Policy, innovation, market or behavior driven effects: Energy green transition and environmental management in Chinese heterogeneous cities.

Energy green transition (EGT) is currently one of the main measures for countries around the world to address the contradiction between economic growth and increasingly deteriorating environmental and climate issues. Cities are the center of energy consumption. The key to EGT lies in urban energy green transition. Therefore, the focus of this study is on the driving mechanism of urban EGT. Firstly, the spatial-temporal characteristic of EGT in Chinese heterogeneous cities is analyzed by using methods such as gravity model. Secondly, the possible paths includes policy driven, innovation driven, market driven, and behavior driven for urban EGT are discussed through theoretical analysis. Finally, combined with panel data of 236 Chinese cities in 2007-2022, this study empirically analyzes the complex driving mechanism of urban EGT. Results show that: (1) The EGT in Chinese cities is continuing. From the perspective of urban heterogeneous, EGT in 1-tier and 2-tier cities is significantly faster than that in 3-, 4-, and 5-tier cities. The EGT speed in eastern cities is the fastest, while that in northeastern cities is the slowest. The difficulty of EGT in energy resource-based cities is actually the greatest. From the perspective of spatial features, the spatial center of EGT in Chinese cities generally shows a changing trend from northwest to southeast. (2) Policy driven, innovation driven, market driven, and behavior driven constitute the complex driving mechanism of urban EGT, and policy driven is the primary driving force for this round of EGT. (3) Positive effect of economic development level and education level improvement on EGT in Chinese cities is significant while resource endowment and population agglomeration level exhibit significant inhibitory effects. (4) There are significant differences in the core driving force for EGT in heterogeneous cities. Both policy driven effect and market driven effect have the highest impact in 1- and 2-tier cities. Innovation driven effect, market driven effect, and behavior driven effect are only significant in eastern and central cities. In energy resource-based cities, innovation driven effect of green innovation is not significant. This study can assist government departments better in formulating relevant policies to support energy transition, promote technological innovation, design market mechanisms, and guide energy consumption behavior.

Design, synthesis and biological activity of phenoxyacetic acid derivatives as novel free fatty acid receptor 1 agonists.

The free fatty acid receptor 1 (FFA1) is a novel antidiabetic target for the treatment of type 2 diabetes based on particular mechanism in amplifying glucose-stimulated insulin secretion. We have previously identified a series of phenoxyacetic acid derivatives. Herein, we describe the further chemical modification of this series directed by ligand efficiency and ligand lipophilicity efficiency. All of these efforts lead to the discovery of the promising candidate 16, an excellent FFA1 agonist with robust agonistic activity (43.6 nM), desired LE and LLE values. Moreover, compound 16 revealed a great potential for improving the hyperglycemia levels in both normal and type 2 diabetic mice without the risk of hypoglycemia even at the high dose of 40 mg/kg.

PS-MPs or their co-exposure with cadmium impair male reproductive function through the miR-199a-5p/HIF-1α-mediated ferroptosis pathway.

Microplastics (MPs) and cadmium (Cd) exist extensively in ambient environments and probably influence negatively on human health. However, the potential reproductive toxicity of MPs or MPs + Cd remains unknown. This study was aimed to observe the reproductive changes of male mice treated orally for 35 days with PS-MPs (100 mg/kg), CdCl2 (5 mg/kg) and PS-MPs plus CdCl2 mixture. We found that subchronic exposure to PS-MPs damaged mouse testicular tissue structure, reduced sperm quality and testosterone levels. Moreover, the reproductive toxicity in 0.1 µm group was stronger than 1 µm group, and mixture group was more severe than single particle size ones. Meanwhile, co-exposure of PS-MPs and Cd exacerbated reproductive injury in male mice, with an ascending toxicity of Cd, 1 µm + Cd, 0.1 µm + Cd, and 0.1+1 µm + Cd. In addition, we discovered that the testicular damage induced by PS-MPs or PS-MPs + Cd was associated with interfering the miR-199a-5p/HIF-1α/ferroptosis pathway. Promisingly, these findings will shed new light on how PS-MPs and PS-MPs + Cd damage male reproductive function.