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Oxidative stress, characterized by an imbalance between oxidative and antioxidant processes, results in excessive accumulation of intracellular reactive oxygen species. Among these responses, the regulation of intracellular hydroxyl radicals (â¢OH) and glutathione (GSH) is vital for physiological processes. Real-time in situ monitoring these two opposing bioactive species and their redox interactions is essential for understanding physiological balance and imbalance. In this study, we developed a dual-site fluorescence chemosensor OG-3, which can independently image both exogenous and endogenous â¢OH and GSH in separate channels both within cells and in vivo, eliminating issues of spatiotemporal inhomogeneous distribution and cross-interference. With its imaging capabilities of monitoring â¢OH-GSH redox, OG-3 elucidated two different pathways for ferroptosis induction: (i) inhibition of system xc- to block cystine uptake (extrinsic pathway) and (ii) GPX4 inactivation, leading to the loss of antioxidant defense (intrinsic pathway). Moreover, we assessed the antiferroptotic function and effects of ferroptosis inhibitors by monitoring â¢OH and GSH fluctuations during ferroptosis. This method provides a reliable platform for identifying potential ferroptosis inhibitors, contributing to our understanding of relevant metabolic and physiological mechanisms. It shows potential for elucidating the regulation of ferroptosis mechanisms and investigating further strategies for therapeutic applications.
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Ferroptosis , Colorantes Fluorescentes , Glutatión , Radical Hidroxilo , Oxidación-Reducción , Ferroptosis/efectos de los fármacos , Glutatión/metabolismo , Glutatión/análisis , Humanos , Radical Hidroxilo/metabolismo , Animales , Colorantes Fluorescentes/química , Ratones , Imagen ÓpticaRESUMEN
The reaction between hydroxyl radical (·OH) and cysteine (Cys) plays an important role in the redox balance of living cells. A deeper insight into this intracellular reaction modulation and process is necessary and draws great interest. A highly effective technique consists of the real-time visualization of the two bioactive species and the perception of their respective changes by using a fluorescent probe. In this study, a dual-site chemosensor SPI based on phenothiazine-cyanine was developed, which realized quantitative detection and real-time imaging of ·OH and Cys at their own fluorescence channels (·OH: λex = 485 nm, λem = 608 nm; Cys: λex = 426 nm, λem = 538 nm) without spectral crosstalk. The fluorescent sensor showed excellent anti-interference and selectivity for common biological substances, apart from the successful imaging of exogenous and endogenous ·OH and Cys. We further visualized the redox dynamic reaction and explored the correlation of ·OH and Cys generated by different inhibitors (sulfasalazine and (1S, 3R)-RSL3). Notably, the chemosensor also possesses the capacity to clearly monitor ·OH and Cys in living mice and zebrafish. This study reports on the first chemosensor to investigate the process of intracellular redox modulation and control between ·OH and Cys, which show potential to further explore some metabolic and physiological mechanisms.
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Cisteína , Pez Cebra , Humanos , Ratones , Animales , Cisteína/metabolismo , Pez Cebra/metabolismo , Células HeLa , Colorantes Fluorescentes/metabolismo , Oxidación-ReducciónRESUMEN
Interest in wearable and stretchable multifunctional sensors has grown rapidly in recent years. The sensing elements must accurately detect external stimuli to expand their applicability as sensors. However, the sensor's self-healing and adhesion to a target object have been major challenges in developing such practical and versatile devices. In this study, we prepared a hydrogel (LM-SA-PAA) composed of liquid metal (LM), sodium alginate (SA), and poly(acrylic acid) (PAA) with ultrastretchable, excellent self-healing, self-adhesive, and high-sensitivity sensing capabilities that enable the conformal contact between the sensor and skin even during dynamic movements. The excellent self-healing performance of the hydrogel stems from its double cross-linked networks, including physical and chemical cross-linked networks. The physical cross-link formed by the ionic interaction between the carboxyl groups of PAA and gallium ions provide the hydrogel with reversible autonomous repair properties, whereas the covalent bond provides the hydrogel with a stable and strong chemical network. Alginate forms a microgel shell around LM nanoparticles via the coordination of its carboxyl groups with Ga ions. In addition to offering exceptional colloidal stability, the alginate shell has sufficient polar groups, ensuring that the hydrogel adheres to diverse substrates. Based on the efficient electrical pathway provided by the LM, the hydrogel exhibited strain sensitivity and enabled the detection of various human motions and electrocardiographic monitoring. The preparation method is simple and versatile and can be used for the low-cost fabrication of multifunctional sensors, which have broad application prospects in human-machine interface compatibility and medical monitoring.
