Detalles de la búsqueda
1.
A Glutamate N-Methyl-d-Aspartate (NMDA) Receptor Subunit 2B-Selective Inhibitor of NMDA Receptor Function with Enhanced Potency at Acidic pH and Oral Bioavailability for Clinical Use.
J Pharmacol Exp Ther;
379(1): 41-52, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34493631
2.
Design and synthesis of a novel series of 4-heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes as α7 nicotinic receptor agonists 2. Development of 4-heteroaryl SAR.
Bioorg Med Chem Lett;
27(5): 1261-1266, 2017 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28169167
3.
Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain.
J Pharmacol Exp Ther;
358(3): 371-86, 2016 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27411717
4.
Pharmacodynamics of selective inhibition of γ-secretase by avagacestat.
J Pharmacol Exp Ther;
344(3): 686-95, 2013 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-23275065
5.
Phase 1 Clinical Results for NP10679, a pH-sensitive GluN2B-selective N-methyl-d-aspartate Receptor Inhibitor.
Clin Pharmacol Drug Dev;
12(7): 706-717, 2023 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-36642931
6.
Synthesis and structure-activity relationships of pyrido[3,2-b]pyrazin-3(4H)-ones and pteridin-7(8H)-ones as corticotropin-releasing factor-1 receptor antagonists.
Bioorg Med Chem Lett;
22(15): 4986-9, 2012 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22749422
7.
Postsynaptic diacylglycerol lipase mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex.
J Physiol;
589(Pt 20): 4857-84, 2011 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21807615
8.
Dihydropyridopyrazinones and dihydropteridinones as corticotropin-releasing factor-1 receptor antagonists: structure-activity relationships and computational modeling.
J Med Chem;
50(9): 2269-72, 2007 May 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-17402721
9.
Nicotinic alpha 7 receptor agonists EVP-6124 and BMS-933043, attenuate scopolamine-induced deficits in visuo-spatial paired associates learning.
PLoS One;
12(12): e0187609, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-29261656
10.
BMS-933043, a Selective α7 nAChR Partial Agonist for the Treatment of Cognitive Deficits Associated with Schizophrenia.
ACS Med Chem Lett;
8(3): 366-371, 2017 Mar 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28337332
11.
Development of 4-Heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes] as α7 Nicotinic Receptor Agonists.
ACS Med Chem Lett;
8(1): 133-137, 2017 Jan 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-28105289
12.
Effects of BMS-902483, an α7 nicotinic acetylcholine receptor partial agonist, on cognition and sensory gating in relation to receptor occupancy in rodents.
Eur J Pharmacol;
807: 1-11, 2017 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28438647
13.
Gamma-secretase inhibitors for Alzheimer's disease: balancing efficacy and toxicity.
Drugs R D;
7(2): 87-97, 2006.
Artículo
en Inglés
| MEDLINE | ID: mdl-16542055
14.
Biochemical and behavioral effects of PDE10A inhibitors: Relationship to target site occupancy.
Neuropharmacology;
102: 121-35, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-26522433
15.
The Novel, Nicotinic Alpha7 Receptor Partial Agonist, BMS-933043, Improves Cognition and Sensory Processing in Preclinical Models of Schizophrenia.
PLoS One;
11(7): e0159996, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27467081
16.
Design and Synthesis of a New Series of 4-Heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes as α7 Nicotinic Receptor Agonists. 1. Development of Pharmacophore and Early Structure-Activity Relationship.
J Med Chem;
59(24): 11171-11181, 2016 12 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-27958732
17.
Binding sites of gamma-secretase inhibitors in rodent brain: distribution, postnatal development, and effect of deafferentation.
J Neurosci;
24(12): 2942-52, 2004 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-15044533
18.
Synthesis, structure-activity relationships, and in vivo properties of 3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-ones as corticotropin-releasing factor-1 receptor antagonists.
J Med Chem;
47(23): 5783-90, 2004 Nov 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-15509177
19.
Design, synthesis, and biological evaluation of 1,2,3,7-tetrahydro-6h-purin-6-one and 3,7-dihydro-1h-purine-2,6-dione derivatives as corticotropin-releasing factor(1) receptor antagonists.
J Med Chem;
47(19): 4741-54, 2004 Sep 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-15341489
20.
Synthesis and evaluation of candidate PET radioligands for corticotropin-releasing factor type-1 receptors.
Nucl Med Biol;
41(6): 524-35, 2014 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-24793011