Detalles de la búsqueda
1.
Acceptable intakes (AIs) for 11 small molecule N-nitrosamines (NAs).
Regul Toxicol Pharmacol;
142: 105415, 2023 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-37257751
2.
A ligand-induced structural change in fatty acid-binding protein 1 is associated with potentiation of peroxisome proliferator-activated receptor α agonists.
J Biol Chem;
294(10): 3720-3734, 2019 03 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-30598509
3.
The hepatotoxic fluoroquinolone trovafloxacin disturbs TNF- and LPS-induced p65 nuclear translocation in vivo and in vitro.
Toxicol Appl Pharmacol;
391: 114915, 2020 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32035082
4.
Identification and characterization of a naïve CD8+ T cell repertoire for benzylpenicillin.
Clin Exp Allergy;
49(5): 636-643, 2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30657219
5.
Stem cell-derived models to improve mechanistic understanding and prediction of human drug-induced liver injury.
Hepatology;
65(2): 710-721, 2017 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-27775817
6.
Tissue influx of neutrophils and monocytes is delayed during development of trovafloxacin-induced tumor necrosis factor-dependent liver injury in mice.
J Appl Toxicol;
38(5): 753-765, 2018 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29377180
7.
A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity.
Arch Toxicol;
91(3): 1385-1400, 2017 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-27344343
8.
Early Alterations of Bile Canaliculi Dynamics and the Rho Kinase/Myosin Light Chain Kinase Pathway Are Characteristics of Drug-Induced Intrahepatic Cholestasis.
Drug Metab Dispos;
44(11): 1780-1793, 2016 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-27538918
9.
Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man.
Arch Toxicol;
90(12): 2979-3003, 2016 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-27659300
10.
PPAR agonists reduce steatosis in oleic acid-overloaded HepaRG cells.
Toxicol Appl Pharmacol;
276(1): 73-81, 2014 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24534255
11.
ATP-dependent transport of statins by human and rat MRP2/Mrp2.
Toxicol Appl Pharmacol;
269(2): 187-94, 2013 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23562342
12.
The evolving role of investigative toxicology in the pharmaceutical industry.
Nat Rev Drug Discov;
22(4): 317-335, 2023 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36781957
13.
A systems approach reveals species differences in hepatic stress response capacity.
Toxicol Sci;
196(1): 112-125, 2023 10 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-37647630
14.
Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models.
Nat Rev Drug Discov;
19(2): 131-148, 2020 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-31748707
15.
Today's Challenges to De-Risk and Predict Drug Safety in Human "Mind-the-Gap".
Toxicol Sci;
167(2): 307-321, 2019 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30371856
16.
Differential toxic effects of bile acid mixtures in isolated mitochondria and physiologically relevant HepaRG cells.
Toxicol In Vitro;
61: 104595, 2019 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-31288073
17.
Trovafloxacin-Induced Liver Injury: Lack in Regulation of Inflammation by Inhibition of Nucleotide Release and Neutrophil Movement.
Toxicol Sci;
167(2): 385-396, 2019 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30247740
18.
Optimizing drug discovery by Investigative Toxicology: Current and future trends.
ALTEX;
36(2): 289-313, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-30570669
19.
ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier.
J Neurochem;
107(6): 1518-28, 2008 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-19094056
20.
Cisplatin nephrotoxicity is mediated by gamma glutamyltranspeptidase, not via a C-S lyase governed biotransformation pathway.
Toxicology;
249(2-3): 184-93, 2008 Jul 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-18583013