Event Probabilities Have a Different Impact on Early and Late Electroencephalographic Measures Regarded as Metrics of Prediction.

The oddball protocol has been used to study the neural and perceptual consequences of implicit predictions in the human brain. The protocol involves presenting a sequence of identical repeated events that are eventually broken by a novel "oddball" presentation. Oddball presentations have been linked to increased neural responding and to an exaggeration of perceived duration relative to repeated events. Because the number of repeated events in such protocols is circumscribed, as more repeats are encountered, the conditional probability of a further repeat decreases-whereas the conditional probability of an oddball increases. These facts have not been appreciated in many analyses of oddballs; repeats and oddballs have rather been treated as binary event categories. Here, we show that the human brain is sensitive to conditional event probabilities in an active, visual oddball paradigm. P300 responses (a relatively late component of visually evoked potentials measured with EEG) tended to be greater for less likely oddballs and repeats. By contrast, P1 responses (an earlier component) increased for repeats as a goal-relevant target presentation neared, but this effect occurred even when repeat probabilities were held constant, and oddball P1 responses were invariant. We also found that later, more likely oddballs seemed to last longer, and this effect was largely independent of the number of preceding repeats. These findings speak against a repetition suppression account of the temporal oddball effect. Overall, our data highlight an impact of event probability on later, rather than earlier, electroencephalographic measures previously related to predictive processes-and the importance of considering conditional probabilities in sequential presentation paradigms.

The precision test of metacognitive sensitivity and confidence criteria.

Humans experience feelings of confidence in their decisions. In perception, these feelings are typically accurate - we tend to feel more confident about correct decisions. The degree of insight people have into the accuracy of their decisions is known as metacognitive sensitivity. Currently popular methods of estimating metacognitive sensitivity are subject to interpretive ambiguities because they assume people have normally shaped distributions of different experiences when they are repeatedly exposed to a single input. If this normality assumption is violated, calculations can erroneously underestimate metacognitive sensitivity. Here, we describe a means of estimating metacognitive sensitivity that is more robust to violations of the normality assumption. This improved method can easily be added to standard behavioral experiments, and the authors provide Matlab code to help researchers implement these analyses and experimental procedures.

On why we lack confidence in some signal-detection-based analyses of confidence.

Signal-detection theory (SDT) is one of the most popular frameworks for analyzing data from studies of human behavior - including investigations of confidence. SDT-based analyses of confidence deliver both standard estimates of sensitivity (d'), and a second estimate informed by high-confidence decisions - meta d'. The extent to which meta d' estimates fall short of d' estimates is regarded as a measure of metacognitive inefficiency, quantifying the contamination of confidence by additional noise. These analyses rely on a key but questionable assumption - that repeated exposures to an input will evoke a normally-shaped distribution of perceptual experiences (the normality assumption). Here we show, via analyses inspired by an experiment and modelling, that when distributions of experience do not conform with the normality assumption, meta d' can be systematically underestimated relative to d'. Our data highlight that SDT-based analyses of confidence do not provide a ground truth measure of human metacognitive inefficiency. We explain why deviance from the normality assumption is especially a problem for some popular SDT-based analyses of confidence, in contrast to other analyses inspired by the SDT framework, which are more robust to violations of the normality assumption.

Effects of calorie labelling and contextual factors on hypothetical coffee shop menu choices.

This study examined the effects of calorie labelling and two key contextual factors (reflective motivation and habits) on the calorie content of hypothetical coffee-shop menu choices. In one exploratory (n = 70) and one pre-registered (n = 300) laboratory study (Studies 1 and 2 respectively), participants viewed a hypothetical calorie-labelled or non calorie-labelled menuboard and selected their preferred item(s). Coffee shop drinking habits were measured using the Self-Report Habit Index, and reflective motivation (relating to calorie intake) was assessed with three items asking about watching weight, eating healthily, and reading calorie labels. In Study 2, participants also estimated calories contained in a subset of the menuboard drinks. Results of both studies showed that labelling did not significantly affect the total calorie content of items selected. However, in Study 2, as predicted, there was a trend toward moderation by reflective motivation (p = .056) with less motivated participants showing relatively greater calorie selection when exposed to labelling. Participants with weaker habits took longer to select items (p = .002) but, contrary to predictions, were not more influenced by labelling. Higher reflective motivation was associated with selecting fewer calories (p = .002), correctly recalling the presence/absence of labelling (p = .016) and better estimating calorie content (p < .001). Overall, participants significantly underestimated calories in higher calorie drinks but overestimated calories in lower calorie drinks. The results highlight the importance of contextual factors such as habits and reflective motivation for obesity interventions and are relevant for the UK's introduction of selective mandatory calorie labelling. In some instances, labelling may actually increase intake among those less motivated by health and weight concerns, but further research is needed to substantiate this concern.

