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Three new labdane-type diterpenoids from Callicarpa macrophylla Vahl.

Wang, Zhen-Hui; Xu, Huan-Jun; Zhai, Yang-Yang; Yang, Lan-Ping; Li, Qiang; Huang, Mei; Chen, Xing-Ying; Zhang, Wen-Kui; Meng, Yue-Li; Zhang, Qing-Ling; Niu, Chao; Zhang, Yan-Ru.

Nat Prod Res ; 33(20): 2904-2910, 2019 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-30445877

RESUMEN

Three new labdane-type diterpenoids, callicapene M3-M5 (1-3) were isolated from the Callicarpa macrophylla Vahl. Their structures were identified by spectroscopic method. The isolated compounds were evaluated for inhibitory activity on NO production in LPS-activated RAW 264.7 macrophage cells by using MTT assays. Compounds 1-3 showed potent inhibitory activity, with IC50 value of 48.15, 46.31 and 38.72 µM respectively.

Asunto(s)

Callicarpa/química , Diterpenos/aislamiento & purificación , Óxido Nítrico/antagonistas & inhibidores , Animales , Diterpenos/química , Diterpenos/farmacología , Concentración 50 Inhibidora , Macrófagos/efectos de los fármacos , Macrófagos/metabolismo , Ratones , Estructura Molecular , Óxido Nítrico/biosíntesis , Hojas de la Planta/química , Células RAW 264.7

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