postmortem plasma samples than hemolyzed samples, thus it is recommended to separate plasma from postmortem blood samples as soon as possible in forensic practice.


Asunto(s)
Medicina Legal , Plasma , Autopsia , Congelación , Inmunoglobulina E
4.
Zhonghua Yu Fang Yi Xue Za Zhi ; 54(9): 1026-1030, 2020 Sep 06.
Artículo en Zh | MEDLINE | ID: mdl-32907296

RESUMEN

Based on the practical application, this paper introduced the basic calculation conditions, methods and epidemiological significance of incubation period. The real data were used for calculations of the incubation period by lognormal, gamma, Weibull and Erlang distribution methods. Both of the complete and incomplete observation data were demonstrated.

5.
Fa Yi Xue Za Zhi ; 36(3): 337-340, 2020 Jun.
Artículo en Inglés, Zh | MEDLINE | ID: mdl-32705846

RESUMEN

ABSTRACT: Objective To investigate the treatment effect of hollow fiber ultrafiltration technology on hemolytic samples and the differences between IgE concentration and serum concentration before hemolysis in ultrafiltrate. Methods The 33 postmortem blood samples of non-frozen corpses within 72 hours after death were collected, 4 mL blood was taken from each case, among which 1 mL was centrifuged to get serum, and the remaining 3 mL blood was frozen-thawed 3-5 times to cause complete hemolysis. The 2 mL hemolytic samples were processed by hollow fiber ultrafiltration to obtain ultrafiltrate. The hemoglobin concentration in serum, complete hemolytic sample and ultrafiltrate was determined by Van-Zij solution-cyanated methemoglobin assay method, and the total IgE in serum and ultrafiltrate was determined by electrochemical luminescence method. Results The hemoglobin concentration in ultrafiltrate was significantly lower than that in complete hemolytic samples (P<0.05). There was a good correlation between the total IgE detection values of ultrafiltrate and serum (r=0.984). The difference between the serum and the value of IgE in ultrafiltrate after correction had no statistical significance, and the differences between the two in positive rates had no statistical significance (P>0.05). Conclusion Ultrafiltration technology has a good treatment effect on complete hemolytic samples, and the correction value of ultrafiltrate detection is close to the serum level before hemolysis, and therefore, it can be applied to the detection of total IgE of frozen corpse hemolytic samples.


Asunto(s)
Hemólisis , Inmunoglobulina E , Ultrafiltración , Autopsia , Humanos , Inmunoglobulina E/análisis , Suero
6.
Fa Yi Xue Za Zhi ; 35(1): 74-77, 2019 Feb.
Artículo en Inglés, Zh | MEDLINE | ID: mdl-30896124

RESUMEN

Because cryopreservation can effectively slow down the putrefaction and prolong the preservation time of corpses, it has become the main way of corpse preservation in China. However, it may cause a certain degree of non-specific effects on the corpses and thus interfere with forensic pathological identification. This paper summarizes relevant problems reported in domestic and foreign literature reports and practical identification, and analyzes the effects of cryopreservation on corpses from aspects of anatomical findings, histomorphology, postmortem biochemistry, and postmortem imaging, therefore to provide Chinese forensic workers assistance on problems in their practice of forensic pathology.


Asunto(s)
Cadáver , Criopreservación , Patologia Forense , Cambios Post Mortem , Autopsia , China , Humanos
7.
Fa Yi Xue Za Zhi ; 35(6): 651-656, 2019 Dec.
Artículo en Inglés, Zh | MEDLINE | ID: mdl-31970949

RESUMEN

ABSTRACT: Objective To investigate the differences of heart mass and lung mass in forensic autopsy cases and to explore their application value in forensic identification. Methods The data from 1 614 autopsy cases accepted by center of Medico-legal Investigation of China Medical University between 2007 to 2016 were collected. The correlation of heart and lung mass with age, height, body weight, and body mass index (BMI), as well as differences in different causes of death were analyzed by GraphPad Prism 6.0 software. Results The heart mass and lung mass of males were higher than those of females (P<0.05). The heart mass of males and females was positively correlated with age, height, body weight and body mass index (BMI) (P<0.05). The heart mass of patients dying from sudden cardiac death (SCD) was significantly higher than those dying from other causes of death. The lung mass of patients dying from drowning and delayed treatment was higher than those dying from other causes of death (P<0.05). Conclusion In forensic practice, measurement of the heart mass and lung mass has certain significance for differential diagnosis and diagnosis of different causes of death.


