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1.
Phys Rev Lett ; 127(10): 104801, 2021 Sep 03.
Artículo en Inglés | MEDLINE | ID: mdl-34533351

RESUMEN

Hollow plasma channels are attractive for lepton acceleration because they provide intrinsic emittance preservation regimes. However, beam breakup instabilities dominate the dynamics. Here, we show that thin, warm hollow channels can sustain large-amplitude plasma waves ready for high-quality positron acceleration. We verify that the combination of warm electrons and thin hollow channels enables positron focusing structures. Such focusing wakefields unlock beam breakup damping mechanisms. We demonstrate that such channels emerge self-consistently during the long-term plasma dynamics in the blowout's regime aftermath, allowing for experimental demonstration.

2.
Virus Genes ; 57(4): 395-399, 2021 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-34086153

RESUMEN

According to modern classification, tick-borne flaviviruses have been divided into a mammalian tick-borne virus group and a seabird tick-borne virus group (STBVG). The STBVG includes the Tyuleniy virus, Meaban virus, Saumarez Reef virus, and the recently discovered Kama virus (KAMV). The latter was isolated from Ixodes lividus, an obligate parasitic tick of the sand martin (Riparia riparia), in 1989 in the central part of the Russian Plain. In 2014, based on molecular genetic analysis, it was shown that KAMV is a new virus belonging to STBVG, genus Flavivirus, fam. Flaviviridae. Very little is known about the Kama virus concerning its range, vectors, and reservoir hosts. GenBank contains a single sequence of the complete genome of this virus. In the present study, the complete genome sequences of two strains, isolated in 1983 in the Omsk region (Western Siberia) from gamasid mites in the nests of rooks (Corvus frugilegus), have been determined. Phylogenetic analyses of their genomes showed a close relationship both with each other (approx. 98.9% nucleotide identity) and with KAMV isolated in European Russia (approx. 98.4% nucleotide identity). The ecological features of KAMV that are due to the species of the vector (gamasid mites) and its hosts (colonial birds of the mainland of Eurasia) indicate that KAMV is an atypical representative STBVG.


Asunto(s)
Virus de la Encefalitis Transmitidos por Garrapatas/genética , Infecciones por Flavivirus/genética , Flavivirus/genética , Genoma Viral/genética , Animales , Antígenos Virales/genética , Aves , Virus de la Encefalitis Transmitidos por Garrapatas/patogenicidad , Flavivirus/patogenicidad , Infecciones por Flavivirus/patología , Infecciones por Flavivirus/virología , Humanos , Ixodes/genética , Ixodes/virología , Conformación de Ácido Nucleico
3.
Nature ; 524(7566): 442-5, 2015 Aug 27.
Artículo en Inglés | MEDLINE | ID: mdl-26310764

RESUMEN

Electrical breakdown sets a limit on the kinetic energy that particles in a conventional radio-frequency accelerator can reach. New accelerator concepts must be developed to achieve higher energies and to make future particle colliders more compact and affordable. The plasma wakefield accelerator (PWFA) embodies one such concept, in which the electric field of a plasma wake excited by a bunch of charged particles (such as electrons) is used to accelerate a trailing bunch of particles. To apply plasma acceleration to electron-positron colliders, it is imperative that both the electrons and their antimatter counterpart, the positrons, are efficiently accelerated at high fields using plasmas. Although substantial progress has recently been reported on high-field, high-efficiency acceleration of electrons in a PWFA powered by an electron bunch, such an electron-driven wake is unsuitable for the acceleration and focusing of a positron bunch. Here we demonstrate a new regime of PWFAs where particles in the front of a single positron bunch transfer their energy to a substantial number of those in the rear of the same bunch by exciting a wakefield in the plasma. In the process, the accelerating field is altered--'self-loaded'--so that about a billion positrons gain five gigaelectronvolts of energy with a narrow energy spread over a distance of just 1.3 metres. They extract about 30 per cent of the wake's energy and form a spectrally distinct bunch with a root-mean-square energy spread as low as 1.8 per cent. This ability to transfer energy efficiently from the front to the rear within a single positron bunch makes the PWFA scheme very attractive as an energy booster to an electron-positron collider.

