Uptake and cellular responses of Microcystis aeruginosa to PFOS in various environmental conditions.

Although PFOS has been banned as a persistent organic pollutant, it still exists in large quantities within the environment, thus impacting the health of aquatic ecosystems. Previous studies focused solely on high PFOS concentrations, disregarding the connection with environmental factors. To gain a more comprehensive understanding of the PFOS effects on aquatic ecosystems amidst changing environmental conditions, this study investigated the cellular responses of Microcystis aeruginosa to varying PFOS concentrations under heatwave and nutrient stress conditions. The results showed that PFOS concentrations exceeding 5.0 µg/L had obvious effects on multiple physiological responses of M. aeruginosa, resulting in the suppression of algal cell growth and the induction of oxidative damage. However, PFOS concentration at levels below 20.0 µg/L has been found to enhance the growth of algal cells and trigger significant oxidative damage under heatwave conditions. Heatwave conditions could enhance the uptake of PFOS in algal cells, potentially leading to heightened algal growth when PFOS concentration was equal to or less than 5.0 µg/L. Conversely, deficiency or limitation of nitrogen and phosphorus significantly decreased algal abundance and chlorophyll content, inducing severe oxidative stress that could be mitigated by exposure to PFOS. This study holds significance in managing the impact of PFOS on algal growth across diverse environmental conditions.

Laser beam steering of 532†nm using a power-efficient focal plane array.

Laser beam steering is important for classical and quantum information processing. On-chip beam steering is a major motivation for developing large-scale photonic integrated circuits such as optical phased arrays. A major challenge for such arrays is to simultaneously control a large number of on-chip phase shifters, which requires a complicated analog control algorithm and rapidly increasing power consumption. We report a green light (532 nm) 1 × 16 focal plane array photonic integrated circuit with simple control and low power consumption. Fabricated on a silicon nitride platform, the focal plane array achieves angular beam steering over a 10° field of view, with ultra-low electrical power consumption (4 × 3.1 mW).

Morchella Effectively Removes Microcystins Produced by Microcystis aeruginosa.

Microcystins (MCs) produced by Microcystis aeruginosa are harmful to animal and human health, and there is currently no effective method for their removal. Therefore, the development of biological approaches that inhibit cyanobacteria and remove MCs is needed. We identified strain MB1, confirmed as Morchella, using morphological and mole-cular evolution methods. To assess the impact of strain MB1 on M. aeruginosa, we conducted an experiment in which we inoculated M. aeruginosa with Morchella strain MB1. After their co-cultivation for 4| |d, the inoculation with 0.9696| |g MB1 completely inhibited and removed M. aeruginosa while concurrently removing up to 95% of the MC content. Moreover, within 3| |d of their co-cultivation, MB1 removed more than 50% of nitrogen and phosphorus from the M. aeruginosa solution. Therefore, the development of effective biological techniques for MC removal is paramount in safeguarding both the environment and human well-being. We herein successfully isolated MB1 from its natural habitat. This strain effectively inhibited and removed M. aeruginosa and also reduced the content of nitrogen and phosphorus in the M. aeruginosa solution. Most importantly, it exhibited a robust capability to eliminate MCs. The present results offer a new method and technical reference for mitigating harmful algal blooms.

Fabricating Spinel-Type High-Entropy Oxides of (Co, Fe, Mn, Ni, Cr)3O4 for Efficient Oxygen Evolution Reaction.

Fabricating efficient oxygen evolution reaction (OER) electrocatalysts is crucial for water electrocatalysis. Herein, the spinel-type high-entropy oxides of (Co, Fe, Mn, Ni, Cr)3O4 were synthesized through the high-temperature calcination approach. The influences of calcination temperatures on structures and electrochemical properties were investigated. The optimized catalyst of HEO-900 contains the hybrid structure of regular polyhedrons and irregular nanoparticles, which is beneficial for the exposure of electrochemically active sites. It was identified that the abundant high-valence metal species of Ni3+, Co3+, Fe3+, Mn4+, and Cr3+ are formed during the OER process, which is generally regarded as the electrochemically active sites for OER. Because of the synergistic effect of multi-metal active sites, the optimized HEO-900 catalyst indicates excellent OER activity, which needs the overpotential of 366 mV to reach the current density of 10 mA cm-2. Moreover, HEO-900 reveals the prominent durability of running for 24 h at the current density of 10 mA cm-2 without clear delay. Therefore, this work supplies a promising route for preparing high-performance multi-metal OER electrocatalysts for water electrocatalysis application.

Short-term antipsychotic treatment reduces functional connectivity of the striatum in first-episode drug-naïve early-onset schizophrenia.

