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1.

Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist.

Hong, Qingmei; Bakshi, Raman K; Palucki, Brenda L; Park, Min K; Ye, Zhixiong; He, Shuwen; Pollard, Patrick G; Sebhat, Iyassu K; Liu, Jian; Guo, Liangqin; Cashen, Doreen E; Martin, William J; Weinberg, David H; MacNeil, Tanya; Tang, Rui; Tamvakopoulos, Constantin; Peng, Qianping; Miller, Randy R; Stearns, Ralph A; Chen, Howard Y; Chen, Airu S; Strack, Alison M; Fong, Tung M; MacIntyre, D Euan; Wyvratt, Matthew J; Nargund, Ravi P.

Bioorg Med Chem Lett; 21(8): 2330-4, 2011 Apr 15.

Artículo en Inglés | MEDLINE | ID: mdl-21439820

2.

Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands.

Hong, Qingmei; Bakshi, Raman K; Dellureficio, James; He, Shuwen; Ye, Zhixiong; Dobbelaar, Peter H; Sebhat, Iyassu K; Guo, Liangqin; Liu, Jian; Jian, Tianying; Tang, Rui; Kalyani, Rubana N; Macneil, Tanya; Vongs, Aurawan; Rosenblum, Charles I; Weinberg, David H; Peng, Qingping; Tamvakopoulos, Constantin; Miller, Randy R; Stearns, Ralph A; Cashen, Doreen; Martin, Willian J; Chen, Airu S; Metzger, Joseph M; Chen, Howard Y; Strack, Allison M; Fong, Tung M; Maclntyre, Euan; Van der Ploeg, Lex H T; Wyvratt, Matthew J; Nargund, Ravi P.

Bioorg Med Chem Lett; 20(15): 4483-6, 2010 Aug 01.

Artículo en Inglés | MEDLINE | ID: mdl-20598533

3.

Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists.

Guo, Liangqin; Ye, Zhixiong; Liu, Jian; He, Shuwen; Bakshi, Raman K; Sebhat, Iyassu K; Dobbelaar, Peter H; Hong, Qingmei; Jian, Tianying; Dellureficio, James P; Tsou, Nancy N; Ball, Richard G; Weinberg, David H; MacNeil, Tanya; Tang, Rui; Tamvakopoulos, Constantin; Peng, Qianping; Chen, Howard Y; Chen, Airu S; Martin, William J; MacIntyre, D Euan; Strack, Alison M; Fong, Tung M; Wyvratt, Matthew J; Nargund, Ravi P.

Bioorg Med Chem Lett; 20(16): 4895-900, 2010 Aug 15.

Artículo en Inglés | MEDLINE | ID: mdl-20621473

4.

Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesity.

He, Shuwen; Ye, Zhixiong; Dobbelaar, Peter H; Bakshi, Raman K; Hong, Qingmei; Dellureficio, James P; Sebhat, Iyassu K; Guo, Liangqin; Liu, Jian; Jian, Tianying; Lai, Yingjie; Franklin, Christopher L; Reibarkh, Mikhail; Holmes, Mark A; Weinberg, David H; MacNeil, Tanya; Tang, Rui; Tamvakopoulos, Constantin; Peng, Qianping; Miller, Randy R; Stearns, Ralph A; Chen, Howard Y; Chen, Airu S; Strack, Alison M; Fong, Tung M; Wyvratt, Matthew J; Nargund, Ravi P.

Bioorg Med Chem Lett; 20(22): 6524-32, 2010 Nov 15.

Artículo en Inglés | MEDLINE | ID: mdl-20933410

5.

Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists.

He, Shuwen; Dobbelaar, Peter H; Liu, Jian; Jian, Tianying; Sebhat, Iyassu K; Lin, Linus S; Goodman, Allan; Guo, Cheng; Guzzo, Peter R; Hadden, Mark; Henderson, Alan J; Ruenz, Megan; Sargent, Bruce J; Yet, Larry; Kelly, Theresa M; Palyha, Oksana; Kan, Yanqing; Pan, Jie; Chen, Howard; Marsh, Donald J; Shearman, Lauren P; Strack, Alison M; Metzger, Joseph M; Feighner, Scott D; Tan, Carina; Howard, Andrew D; Tamvakopoulos, Constantin; Peng, Qianping; Guan, Xiao-Ming; Reitman, Marc L; Patchett, Arthur A; Wyvratt, Matthew J; Nargund, Ravi P.

Bioorg Med Chem Lett; 20(6): 1913-7, 2010 Mar 15.

Artículo en Inglés | MEDLINE | ID: mdl-20167483

6.

Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist.