Asunto(s)
Patologia Forense , Corazón , Pulmón , Autopsia , Causas de Muerte , China , Muerte Súbita Cardíaca , Femenino , Corazón/anatomía & histología , Humanos , Pulmón/anatomía & histología , Masculino , Tamaño de los Órganos
8.
Fa Yi Xue Za Zhi ; 35(6): 721-725, 2019 Dec.
Artículo en Inglés, Zh | MEDLINE | ID: mdl-31970961

RESUMEN

ABSTRACT: With the rapid development of the social economy in China, the incidence of diseases caused by excessive drinking is gradually increasing as well. Alcoholic cardiomyopathy refers to long-term high intake of ethanol, and has typical dilated cardiomyopathy characteristics, such as, hemodynamic changes, symptoms, signs, and morphological features. It is a kind of cardiomyopathy that excludes other causes of dilated cardiomyopathy. Due to the lack of specific pathological changes, the forensic pathological identification of alcoholic cardiomyopathy can only be based on the patient's medical history and by ruling out other causes of cardiomyopathy. This paper reviews the pathogenesis and forensic identification of alcoholic cardiomyopathy in order to provide reference for forensic pathologists and clinicians.


Asunto(s)
Cardiomiopatía Alcohólica , Patologia Forense , Cardiomiopatía Alcohólica/diagnóstico , Cardiomiopatía Alcohólica/patología , China , Etanol , Patologia Forense/normas , Patologia Forense/tendencias , Humanos
9.
Curr Oncol ; 23(4): e355-61, 2016 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-27536184

RESUMEN

BACKGROUND: Venous thromboembolism (vte) is a recognized complication in patients treated with asparaginase-containing chemotherapy regimens; the optimal preventive strategy is unclear. We assessed the safety and efficacy of prophylaxis using low-dose low molecular weight heparin in adult patients with acute lymphoblastic leukemia in complete remission treated with an asparaginase-based post-remission chemotherapy regimen. METHODS: As part of the intensification phase of the Dana-Farber Cancer Institute 91-01 regimen, asparaginase was administered weekly to 41 consecutive patients for 21-30 weeks; these patients also received prophylaxis with enoxaparin 40 mg daily (60 mg for patients ≥80 kg). Outcomes were assessed against outcomes in a comparable cohort of 99 patients who received the same chemotherapy regimen without anticoagulation prophylaxis. RESULTS: The overall rate of symptomatic venous thrombosis was not significantly different in the prophylaxis and non-prophylaxis cohorts (18.92% and 21.74% respectively). Among patients receiving prophylaxis, vte occurred in higher proportion in those who weighed at least 80 kg (42.86% vs. 4.35%, p = 0.0070). No major bleeding complications occurred in the prophylaxis group (minor bleeding: 8.1%). CONCLUSIONS: Prophylaxis with low-dose enoxaparin during the intensification phase was safe, but was not associated with a lower overall proportion of vte.

10.
Eur Rev Med Pharmacol Sci ; 27(9): 4211-4220, 2023 05.
Artículo en Inglés | MEDLINE | ID: mdl-37203847

RESUMEN

OBJECTIVE: This study aims to assess the efficacy and safety of midodrine on treating patients with septic shock. MATERIALS AND METHODS: Literature search was conducted in PubMed, the Cochrane Library, and Embase. The Mantel-Haenszel method was used to calculate pooled relative risks (RRs) and 95% confidence intervals (95% CI). The mean differences (MD) or standardized mean difference (SMD) were calculated using the inverse variance for continuous variables. Data analysis was performed using Review Manager 5.3. RESULTS: A total of 6 studies were finally included in this meta-analysis. Adding midodrine to patients with septic shock was associated with a reduction in hospital mortality [risk ratio (RR) 0.76; 95% CI, 0.57-1.00; p=0.05] and intensive care unit (ICU) mortality (RR 0.59; 95% CI, 0.41-0.87; p=0.008). However, there were no significant differences in the duration of intravenous vasopressors [standardized mean difference (SMD) -0.18; 95% CI, -0.47-0.11; p=0.23], intravenous vasopressor reinstitution (RR 0.58; 95% CI, 0.19-1.80; p=0.35), the length of ICU stay [mean difference (MD) -0.53 days; 95% CI, -2.24-1.17; p=0.54], and the length of hospital stay (MD -2.40 days; 95% CI, -5.26-0.46; p=0.10) between midodrine group and intravenous vasopressor alone group. CONCLUSIONS: The additional use of midodrine might reduce hospital mortality and ICU mortality in patients with septic shock. More high-quality randomized controlled trials are needed to verify this conclusion.