BACKGROUND: The striatum is thought to play a critical role in the pathophysiology and antipsychotic treatment of schizophrenia. Previous studies have revealed abnormal functional connectivity (FC) of the striatum in early-onset schizophrenia (EOS) patients. However, no prior studies have examined post-treatment changes of striatal FC in EOS patients. METHODS: We recruited 49 first-episode drug-naïve EOS patients to have resting-state functional magnetic resonance imaging scans at baseline and after 8 weeks of treatment with antipsychotics, along with baseline scanning of 34 healthy controls (HCs) for comparison purposes. We examined the FC values between each seed in striatal subregion and the rest of the brain. The Positive and Negative Syndrome Scale (PANSS) was applied to measure psychiatric symptoms in patients. RESULTS: Compared with HCs at baseline, EOS patients exhibited weaker FC of striatal subregions with several brain regions of the salience network and default mode network. Meanwhile, FC between the dorsal caudal putamen (DCP) and left supplementary motor area, as well as between the DCP and right postcentral gyrus, was negatively correlated with PANSS negative scores. Furthermore, after 8 weeks of treatment, EOS patients showed decreased FC between subregions of the putamen and the triangular part of inferior frontal gyrus, middle frontal gyrus, supramarginal gyrus and inferior parietal lobule. CONCLUSIONS: Decreased striatal FC is evident, even in the early stages of schizophrenia, and enhance our understanding of the neurodevelopmental abnormalities in schizophrenia. The findings also demonstrate that reduced striatal FC occurs after antipsychotic therapy, indicating that antipsychotic effects need to be accounted for when considering striatal FC abnormalities in schizophrenia.

Co-emissions of fluoride ion, fluorinated greenhouse gases, and per- and polyfluoroalkyl substances (PFAS) from different fluorochemical production processes.

Fluorochemical industry is an emerging industry leading to environmental emissions of fluoride ion, fluorinated greenhouse gases (GHGs) and per- and polyfluoroalkyl substances (PFASs) globally. Chlorofluorocarbon (CFCs) and hydrochlorofluorocarbon (HCFCs) are the primary causes of ozone layer depletion, and together with hydrofluorocarbons (HFCs), they contribute to global climate warming. PFAS are emerging persistent organic pollutants, comprising thousands of materials including perfluoroalkyl acids (PFAAs), perfluoroalkane sulfonamides (FASAs), and fluoropolymers.As the implementation of the Montreal Protocol and the Stockholm Convention makes progress, fluorochemical industry is searching for alternatives like HFCs, perfluoroalkyl ether carboxylic acids (PFECAs) and etc. Even though studies on chemical processes and environmental influences of the fluorochemical industry are plentiful, research on emissions of fluorine chemicals from different fluorochemical industry is still scarce. In this study, we conducted on-site sampling to analyze the distribution of fluorine chemicals in the surrounding environment of the fluorochemical industrial sites. The sampling sites represent different stages of fluorochemical industry production, including fluorite mining, synthesis of fluorochemical raw materials like fluorocarbons, and fine fluorine product processing which is mostly PFAS. Results show that at the fluorite mining stage, concurrent emissions of fluoride ion and CFC-12 contribute to the primary environmental issue. Perfluorooctanoic acid (PFOA) and some short-chain PFASs like perfluorobutanoic acid (PFBA), perfluoropentanoic acid (PFPeA), perfluoroheptanoic acid (PFHpA), and perfluorobutanesulfonic acid (PFBS) are the main pollutants from fluocarbons production, accompanied by emissions of fluorinated GHGs such as HFC-32, and HCFC-22. At the fine fluorine product synthesis stage where produces fluoropolymers, perfluoropolyethers and fluorinated surfactants, PFAS especially for emerging alternatives PFECAs like hexafluoropropylene oxide dimer acid (HFPODA) and Perfluoro-4-oxapentanoic acid (PF4OPeA), as well as fluorinated GHGs like HFC-23 and HFC-227ea, require increasing attention.

Wireless Optogenetic Targeting Nociceptors Helps Host Cells Win the Competitive Colonization in Implant-Associated Infections.

The role of nociceptive nerves in modulating immune responses to harmful stimuli via pain or itch induction remains controversial. Compared to conventional surgery, various implant surgeries are more prone to infections even with low bacterial loads. In this study, an optogenetic technique is introduced for selectively activating peripheral nociceptive nerves using a fully implantable, wirelessly rechargeable optogenetic device. By targeting nociceptors in the limbs of awake, freely moving mice, it is found that activation induces anticipatory immunity in the innervated territory and enhances the adhesion of various host cells to the implant surface. This effect mediates acute immune cell-mediated killing of Staphylococcus aureus on implants and enables the host to win "implant surface competition" against Staphylococcus aureus. This finding provides new strategies for preventing and treating implant-associated infections.