Effects of microRNA-320 on learning and memory in mice with vascular cognitive impairment caused via cerebral ischemia.

We aimed to explore microRNA (miR)-320's impacts on learning and memory in mice with vascular cognitive impairment induced via cerebral ischemia. After establishment of a cerebral small vessel disease (CSVD) cognitive impairment model, application of corresponding treatment methods was in the model mice to inject miR-320 antagomir/agomir and their negative controls to the lateral ventricles: Test of the learning and memory abilities of mice was conducted; Detection of oxidative stress, inflammation, miR-320, Vascular endothelial growth factor (VEGF) and endostatin (ES) was implemented; Taking mouse hippocampal neuron cells was to detect the cell advancement. MiR-320 was elevated in the CSVD model; MiR-320 was negatively linked with the learning and memory abilities of mice; Repressing miR-320 was available to memorably elevate the learning and memory abilities of CSVD mice; Depressing miR-320 clearly drove CSVD mouse neovascular protein VEGF, but reduced inflammation, oxidative stress response and ES; Restraining miR-320 was available to contribute to mouse neuronal cell advancement. MiR-320 mitigates the learning and memory abilities of cerebral ischemia-induced vascular cognitive dysfunction mice to a certain extent.

Case Report: Perianal infection in children caused by ingested jujube pits: a report of two cases.

Background: The ingestion of jujube pits by children is a rare cause of perianal infection.This article aimed to report two cases of perianal infection in children resulting from the ingestion of jujube pits. Methods: We reviewed the clinical records of perianal infection caused by jujube pits at our hospital. Details of the patients' presentation, imaging studies, complications and treatment were recorded. Results: Both pediatric patients presented with perianal swelling and pain. The caregivers of both patients denied a history of jujube consumption. Magnetic resonance imaging (MRI) indicated the presence of jujube pits, which were subsequently removed during surgery. Postoperatively, both patients recovered well, and follow-up showed no recurrence or the formation of anal fistulas. Conclusion: The ingestion of jujube pits leading to perianal infection is rare and inconspicuous. Early diagnosis and treatment are beneficial in preventing the occurrence of serious complications.