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1.
Clin Neuropathol ; 43(3): 83-91, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38726568

RESUMEN

BACKGROUND: Polymorphous low-grade neuroepithelial tumor of the young (PLNTY) is a rare entity of low-grade neuroepithelial tumors that primarily affects children and young adults. This distinct type of tumor presents unique challenges in diagnosis and management. With its relatively recent identification, researchers and clinicians are striving to understand the characteristics, behavior, and optimal treatment strategies. The symptoms are primarily related to seizures. However, PLNTY can be asymptomatic in some cases. MATERIALS AND METHODS: This is a single-center case report study and a literature review paper. We reviewed a case treated and diagnosed at the Ankara University Faculty of Medicine, Department of Neurosurgery. The demographic data, clinical follow-ups, laboratory, and radiological data of the patients were assessed. RESULTS: We present a 32-year-old male patient who has undergone gross total surgical excision with strict clinical follow-up. Clinical course as well as surgical data of the patient were observed and analyzed. CONCLUSION: On imaging, morphologic resembling and indistinctive clinical course can be nonspecific, contributing to diagnostic uncertainties. This case report was written with the notion that rare diagnoses present an opportunity to understand the progression and patho-oncological factors that can pave the way for better treatment.


Asunto(s)
Neoplasias Encefálicas , Neoplasias Neuroepiteliales , Humanos , Masculino , Neoplasias Neuroepiteliales/patología , Neoplasias Neuroepiteliales/diagnóstico , Neoplasias Neuroepiteliales/cirugía , Adulto , Neoplasias Encefálicas/patología , Neoplasias Encefálicas/diagnóstico , Neoplasias Encefálicas/cirugía , Diagnóstico Diferencial
2.
Childs Nerv Syst ; 2024 Jun 08.
Artículo en Inglés | MEDLINE | ID: mdl-38850294

RESUMEN

INTRODUCTION: Endoscopic approaches for skull base pathologies are increasingly being performed, and the subsequent complications, especially in the long term, have also been partially clarified. However, there is no information on the effects of endoscopic endonasal skull base surgeries (EESBS) in children on odor and facial development in parallel with long-term development. We conducted this study to investigate postoperative olfactory function and facial development in pediatric patients who underwent skull base surgery using the endoscopic endonasal method. METHODS: We evaluated the smell test, sinonasal symptoms, and facial development of pediatric patients who underwent endoscopic endonasal skull base surgery after long-term follow-up. Odor was evaluated using the "Sniffin' Sticks" test kit, which assessed the T (odor threshold), D (odor discrimination), and I (odor identification) parameters. Sinonasal symptoms were evaluated using the SNOT-22 (sinus-nose outcome test) questionnaire. SNA (sella-nasion-A point), SNB (sella-nasion-B point), and ANB (A point-nasion-B point) angles were calculated from maxillofacial tomography and magnetic resonance imaging) to evaluate facial development. Data were compared with those of the healthy control group. RESULTS: We included 30 patients comprising 19 (63.3%) boys and 11 (36.7%) girls, with no age difference between case and control groups. The mean follow-up period was 7 years. Odor test data, cephalometric measurements, and SNOT-22 analysis results showed no statistically significant differences between the two groups. CONCLUSION: To our knowledge, this is a comprehensive study with the longest follow-up period in terms of evaluation of facial development after EESBS in children to analyze odor using the Sniffin' Sticks test kit and the quality of life using SNOT-22. Olfactory function, facial development, and quality of life remained unaffected after long-term follow-up after EESBS  in children. Although this surgical approach is minimally invasive, we recommend considering the possibility of complications, and the procedure should be performed by an experienced surgical team with adequate equipment.

