Asunto(s)
Hipersensibilidad a los Alimentos , Prunus persica , Alérgenos , Antígenos de Plantas , Frutas , Humanos , Proteínas de PlantasRESUMEN
BACKGROUND: The role of specific IgE (sIgE) against Der p 1 and Der p 2 in Chinese patients with house dust mite (HDM) allergy has not yet been well investigated. METHODS: One hundred patients were enrolled, based on sensitization and doctor-diagnosed allergy to HDM. Questionnaires were administered to document demographic and clinical characteristics. Serum IgE reactivity to Dermatophagoides pteronyssinus (Dp) extract, Der p 1, Der p 2 and Der p 10 was measured by ImmunoCAP. RESULTS: Almost all patients were sensitized to Der p 1 (95%) and Der p 2 (93%), with both allergens together being largely responsible for the total anti-HDM IgE response. No evidence for a significant role of Der p 10 was found. Overall, IgE responses to HDM and its 2 major allergens were higher in children than in adults in this cross-sectional study. With increasing age, IgE responses to Der p 2 become more important. A positive correlation was observed between the reaction of sIgE against Dp, Der p 1 and Der p 2 and the number of organs (including the eyes, nose, lungs and skin) that were affected in patients. CONCLUSIONS: In China, Der p 1 and Der p 2 are the dominant allergens in patients with HDM allergy. The relative importance of Der p 1 and Der p 2 changes with age, in favor of Der p 2. Overall, sIgE titers were positively associated with the number of organs affected.
Asunto(s)
Alérgenos/inmunología , Antígenos Dermatofagoides/inmunología , Proteínas de Artrópodos/inmunología , Cisteína Endopeptidasas/inmunología , Hipersensibilidad/inmunología , Inmunoglobulina E/inmunología , Adolescente , Adulto , Factores de Edad , Animales , Niño , Preescolar , Femenino , Humanos , Hipersensibilidad/sangre , Hipersensibilidad/epidemiología , Inmunoglobulina E/sangre , Masculino , Persona de Mediana Edad , Prevalencia , Factores de Riesgo , Pruebas Cutáneas , Adulto JovenAsunto(s)
Linfocitos T CD4-Positivos/metabolismo , Relojes Circadianos/genética , Ritmo Circadiano/genética , Factores de Transcripción Forkhead/genética , Intestinos/inmunología , Transcripción Genética/genética , Adulto , Animales , Linfocitos T CD4-Positivos/inmunología , Relojes Circadianos/inmunología , Ritmo Circadiano/inmunología , Femenino , Hipersensibilidad a los Alimentos/sangre , Hipersensibilidad a los Alimentos/genética , Hipersensibilidad a los Alimentos/inmunología , Factores de Transcripción Forkhead/inmunología , Humanos , Inmunoglobulina E/sangre , Subunidad alfa del Receptor de Interleucina-2/genética , Subunidad alfa del Receptor de Interleucina-2/inmunología , Interleucina-4/sangre , Mucosa Intestinal/metabolismo , Masculino , Ratones , Ratones Endogámicos BALB C , Linfocitos T Reguladores/inmunología , Transcripción Genética/inmunologíaAsunto(s)
Alérgenos/inmunología , Antígenos de Plantas/inmunología , Proteínas Portadoras/inmunología , Hipersensibilidad a los Alimentos/inmunología , Polen/inmunología , Prunus/inmunología , Alérgenos/metabolismo , Antígenos de Plantas/metabolismo , Artemisia/inmunología , Proteínas Portadoras/metabolismo , China , Hipersensibilidad a los Alimentos/metabolismo , Humanos , Inmunoglobulina E/inmunología , Inmunoglobulina E/metabolismo , Unión Proteica/inmunología , Prunus/efectos adversosRESUMEN
OBJECTIVE: To determine Th1/Th2 cytokines and chemokines in patients with allergic diseases and its clinic significance. METHODS: Serum levels of IFN-gamma, IL-4, IL-5, IL-13, Eotaxin, RANTES and LTB4 were determined from peripheral blood of 64 allergic patients and 21 healthy controls with ELISA. RESULTS: IL-4, IL-5, IL-13 and Eotaxin, LTB4 were increased significantly in serum of allergic patients compared with those of controls (P<0.05). There were no significant differences in serum levels of IFN-gamma and RANTES between patients and controls (P>0.05). Serum levels of IL-4, IL-5, IL-13 and LTB4 were correlated with each other (P<0.01). Eotaxin, RANTES and IFN-gamma levels were also significantly correlated with each other (P<0.05). LTB4 was correlated with Eotaxin as well (P<0.01). CONCLUSION: A wide range of cytokines and chemokines is involved in allergic diseases,which may play their roles in a complex interactive manner.