Asunto(s)
Midodrina , Choque Séptico , Humanos , Choque Séptico/diagnóstico , Choque Séptico/tratamiento farmacológico , Choque Séptico/inducido químicamente , Midodrina/uso terapéutico , Midodrina/efectos adversos , Unidades de Cuidados Intensivos , Mortalidad Hospitalaria , Tiempo de Internación , Pronóstico
11.
Zhonghua Liu Xing Bing Xue Za Zhi ; 44(4): 607-610, 2023 Apr 10.
Artículo en Zh | MEDLINE | ID: mdl-37147833

RESUMEN

Objective: To analyze the genetic characteristics of varicella-zoster virus (VZV) in people aged 20 years and under in Yichang City of Hubei Province from 2019 to 2020. Methods: Based on the Yichang Health Big Data Platform, we investigated cases 20 and under clinically diagnosed as herpes zoster in three hospitals from March 2019 to September 2020. Collecting vesicle fluid and throat swab samples of the cases and completing questionnaires to obtain basic information. Real-time fluorescent quantitative PCR was used for positive identification of the virus. PCR amplification of VZV's open reading frame (ORF) and sequencing of the products to determine the VZV genotype. Analyze mutations at some specific single nucleotide polymorphism (SNP) sites. Results: Among 46 cases of herpes zoster, the male to female ratio was 1.3∶1 (26∶20) and the age ranged from 7 to 20 years old. Fifteen cases had been vaccinated against varicella, including 13 and 2 cases of 1 and 2 doses, respectively. VZV strains were detected in 34 samples (73.91%), all belonging to Clade 2. Phylogenetic tree analysis of the nucleotide of ORF22 showed, compared with Clade 2 referenced strains, the sequence matching degree of nucleotide for all 34 samples was 99.0% to 100.0%. Conclusion: The main VZV strain causing herpes zoster in people aged 20 years and under in Yichang from 2019 to 2020 was Clade 2.


Asunto(s)
Herpes Zóster , Herpesvirus Humano 3 , Humanos , Niño , Adolescente , Adulto Joven , Adulto , Herpesvirus Humano 3/genética , Filogenia , Herpes Zóster/epidemiología , Polimorfismo de Nucleótido Simple , Reacción en Cadena en Tiempo Real de la Polimerasa , Nucleótidos
12.
Zhonghua Liu Xing Bing Xue Za Zhi ; 44(12): 1893-1898, 2023 Dec 10.
Artículo en Zh | MEDLINE | ID: mdl-38129145

RESUMEN

Objective: To understand the epidemiological characteristics of public health emergency events (PHEE) of varicella in China from 2006 to 2021 and related response performances. Methods: The data of varicella PHEE in 31 provinces of China from 2006 to 2021 were collected through the Public Health Emergency Management Information System, Microsoft Excel 2019 software and SPSS 26.0 statistical software were used to conduct descriptive epidemiological, statistical analysis on the time, area, location distribution, scale and epidemic management. Results: A total of 11 443 PHEE involving 341 048 related cases were reported from 2006 to 2021, with an annual attack rate of 1.78%-3.80% and a total attack rate of 2.33% (341 048/14 624 042). The number of PHEE and related cases of varicella decreased from 1 107 (35 349) in 2007 to 262 (6 884) in 2012 (Z=-2.40, P<0.001), then increased year by year to 1 318 (42 649) in 2019 (Z=2.58, P<0.001), with a significant decline since 2020. The varicella PHEE in China presents the seasonal characteristics,the peak is from April to June and from October to December, respectively. The sub-peak of varicella PHEE in eastern China generally appears 1-2 months earlier than in central and western China. Varicella PHEE reports are mainly distributed in eastern China, the attack rate is relatively high in western China, school-reported varicella PHEE was 88.26% of the total reports (10 099/11 443). The epidemic scale of varrcella PHEE typically range from 10 to 29 cases per year among the given outbreaks. The M (Q1, Q3) of average number of cases, average duration, and average reporting interval of PHEE were 23 (16,35), 20 (14, 26) days, and 9 (5,19) days, respectively, and the reporting interval was positively correlated with the duration (r=0.854, P<0.001). Conclusions: The varicella PHEE in China from 2006 to 2021 has not been effectively controlled. Schools are the key places to prevent and control varicella PHEE. Improving the sensitivity of varicella PHEE monitoring, strengthening the timely disposal of varicella epidemic, and promoting varicella vaccination are effective measures to prevent and control varicella PHEE.