3.
Childs Nerv Syst ; 2024 Aug 19.
Artículo en Inglés | MEDLINE | ID: mdl-39158633

RESUMEN

PURPOSE: To describe pneumatization and topographic position of the posterior clinoid process (PCP) in healthy children when approaching the anterior and middle fossae. METHODS: The study consisted of computed tomography images of 180 pediatric patients (90 males / 90 females), aged 1-18 years. The presence or absence of PCP pneumatization was noted, and the distances of certain landmarks to PCP were measured. RESULTS: The distances of the foramen ovale, foramen rotundum, superior orbital fissure, anterior clinoid process (ACP), foramen magnum and crista galli to PCP were measured as 18.59 ± 3.36 mm, 15.37 ± 3.45 mm, 14.60 ± 3.05 mm, 5.27 ± 3.24 mm, 32.03 ± 3.27 mm, and 30.45 ± 3.93 mm, respectively. These parameters increased with growth (between 1-18 years), but the distance between PCP and ACP decreased with an irregular pattern. In 11 sides (3.10%), a fusion between PCP and ACP was determined. PCP pneumatization was identified in 32 sides (8.9%). Its pneumatization correlated with pediatric ages (p < 0.001), but not gender (p = 0.459) or side (p = 0.711). Most of PCP pneumatization appeared after late childhood period (i.e., between 10-18 years). CONCLUSION: Our study provides beneficial data for neurosurgeons to use PCP as a reference point for creating a skull base map in children, because of the incomparable position of PCP in the skull base center.

4.
Neurosurg Focus ; 56(1): E4, 2024 01.
Artículo en Inglés | MEDLINE | ID: mdl-38163350

RESUMEN

OBJECTIVE: Virtual simulation and imaging systems have evolved as advanced products of computing technology over the years. With advancements in mobile technology, smartphones, and tablets, the quality of display and processing speed have gradually improved, thanks to faster central processing units with higher capacity. Integrating these two technologies into the fields of healthcare and medical education has had a positive impact on surgical training. However, contemporary neurosurgical planning units are expensive and integrated neuronavigation systems in operating rooms require additional accessories. The aim of this study was to investigate the compatibility of smartphone applications in augmented reality (AR)-based craniotomy planning, which can be available even in disadvantaged workplaces with insufficient facilities. METHODS: Thirty patients diagnosed with supratentorial glial tumor and who underwent operations between January 2022 and March 2023 were included in the study. The entire stages of the surgical procedures and the surgical plans were executed with neuronavigation systems. The patient CT scans were reconstructed using software and exported as a 3D figure to an AR-enhanced smartphone application. The evaluation of the application's success was based on the spatial relationship of the AR-based artificial craniotomy to the neuronavigation-based craniotomy, with each AR-based craniotomy scaled from 0 to 3. RESULTS: In the comparison between neuronavigation-based and AR fusion-based craniotomies, 8 of 30 (26.6%) patients scored 0 and were considered failed, 6 (20%) scored 1 and were considered ineffective, 7 (23.3%) scored 2 and were considered acceptable, and 9 (30%) scored 3 and were considered favorable. CONCLUSIONS: AR technology has great potential to be a revolutionary milestone of neurosurgical planning, training, and education in the near future. In the authors' opinion, with the necessary legal permissions, there is no obstacle to the integration of surgical technological systems with mobile technology devices such as smartphones and tablets that benefit from their low-budget requirements, wide-range availability, and built-in operating systems.


Asunto(s)
Realidad Aumentada , Neoplasias Supratentoriales , Humanos , Teléfono Inteligente , Procedimientos Neuroquirúrgicos/métodos , Craneotomía , Neuronavegación/métodos , Cráneo
5.
J Craniofac Surg ; 35(7): 2167-2171, 2024 Oct 01.
Artículo en Inglés | MEDLINE | ID: mdl-39207159

RESUMEN

OBJECTIVE: To evaluate the position and dimension of the Vidian canal (VC) in Chiari type I malformation (CIM). MATERIALS AND METHODS: Radiologic views of 49 CIM (mean age: 23.58±15.62 y, sex: 23 males/26 females) and 51 healthy subjects (mean age: 42.50±20.12 y, sex: 21 males/30 females) were included in this computed tomography study. RESULTS: In comparison with controls, the VC angle and the distance of the round foramen to VC were greater in CIM, but VC length and the distances of the superior wall of the bony sphenoidal sinus, midsagittal plane, and vomerine crest to VC were smaller in CIM. Relative to the sphenoid bone, the position of VC in CIM was determined as type 1 (59.2%) >type 2 (28.6%) >type 3 (12.2%), whereas in controls as type 1 (54.9%) >type 3 (25.5%) >type 2 (19.6%). Relative to the medial pterygoid plate, the position of VC in CIM was determined as type A (63.3%) >type B (20.4%) >type C (16.3%), while in controls as type B (43.1%) >type A (40.2%) >type C (16.7%). CONCLUSION: VC size and position correlated with CIM. Compared with controls, CIM patients had more partially protruded VC into the bony sphenoidal sinus and more medially located VC according to the medial pterygoid plate.