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Harmful particles such as heavy metal particles in the human body can cause many problems such as kidney stones, gallstones, and cerebrovascular diseases. Therefore, it is critical to separate them from the blood and perform a systematic analysis as early as possible. Here, we apply eutectic gallium indium (EGaIn) microparticles as a model to study the separation of particles from blood, thanks to their properties of low toxicity, excellent degradability, and negligible vapor pressure. In particular, the dielectrophoresis (DEP) separation method is employed to separate EGaIn of different sizes and characteristics in blood. First, the screen-printing method is used to create EGaIn microparticles with diameters of 15, 23, 18, and 11 µm. According to the lifetime test, these microparticles can last more than 1 month, as evidenced by their surface oxidation characteristics. Moreover, a DEP platform with W-type electrodes is developed to sort EGaIn particles from whole human blood. The results show that a sorting efficiency of 95% can be attained, which is similar to the separation efficiency of 98% achieved by finite element analysis (FEA) using COMSOL software based on the orthogonal array experiment method. The proposed study successfully validates the use of the DEP method to separate particles from human blood, providing insights into heavy metal particle separating, drug screening, and cell sorting and potentially broadening the applications in environmental analysis, food engineering, and bioengineering.
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Galio , Indio , Humanos , Electroforesis/métodos , Electrodos , Separación Celular/métodosRESUMEN
The abuse of pesticides has introduced a large number of residues in soil and drinking water, which can then enter the food chain and the human body. Monitoring pesticide residues and developing simple and fast detection systems for pesticide residues is urgently needed. In this study, we presented one-pot prepared CdS fluorescent quantum dots (QDs) and explored their sensing application for organic pesticides. The CdS QDs can sensitively and selectively detect three different pesticides, dichlorvos (DDVP), paraquat, and glufosinate-ammonium, through different fluorescence responses. Paraquat can effectively quench the fluorescence of the QDs and DDVP can cause remarkable fluorescent enhancement. Glufosinate-ammonium can induce both 150 nm fluorescent blueshifting and 30-fold fluorescent enhancement. The probe exhibited low detection limits for the three pesticides: 1.44 µM for paraquat, 0.23 mM for DDVP, and 49.8 µM for glufosinate-ammonium. Furthermore, based on the results, we utilized the powerful functions of smartphones to establish a concentration-gray value standard curve through RGB values and gray values to realize the qualitative detection and quantitative analysis of DDVP. It is believed that this work presents a new platform for the simultaneous detection of multiple pesticides using a single QDs probe. The present on-site method using a smartphone is of great potential for water monitoring in rural areas.
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Agua Potable , Residuos de Plaguicidas , Plaguicidas , Puntos Cuánticos , Diclorvos/análisis , Agua Potable/análisis , Colorantes Fluorescentes/química , Humanos , Paraquat/análisis , Residuos de Plaguicidas/análisis , Plaguicidas/análisis , Puntos Cuánticos/química , Espectrometría de Fluorescencia/métodosRESUMEN
Triarylboron-based Lewis acids as fluoride sensors face a stimulating academic challenge because of the high hydration enthalpy of fluoride, and are usually influenced by a competing response for cyanide ion. Herein, we present a new triarylborane functionalized by a metal-ion ligand, di-(2-picolyl)-N-(2-quinolinylmethyl)amine, with subsequent metalation. In aqueous solution, this triarylborane (QB) can capture fluoride and cyanide anions through chelation induced by the synergy of boron and metal ions. Moreover, this triarylborane moiety acts as a fluorescent reporter of the binding, allowing for discrimination between fluoride and cyanide anions through dual-channel fluorescence changes. The different chelation models and fluorogenic responses of this sensor toward F- and CN- were verified by the single-crystal structures of 2-to-2 adduct for KCN and 1-to-1 for KF.
