Búsqueda | Portal de Búsqueda de la BVS España

1.

Targeted protein degradation via intramolecular bivalent glues.

Hsia, Oliver; Hinterndorfer, Matthias; Cowan, Angus D; Iso, Kentaro; Ishida, Tasuku; Sundaramoorthy, Ramasubramanian; Nakasone, Mark A; Imrichova, Hana; Schätz, Caroline; Rukavina, Andrea; Husnjak, Koraljka; Wegner, Martin; Correa-Sáez, Alejandro; Craigon, Conner; Casement, Ryan; Maniaci, Chiara; Testa, Andrea; Kaulich, Manuel; Dikic, Ivan; Winter, Georg E; Ciulli, Alessio.

Nature; 627(8002): 204-211, 2024 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-38383787

2.

Fast-acting chemical tools to delineate causality in transcriptional control.

Jaeger, Martin G; Winter, Georg E.

Mol Cell; 81(8): 1617-1630, 2021 04 15.

Artículo en Inglés | MEDLINE | ID: mdl-33689749

3.

Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation.

Mayor-Ruiz, Cristina; Jaeger, Martin G; Bauer, Sophie; Brand, Matthias; Sin, Celine; Hanzl, Alexander; Mueller, André C; Menche, Jörg; Winter, Georg E.

Mol Cell; 75(4): 849-858.e8, 2019 08 22.

Artículo en Inglés | MEDLINE | ID: mdl-31442425

4.

Design principles for cyclin K molecular glue degraders.

Kozicka, Zuzanna; Suchyta, Dakota J; Focht, Vivian; Kempf, Georg; Petzold, Georg; Jentzsch, Marius; Zou, Charles; Di Genua, Cristina; Donovan, Katherine A; Coomar, Seemon; Cigler, Marko; Mayor-Ruiz, Cristina; Schmid-Burgk, Jonathan L; Häussinger, Daniel; Winter, Georg E; Fischer, Eric S; Slabicki, Mikolaj; Gillingham, Dennis; Ebert, Benjamin L; Thomä, Nicolas H.

Nat Chem Biol; 20(1): 93-102, 2024 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-37679459

5.

Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders.

Hanzl, Alexander; Casement, Ryan; Imrichova, Hana; Hughes, Scott J; Barone, Eleonora; Testa, Andrea; Bauer, Sophie; Wright, Jane; Brand, Matthias; Ciulli, Alessio; Winter, Georg E.

Nat Chem Biol; 19(3): 323-333, 2023 03.

Artículo en Inglés | MEDLINE | ID: mdl-36329119

6.

BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment.

Winter, Georg E; Mayer, Andreas; Buckley, Dennis L; Erb, Michael A; Roderick, Justine E; Vittori, Sarah; Reyes, Jaime M; di Iulio, Julia; Souza, Amanda; Ott, Christopher J; Roberts, Justin M; Zeid, Rhamy; Scott, Thomas G; Paulk, Joshiawa; Lachance, Kate; Olson, Calla M; Dastjerdi, Shiva; Bauer, Sophie; Lin, Charles Y; Gray, Nathanael S; Kelliher, Michelle A; Churchman, L Stirling; Bradner, James E.

Mol Cell; 67(1): 5-18.e19, 2017 Jul 06.

Artículo en Inglés | MEDLINE | ID: mdl-28673542

7.

Discovery of a DCAF11-dependent cyanoacrylamide-containing covalent degrader of BET-proteins.

Tin, Gary; Cigler, Marko; Hinterndorfer, Matthias; Dong, Kevin D; Imrichova, Hana; Gygi, Steven P; Winter, Georg E.

Bioorg Med Chem Lett; 107: 129779, 2024 Jul 15.

Artículo en Inglés | MEDLINE | ID: mdl-38729317

8.

Discovery and Mechanistic Elucidation of NQO1-Bioactivatable Small Molecules That Overcome Resistance to Degraders.