4.
Nature ; 515(7525): 92-5, 2014 Nov 06.
Artículo en Inglés | MEDLINE | ID: mdl-25373678

RESUMEN

High-efficiency acceleration of charged particle beams at high gradients of energy gain per unit length is necessary to achieve an affordable and compact high-energy collider. The plasma wakefield accelerator is one concept being developed for this purpose. In plasma wakefield acceleration, a charge-density wake with high accelerating fields is driven by the passage of an ultra-relativistic bunch of charged particles (the drive bunch) through a plasma. If a second bunch of relativistic electrons (the trailing bunch) with sufficient charge follows in the wake of the drive bunch at an appropriate distance, it can be efficiently accelerated to high energy. Previous experiments using just a single 42-gigaelectronvolt drive bunch have accelerated electrons with a continuous energy spectrum and a maximum energy of up to 85 gigaelectronvolts from the tail of the same bunch in less than a metre of plasma. However, the total charge of these accelerated electrons was insufficient to extract a substantial amount of energy from the wake. Here we report high-efficiency acceleration of a discrete trailing bunch of electrons that contains sufficient charge to extract a substantial amount of energy from the high-gradient, nonlinear plasma wakefield accelerator. Specifically, we show the acceleration of about 74 picocoulombs of charge contained in the core of the trailing bunch in an accelerating gradient of about 4.4 gigavolts per metre. These core particles gain about 1.6 gigaelectronvolts of energy per particle, with a final energy spread as low as 0.7 per cent (2.0 per cent on average), and an energy-transfer efficiency from the wake to the bunch that can exceed 30 per cent (17.7 per cent on average). This acceleration of a distinct bunch of electrons containing a substantial charge and having a small energy spread with both a high accelerating gradient and a high energy-transfer efficiency represents a milestone in the development of plasma wakefield acceleration into a compact and affordable accelerator technology.

5.
Phys Rev Lett ; 123(13): 134801, 2019 Sep 27.
Artículo en Inglés | MEDLINE | ID: mdl-31697514

RESUMEN

An intense, subpicosecond, relativistic electron beam traversing a dielectric-lined waveguide generates very large amplitude electric fields at terahertz (THz) frequencies through the wakefield mechanism. In recent work employing this technique to accelerate charged particles, the generation of high-power, narrow-band THz radiation was demonstrated. The radiated waves contain fields with measured amplitude exceeding 2 GV/m, orders of magnitude greater than those available by other THz generation techniques at a narrow bandwidth. For fields approaching the GV/m level, a strong damping has been observed in SiO_{2}. This wave attenuation with an onset near 850 MV/m is consistent with changes to the conductivity of the dielectric lining and is characterized by a distinctive latching mechanism that is reversible on longer timescales. We describe the detailed measurements that serve to clarify the underlying physical mechanisms leading to strong field-induced damping of THz radiation (hω=1.59 meV, f=0.38 THz) in SiO_{2}, a bulk, wide band-gap (8.9 eV) dielectric.

6.
Phys Rev Lett ; 122(19): 190404, 2019 May 17.
Artículo en Inglés | MEDLINE | ID: mdl-31144933

RESUMEN

We demonstrate the experimental feasibility of probing the fully nonperturbative regime of quantum electrodynamics with a 100 GeV-class particle collider. By using tightly compressed and focused electron beams, beamstrahlung radiation losses can be mitigated, allowing the particles to experience extreme electromagnetic fields. Three-dimensional particle-in-cell simulations confirm the viability of this approach. The experimental forefront envisaged has the potential to establish a novel research field and to stimulate the development of a new theoretical methodology for this yet unexplored regime of strong-field quantum electrodynamics.

