[The Evaluation of Calcium Alginate Dressing Helping Wound Healing of Nail Surgery].

OBJECTIVE: To determine the effect of calcium alginate dressing therapy on wound healing after nail surgery. METHODS: Patients with nail surgery on nail bed of great toe were divide into two groups (20 caces for each group) randomly based on random number table. Calcium alginate dressing were used in treatment group after nail surgery and the vaseline gauze were applied in control group after surgery. The number of wound remain bleeding and the rating of pain [visual analogue scale (VAS)] scores were observed for three times (24 h, 48 h and 72 h). Median time of pain bearing and time of wound healing were also observed. RESULTS: There were 16 males and 4 females in control group [mean age (37.45±3.30) yr.]. There were 12 males and 8 females in treatment group [mean age (33.40±3.13) yr.].There were no significant differences in sex ratio and age between the two groups (P>0.05). No infection was found in the treatment group, but 1 case in the control group. The number of bleeding cases in treatment group was less than that in control group (P<0.05), as well as the VAS scores 24 h after nail surgery (P<0.05). At 48 h, no bleeding occurred in the traetment group, while there were 2 cases of bleeding in the control group (P>0.05); the VAS score in treatment group was less than that in control group (P<0.05). At 72 h, no bleeding was observed in both groups, and the difference in VAS score between the two groups was not statistically significant (P>0.05). The median time of pain bearing was 24 h in treatment group while 72 h in control group. Wound healing time of treatment group (9.40 d) and control group (11.35 d) was statistically significant (P<0.05). CONCLUSION: Calcium alginate dressing therapy can promote postoperative wound recovery and block bleeding and pain after nail surgery.

[The Comparison and Evaluation of Partial Nail Avulsion and Total Nail Avulsion with Plate Replacement with Traditional Total Nail Avulsion].

OBJECTIVES: To determine the different effects of partial nail avulsion and total nail avulsion with plate replacement with traditional total nail avulsion. METHODS: Patients were divided into three groups randomly ( n=20): total nail avulsion group (control group), partial nail avulsion group, and total nail avulsion with plate replacement group (nail replacement group). The rating of pain [visual analogue scale (VAS) score], the wound healing time, the nail growth time , and the score of satisfaction were analyzed. RESULTS: The baseline data of three groups had no significant difference. From 8 h, VAS score of partial nail avulsion group and nail plate replacement group was different with that in control group ( P<0.05) . 48 h after surgery, the pain disappeared totally in partial nail avulsion group, largely in nail replacement group [90% (18/20) ] , which were both significantly different with that of control group [45%(9/20)] ( P<0.05) . Healing time of three groups was listed as follow: control group>nail replacement group>partial nail avulsion group ( P<0.05) . Nail growth time was the longest in control group, the shortest in partial nail avulsion group ( P<0.05, vs. control group), and median in nail replacement group. The score of satisfaction in control group was lower than that in partial avulsion group and nail replacement group ( P<0.05) , of the later two there was no statistic difference. CONCLUSIONS: By decreasing the defect of nail plate and the injury of nail bed, and by smoothing the pain, partial nail avulsion benefits the wound-healing. Nail plate should be replace to get further benefits.

[Clinical MedicineThe Evaluation of He-Ne Laser Therapy Help Wound Healing of Nail Surgery].

OBJECTIVES: To investigate the effect of He-Ne laser therapy on wound healing after nail surgery. METHODS: Patients who needed nail surgery were divided into treatment group (n=20) and control group (n=20) randomly.The He-Ne laser was applied to the wound after nail surgery in treatment group. The wound healing time, the inflammation duration, the pain rating, and the nail plate full-grown time were compared with control group. RESULTS: No significant differences in baseline of two groups were observed. The wound healing time was (16.00±2.51) d in control group and (11.35±1.73 ) d in treatment group, the inflammation duration was (9.10±2.10) d in control group and (7.20±1.44) d in treatment group (P<0.05), both above differences were significant (P<0.05).The nail plate full-grown time was (21.00±2.13) weeks in treatment group, whereas (21.40±1.05) weeks in control group (P>0.05).The pain rating of the 2 groups was different from 25 h (after 3 times treatment)(P<0.05). Pain disappeared in 85.0% (17/20) patients of treatment group after 49 h (5 times treatment), and completely disappeared (20/20) after 54 h (6 times treatment), which were faster than those of control group at the same time points (pain disappeared only in 50.0% and 98.5% of patients respectively). CONCLUSIONS: He-Ne laser therapy can help wound healing after nail surgery.

[Effects of Human Acellular Amniotic Membrane on Postsurgical Recovery of Nail Beds].

OBJECTIVES: To determine the effects of human acellular amniotic membrane(HAAM) on postsurgical recovery of nail beds. METHODS: Patients undergoing nail surgery were randomly divided into two groups: 19 in the experimental and 19 in the control groups. Patients in the experimental group were given HAAM before the wounds were covered with vaseline gauze the next day after surgery; whereas those in the control group received vaseline gauze dressing only. Ratings of pain were recorded when 1, 4, 8, 12, 24, 36, 48 and 72 h after the dressing was changed. The time when the wounds healed and the nail grew thoroughly were observed. RESULTS: The characteristics of patients in the two groups were similar. The patients in the experimental group reported significantly less pain at 4 h and 48 h than those in the control group ( P<0.05). After dress changing 24 h, pain disappear in the experimental group. The wounds of the patients in the experimental group also healed quicker [(12.37±2.48) d] than those in the control group [(17.68±2.86) d, P<0.05]. It took (13.95±1.72) weeks for the patients in the experimental group to have their nails grown completely, compared with (15.63±2.00) weeks for those in the control group ( P=0.016). The experimental group had a similar degree of satisfaction (7.61±1.38) towards the cosmetic appearance of their nails compare the control group (7.58±1.18, P=0.919). CONCLUSIONS: HAAM can promote healing of surgical wounds on nail beds.

[Effect of Dermal Multipotent Cells Transplantation on Skin Elasticity in Aged Murine].

OBJECTIVE: To investigate the elasticity changes in aged dermis after injection of dermal multipotent cells (DMCs). METHODS: Dermal multipotent cells were isolated and cultured from 3-day-old BALB/c mice and then transplanted into the dermis of aged (12-week-old) BALB/c mice. Adult fibroblasts (FBs) were employed as control. At 2 and 4 weeks after the transplantation, we examined dermal elasticity by MPA580 skin test machine. RESULTS: The skin elasticity were improve at 2 weeks after the transplantion in both DMCs group and FBs group (P=0. 000) but have no statistical difference between these two groups (P=0. 216). The different effect between these two groups appeared in 4 weeks after the transplantation (P=0. 031). CONCLUSION: Dermal multipotent cells appear more effective than fibroblasts in increasing skin elasticity.

Oral potassium iodide for the treatment of sporotrichosis.

Potassium Iodide is the antimycotic of choice for the treatment of cutaneous sporotrichosis, because of its efficacy, safety and low cost. We carried out a review of published studies on the benefits and adverse reactions of using SSKI (Saturated Solution Potassium Iodide) as treatment for sporotrichosis, but could not identify any well-designed clinical trails. There is an urgent need to conduct randomized double-blind placebo-controlled trials and critically assess usefulness of SSKI by using a standardize monitoring or an effective self-report system.

[The expressions of PPAR-gamma, COX-2 in the lesions of patients with condyloma acuminatum and bowenoid papulosis].

OBJECTIVE: To investigate the expression of PPAR-gamma, COX-2 in the skin lesion of condyloma acuminatum and bowenoid papulosis. METHODS: The expression levels of PPAR-gamma, COX-2 were measured by immunohistochemistry in 17 cases of condyloma acuminatum, 17 cases of bowenoid papulosis, as well as 17 cases of normal foreskin lesions. RESULTS: The immunohistochemical study showed that PPAR-gamma and COX-2 weakly expressed in normal foreskin, but overexepressed in the skin lesions of both condyloma acuminatum and bowenoid papulosis (P<0.01). There was straight linear correlation between the expressions of PPAR-gamma and COX-2 not only in condyloma acuminatum (r=0.505, P=0.038) but also in bowenoid papulosis (r=0.562, P=0.019). CONCLUSION: PPAR-gamma and COX-2 may have important roles in proliferative dermatosis associated with human papilloma virus.

Human acellular amniotic membrane implantation for lower third nasal reconstruction: a promising therapy to promote wound healing.

BACKGROUND: The lower third of the nose is one of the most important cosmetic units of the face, and its reconstructive techniques remain a big challenge. As an alternative approach to repair or regenerate the nasal tissue, the biomaterial-based strategy has been extensively investigated. The aim of this study is to determine the safety and efficacy of human acellular amniotic membrane (HAAM) to repair the full-thickness defects in the lower third of the nose in humans. METHODS: In this study, 180 patients who underwent excision of skin lesions of the lower third of the nose from 2012 to 2016 were included; of the patients, 92 received HAAM and Vaseline gauze treatments, and the other 88 patients received Vaseline gauze treatment only. The haemostasis time and the duration of operation were recorded during surgery; after surgery, the time to pain disappearance, scab formation and wound healing, and the wound healing rate were measured. RESULTS: Immediately after the HAAM implantation, a reduction of the haemostasis time and an accelerated disappearance of pain were observed. Compared with the control group, the formation and detachment of scab in patients who received the HAAM implantation were notably accelerated, postoperatively. When the diameter of the lesion exceeded 5 mm, the HAAM implantation was found to enhance the wound healing, although this enhancement was not seen when the diameter was less than 5 mm. Additionally, the HAAM implantation significantly reduced bleeding, wound infection and scar formation, postoperatively. CONCLUSIONS: HAAM-assisted healing is a promising therapy for lower third nasal reconstruction leading to rapid wound healing and fewer complications and thus has considerable potential for extensive clinical application in repairing skin wounds. TRIAL REGISTRATION: ChiCTR1800017618, retrospectively registered on July 08, 2018.