He, Shuwen; Ye, Zhixiong; Dobbelaar, Peter H; Sebhat, Iyassu K; Guo, Liangqin; Liu, Jian; Jian, Tianying; Lai, Yingjie; Franklin, Christopher L; Bakshi, Raman K; Dellureficio, James P; Hong, Qingmei; Tsou, Nancy N; Ball, Richard G; Cashen, Doreen E; Martin, William J; Weinberg, David H; Macneil, Tanya; Tang, Rui; Tamvakopoulos, Constantin; Peng, Qianping; Miller, Randy R; Stearns, Ralph A; Chen, Howard Y; Chen, Airu S; Strack, Alison M; Fong, Tung M; Macintyre, D Euan; Wyvratt, Matthew J; Nargund, Ravi P.

Bioorg Med Chem Lett; 20(7): 2106-10, 2010 Apr 01.

Artículo en Inglés | MEDLINE | ID: mdl-20207541

7.

Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity.

Liu, Jian; He, Shuwen; Jian, Tianying; Dobbelaar, Peter H; Sebhat, Iyassu K; Lin, Linus S; Goodman, Allan; Guo, Cheng; Guzzo, Peter R; Hadden, Mark; Henderson, Alan J; Pattamana, Kevin; Ruenz, Megan; Sargent, Bruce J; Swenson, Brian; Yet, Larry; Tamvakopoulos, Constantin; Peng, Qianping; Pan, Jie; Kan, Yanqing; Palyha, Oksana; Kelly, Theresa M; Guan, Xiao-Ming; Howard, Andrew D; Marsh, Donald J; Metzger, Joseph M; Reitman, Marc L; Wyvratt, Matthew J; Nargund, Ravi P.

Bioorg Med Chem Lett; 20(7): 2074-7, 2010 Apr 01.

Artículo en Inglés | MEDLINE | ID: mdl-20219372

8.

Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity.

He, Shuwen; Ye, Zhixiong; Dobbelaar, Peter H; Sebhat, Iyassu K; Guo, Liangqin; Liu, Jian; Jian, Tianying; Lai, Yingjie; Franklin, Christopher L; Bakshi, Raman K; Dellureficio, James P; Hong, Qingmei; Weinberg, David H; Macneil, Tanya; Tang, Rui; Strack, Alison M; Tamvakopoulos, Constantin; Peng, Qianping; Miller, Randy R; Stearns, Ralph A; Chen, Howard Y; Chen, Airu S; Fong, Tung M; Wyvratt, Matthew J; Nargund, Ravi P.

Bioorg Med Chem Lett; 20(15): 4399-405, 2010 Aug 01.

Artículo en Inglés | MEDLINE | ID: mdl-20598882

9.

Synthesis and biological activity of anticoccidial agents: 2,3-diarylindoles.

Scribner, Andrew; Moore, Joseph A; Ouvry, Gilles; Fisher, Michael; Wyvratt, Matthew; Leavitt, Penny; Liberator, Paul; Gurnett, Anne; Brown, Chris; Mathew, John; Thompson, Donald; Schmatz, Dennis; Biftu, Tesfaye.

Bioorg Med Chem Lett; 19(5): 1517-21, 2009 Mar 01.

Artículo en Inglés | MEDLINE | ID: mdl-19195883

10.

Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines.

Kim, Dooseop; Kowalchick, Jennifer E; Brockunier, Linda L; Parmee, Emma R; Eiermann, George J; Fisher, Michael H; He, Huaibing; Leiting, Barbara; Lyons, Kathryn; Scapin, Giovanna; Patel, Sangita B; Petrov, Aleksandr; Pryor, Kellyann D; Roy, Ranabir Sinha; Wu, Joseph K; Zhang, Xiaoping; Wyvratt, Matthew J; Zhang, Bei B; Zhu, Lan; Thornberry, Nancy A; Weber, Ann E.

J Med Chem; 51(3): 589-602, 2008 Feb 14.

Artículo en Inglés | MEDLINE | ID: mdl-18201067

11.

Synthesis and biological activity of anticoccidial agents: 5,6-diarylimidazo[2,1-b][1,3]thiazoles.

Scribner, Andrew; Meitz, Susan; Fisher, Michael; Wyvratt, Matthew; Leavitt, Penny; Liberator, Paul; Gurnett, Anne; Brown, Chris; Mathew, John; Thompson, Donald; Schmatz, Dennis; Biftu, Tesfaye.

Bioorg Med Chem Lett; 18(19): 5263-7, 2008 Oct 01.

Artículo en Inglés | MEDLINE | ID: mdl-18789686

12.

3-Amino-1,5-benzodiazepinones: potent, state-dependent sodium channel blockers with anti-epileptic activity.

Hoyt, Scott B; London, Clare; Wyvratt, Matthew J; Fisher, Michael H; Cashen, Doreen E; Felix, John P; Garcia, Maria L; Li, Xiaohua; Lyons, Kathryn A; Euan MacIntyre, D; Martin, William J; Priest, Birgit T; Smith, McHardy M; Warren, Vivien A; Williams, Brande S; Kaczorowski, Gregory J; Parsons, William H.