7.
Philos Trans A Math Phys Eng Sci ; 377(2151): 20180184, 2019 Aug 12.
Artículo en Inglés | MEDLINE | ID: mdl-31230576

RESUMEN

This paper discusses the properties of electron beams formed in plasma wakefield accelerators through ionization injection. In particular, the potential for generating a beam composed of co-located multi-colour beamlets is demonstrated in the case where the ionization is initiated by the evolving charge field of the drive beam itself. The physics of the processes of ionization and injection are explored through OSIRIS simulations. Experimental evidence showing similar features are presented from the data obtained in the E217 experiment at the FACET facility of the SLAC National Laboratory. This article is part of the Theo Murphy meeting issue 'Directions in particle beam-driven plasma wakefield acceleration'.

8.
Philos Trans A Math Phys Eng Sci ; 377(2151): 20180173, 2019 Aug 12.
Artículo en Inglés | MEDLINE | ID: mdl-31230577

RESUMEN

Beam-driven plasma wakefield acceleration (PWFA) has demonstrated significant progress during the past two decades of research. The new Facility for Advanced Accelerator Experimental Tests (FACET) II, currently under construction, will provide 10 GeV electron beams with unprecedented parameters for the next generation of PWFA experiments. In the context of the FACET II facility, we present simulation results on expected betatron radiation and its potential application to diagnose emittance preservation and hosing instability in the upcoming PWFA experiments. This article is part of the Theo Murphy meeting issue 'Directions in particle beam-driven plasma wakefield acceleration'.

9.
Phys Rev Lett ; 120(12): 124802, 2018 Mar 23.
Artículo en Inglés | MEDLINE | ID: mdl-29694092

RESUMEN

Hollow channel plasma wakefield acceleration is a proposed method to provide high acceleration gradients for electrons and positrons alike: a key to future lepton colliders. However, beams which are misaligned from the channel axis induce strong transverse wakefields, deflecting beams and reducing the collider luminosity. This undesirable consequence sets a tight constraint on the alignment accuracy of the beam propagating through the channel. Direct measurements of beam misalignment-induced transverse wakefields are therefore essential for designing mitigation strategies. We present the first quantitative measurements of transverse wakefields in a hollow plasma channel, induced by an off-axis 20 GeV positron bunch, and measured with another 20 GeV lower charge trailing positron probe bunch. The measurements are largely consistent with theory.

10.
Vopr Virusol ; 60(6): 32-7, 2015.
Artículo en Ruso | MEDLINE | ID: mdl-27024915

RESUMEN

Three basic genotypes of the tick-borne encephalitis virus have wide geographical spread; several strains have local spread. In this work, we studied the strategy of the synonymous codon usage in basic genotypes by means of calculation of relative synonymous codon usage values for each complete encoding sequences of viruses. Then, these values were analyzed by methods of the discriminant analysis. In the result of this work the conclusion about the available distinctions in the strategy of synonymous codon usage of various genotypes tick-borne encephalitis viruses was made.


Asunto(s)
Codón , Virus de la Encefalitis Transmitidos por Garrapatas/genética , Regulación Viral de la Expresión Génica , Genoma Viral , Mutación Silenciosa , Análisis Discriminante , Virus de la Encefalitis Transmitidos por Garrapatas/clasificación , Evolución Molecular , Código Genético , Genotipo , Filogenia
11.
Phys Rev Lett ; 112(4): 045001, 2014 Jan 31.
Artículo en Inglés | MEDLINE | ID: mdl-24580460

RESUMEN

We demonstrate experimentally that a relativistic electron bunch shaped with a sharp rising edge drives plasma wakefields with one to seven periods along the bunch as the plasma density is increased. The plasma density is varied in the 10(15)-10(17) cm(-3) range. The wakefields generation is observed after the plasma as a periodic modulation of the correlated energy spectrum of the incoming bunch. We choose a low bunch charge of 50 pC for optimum visibility of the modulation at all plasma densities. The longitudinal wakefields creating the modulation are in the MV/m range and are indirect evidence of the generation of transverse wakefields that can seed the self-modulation instability, although the instability does not grow significantly over the short plasma length (2 cm). We show that the seeding provides a phase reference for the wakefields, a necessary condition for the deterministic external injection of a witness bunch in an accelerator. This electron work supports the concept of similar experiments in the future, e.g., SMI experiments using long bunches of relativistic protons.