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Copper-free click chemistry has been used to graft quaternized poly(dimethylaminoethyl methacrylate) (QPA) modified with azide to the quantum dots (QDs) derived with dibenzocyclooctynes (DBCO). The success of the quaternary ammonium polymer-modified QDs was confirmed by ultraviolet-visible spectrophotometry (UV-Vis), fluorescence spectroscopy, zeta (ζ) potential, size distribution, and transmission electron microscopy (TEM). The QPA-modified QDs exhibited properties of selective recognition and killing of bacteria. The novelty of this study lies in fact that the synthesis method of the antimicrobial QPA-modified QDs is simple. Moreover, from another standpoint, QPA-modified QDs simultaneously possess abilities of selective recognition and killing of bacteria over mammalian cells, which is very different from the currently designed multifunctional antimicrobial systems composed of complicated systematic compositions.
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Bacterias/efectos de los fármacos , Metacrilatos/química , Puntos Cuánticos , Compuestos de Amonio Cuaternario/química , Células A549 , Compuestos de Cadmio , Química Clic , Células Hep G2 , Células Endoteliales de la Vena Umbilical Humana , Humanos , Espectrometría de FluorescenciaRESUMEN
In this paper, we designed and synthesized a novel TBET-based ratiometric fluorescent chemodosimeter, RH-Au, for Au(3+). It was found that the probe RH-Au displayed highly selective, sensitive and naked-eye detection upon the addition of Au(3+). The probe RH-Au can be used in the pH range 6.0-7.5 and the detection limit was determined to be as low as 2.91 nM (0.57 ppb). We also demonstrated a successful application of imaging Au(3+) in living cells using RH-Au.
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Transferencia de Energía , Oro/análisis , Espectrometría de Fluorescencia/instrumentación , Supervivencia Celular , Color , Oro/química , Células HeLa , Humanos , Concentración de Iones de Hidrógeno , Límite de Detección , Modelos Moleculares , Conformación Molecular , Imagen MolecularRESUMEN
ß-BiNbO4 with a high temperature triclinic form was prepared via a high-temperature solid-state reaction ceramic method. Structural refinement and surface characteristic studies were performed. The optical absorption, and electronic calculation of the band structures and density of states were also studied. ß-BiNbO4 ceramic has an indirect transition with a band energy of 3.05 eV. The valence band is dominated by O-2p states whereas the conduction band has predominantly Nb 4d and Bi 6s character. The intrinsic luminescence properties of ß-BiNbO4 were reported, and present a blue emission band peak at 435 nm under the excitation of UV light. The ß-BiNbO4 ceramic presents scintillation properties under high energy irradiation. The luminescence was studied via the combinations of the color centers, band calculation and energy transfer from NbO6 to Bi(3+) in the lattices. The thermal quenching and activation energy for the luminescence were reported. ß-BiNbO4 has potential applications in photoluminescence and scintillation materials.
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Fluoride anion (F(-)) significantly affects chemical, biological, and environmental processes. Fluoride recognition and detection have received increasing attention. Convenient, effective, and sensitive fluorescent probes for F(-) should urgently be designed and synthesized. In this study, we describe a strategy for constructing two triarylborane-based fluoride fluorescent probes: 2,7,12-tri(2-(5-(dimesitylboryl)thiophen-2-yl)ethynyl)-5,5',10,10',15,15'-hexaethyltruxene (C3B3) with π-3A (acceptor) configuration and 2,7-di(N,N-diphenylamino)-12-(5-(dimesitylboryl)thiophen-2-yl)-5,5',10,10',15,15'-hexaethyltruxene (N2SB) with 2D (donor)-π-A configuration. The loss of color of the tetrahydrofuran solution of these probes from greenish yellow suggests that they can conveniently monitor F(-) at a low concentration (10 µM) free of apparatus. The different structural features of these probes varied their fluorescent responses to F(-). The single-photon fluorescence intensity of C3B3 declined to 90% upon the addition of 4.5 equivalents of F(-) to its tetrahydrofuran solution. However, the single-photon fluorescence intensity of N2SB was enhanced six-fold upon addition of 2.5 equivalents of the F(-). Under the experimental conditions, the detection limits of the two probes for F(-) can reach 12-13 µM (C3B3) and 3-5 µM (N2SB). The ability of the two probes in detecting F(-) in their toluene solutions in the two-photon mode was also investigated. The sensitive two-photon fluorescence responses of both probes make them excellent two-photon fluorescence probes.