Asunto(s)
Varicela , Epidemias , Humanos , Varicela/epidemiología , Varicela/prevención & control , Salud Pública , Brotes de Enfermedades/prevención & control , China/epidemiología , Vacunación
13.
Eur Rev Med Pharmacol Sci ; 23(11): 4584-4590, 2019 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-31210284

RESUMEN

OBJECTIVE: Long non-coding ribonucleic acids (lncRNAs) play a vital role in bone development, but the function of lncRNA taurine up-regulated gene 1 (TUG1) in osteoblast proliferation and differentiation is still unknown. MATERIALS AND METHODS: The expression of TUG1 and the messenger RNA (mRNA) expressions of the Wnt/ß-catenin signaling pathway markers [Runt-related transcription factor 2 (Runx2), Frizzled-2, axis inhibition protein 2 (Axin 2) and ß-catenin] at 0 d, 1 d, 7 d and 14 d after in vitro culture of osteoblasts were detected, respectively, by Reverse Transcription-Polymerase Chain Reaction (RT-PCR). The effects of TUG1 on the Wnt/ß-catenin signaling pathway markers and osteoblast proliferation and differentiation were studied through the silencing of TUG1 by short hairpin TUG1 (shTUG1). Furthermore, the effects of the Wnt/ß-catenin signal on osteoblast proliferation and differentiation was verified by Wnt/ß-catenin signal inhibitors. RESULTS: With the continuous differentiation of osteoblasts, the level of TUG1 was significantly increased. The mRNA levels of the Wnt/ß-catenin signaling pathway markers (Runx2, Frizzled-2, Axin 2 and ß-catenin) also showed the same increasing trend. ShTUG1 notably reduced the activity of alkaline phosphatases (ALPs), the levels of osteocalcin and osteopontin and osteoblast proliferation activity. In addition, the silencing of TUG1 by shTUG1 resulted in significant reductions in the proteins of the Wnt/ß-catenin signaling pathway markers (Runx2, Frizzled-2, Axin 2 and ß-catenin), and Wnt/ß-catenin inhibitors markedly reduced osteoblast proliferation and differentiation activity. CONCLUSIONS: LncRNA TUG1 inhibition can suppress the Wnt/ß-catenin signaling pathway and reduce osteoblast proliferation and differentiation.


Asunto(s)
Osteoblastos/citología , Osteogénesis , ARN Largo no Codificante/genética , Regulación hacia Arriba , Animales , Diferenciación Celular , Proliferación Celular , Células Cultivadas , Osteoblastos/química , Fosforilación , Cultivo Primario de Células , Ratas , Vía de Señalización Wnt
16.
Trop Biomed ; 32(3): 540-4, 2015 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-26695215

RESUMEN

Toxoplasma gondii is an obligate intracellular parasite that has a remarkable ability to infect almost all warm-blooded animals, including humans. This study was aimed to determine the genetic characteristics of T. gondii isolates from domestic animals in Henan Province, central China. A total of 363 DNA samples, including 208 from hilar lymph nodes of pigs, 36 from blood samples of cats, 12 from tissues of aborted bovine fetuses and 107 from blood samples of dams with history of abortion in Henan Province, were examined for the presence of T. gondii by nested PCR based on B1 gene. The positive DNA samples were further genotyped by PCR-RFLP at 11 markers, including SAG1, (3'+ 5') SAG2, alt.SAG2, SAG3, BTUB, GRA6, c22-8, c29-2, L358, PK1, and Apico. DNA samples from 9 pigs, 5 cats, and 4 dairy cows were T. gondii B1 gene positive. Nine samples were successfully genotyped at all genetic loci, of which 5 samples from pigs, and 2 from cats were identified as ToxoDB genotype #9, and 2 samples from cows belonged to ToxoDB genotype #225. To our knowledge, the present study is the second report of genetic typing of T. gondii isolates from cattle in China, and the first report of T. gondii ToxoDB#225 from cattle.