Centroparietal activity mirrors the decision variable when tracking biased and time-varying sensory evidence.

Decision-making is a fundamental human activity requiring explanation at the neurocognitive level. Current theoretical frameworks assume that, during sensory-based decision-making, the stimulus is sampled sequentially. The resulting evidence is accumulated over time as a decision variable until a threshold is reached and a response is initiated. Several neural signals, including the centroparietal positivity (CPP) measured from the human electroencephalogram (EEG), appear to display the accumulation-to-bound profile associated with the decision variable. Here, we evaluate the putative computational role of the CPP as a model-derived accumulation-to-bound signal, focussing on point-by-point correspondence between model predictions and data in order to go beyond simple summary measures like average slope. In two experiments, we explored the CPP under two manipulations (namely non-stationary evidence and probabilistic decision biases) that complement one another by targeting the shape and amplitude of accumulation respectively. We fit sequential sampling models to the behavioural data, and used the resulting parameters to simulate the decision variable, before directly comparing the simulated profile to the CPP waveform. In both experiments, model predictions deviated from our naïve expectations, yet showed similarities with the neurodynamic data, illustrating the importance of a formal modelling approach. The CPP appears to arise from brain processes that implement a decision variable (as formalised in sequential-sampling models) and may therefore inform our understanding of decision-making at both the representational and implementational levels of analysis, but at this point it is uncertain whether a single model can explain how the CPP varies across different kinds of task manipulation.

Post-stroke object affordances: An EEG investigation.

Rehabilitating upper limb function after stroke is a key therapeutic goal. In healthy brains, objects, especially tools, are said to cause automatic motoric 'affordances'; affecting our preparation to handle objects. For example, the N2 event-related potential has been shown to correlate with the functional properties of objects in healthy adults during passive viewing. We posited that such an affordance effect might also be observed in chronic-stage stroke survivors. With either dominant or non-dominant hand forward, we presented three kinds of stimuli in stereoscopic depth; grasp objects affording a power-grip, pinch objects affording a thumb and forefinger precision-grip and an empty desk, affording no action. EEG data from 10 stroke survivors and 15 neurologically healthy subjects were analysed for the N1 and N2 ERP components. Both components revealed differences between the two object stimuli categories and the empty desk for both groups, suggesting the presence of affordance-related motor priming from around 100 to 370 ms after stimulus onset. Hence, we speculate that stroke survivors with loss of upper limb function may benefit from object presentation regimes designed to maximise motor priming when attempting movements with manipulable objects. However, further investigation would be necessary with acute stage patients, especially those diagnosed with apraxia.

The Neurodynamic Decision Variable in Human Multi-alternative Perceptual Choice.

The neural dynamics underpinning binary perceptual decisions and their transformation into actions are well studied, but real-world decisions typically offer more than two response alternatives. How does decision-related evidence accumulation dynamically influence multiple action representations in humans? The heightened conservatism required in multiple compared with binary choice scenarios suggests a mechanism that compensates for increased uncertainty when multiple choices are present by suppressing baseline activity. Here, we tracked action representations using corticospinal excitability during four- and two-choice perceptual decisions and modeled them using a sequential sampling framework. We found that the predictions made by leaky competing accumulator models to accommodate multiple choices (i.e., reduced baseline activity to compensate increased uncertainty) were borne out by dynamic changes in human action representations. This suggests a direct and continuous influence of interacting evidence accumulators, each favoring a different decision alternative, on downstream corticospinal excitability during complex choice.

Objects rapidly prime the motor system when located near the dominant hand.