12.
Vopr Virusol ; 59(6): 5-11, 2014.
Artículo en Ruso | MEDLINE | ID: mdl-25929029

RESUMEN

The main aspects of epidemiology and epizootology of the Omsk hemorrhagic fever (OHF) are analyzed. The discovery of the virus OHF in 1947, as well as the first outbreak of new diseases in the districts of the Omsk region, is described. Comprehensive work for decryption of the etiology of the OHF by specialists from the Omsk and Moscow Institutes is carried out. Long-term dynamics of activity of natural foci of OHF contains four periods of variable intensity of epidemic and epizootic processes. The main reservoir of the virus OHF in natural foci and the source of human infection is muskrat. Metaxenosis provides maintaining of the population of the virus, which is of some significance for hosts. Independent position of the virus OHF in the group of the Flaviviruses of mammals transmitted by ticks is established. There are two aenovariants of the virus OHF.


Asunto(s)
Vectores Arácnidos , Virus de la Encefalitis Transmitidos por Garrapatas/genética , Infección Focal , Fiebre Hemorrágica de Omsk/epidemiología , Garrapatas/virología , Animales , Arvicolinae/virología , Reservorios de Enfermedades , Virus de la Encefalitis Transmitidos por Garrapatas/clasificación , Virus de la Encefalitis Transmitidos por Garrapatas/aislamiento & purificación , Genotipo , Fiebre Hemorrágica de Omsk/transmisión , Fiebre Hemorrágica de Omsk/virología , Humanos , Filogenia , Estudios Retrospectivos , Siberia/epidemiología , Proteínas del Envoltorio Viral/genética , Proteínas no Estructurales Virales/genética
13.
Phys Rev Lett ; 111(13): 134802, 2013 Sep 27.
Artículo en Inglés | MEDLINE | ID: mdl-24116784

RESUMEN

A strong energy modulation in an electron bunch passing through a dielectric-lined waveguide was recently demonstrated in Antipov et al., Phys. Rev. Lett. 108, 144801 (2012). In this Letter, we demonstrate a successful conversion of this energy modulation into a beam density modulation, and the formation of a series of microbunches with a subpicosecond periodicity by means of magnetic optics (chicane). A strong coherent transition radiation signal produced by the microbunches is obtained and the tunability of its carrier frequency in the 0.68-0.9 THz range by regulating the energy chirp in the incoming electron bunch is demonstrated using infrared interferometry. A tabletop, compact, tunable, and narrowband source of intense THz radiation based on this technology is proposed.

14.
Phys Rev Lett ; 109(18): 185007, 2012 Nov 02.
Artículo en Inglés | MEDLINE | ID: mdl-23215291

RESUMEN

Current filamentation instability is observed and studied in a laboratory environment with a 60 MeV electron beam and a plasma capillary discharge. Multiple filaments are observed and imaged transversely at the plasma exit with optical transition radiation. By varying the plasma density the transition between single and multiple filaments is found to be k(p)σ(r)~2.2. Scaling of the transverse filament size with the plasma skin depth is predicted in theory and observed over a range of plasma densities. Lowering the bunch charge, and thus the bunch density, suppresses the instability.

15.
Phys Rev Lett ; 109(16): 164802, 2012 Oct 19.
Artículo en Inglés | MEDLINE | ID: mdl-23215085

RESUMEN

We describe the first direct observation of the significant suppression of the energy spread induced by coherent synchrotron radiation by a pair of conductive plates placed inside a dipole magnet. In addition to various feedback loops improving the energy stability of the beam parameters, our key innovation for this experiment is the observation of the time-resolved energy variation within the electron bunch, instead of the traditionally measured rms energy spread. We present the results of the experiments and compare them with a rigorous analytical theory.

16.
Phys Rev Lett ; 108(14): 144801, 2012 Apr 06.
Artículo en Inglés | MEDLINE | ID: mdl-22540797

RESUMEN

We report the observation of a strong wakefield induced energy modulation in an energy-chirped electron bunch passing through a dielectric-lined waveguide. This modulation can be effectively converted into a spatial modulation forming microbunches with a periodicity of 0.5-1 ps and, hence, capable of driving coherent terahertz radiation. The experimental results agree well with theoretical predictions.

