RESUMEN
Different F5 recombinant inbred lines from the cross Yumai 34×Ukrainka were grown in replicated trials on a single site in one harvest year at Rothamsted Research. A total of 10 samples from those lines were harvested and used in a broiler experiment. Twenty nutritionally complete meal-form diets that had 630 g/kg of wheat with different amounts of pentosan, with and without exogenous xylanase supplementation, were used to compare broiler growth performance and determine apparent metabolizable energy corrected for N retention (AMEn). We examined the relationship between the nutritive value of the wheat samples and their chemical compositions and results of quality tests. The amounts of total and water soluble pentosans in wheat samples ranged from 36.7 to 48.0 g/kg DM, and 6.7 to 11.6 g/kg DM, respectively. The mean crude oil and protein contents of the wheat samples were 10.5 and 143.9 g/kg DM, respectively. The average determined value for the kinematic viscosity was 0.0018 mPa.s, and 2.1 mPa.s for the dynamic viscosity. The AMEn of the wheat-based diets had a maximum range of 0.47 MJ/kg DM within the ten wheat samples that were tested. Xylanase supplementation improved (P<0.05) dietary AMEn, dry matter, and fat digestibility coefficients. There was a positive (P<0.05) relationship between in vitro kinematic viscosity of the wheat samples and the total pentosan content. There was a negative relationship between the total pentosan content in the wheat and broiler growth performance. An increase by 10 g of pentosan per kg of wheat reduced (P<0.001) daily feed intake and weight gain by 2.9 g and 3.5 g, respectively. The study shows that the feeding quality of wheat samples can be predicted by their total pentosan content. Supplementary xylanase improved energy and nutrient availability of all wheat samples that was independent of differences in pentosan content.
Asunto(s)
Alimentación Animal/análisis , Pollos/crecimiento & desarrollo , Endo-1,4-beta Xilanasas/farmacología , Metabolismo Energético/efectos de los fármacos , Poliéster Pentosan Sulfúrico/metabolismo , Polisacáridos/metabolismo , Triticum/química , Fenómenos Fisiológicos Nutricionales de los Animales , Animales , Dieta/veterinaria , Suplementos Dietéticos , Endo-1,4-beta Xilanasas/administración & dosificación , Metabolismo Energético/fisiología , Regulación de la Expresión Génica de las Plantas , Masculino , Poliéster Pentosan Sulfúrico/genética , Polisacáridos/genética , Triticum/genética , Triticum/metabolismoRESUMEN
The malaria situation in Sri Lanka worsened during the 1990s with the emergence and spread of resistance to the drugs and insecticides used for control. Chloroquine resistance has increased rapidly over this period, but adverse changes in malaria transmission are more closely associated with insecticide use rather than drug resistance. Insecticide susceptibility tests were routinely carried out in key anopheline vectors across the country for more than a decade. These sentinel data were combined with data collected by other research programmes and used to map the spatial and temporal trends of insecticide resistance in the main vectors, Anopheles culicifacies and A. subpictus, and to examine the relationship between insecticide resistance, changes in national spraying regimens and malaria prevalence. Both species had widespread resistance to malathion, the insecticide of choice in the early 1990s. Both species were initially susceptible to the organophosphate and pyrethroid insecticides used operationally from 1993, but some resistance has now been selected. The levels of malathion and fenitrothion resistance in A. subpictus were higher in some ecological regions than others, which may be related to the distribution of sibling species, agricultural pesticide exposure and/or environmental factors. The study highlights that the emergence and spread of insecticide resistance is a constant threat and that active surveillance systems are vital in identifying key vectors and evidence of resistance.