Objects are said to automatically "afford" various actions depending upon the motor repertoire of the actor. Such affordances play a part in how we prepare to handle or manipulate tools and other objects. Evidence obtained through fMRI, EEG and TMS has proven that this is the case but, as yet, the temporal evolution of affordances has not been fully investigated. The aim here was to further explore the timing of evoked motor activity using visual stimuli tailored to drive the motor system. Therefore, we presented three kinds of stimuli in stereoscopic depth; whole hand grasp objects which afforded a power-grip, pinch-grip objects which afforded a thumb and forefinger precision-grip and an empty desk, affording no action. In order to vary functional motor priming while keeping visual stimulation identical, participants adopted one of two postures, with either the dominant or non-dominant hand forward. EEG data from 29 neurologically healthy subjects were analysed for the N1 evoked potential, observed in visual discrimination tasks, and for the N2 ERP component, previously shown to correlate with affordances (Proverbio, Adorni, & D'Aniello, 2011). We observed a link between ERPs, previously considered to reflect motor priming, and the positioning of the dominant hand. A significant interaction was detected in the left-hemisphere N2 between the participants' posture and the object category they viewed. These results indicate strong affordance-related activity around 300ms after stimulus presentation, particularly when the dominant hand can easily reach an object.

A model-based comparison of three theories of audiovisual temporal recalibration.

Observers change their audio-visual timing judgements after exposure to asynchronous audiovisual signals. The mechanism underlying this temporal recalibration is currently debated. Three broad explanations have been suggested. According to the first, the time it takes for sensory signals to propagate through the brain has changed. The second explanation suggests that decisional criteria used to interpret signal timing have changed, but not time perception itself. A final possibility is that a population of neurones collectively encode relative times, and that exposure to a repeated timing relationship alters the balance of responses in this population. Here, we simplified each of these explanations to its core features in order to produce three corresponding six-parameter models, which generate contrasting patterns of predictions about how simultaneity judgements should vary across four adaptation conditions: No adaptation, synchronous adaptation, and auditory leading/lagging adaptation. We tested model predictions by fitting data from all four conditions simultaneously, in order to assess which model/explanation best described the complete pattern of results. The latency-shift and criterion-change models were better able to explain results for our sample as a whole. The population-code model did, however, account for improved performance following adaptation to a synchronous adapter, and best described the results of a subset of observers who reported least instances of synchrony.

Involvement of human internal globus pallidus in the early modulation of cortical error-related activity.

The detection and assessment of errors are a prerequisite to adapt behavior and improve future performance. Error monitoring is afforded by the interplay between cortical and subcortical neural systems. Ample evidence has pointed to a specific cortical error-related evoked potential, the error-related negativity (ERN), during the detection and evaluation of response errors. Recent models of reinforcement learning implicate the basal ganglia (BG) in early error detection following the learning of stimulus-response associations and in the modulation of the cortical ERN. To investigate the influence of the human BG motor output activity on the cortical ERN during response errors, we recorded local field potentials from the sensorimotor area of the internal globus pallidus and scalp electroencephalogram representing activity from the posterior medial frontal cortex in patients with idiopathic dystonia (hands not affected) during a flanker task. In error trials, a specific pallidal error-related potential arose 60 ms prior to the cortical ERN. The error-related changes in pallidal activity-characterized by theta oscillations-were predictive of the cortical error-related activity as assessed by Granger causality analysis. Our findings show an early modulation of error-related activity in the human pallidum, suggesting that pallidal output influences the cortex at an early stage of error detection.

Perceptual confidence demonstrates trial-by-trial insight into the precision of audio-visual timing encoding.

Peoples' subjective feelings of confidence typically correlate positively with objective measures of task performance, even when no performance feedback is provided. This relationship has seldom been investigated in the field of human time perception. Here we find a positive relationship between the precision of human timing perception and decisional confidence. We first demonstrate that subjective audio-visual timing judgements are more precise when people report a high, as opposed to a low, level of confidence. We then find that this relationship is more likely to result from variance in sensory timing estimates than the application of variable decision criteria, as the relationship held when we adopted a measure of timing sensitivity designed to limit the influence of subjective criteria. Our results suggest analyses of timing perception and associated decisional confidence reflect the trial-by-trial variability with which timing has been encoded.

An object-centered aftereffect of a latent material property: A squishiness visual aftereffect, not causality adaptation.

Visual aftereffects are characterized by a changed perceptual experience after exposure to a visual input. For instance, exposure to rightward motion can make a static input seem to drift leftward-the motion aftereffect. Such aftereffects have been integral to building our understanding of the neural mechanisms and computational processes that underlie perception. Increasingly complex characteristics have been found to be susceptible to visual aftereffects, such as the appearance of human faces, the apparent number of visual elements, and the glossiness of a surface. Here we report that the apparent elasticity, or squishiness, of an object is also subject to a visual aftereffect. This relationship can explain data previously interpreted in terms of a causality aftereffect.

