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1.

Anti-tumor effects of RTX-240: an engineered red blood cell expressing 4-1BB ligand and interleukin-15.

McArdel, Shannon L; Dugast, Anne-Sophie; Hoover, Maegan E; Bollampalli, Arjun; Hong, Enping; Castano, Zafira; Leonard, Shannon Curtis; Pawar, Sneha; Mellen, Jennifer; Muriuki, Kelvin; McLaughlin, Douglas C; Bayhi, Nicholas; Carpenter, Christopher L; Turka, Laurence A; Wickham, Thomas J; Elloul, Sivan.

Cancer Immunol Immunother; 70(9): 2701-2719, 2021 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-34244816

2.

Nanoliposome targeting in breast cancer is influenced by the tumor microenvironment.

Dumont, Nancy; Merrigan, Samantha; Turpin, Jason; Lavoie, Cynthia; Papavasiliou, Vasilios; Geretti, Elena; Espelin, Christopher W; Luus, Lia; Kamoun, Walid S; Ghasemi, Omid; Sahagian, G Gary; Muller, William J; Hendriks, Bart S; Wickham, Thomas J; Drummond, Daryl C.

Nanomedicine; 17: 71-81, 2019 04.

Artículo en Inglés | MEDLINE | ID: mdl-30654182

3.

Safety and pharmacokinetics of MM-302, a HER2-targeted antibody-liposomal doxorubicin conjugate, in patients with advanced HER2-positive breast cancer: a phase 1 dose-escalation study.

Munster, Pamela; Krop, Ian E; LoRusso, Patricia; Ma, Cynthia; Siegel, Barry A; Shields, Anthony F; Molnár, István; Wickham, Thomas J; Reynolds, Joseph; Campbell, Karen; Hendriks, Bart S; Adiwijaya, Bambang S; Geretti, Elena; Moyo, Victor; Miller, Kathy D.

Br J Cancer; 119(9): 1086-1093, 2018 10.

Artículo en Inglés | MEDLINE | ID: mdl-30361524

4.

HERMIONE: a randomized Phase 2 trial of MM-302 plus trastuzumab versus chemotherapy of physician's choice plus trastuzumab in patients with previously treated, anthracycline-naïve, HER2-positive, locally advanced/metastatic breast cancer.

Miller, Kathy; Cortes, Javier; Hurvitz, Sara A; Krop, Ian E; Tripathy, Debu; Verma, Sunil; Riahi, Kaveh; Reynolds, Joseph G; Wickham, Thomas J; Molnar, Istvan; Yardley, Denise A.

BMC Cancer; 16: 352, 2016 06 03.

Artículo en Inglés | MEDLINE | ID: mdl-27259714

5.

Single-cell quantitative HER2 measurement identifies heterogeneity and distinct subgroups within traditionally defined HER2-positive patients.

Onsum, Matthew D; Geretti, Elena; Paragas, Violette; Kudla, Arthur J; Moulis, Sharon P; Luus, Lia; Wickham, Thomas J; McDonagh, Charlotte F; MacBeath, Gavin; Hendriks, Bart S.

Am J Pathol; 183(5): 1446-1460, 2013 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-24035511

6.

GNTI-122: an autologous antigen-specific engineered Treg cell therapy for type 1 diabetes.

Uenishi, Gene I; Repic, Marko; Yam, Jennifer Y; Landuyt, Ashley; Saikumar-Lakshmi, Priya; Guo, Tingxi; Zarin, Payam; Sassone-Corsi, Martina; Chicoine, Adam; Kellogg, Hunter; Hunt, Martina; Drow, Travis; Tewari, Ritika; Cook, Peter J; Yang, Soo Jung; Cerosaletti, Karen; Schweinoch, Darius; Guiastrennec, Benjamin; James, Eddie; Patel, Chandra; Chen, Tiffany F; Buckner, Jane H; Rawlings, David J; Wickham, Thomas J; Mueller, Karen T.

JCI Insight; 9(6)2024 Feb 08.

Artículo en Inglés | MEDLINE | ID: mdl-38516892

7.

HER2-targeted liposomal doxorubicin displays enhanced anti-tumorigenic effects without associated cardiotoxicity.

Reynolds, Joseph G; Geretti, Elena; Hendriks, Bart S; Lee, Helen; Leonard, Shannon C; Klinz, Stephan G; Noble, Charles O; Lücker, Petra B; Zandstra, Peter W; Drummond, Daryl C; Olivier, Kenneth J; Nielsen, Ulrik B; Niyikiza, Clet; Agresta, Samuel V; Wickham, Thomas J.

Toxicol Appl Pharmacol; 262(1): 1-10, 2012 Jul 01.

Artículo en Inglés | MEDLINE | ID: mdl-22676972

8.

Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic.

Zhang, Xuqing; Luo, Mengyao; Dastagir, Shamael R; Nixon, Mellissa; Khamhoung, Annie; Schmidt, Andrea; Lee, Albert; Subbiah, Naren; McLaughlin, Douglas C; Moore, Christopher L; Gribble, Mary; Bayhi, Nicholas; Amin, Viral; Pepi, Ryan; Pawar, Sneha; Lyford, Timothy J; Soman, Vikram; Mellen, Jennifer; Carpenter, Christopher L; Turka, Laurence A; Wickham, Thomas J; Chen, Tiffany F.

Nat Commun; 12(1): 2637, 2021 05 11.

Artículo en Inglés | MEDLINE | ID: mdl-33976146

9.

Protection against P. aeruginosa with an adenovirus vector containing an OprF epitope in the capsid.