Bioorg Med Chem Lett; 18(6): 1963-6, 2008 Mar 15.

Artículo en Inglés | MEDLINE | ID: mdl-18289851

13.

Synthesis and SAR of potent and orally bioavailable tert-butylpyrrolidine archetype derived melanocortin subtype-4 receptor modulators.

Guo, Liangqin; Ye, Zhixiong; Ujjainwalla, Feroze; Sings, Heather L; Sebhat, Iyassu K; Huber, John; Weinberg, David H; Tang, Rui; MacNeil, Tanya; Tamvakopoulos, Constantin; Peng, Qianping; MacIntyre, Euan; van der Ploeg, Lex H T; Goulet, Mark T; Wyvratt, Matthew J; Nargund, Ravi P.

Bioorg Med Chem Lett; 18(11): 3242-7, 2008 Jun 01.

Artículo en Inglés | MEDLINE | ID: mdl-18479920

14.

N-alkyl-4-piperidinyl-2,3-diarylpyrrole derivatives with heterocyclic substitutions as potent and broad spectrum anticoccidial agents.

Liang, Gui-Bai; Qian, Xiaoxia; Feng, Dennis; Fisher, Michael; Crumley, Tami; Darkin-Rattray, Sandra J; Dulski, Paula M; Gurnett, Anne; Leavitt, Penny Sue; Liberator, Paul A; Misura, Andrew S; Samaras, Samantha; Tamas, Tamas; Schmatz, Dennis M; Wyvratt, Matthew; Biftu, Tesfaye.

Bioorg Med Chem Lett; 18(6): 2019-22, 2008 Mar 15.

Artículo en Inglés | MEDLINE | ID: mdl-18276140

15.

Synthesis and biological activity of imidazopyridine anticoccidial agents: Part II.

Scribner, Andrew; Dennis, Richard; Lee, Shuliang; Ouvry, Gilles; Perrey, David; Fisher, Michael; Wyvratt, Matthew; Leavitt, Penny; Liberator, Paul; Gurnett, Anne; Brown, Chris; Mathew, John; Thompson, Donald; Schmatz, Dennis; Biftu, Tesfaye.

Eur J Med Chem; 43(6): 1123-51, 2008 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-17981367

16.

Arthur A. Patchett Memorial Issue.

Wyvratt, Matthew; Greenlee, William.

J Med Chem; 66(23): 15565-15566, 2023 12 14.

Artículo en Inglés | MEDLINE | ID: mdl-38032078

17.

Annotated Bibliography of Dr. Arthur A. Patchett.

Nargund, Ravi; Wyvratt, Matthew; Lin, Songnian; Sebhat, Iyassu; Greenlee, William.

J Med Chem; 66(23): 15567-15575, 2023 12 14.

Artículo en Inglés | MEDLINE | ID: mdl-38032081

18.

Synthesis and biological activity of imidazopyridine anticoccidial agents: part I.

Scribner, Andrew; Dennis, Richard; Hong, Jean; Lee, Shuliang; McIntyre, Donald; Perrey, David; Feng, Dennis; Fisher, Michael; Wyvratt, Matthew; Leavitt, Penny; Liberator, Paul; Gurnett, Anne; Brown, Chris; Mathew, John; Thompson, Donald; Schmatz, Dennis; Biftu, Tesfaye.

Eur J Med Chem; 42(11-12): 1334-57, 2007.

Artículo en Inglés | MEDLINE | ID: mdl-17433505

19.

(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

Kim, Dooseop; Wang, Liping; Beconi, Maria; Eiermann, George J; Fisher, Michael H; He, Huaibing; Hickey, Gerard J; Kowalchick, Jennifer E; Leiting, Barbara; Lyons, Kathryn; Marsilio, Frank; McCann, Margaret E; Patel, Reshma A; Petrov, Aleksandr; Scapin, Giovanna; Patel, Sangita B; Roy, Ranabir Sinha; Wu, Joseph K; Wyvratt, Matthew J; Zhang, Bei B; Zhu, Lan; Thornberry, Nancy A; Weber, Ann E.

J Med Chem; 48(1): 141-51, 2005 Jan 13.

Artículo en Inglés | MEDLINE | ID: mdl-15634008

20.

Structure-activity relationship of linear tetrapeptides Tic-DPhe-Arg-Trp-NH2 at the human melanocortin-4 receptor and effects on feeding behaviors in rat.

Ye, Zhixiong; MacNeil, Tanya; Weinberg, David H; Kalyani, Rubana N; Tang, Rui; Strack, Alison M; Murphy, Beth A; Mosley, Ralph T; Euan MacIntyre, D; Van der Ploeg, Lex H T; Patchett, Arthur A; Wyvratt, Matthew J; Nargund, Ravi P.

Peptides; 26(10): 2017-25, 2005 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-15993513

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