Inside the brain of an elite athlete: the neural processes that support high achievement in sports.

Events like the World Championships in athletics and the Olympic Games raise the public profile of competitive sports. They may also leave us wondering what sets the competitors in these events apart from those of us who simply watch. Here we attempt to link neural and cognitive processes that have been found to be important for elite performance with computational and physiological theories inspired by much simpler laboratory tasks. In this way we hope to inspire neuroscientists to consider how their basic research might help to explain sporting skill at the highest levels of performance.

Scaling of movement is related to pallidal γ oscillations in patients with dystonia.

Neuronal synchronization in the gamma (γ) band is considered important for information processing through functional integration of neuronal assemblies across different brain areas. Movement-related γ synchronization occurs in the human basal ganglia where it is centered at ~70 Hz and more pronounced contralateral to the moved hand. However, its functional significance in motor performance is not yet well understood. Here, we assessed whether event-related γ synchronization (ERS) recorded from the globus pallidus internus in patients undergoing deep brain stimulation for medically intractable primary focal and segmental dystonia might code specific motor parameters. Pallidal local field potentials were recorded in 22 patients during performance of a choice-reaction-time task. Movement amplitude of the forearm pronation-supination movements was parametrically modulated with an angular degree of 30°, 60°, and 90°. Only patients with limbs not affected by dystonia were tested. A broad contralateral γ band (35-105 Hz) ERS occurred at movement onset with a maximum reached at peak velocity of the movement. The pallidal oscillatory γ activity correlated with movement parameters: the larger and faster the movement, the stronger was the synchronization in the γ band. In contrast, the event-related decrease in beta band activity was similar for all movements. Gamma band activity did not change with movement direction and did not occur during passive movements. The stepwise increase of γ activity with movement size and velocity suggests a role of neuronal synchronization in this frequency range in basal ganglia control of the scaling of ongoing movements.

Binocular vision enhances a rapidly evolving affordance priming effect: behavioural and TMS evidence.

Extensive research has suggested that simply viewing an object can automatically prime compatible actions for object manipulation, known as affordances. Here we explored the generation of covert motor plans afforded by real objects with precision ('pinchable') or whole-hand/power ('graspable') grip significance under different types of vision. In Experiment 1, participants viewed real object primes either monocularly or binocularly and responded to orthogonal auditory stimuli by making precision or power grips. Pinchable primes facilitated congruent precision grip responses relative to incongruent power grips, and vice versa for graspable primes, but only in the binocular vision condition. To examine the temporal evolution of the binocular affordance effect, participants in Experiment 2 always viewed the objects binocularly but made no responses, instead receiving a transcranial magnetic stimulation pulse over their primary motor cortex at three different times (150, 300, 450ms) after prime onset. Motor evoked potentials (MEPs) recorded from a pinching muscle were selectively increased when subjects were primed with a pinchable object, whereas MEPs from a muscle associated with power grips were increased when viewing graspable stimuli. This interaction was obtained both 300 and 450ms (but not 150ms) after the visual onset of the prime, characterising for the first time the rapid development of binocular grip-specific affordances predicted by functional accounts of the affordance effect.

Spatial attention is not affected by alpha or beta transcranial alternating current stimulation: A registered report.

Using Electroencephalography (EEG) an event-related change in alpha activity has been observed over primary sensory cortices during the allocation of spatial attention. This is most prominent during top-down, or endogenous, attention, and nearly absent in bottom-up, or exogenous orienting. These changes are highly lateralised, such that an increase in alpha power is seen ipsilateral to the attended region of space and a decrease is seen contralaterally. Whether these changes in alpha oscillatory activity are causally related to attentional resources, or to perceptual processes, or are simply epiphenomenal, is unknown. If alpha oscillations are indicative of a causal mechanism whereby attention is allocated to a region of space, it remains an open question as to whether this is driven by ipsilateral increases or contralateral decreases in alpha power. This preregistered report set out to test these questions. To do so, we used transcranial Alternating Current Stimulation (tACS) to modulate alpha activity in the somatosensory cortex whilst measuring performance on established tactile attention paradigms. All participants completed an endogenous and exogenous tactile attention task in three stimulation conditions; alpha, sham and beta. Sham and beta stimulation operated as controls so that any observed effects could be attributed to alpha stimulation specifically. We replicated previous behavioural findings in all stimulation conditions showing a facilitation of cued trials in the endogenous task, and inhibition of return in the exogenous task. However, these were not affected by stimulation manipulations. Using Bayes-factor analysis we show strong support for the null hypotheses - that the manipulation of Alpha by tACS does not cause changes in tactile spatial attention. This well-powered study, conducted over three separate days, is an important contribution to the current debate regarding the efficiency of brain stimulation.