Barbosa, Bárbara M G; Sfyaki, Aikaterini; Rafael, Sergi; José-Duran, Ferran; Pous, Joan; Sánchez-Zarzalejo, Carolina; Perez-Lopez, Carles; Vilanova, Mar; Cigler, Marko; Gay, Marina; Vilaseca, Marta; Winter, Georg E; Riera, Antoni; Mayor-Ruiz, Cristina.

Angew Chem Int Ed Engl; 63(12): e202316730, 2024 Mar 18.

Artículo en Inglés | MEDLINE | ID: mdl-38153885

9.

Advancing Targeted Protein Degradation via Multiomics Profiling and Artificial Intelligence.

Duran-Frigola, Miquel; Cigler, Marko; Winter, Georg E.

J Am Chem Soc; 145(5): 2711-2732, 2023 02 08.

Artículo en Inglés | MEDLINE | ID: mdl-36706315

10.

E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance.

Hanzl, Alexander; Barone, Eleonora; Bauer, Sophie; Yue, Hong; Nowak, Radoslaw P; Hahn, Elisa; Pankevich, Eugenia V; Koren, Anna; Kubicek, Stefan; Fischer, Eric S; Winter, Georg E.

J Am Chem Soc; 145(2): 1176-1184, 2023 01 18.

Artículo en Inglés | MEDLINE | ID: mdl-36602777

11.

Transcription control by the ENL YEATS domain in acute leukaemia.

Erb, Michael A; Scott, Thomas G; Li, Bin E; Xie, Huafeng; Paulk, Joshiawa; Seo, Hyuk-Soo; Souza, Amanda; Roberts, Justin M; Dastjerdi, Shiva; Buckley, Dennis L; Sanjana, Neville E; Shalem, Ophir; Nabet, Behnam; Zeid, Rhamy; Offei-Addo, Nana K; Dhe-Paganon, Sirano; Zhang, Feng; Orkin, Stuart H; Winter, Georg E; Bradner, James E.

Nature; 543(7644): 270-274, 2017 03 09.

Artículo en Inglés | MEDLINE | ID: mdl-28241139

12.

Rational discovery of molecular glue degraders via scalable chemical profiling.

Mayor-Ruiz, Cristina; Bauer, Sophie; Brand, Matthias; Kozicka, Zuzanna; Siklos, Marton; Imrichova, Hana; Kaltheuner, Ines H; Hahn, Elisa; Seiler, Kristina; Koren, Anna; Petzold, Georg; Fellner, Michaela; Bock, Christoph; Müller, André C; Zuber, Johannes; Geyer, Matthias; Thomä, Nicolas H; Kubicek, Stefan; Winter, Georg E.

Nat Chem Biol; 16(11): 1199-1207, 2020 11.

Artículo en Inglés | MEDLINE | ID: mdl-32747809

13.

BRD4 degradation blocks expression of MYC and multiple forms of stem cell resistance in Ph⁺ chronic myeloid leukemia.

Peter, Barbara; Eisenwort, Gregor; Sadovnik, Irina; Bauer, Karin; Willmann, Michael; Rülicke, Thomas; Berger, Daniela; Stefanzl, Gabriele; Greiner, Georg; Hoermann, Gregor; Keller, Alexandra; Wolf, Dominik; Culen, Martin; Winter, Georg E; Hoffmann, Thomas; Schiefer, Ana-Iris; Sperr, Wolfgang R; Zuber, Johannes; Mayer, Jirí; Valent, Peter.

Am J Hematol; 97(9): 1215-1225, 2022 09.

Artículo en Inglés | MEDLINE | ID: mdl-35794848

14.

Suv39h-dependent H3K9me3 marks intact retrotransposons and silences LINE elements in mouse embryonic stem cells.