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Boranos/química , Colorantes Fluorescentes/química , Fluoruros/análisis , Límite de Detección , Modelos Moleculares , Espectrometría de Fluorescencia/métodosRESUMEN
Diabetes-related slow healing of wounds is primarily driven by bacterial infections and angiogenesis disorder and presents a substantial hurdle in clinical treatment. To solve the above problems, an advanced multifunctional hydrogel system based on natural polymer was created here to facilitate wound healing in patients with chronic diabetes. The prepared dressing was composed of an outer hydrogel containing polyvinyl alcohol and hydroxypropyl methyl cellulose in dimethyl sulfoxide and water as binary solvents, and an inner hydrogel containing chitosan quaternary ammonium salt, flaxseed gum, and polyvinyl alcohol. Thus, a polysaccharide based bilayer hydrogel (BH) with superior mechanical strength and biocompatibility was created. This bilayer hydrogel could easily bind to dynamic tissue surfaces, thereby generating a protective barrier. Meanwhile, L-arginine-modified polyoxometalate (POM@L-Arg) nanoclusters were loaded in the inner hydrogel. They released NO when stimulated by the peroxide microenvironment of diabetic wounds. NO as a signal molecule regulated vascular tension and promoted cell proliferation and migration. Additionally, because of the synergistic effect of NO and the chitosan quaternary ammonium salt, the hydrogel system exhibited excellent antibacterial performance. The NO released reduced the levels of proinflammatory factors IL-6 and TNF-α in the diabetic wounds, which thus accelerated wound healing. In short, BH + POM@L-Arg is expected to serve as an ideal wound dressing as it exerts a good promotion effect on diabetes-related wound healing.
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Antibacterianos , Arginina , Hidrogeles , Derivados de la Hipromelosa , Compuestos de Tungsteno , Cicatrización de Heridas , Cicatrización de Heridas/efectos de los fármacos , Arginina/química , Arginina/farmacología , Hidrogeles/química , Hidrogeles/farmacología , Animales , Antibacterianos/farmacología , Antibacterianos/química , Compuestos de Tungsteno/química , Compuestos de Tungsteno/farmacología , Derivados de la Hipromelosa/química , Vendajes , Masculino , Humanos , Quitosano/química , Quitosano/farmacología , Proliferación Celular/efectos de los fármacos , Ratones , Diabetes Mellitus Experimental/tratamiento farmacológico , Ratas , Ratas Sprague-DawleyRESUMEN
Two series of apigenin [5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one] derivatives, 3a-3j and 4a-4j, were synthesized. The apigenin and alkyl amines moieties of these compounds were separated by C2 or C3 spacers, respectively. The chemical structures of the apigenin derivatives were confirmed using ¹H-NMR, ¹³C-NMR, and electrospray ionization mass spectroscopy. The in vitro antibacterial and antiproliferative activities of all synthesized compounds were determined. Among the tested compounds, 4a-4j displayed significant antibacterial activity against the tested strains (Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa). Additionally, 4i showed the best inhibitory activity with minimum inhibitory concentrations of 1.95, 3.91, 3.91, and 3.91 µg/mL against S. aureus, B. subtilis, E. coli, and P. aeruginosa, respectively. The antiproliferative activity of the apigenin derivatives was evaluated by an MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] assay. We determined that 4a-4j displayed better growth inhibition activity against four human cancer cell lines, namely, human lung (A549), human cervical (HeLa), human hepatocellular liver (HepG2), and human breast (MCF-7) cancer cells, than the parent apigenin. Compound 4j was found to be the most active antiproliferative compound against the selected cancer cells. Structure-activity relationships were also discussed based on the obtained experimental data.
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Antibacterianos/síntesis química , Antineoplásicos/síntesis química , Flavonas/síntesis química , Antibacterianos/farmacología , Antineoplásicos/farmacología , Bacillus subtilis/efectos de los fármacos , Línea Celular Tumoral , Proliferación Celular/efectos de los fármacos , Pruebas Antimicrobianas de Difusión por Disco , Ensayos de Selección de Medicamentos Antitumorales , Escherichia coli/efectos de los fármacos , Flavonas/farmacología , Humanos , Pseudomonas aeruginosa/efectos de los fármacos , Staphylococcus aureus/efectos de los fármacosRESUMEN
Seven homoserine-lactone (HL) acylated derivatives (HL1-HL7) were synthesized to determine the differences in antifeedant affects. The differences between these derivatives and tutin against Mythimna separata were tested. The structural assignments of these semisynthetic compounds were examined based on their infrared radiaion (IR), electrospray ionization mass spectrometry (ESIMS), and ¹H- and ¹³C-nuclear magnetic resonance (¹³C-NMR) spectral data. Compound HL1 (N-(4-nitrobenzoyl)-homoserinelactone) is the optimized insecticidal agent among these compounds. In addition, the antifeedant activities between homoserinelactone and 7-hydroxycoumarin, tutin derivatives with the same acidylated substitutions were compared, which could help design and synthesize stronger novel botanical insecticides.
