RESUMEN
Transplantation is now lifesaving therapy for patients with end-stage organ failure but requires lifelong immunosuppression with resultant morbidity. Current immunosuppressive strategies inhibit T cell activation and prevent donor-recipient engagement. Therefore, it is not surprising that few host cells are demonstrated in donor grafts. However, our recent small animal studies found large numbers of recipient stem cells present after transplantation and pharmacological mobilization, resulting in a chimeric, repopulated organ. We now confirm these findings in a well-characterized large animal preclinical model. Here, we show that AMD3100 and FK506 mobilization of endogenous stem cells immediately post kidney transplantation combined with repeat therapy at 1, 2, and 3 months led to drug-free long-term survival in maximally immunologically mismatched swine. Three long-term recipients have stable chimeric transplants, preserved antidonor skin graft responses, and normal serum creatinine levels despite withdrawal of all medication for 3 years.
Asunto(s)
Rechazo de Injerto/prevención & control , Compuestos Heterocíclicos/farmacología , Trasplante de Riñón/efectos adversos , Trasplante de Células Madre de Sangre Periférica , Tacrolimus/farmacología , Quimera por Trasplante , Tolerancia al Trasplante/inmunología , Aloinjertos , Animales , Fármacos Anti-VIH/farmacología , Bencilaminas , Inhibidores de la Calcineurina/farmacología , Ciclamas , Rechazo de Injerto/etiología , Rechazo de Injerto/patología , Supervivencia de Injerto/inmunología , Movilización de Célula Madre Hematopoyética , Fallo Renal Crónico/cirugía , Trasplante de Piel , Porcinos , Porcinos EnanosRESUMEN
The detection of circumstellar water vapour around the ageing carbon star IRC +10216 challenged the current understanding of chemistry in old stars, because water was predicted to be almost absent in carbon-rich stars. Several explanations for the water were postulated, including the vaporization of icy bodies (comets or dwarf planets) in orbit around the star, grain surface reactions, and photochemistry in the outer circumstellar envelope. With a single water line detected so far from this one carbon-rich evolved star, it is difficult to discriminate between the different mechanisms proposed. Here we report the detection of dozens of water vapour lines in the far-infrared and sub-millimetre spectrum of IRC +10216 using the Herschel satellite. This includes some high-excitation lines with energies corresponding to approximately 1,000 K, which can be explained only if water is present in the warm inner sooty region of the envelope. A plausible explanation for the warm water appears to be the penetration of ultraviolet photons deep into a clumpy circumstellar envelope. This mechanism also triggers the formation of other molecules, such as ammonia, whose observed abundances are much higher than hitherto predicted.
RESUMEN
The nearby Supernova 1987A was accompanied by a burst of neutrino emission, which indicates that a compact object (a neutron star or black hole) was formed in the explosion. There has been no direct observation of this compact object. In this work, we observe the supernova remnant with JWST spectroscopy, finding narrow infrared emission lines of argon and sulfur. The line emission is spatially unresolved and blueshifted in velocity relative to the supernova rest frame. We interpret the lines as gas illuminated by a source of ionizing photons located close to the center of the expanding ejecta. Photoionization models show that the line ratios are consistent with ionization by a cooling neutron star or a pulsar wind nebula. The velocity shift could be evidence for a neutron star natal kick.
RESUMEN
Residuals for P-wave traveltimes at a seismnograph station near Bear Valley, California, for small, precisely located local earthquakes at distances of 20 to 70 kilometers show a sharp increase of nearly 0.3 second about 2 months before a magnitude 5.0 earthquake that occurred within a few kilometers of the station. This indicates that velocity changes observed elsewhere premonitory to earthquakes, possibly related to dilatancy, occur along the central section of the San Andreas fault system.