RESUMEN
OBJECTIVE: Congenital corrected transposition of the great arteries (ccTGA) is a rare congenital cardiac anomaly which remains difficult to diagnose prenatally. We aim to investigate the natural history, associated anomalies and the outcome of patients in prenatally diagnosed ccTGA. METHOD: This was an international multicenter retrospective analysis of fetuses with a diagnosis of ccTGA from 2002 to 2017. We reviewed clinical and echocardiographic databases of seven centers. Anatomic survey and fetal echocardiography were performed according to international guidelines of ISUOG. RESULTS: We considered 69 fetuses with prenatally suspected ccTGA. There was an overall survival rate of 91â% among 54 patients with a confirmed diagnosis. Survival to live birth was 96â% (52/54) and survival on an intention-to-treat basis was 94â% (49/52). The mean gestational age at the time of diagnosis was 25.6â±â5.9 weeks of gestation. In 7 out of 54 fetuses (13â%), ccTGA was an isolated finding. Dextro/mesocardia was present in 15 cases (27.8â%). Intracardiac anomalies were present in 46/54 cases (85.2â%) with the most frequent anomaly being a ventricular septal defect present in 41 fetuses (75.9â%). Complete heart block was diagnosed in 10 cases (18.5â%). Extracardiac anomalies were observed in 9 out of 54 cases (16.7â%). Prenatal karyotyping of the fetus was available in 30/54 (55.6â%) cases with chromosomal anomalies in 4/30 (13.3â%). CONCLUSION: ccTGA is a rare cardiac anomaly often accompanied by a variable spectrum of further intracardiac abnormalities. Accurate diagnosis of ccTGA, which can be integrated into parental counselling, is feasible with a favorable short-term outcome for affected neonates.