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Acil-Butirolactonas/química , Insecticidas/síntesis química , Insecticidas/farmacología , Mariposas Nocturnas/efectos de los fármacos , 4-Butirolactona/análogos & derivados , 4-Butirolactona/síntesis química , 4-Butirolactona/química , 4-Butirolactona/farmacología , Animales , Benzamidas/síntesis química , Benzamidas/química , Benzamidas/farmacología , Insecticidas/química , Espectroscopía de Resonancia Magnética , Estructura Molecular , Picrotoxina/análogos & derivados , Picrotoxina/química , Picrotoxina/farmacología , Sesquiterpenos/química , Sesquiterpenos/farmacología , Espectrometría de Masa por Ionización de Electrospray , Relación Estructura-Actividad , Umbeliferonas/química , Umbeliferonas/farmacologíaRESUMEN
The healing of infected wounds has always been a clinical challenge. With the increasing threat of drug resistance due to antibiotic overuse, it is imperative to improve antibacterial wound dressings. In this study, we designed a double network (DN) hydrogel via a "one pot method" with antibacterial activity, and natural polysaccharides with the potential to promote skin wound healing were used. That is, a DN hydrogel matrix was formed by the hydrogen bond crosslinking of curdlan and the covalent crosslinking of flaxseed gum under the action of borax. We added ε-polylysine (ε-PL) as a bactericide. Tannic acid/ferric ion (TA/Fe3+) complex was also introduced into the hydrogel network as a photothermal agent to induce photothermal antibacterial properties. The hydrogel had fast self-healing, tissue adhesion, mechanical stability, good cell compatibility and photothermal antibacterial activity. In vitro studies of hydrogel showed its ability to inhibit S. aureus and E. coli. In vivo experiments also demonstrated the significant healing effect of hydrogel when used to treat wounds infected by S. aureus by promoting collagen deposition and accelerating the formation of skin appendage. This work provides a new design for the preparation of safe antibacterial hydrogel wound dressings and demonstrates great potential for promoting wound healing of bacterial infections.
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Lino , Hidrogeles , Escherichia coli , Staphylococcus aureus , Cicatrización de Heridas , Antibacterianos/farmacologíaRESUMEN
Studies on the degeneration and regeneration of neurons as individual compartments of axons or somata can provide critical information for the clinical therapy of nervous system diseases. A controllable in vitro platform for multiple purposes is key to such studies. In the present study, we describe an integrated microfluidic device designed for achieving localized stimulation to neuronal axons or somata. We observed neuronal compartment degeneration after localized chemical stimulation and regeneration under the accessorial function of an interesting compound treatment or coculture with desired cells in controllable chambers. In a spatiotemporally controlled manner, this device was used to investigate hippocampal neuronal soma and axon degeneration after acrylamide stimulation, as well as subsequent regeneration after treatment with the monosialoganglioside GM1 or with cocultured glial cells (astrocytes or Schwann cells). To gain insight into the molecular mechanisms that mediate neuronal injury and regeneration, as well as to investigate whether acrylamide stimulation to neurons induces changes in Ca(2+) concentrations, the related neuronal genes and real-time Ca(2+) signal in neurons were also analyzed. The results showed that neuronal axons were more resistant to acrylamide injury than neuronal somata. Under localized stimulation, axons had self-destruct programs different from somata, and somatic injury caused the secondary response of axon collapse. This study provides a foundation for future in-depth analyses of spatiotemporally controlled and multifactor neuronal compartment regeneration after various injuries. The microfluidic device is also useful in evaluating potential therapeutic strategies to treat chemical injuries involving the central nervous system.