Worgall, Stefan; Krause, Anja; Rivara, Michael; Hee, Kyung-Kim; Vintayen, Enrico V; Hackett, Neil R; Roelvink, Peter W; Bruder, Joseph T; Wickham, Thomas J; Kovesdi, Imre; Crystal, Ronald G.

J Clin Invest; 115(5): 1281-9, 2005 May.

Artículo en Inglés | MEDLINE | ID: mdl-15841217

10.

Experimental treatment of ovarian cancers by adenovirus vectors combining receptor targeting and selective expression of tumor necrosis factor.

Murugesan, Selva R; Akiyama, Masaki; Einfeld, David A; Wickham, Thomas J; King, C Richter.

Int J Oncol; 31(4): 813-22, 2007 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-17786312

11.

⁶⁴Cu-MM-302 Positron Emission Tomography Quantifies Variability of Enhanced Permeability and Retention of Nanoparticles in Relation to Treatment Response in Patients with Metastatic Breast Cancer.

Lee, Helen; Shields, Anthony F; Siegel, Barry A; Miller, Kathy D; Krop, Ian; Ma, Cynthia X; LoRusso, Patricia M; Munster, Pamela N; Campbell, Karen; Gaddy, Daniel F; Leonard, Shannon C; Geretti, Elena; Blocker, Stephanie J; Kirpotin, Dmitri B; Moyo, Victor; Wickham, Thomas J; Hendriks, Bart S.

Clin Cancer Res; 23(15): 4190-4202, 2017 Aug 01.

Artículo en Inglés | MEDLINE | ID: mdl-28298546

12.

Ligand-directed targeting of genes to the site of disease.

Wickham, Thomas J.

Nat Med; 9(1): 135-9, 2003 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-12514727

13.

Dual HER2 Targeting with Trastuzumab and Liposomal-Encapsulated Doxorubicin (MM-302) Demonstrates Synergistic Antitumor Activity in Breast and Gastric Cancer.

Espelin, Christopher W; Leonard, Shannon C; Geretti, Elena; Wickham, Thomas J; Hendriks, Bart S.

Cancer Res; 76(6): 1517-27, 2016 Mar 15.

Artículo en Inglés | MEDLINE | ID: mdl-26759238

14.

Whole-body organ-level and kidney micro-dosimetric evaluations of (64)Cu-loaded HER2/ErbB2-targeted liposomal doxorubicin ((64)Cu-MM-302) in rodents and primates.

Gaddy, Daniel F; Lee, Helen; Zheng, Jinzi; Jaffray, David A; Wickham, Thomas J; Hendriks, Bart S.

EJNMMI Res; 5: 24, 2015.

Artículo en Inglés | MEDLINE | ID: mdl-25918676

15.

Cyclophosphamide-Mediated Tumor Priming for Enhanced Delivery and Antitumor Activity of HER2-Targeted Liposomal Doxorubicin (MM-302).

Geretti, Elena; Leonard, Shannon Curtis; Dumont, Nancy; Lee, Helen; Zheng, Jinzi; De Souza, Raquel; Gaddy, Daniel F; Espelin, Christopher W; Jaffray, David A; Moyo, Victor; Nielsen, Ulrik B; Wickham, Thomas J; Hendriks, Bart S.

Mol Cancer Ther; 14(9): 2060-71, 2015 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-26162690

16.

The role of capsid-endothelial interactions in the innate immune response to adenovirus vectors.

Liu, Qiang; Zaiss, Anne K; Colarusso, Pina; Patel, Kamala; Haljan, Gregory; Wickham, Thomas J; Muruve, Daniel A.

Hum Gene Ther; 14(7): 627-43, 2003 May 01.

Artículo en Inglés | MEDLINE | ID: mdl-12804145

17.

Binding of adenoviral fiber knob to the coxsackievirus-adenovirus receptor is crucial for transduction of fetal muscle.

Bilbao, Roberto; Srinivasan, Suchitra; Reay, Daniel; Goldberg, Laura; Hughes, Tiffany; Roelvink, Peter W; Einfeld, David A; Wickham, Thomas J; Clemens, Paula R.

Hum Gene Ther; 14(7): 645-9, 2003 May 01.

Artículo en Inglés | MEDLINE | ID: mdl-12804146

18.

Selective gene transfer into primary human gastric tumors using epithelial cell adhesion molecule-targeted adenoviral vectors with ablated native tropism.

Heideman, Daniëlle A M; van Beusechem, Victor W; Offerhaus, G Johan A; Wickham, Thomas J; Roelvink, Peter W; Craanen, Mikael E; Pinedo, Herbert M; Meijer, Chris J L M; Gerritsen, Winald R.

Hum Gene Ther; 13(14): 1677-85, 2002 Sep 20.

Artículo en Inglés | MEDLINE | ID: mdl-12396621

19.

Histone deacetylase inhibitors upregulate expression of the coxsackie adenovirus receptor (CAR) preferentially in bladder cancer cells.

Sachs, Markus D; Ramamurthy, Meera; Poel, Henk van der; Wickham, Thomas J; Lamfers, Martine; Gerritsen, Winald; Chowdhury, Wasim; Li, Ying; Schoenberg, Mark P; Rodriguez, Ronald.

Cancer Gene Ther; 11(7): 477-86, 2004 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-15118762

20.

Impact of tumor HER2/ERBB2 expression level on HER2-targeted liposomal doxorubicin-mediated drug delivery: multiple low-affinity interactions lead to a threshold effect.

Hendriks, Bart S; Klinz, Stephan G; Reynolds, Joseph G; Espelin, Christopher W; Gaddy, Daniel F; Wickham, Thomas J.

Mol Cancer Ther; 12(9): 1816-28, 2013 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-23723124

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