Asunto(s)
Animales Domésticos , Genotipo , Toxoplasma/clasificación , Toxoplasma/genética , Toxoplasmosis Animal/parasitología , Animales , Gatos , Bovinos , China , ADN Protozoario/genética , ADN Protozoario/aislamiento & purificación , Reacción en Cadena de la Polimerasa , Polimorfismo de Longitud del Fragmento de Restricción , Porcinos , Toxoplasma/aislamiento & purificación
17.
Talanta ; 39(2): 155-8, 1992 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-18965355

RESUMEN

A piezoelectric sensor is used for the determination of sulpha-drugs, as pure substances and in their dosage forms, by an indirect micro method based on reaction of the sulpha-drug with bromine and reduction of the resultant N-bromoderivative with iodide to form iodine, which after extraction is monitored with a piezoelectric quartz sensor. The response of the sensor is linear from 2 x 10(-5) to 4 x 10(-4)M sulpha-drug.

18.
Phys Ther ; 79(11): 1026-31, 1999 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-10534795

RESUMEN

BACKGROUND AND PURPOSE: The purpose of this study was to compare the cough threshold between people with and without spinal cord injury (SCI). The effect of smoking on cough threshold was also investigated. SUBJECTS: The participants were 26 people with SCI (15 smokers, 11 nonsmokers) and 18 people without SCI (9 smokers, 9 nonsmokers). METHODS: Aerosols of citric acid were delivered with incremental doubling concentration from 62.5 mmol to 2 mol. Cough threshold was defined as the first concentration of citric acid that induced at least 2 coughs, which is associated with large chest excursion and concurrently acoustic response. RESULTS: The mean cough thresholds of smokers and nonsmokers with SCI (209 and 417 mmol, respectively) were lower than those of smokers and nonsmokers without SCI (467 and 1,072 mmol, respectively). The mean citric acid cough thresholds decreased in smokers with and without SCI when compared with nonsmokers with and without SCI. CONCLUSION AND DISCUSSION: The cough sensitivity increased in subjects with SCI, and smoking could also increase the cough sensitivity. Training about the frequency and technique of cough in patients with SCI should be carefully monitored.


Asunto(s)
Tos/fisiopatología , Paraplejía/fisiopatología , Cuadriplejía/fisiopatología , Fumar/efectos adversos , Traumatismos de la Médula Espinal/fisiopatología , Adulto , Análisis de Varianza , Ácido Cítrico/farmacología , Volumen Espiratorio Forzado , Humanos , Irritantes/farmacología , Masculino , Umbral Sensorial , Capacidad Vital
19.
J Formos Med Assoc ; 97(4): 292-5, 1998 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-9585684

RESUMEN

We explored the effect of an abdominal binder, with or without electrical stimulation, on peak expiratory flow rate (PEFR) in 12 paraplegics with complete thoracic cord (T2-T12) injury (mean age 36.0 +/- 1.5 yr) and 12 quadriplegics with complete cervical cord (C4-C8) injury (mean age 36.2 +/- 1.9 yr). The cough was assessed by measuring the PEFR during forceful expiration in a sitting position. The subjects underwent the following experimental maneuvers in a random order with a 10-minute interval between any two maneuvers: 1) voluntary coughing, 2) voluntary coughing with an abdominal binder, and 3) voluntary coughing with an abdominal binder and electrical stimulation. The electrical stimulator (50 Hz with 300 microseconds pulse width) was applied to the abdominal wall. Data were analyzed using multivariate analysis of variance for repeated measures. The abdominal binder did not significantly increase PEFR in either paraplegics or quadriplegics; the abdominal binder combined with electrical stimulation significantly increased PEFR by 15% in the paraplegics and 18% in the quadriplegics. These results indicate that electrical stimulation combined with an abdominal binder improves the cough ability in patients with cervical or thoracic spinal cord injury.


Asunto(s)
Músculos Abdominales/fisiopatología , Tos/fisiopatología , Traumatismos de la Médula Espinal/fisiopatología , Adulto , Estimulación Eléctrica , Humanos , Ápice del Flujo Espiratorio , Presión , Distribución Aleatoria
20.
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