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Técnicas Analíticas Microfluídicas/métodos , Neuronas/citología , Regeneración/efectos de los fármacos , Acrilamida/toxicidad , Animales , Astrocitos/citología , Astrocitos/efectos de los fármacos , Axones/fisiología , Calcio/metabolismo , Células Cultivadas , Técnicas de Cocultivo , Gangliósido G(M1)/farmacología , Técnicas Analíticas Microfluídicas/instrumentación , Neuronas/efectos de los fármacos , Neuronas/fisiología , Ratas , Ratas Sprague-Dawley , Células de Schwann/citología , Células de Schwann/efectos de los fármacosRESUMEN
Pharmaceuticals and personal care products (PPCPs) are gaining attention due to their persistence in the environment. Therefore, the development of novel adsorbents to remove them is strongly anticipated. In this study, an improved dual ice-template assembly method had been used for the preparation of ZIF-67/QGO/SB-CS aerogel through ZIF-67, benzoquinone-modified graphene oxide (QGO), and sulfobetaine-modified chitosan (SB-CS) for the adsorption and removal of PPCPs in water. We reported for the first time that the chitosan composite aerogel has antifouling, bacterial filtration and oil-water separation abilities with excellent PPCPs adsorption performance and reusable, which would be a viable option for long-lasting adsorbents for PPCPs in water.
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Quitosano , Cosméticos , Contaminantes Químicos del Agua , Adsorción , Benzoquinonas , Hielo , Preparaciones Farmacéuticas , Agua , Contaminantes Químicos del Agua/análisisRESUMEN
In this study, we successfully developed a new multifunctional chemosensor 4',4â´-(2,2-diphenylethene-1,1-diyl)bis(N,N-bis (pyridin-2-ylmethyl)-[1,1'-biphenyl]-4-amine (T-D), based on the cooperation of tetraphenylethylene and di-(2-picolyl)amine (DPA), for sensitive, selective, and quick detection of Cu2+, PO43- and pesticide glyphosate in aqueous solution. In our research, we made full use of the Cu2+-indicator displacement strategy to achieve the construction of an "on-off-on" fluorescent switch platform. Due to the presence of the DPA moiety in T-D, Cu2+ could be captured quickly to form the complex T-D-Cu and caused fluorescence quenching. With the addition of PO43- and glyphosate, the system could rapidly restore the fluorescence by squeezing Cu2+ from T-D-Cu and blocking the photo induced electron transfer (PET) process to display the aggregation-induced emission. To demonstrate the possibility of practical applications, we detected PO43- and glyphosate in spiked real samples. The detection limit for PO43- and glyphosate reached 19 nM and 25 nM, respectively. Furthermore, test strips using T-D-Cu solution simplified the detection process of glyphosate. More importantly, the sensor could be used in visual semi-quantitative determination of PO43- concentrations in both living cells and living zebra fish. Therefore, the chemosensor presented here will not only be a powerful tool for the detection of phosphate anions in aqueous solution and biological systems, but also provides a new template for the design of other multifunctional chemosensors.
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Aminas , Estilbenos , Cobre , Colorantes Fluorescentes , AguaRESUMEN
The ongoing poisoning of agricultural products has pushed the security problem to become an important issue. Among them, exceeding the standard rate of pesticide residues is the main factor influencing the quality and security of agricultural products. Moreover, the abuse of pesticides has introduced a large amount of residues in soil and drinking water, which will enter the food chain to the human body, leading to neurological disorders and cancer. Therefore, great efforts have been devoted to developing fluorescent sensors for detecting pesticide in a facile, quickly, sensitive, selective, accurate manner, which exhibit greater advantages than some traditional methods. In this review, we mainly focus on summarizing the non-biological fluorescent probes for organic pesticides detection with the detection limit of micromole to nanomole, including organic functional small molecules, calixarenes and pillararenes, metal organic framework systems, and nanomaterials. Meanwhile, we described the different sensing mechanisms for pesticides detection of these mentioned fluorescent sensors, the detection limit of each pesticide, the application in detecting actual samples, as well as their respective advantages and development prospects associated with present non-biological fluorescent sensors.
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Estructuras Metalorgánicas , Residuos de Plaguicidas , Plaguicidas , Agricultura , Humanos , Residuos de Plaguicidas/análisis , Plaguicidas/análisis , SueloRESUMEN
In the title mol-ecule, C(10)H(9)NO, the dihedral angle between the mean plane of the cyclo-propane ring and the essentially planar [maximum deviation = 0.032â (2)â Å] indole ring system is 87.65â (17)°. In the crystal, inter-molecular N-Hâ¯O hydrogen bonds link mol-ecules into one-dimensional chains along [100].