17.
Phys Rev Lett ; 108(24): 244801, 2012 Jun 15.
Artículo en Inglés | MEDLINE | ID: mdl-23004279

RESUMEN

We report first evidence of wakefield acceleration of a relativistic electron beam in a dielectric-lined slab-symmetric structure. The high energy tail of a ∼60 MeV electron beam was accelerated by ∼150 keV in a 2 cm-long, slab-symmetric SiO2 waveguide, with the acceleration or deceleration clearly visible due to the use of a beam with a bifurcated longitudinal distribution that serves to approximate a driver-witness beam pair. This split-bunch distribution is verified by longitudinal reconstruction analysis of the emitted coherent transition radiation. The dielectric waveguide structure is further characterized by spectral analysis of the emitted coherent Cherenkov radiation at THz frequencies, from a single electron bunch, and from a relativistic bunch train with spacing selectively tuned to the second longitudinal mode (TM02). Start-to-end simulation results reproduce aspects of the electron beam bifurcation dynamics, emitted THz radiation properties, and the observation of acceleration in the dielectric-lined, slab-symmetric waveguide.

18.
Opt Express ; 19(3): 2748-53, 2011 Jan 31.
Artículo en Inglés | MEDLINE | ID: mdl-21369096

RESUMEN

Quantitative phase retrieval is experimentally demonstrated using the Inverse Compton Scattering X-ray source available at the Accelerator Test Facility (ATF) in the Brookhaven National Laboratory. Phase-contrast images are collected using in-line geometry, with a single X-ray pulse of approximate duration of one picosecond. The projected thickness of homogeneous samples of various polymers is recovered quantitatively from the time-averaged intensity of transmitted X-rays. The data are in good agreement with the expectations showing that ATF Inverse Compton Scattering source is suitable for performing phase-sensitive quantitative X-ray imaging on the picosecond scale. The method shows promise for quantitative imaging of fast dynamic phenomena.


Asunto(s)
Aceleradores de Partículas , Radiometría/métodos , Dispersión de Radiación , Rayos X
19.
Phys Rev Lett ; 106(1): 014801, 2011 Jan 07.
Artículo en Inglés | MEDLINE | ID: mdl-21231748

RESUMEN

We report on the acceleration of impurity-free quasimononenergetic proton beams from an initially gaseous hydrogen target driven by an intense infrared (λ=10 µm) laser. The front surface of the target was observed by optical probing to be driven forward by the radiation pressure of the laser. A proton beam of ∼MeV energy was simultaneously recorded with narrow energy spread (σ∼4%), low normalized emittance (∼8 nm), and negligible background. The scaling of proton energy with the ratio of intensity over density (I/n) confirms that the acceleration is due to the radiation pressure driven shock.

20.
Ticks Tick Borne Dis ; 12(2): 101627, 2021 03.
Artículo en Inglés | MEDLINE | ID: mdl-33388558

RESUMEN

Omsk hemorrhagic fever virus (OHFV) is the etiological agent of Omsk hemorrhagic fever, a disease described in the 1940s in Western Siberia. However, until now, it has been represented in GenBank by just four complete genome sequences, which do not reflect the real genetic diversity of the virus in nature. In this study, we analyzed the molecular variability and genetic structure of OHFV based on 20 complete genome sequences, fifteen of which were obtained for the first time. All these sequences belong to virus strains isolated at different times from three regions of Western Siberia. The results suggest that the genetic diversity of OHFV is significantly wider than previously thought and is represented by at least three subtypes, rather than two. This broadens our understanding of the evolutionary history of OHFV. Also, it is argued that the OHFV reference strain Bogoluvovska (NC_005062) is actually a Kubrin strain and that either cross-contamination or a laboratory error was the cause of this.


Asunto(s)
Virus de la Encefalitis Transmitidos por Garrapatas/genética , Variación Genética , Genoma Viral , Filogenia , Siberia , Secuenciación Completa del Genoma
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