Bulut-Karslioglu, Aydan; De La Rosa-Velázquez, Inti A; Ramirez, Fidel; Barenboim, Maxim; Onishi-Seebacher, Megumi; Arand, Julia; Galán, Carmen; Winter, Georg E; Engist, Bettina; Gerle, Borbala; O'Sullivan, Roderick J; Martens, Joost H A; Walter, Jörn; Manke, Thomas; Lachner, Monika; Jenuwein, Thomas.

Mol Cell; 55(2): 277-90, 2014 Jul 17.

Artículo en Inglés | MEDLINE | ID: mdl-24981170

15.

Proximity-inducing pharmacology.

Winter, Georg E; Mayor-Ruiz, Cristina.

Nat Chem Biol; 20(1): 13-14, 2024 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-37978259

16.

Targetable BET proteins- and E2F1-dependent transcriptional program maintains the malignancy of glioblastoma.

Xu, Liang; Chen, Ye; Mayakonda, Anand; Koh, Lynnette; Chong, Yuk Kien; Buckley, Dennis L; Sandanaraj, Edwin; Lim, See Wee; Lin, Ruby Yu-Tong; Ke, Xin-Yu; Huang, Mo-Li; Chen, Jianxiang; Sun, Wendi; Wang, Ling-Zhi; Goh, Boon Cher; Dinh, Huy Q; Kappei, Dennis; Winter, Georg E; Ding, Ling-Wen; Ang, Beng Ti; Berman, Benjamin P; Bradner, James E; Tang, Carol; Koeffler, H Phillip.

Proc Natl Acad Sci U S A; 115(22): E5086-E5095, 2018 05 29.

Artículo en Inglés | MEDLINE | ID: mdl-29764999

17.

CIDE-stepping E3s.

Tin, Gary; Winter, Georg E.

Nat Chem Biol; 19(1): 3-4, 2023 01.

Artículo en Inglés | MEDLINE | ID: mdl-36577874

18.

Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation.

Olson, Calla M; Jiang, Baishan; Erb, Michael A; Liang, Yanke; Doctor, Zainab M; Zhang, Zinan; Zhang, Tinghu; Kwiatkowski, Nicholas; Boukhali, Myriam; Green, Jennifer L; Haas, Wilhelm; Nomanbhoy, Tyzoon; Fischer, Eric S; Young, Richard A; Bradner, James E; Winter, Georg E; Gray, Nathanael S.

Nat Chem Biol; 14(2): 163-170, 2018 02.

Artículo en Inglés | MEDLINE | ID: mdl-29251720

19.

The dTAG system for immediate and target-specific protein degradation.

Nabet, Behnam; Roberts, Justin M; Buckley, Dennis L; Paulk, Joshiawa; Dastjerdi, Shiva; Yang, Annan; Leggett, Alan L; Erb, Michael A; Lawlor, Matthew A; Souza, Amanda; Scott, Thomas G; Vittori, Sarah; Perry, Jennifer A; Qi, Jun; Winter, Georg E; Wong, Kwok-Kin; Gray, Nathanael S; Bradner, James E.

Nat Chem Biol; 14(5): 431-441, 2018 05.

Artículo en Inglés | MEDLINE | ID: mdl-29581585

20.

Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands.

Gechijian, Lara N; Buckley, Dennis L; Lawlor, Matthew A; Reyes, Jaime M; Paulk, Joshiawa; Ott, Christopher J; Winter, Georg E; Erb, Michael A; Scott, Thomas G; Xu, Mousheng; Seo, Hyuk-Soo; Dhe-Paganon, Sirano; Kwiatkowski, Nicholas P; Perry, Jennifer A; Qi, Jun; Gray, Nathanael S; Bradner, James E.

Nat Chem Biol; 14(4): 405-412, 2018 04.

Artículo en Inglés | MEDLINE | ID: mdl-29507391

Portal de Búsqueda de la BVS España

Información y Conocimiento para la Salud

Configurar filtros

Su selección (0)

Formato de exportación:

Exportar: