1.
Org Lett
; 25(31): 5856-5861, 2023 Aug 11.
Artículo
en Inglés
| MEDLINE
| ID: mdl-37499637
RESUMEN
Herein, a novel route to atropisomeric N-aryl quinolones with low rotational barriers is demonstrated, leveraging a dual photochemical/organocatalytic approach to the required ring closure in up to 94% yield and up to >99% ee. The use of a continuous flow system allows for impurity suppression and enables rapid scale-up to a decagram scale.