Asunto(s)
Síndrome de Stevens-Johnson/terapia , Corticoesteroides/uso terapéutico , Adulto , Cuidados Posteriores , Analgesia/métodos , Apósitos Biológicos , Vías Clínicas , Ciclosporina/uso terapéutico , Oftalmopatías/terapia , Femenino , Enfermedades Urogenitales Femeninas/terapia , Fluidoterapia/métodos , Predicción , Humanos , Inmunoglobulinas Intravenosas/uso terapéutico , Activación de Linfocitos , Masculino , Enfermedades Urogenitales Masculinas/terapia , Enfermedades de la Boca/terapia , Apoyo Nutricional/métodos , Pronóstico , Enfermedades Respiratorias/terapia , Cuidados de la Piel/métodos , Pruebas de Irritación de la Piel/métodos , Síndrome de Stevens-Johnson/etiología , Síndrome de Stevens-Johnson/patologíaRESUMEN
The overall objective of the guideline is to provide up-to-date, evidence-based recommendations for the diagnosis and management of the full spectrum of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and SJS-TEN overlap in adults during the acute phase of the disease. The document aims to.
Asunto(s)
Manejo de la Enfermedad , Guías de Práctica Clínica como Asunto , Síndrome de Stevens-Johnson , Adulto , Diagnóstico Diferencial , Práctica Clínica Basada en la Evidencia , Humanos , Gravedad del Paciente , Piel/patología , Síndrome de Stevens-Johnson/diagnóstico , Síndrome de Stevens-Johnson/fisiopatología , Síndrome de Stevens-Johnson/terapia , Reino UnidoRESUMEN
All types of leukaemia can disseminate to the skin, producing cutaneous deposits known as leukaemia cutis (LC). We undertook a retrospective study to review the clinical presentations, treatment and outcome of eight patients with LC managed in our department over a period of 12 years. The clinical phenotype varied, with erythematous papules and nodules occurring with greatest frequency. Infiltrated haemorrhagic plaques and perifollicular acneiform papules were also seen. Although patients were treated aggressively for their underlying leukaemia, and received therapy directed towards LC, they tended to be refractory to treatment and the diagnosis was generally associated with a poor prognosis. The exception was a patient with chronic lymphocytic leukaemia, who survived 3 years after developing LC.
Asunto(s)
Leucemia Linfocítica Crónica de Células B/patología , Leucemia Mieloide/patología , Infiltración Leucémica/terapia , Piel/patología , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Resultado del TratamientoRESUMEN
Purpura fulminans is a rare syndrome of haemorrhagic necrosis of the skin and intravascular thrombosis associated with disseminated intravascular coagulopathy. It has not previously been reported as a presenting feature of Churg Strauss syndrome.
Asunto(s)
Síndrome de Churg-Strauss/diagnóstico , Vasculitis por IgA/diagnóstico , Adulto , Síndrome de Churg-Strauss/patología , Femenino , Humanos , Vasculitis por IgA/patologíaRESUMEN
The incidence of syphilis in the UK is rising, particularly in HIV-positive men. We describe a Caucasian, HIV-negative woman who presented with secondary syphilis taking the form known as lues maligna. She also demonstrated the prozone phenomenon whereby the rapid plasmin reagin test was negative, but the Venereal Disease Research Laboratory and Treponema pallidum haemagglutination tests were positive.