The temporal visual oddball effect is not caused by repetition suppression.

The oddball paradigm is commonly used to investigate human time perception. Trains of identical repeated events ('standards') are presented, only to be interrupted by a different 'oddball' that seems to have a relatively protracted duration. One theoretical account has been that this effect is driven by repetition suppression for repeated standards. The idea is that repeated events seem shorter as they incur a progressively reduced neural response, which is supported by the finding that oddball perceived duration increases linearly with the number of preceding repeated standards. However, typical oddball paradigms confound the probability of oddball presentations with variable numbers of standard repetitions on each trial, allowing people to increasingly anticipate an oddball presentation as more standards are presented. We eliminated this by making participants aware of what fixed number of standards they would encounter before a final test input and tested different numbers of standards in separate experimental sessions. The final event of sequences, the test event, was equally likely to be an oddball or another repeat. We found a positive linear relationship between the number of preceding repeated standards and the perceived duration of oddball test events. However, we also found this for repeat tests events, which speaks against the repetition suppression account of the temporal oddball effect.

The best fitting of three contemporary observer models reveals how participants' strategy influences the window of subjective synchrony.

When experimenters vary the timing between two intersensory events, and participants judge their simultaneity, an inverse-U-shaped psychometric function is obtained. Typically, this simultaneity function is first fitted with a model for each participant separately, before best-fitting parameters are utilized (e.g., compared across conditions) in the second stage of a two-step inferential procedure. Often, simultaneity-function width is interpreted as representing sensitivity to asynchrony, and/or ascribed theoretical equivalence to a window of multisensory temporal binding. Here, we instead fit a single (principled) multilevel model to data from the entire group and across several conditions at once. By asking 20 participants to sometimes be more conservative in their judgments, we demonstrate how the width of the simultaneity function is prone to strategic change and thus questionable as a measure of either sensitivity to asynchrony or multisensory binding. By repeating our analysis with three different models (two implying a decision based directly on subjective asynchrony, and a third deriving this decision from the correlation between filtered responses to sensory inputs) we find that the first model, which hypothesizes, in particular, Gaussian latency noise and difficulty maintaining the stability of decision criteria across trials, is most plausible for these data. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Occipital alpha-band brain waves when the eyes are closed are shaped by ongoing visual processes.

One of the seminal findings of cognitive neuroscience is that the power of occipital alpha-band (~ 10 Hz) brain waves is increased when peoples' eyes are closed, rather than open. This has encouraged the view that alpha oscillations are a default dynamic, to which the visual brain returns in the absence of input. Accordingly, we might be unable to increase the power of alpha oscillations when the eyes are closed, above the level that would normally ensue when people close their eyes. Here we report counter evidence. We used electroencephalography (EEG) to record brain activity when people had their eyes open and closed, both before and after they had adapted to radial motion. The increase in alpha power when people closed their eyes was increased by prior adaptation to a broad range of radial motion speeds. This effect was greatest for 10 Hz motion, but robust for other frequencies (and especially 7.5 Hz). This discredits a persistent entrainment of activity at the adaptation frequency as an explanation for our findings. Our data show that the power of occipital alpha-band brain waves can be increased by motion sensitive visual processes that persist when the eyes are closed. Consequently, we suggest that the power of these brain waves is, at least in part, an index of the degree to which visual brain activity is being subjected to inhibition. This is increased when people close their eyes, but can be even further increased by pre-adaptation to radial motion.

Neural prediction errors depend on how an expectation was formed.

When a visual event is unexpected, because it violates a train of repeated events, it excites a greater positive electrical potential at sensors positioned above occipital-parietal human brain regions (the P300). Such events can also seem to have an increased duration relative to repeated (implicitly expected) events. However, recent behavioural evidence suggests that when events are unexpected because they violate a declared prediction-a guess-there is an opposite impact on duration perception. The neural consequences of incorrect declared predictions have not been examined. We replicated the finding whereby repetition violating events elicit a larger P300 response. However, we found that events that violated a declared prediction entrained an opposite pattern of response-a smaller P300. These data suggest that the neural consequences of a violated prediction are not uniform but depend on how the prediction was formed.