Asunto(s)
Anopheles/efectos de los fármacos , Resistencia a los Insecticidas , Malaria/epidemiología , Animales , Incidencia , Control de Mosquitos , Sri Lanka/epidemiologíaRESUMEN
The study was conducted in eight adjacent villages in central Sri Lanka where there are many shallow pits dug by gem miners that fill with water. These become breeding places of the main malarial vector Anopheles culicifacies, and of the second most important vector Anopheles subpictus, but not of Anopheles varuna, the third most important vector. With the help of local volunteers, data on the adult populations of these three species was collected by various standard methods, and data on the incidence of malaria cases was collected by two clinics set up for the project and through the existing hospitals. Prevalence of malaria infection in symptom-less people was investigated by mass blood surveys. On the basis of a year's pre-intervention data the villages were stratified into four with high levels of malaria transmission and four with lower transmission. Within each stratum two villages were randomly assigned for mosquito control by treating all the gem pits, as well as river bed pools, with a granular formulation of the insect growth regulator pyriproxyfen at a target dose of 0.01 mg a.i./litre. The intervention caused significant reductions in the adult populations of An. culicifacies and An. subpictus. Similarly, incidence of malaria was reduced in the intervention villages to about 24% (95% c.l. 20-29%) of that in the controls. Prevalence of parasitaemia also declined significantly. It is concluded that in this situation where, with active community participation, the breeding sites of the main vectors could be located; vector control by a highly active and persistent insect growth regulator can be a very effective means of malaria control.
Asunto(s)
Anopheles/efectos de los fármacos , Hormonas Juveniles/farmacología , Malaria/prevención & control , Minería , Control de Mosquitos/métodos , Piridinas/farmacología , Adolescente , Adulto , Animales , Anopheles/clasificación , Anopheles/fisiología , Niño , Preescolar , Femenino , Humanos , Incidencia , Lactante , Recién Nacido , Insectos Vectores/clasificación , Insectos Vectores/efectos de los fármacos , Insectos Vectores/fisiología , Malaria/parasitología , Masculino , Parasitemia/parasitología , Parasitemia/prevención & control , Plasmodium falciparum/aislamiento & purificación , Plasmodium vivax/aislamiento & purificación , Sri LankaRESUMEN
Marine animals, especially those from tropical waters, are often brilliantly coloured, and bright colouration is widespread in both sessile and non-sessile invertebrates. These spectacular natural colours are common in species inhabiting shallow waters, and appear not only in animals exposed to bright light, but also in those living in dark areas where colours are visible only with artificial illumination. Marine organisms also show variation in colour with depth and geographical location, and display great variety in colour patterning. These colour characteristics are the result of several different processes, and serve various purposes - the distribution and function of pigments seems to vary between invertebrate groups. In addition to playing an important role in how marine organisms interact, pigments may be involved in physiological processes. Although nitrogenous pigments predominate, marine organisms contain pigments belonging to all the major structural classes of natural products, as well as some that are unique to the marine environment. This review discusses the nature and significance of such pigments, the chemical and biological processes involved, the factors responsible for and affecting bright colourations, as well as their evolution and speculation as to their function.
Asunto(s)
Invertebrados/fisiología , Biología Marina , Pigmentos Biológicos , Animales , Evolución Biológica , Invertebrados/genética , Luminiscencia , Estructura Molecular , Pigmentos Biológicos/química , Pigmentos Biológicos/fisiologíaRESUMEN
The clinical features and cutaneous hypersensitivity to skin prick tests were studied in 64 asthmatic patients in General Hospital, Kandy (Sri Lanka). The onset of asthma was mostly in adult life; associated atopic disease and family history of allergy were less frequent when compared with asthmatics in industrialised countries in the temperate zone. In these respects the clinical pattern of asthma in our study resembles that described in other tropical countries. Cutaneous hypersensitivity to one or more of the 10 allergens tested was observed in 75% of asthmatics and 55% of non-asthmatic controls. Although there was a higher incidence of associated allergic disorders, family history of allergy and the onset of asthma before the age of 10 years in the skin test positive group when compared with the skin test negative group of asthmatics, this difference was not statistically significant.
Asunto(s)
Asma/inmunología , Adolescente , Adulto , Anciano , Asma/complicaciones , Femenino , Humanos , Hipersensibilidad Inmediata/complicaciones , Masculino , Persona de Mediana Edad , Pruebas Cutáneas , Sri LankaRESUMEN
Rectal bleeding is associated with colorectal cancer, but does not occur in all cases and is usually a symptom of minor colorectal disorders. Colorectal cancer presents only Infrequently with rectal bleeding in isolation.