Asunto(s)
Malformación de Arnold-Chiari , Tomografía Computarizada por Rayos X , Humanos , Masculino , Femenino , Malformación de Arnold-Chiari/diagnóstico por imagen , Malformación de Arnold-Chiari/patología , Adulto , Estudios de Casos y Controles , Hueso Esfenoides/diagnóstico por imagen , Hueso Esfenoides/patología , Seno Esfenoidal/diagnóstico por imagen , Seno Esfenoidal/patología , Adolescente
6.
Surg Radiol Anat ; 46(2): 137-152, 2024 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-38191743

RESUMEN

PURPOSE: This retrospective magnetic resonance imaging investigation aimed to obtain information related to the anatomy of the massa intermedia (MI) in an adult population. METHODS: The work conducted on MRI views of 1058 (539 males and 519 females) healthy adult samples aged with 48.93 ± 17.63 years. Initially, the presence or absence of MI was noted, and then if present, its numbers and location in the third ventricle were recorded. Its horizontal (HDMI) and vertical (VDMI) diameters were measured on MRI views, while the cross-sectional area (CSAMI) was calculated using its diameters. RESULTS: MI was missing in 2.6% (27 cases) of 1058 adult samples. Six subjects (0.6%) had a double MI. HDMI, VDMI and CSAMI were measured as 4.83 ± 1.01 mm, 4.86 ± 0.98 mm, and 19.11 ± 7.23 mm2, respectively. MI size did not show a significant alteration from 19 up to 49 years, but then its size distinctly decreased between 50 and 60 years. After age 60, MI dimension did not display an important change. MI was settled in the antero-superior quadrant in 929 cases (90.63% of 1025 subjects), in the postero-superior quadrant in 22 cases (2.15%), in the antero-inferior quadrant in 32 cases (3.12%), in the postero-inferior quadrant in 8 cases (0.78%), and in the central part in 34 cases (3.32%). CONCLUSIONS: The size, position and incidence of MI were not affected by sex, and its position and incidence were not affected by adult age periods. In adults, MI size demonstrated a significant decrease in the middle age.


Asunto(s)
Relevancia Clínica , Tercer Ventrículo , Masculino , Adulto , Persona de Mediana Edad , Femenino , Humanos , Anciano , Estudios Retrospectivos , Incidencia , Tálamo , Imagen por Resonancia Magnética/métodos
7.
Childs Nerv Syst ; 39(5): 1123-1129, 2023 05.
Artículo en Inglés | MEDLINE | ID: mdl-36884098

RESUMEN

PURPOSE: Cribriform neuroepithelial tumor (CRINET) is a provisional category of intraventricular tumors, sharing similarities with AT/RTs, and there is a lack of data about its pathology, prognosis, and surgical approaches in the literature. We have been challenged to describe the surgical approach to a rare case of CRINET and describe the intraoperative features since none has been described before. Surgical resection and chemotherapy hold a great importance of favorable prognosis. METHODS: Twenty-month-old male with intraventricular tumor underwent transcallosal intraventricular tumor resection and endoscopic intraventricular second look stages. The tumor was initially considered choroid plexus carcinoma and histopathological results pointed CRINET. The patient also received Ommaya reservoir for intrathecal chemotherapy employment. The patient's preoperative and postoperative MRI scans and tumor's pathological features are described with a brief history of the disease in the literature. RESULTS: Lack of SMARCB1 gene immunoreactivity and presence of cribriform non-rhabdoid trabecular neuroepithelial cells led to the CRINET diagnosis. The surgical technique helped us to approach directly into the third ventricle and perform total resection and intraventricular lavage. The patient recovered without any perioperative complications and is consulted pediatric oncology for further treatment planning. CONCLUSION: With our limited knowledge on the matter, our presentation may provide an inside to the course and progress of the CRINET as a very rare tumor and may help to set a basis for future investigations focused on its clinical and pathological features. Long courses of follow-up periods are required for establishing treatment modules and assessing the responses to surgical resection techniques and chemotherapy protocols.


Asunto(s)
Carcinoma , Neoplasias del Ventrículo Cerebral , Neoplasias del Plexo Coroideo , Neoplasias Neuroepiteliales , Niño , Humanos , Masculino , Lactante , Neoplasias del Ventrículo Cerebral/diagnóstico por imagen , Neoplasias del Ventrículo Cerebral/cirugía , Neoplasias del Ventrículo Cerebral/patología , Neoplasias del Plexo Coroideo/diagnóstico por imagen , Neoplasias del Plexo Coroideo/cirugía , Carcinoma/patología , Neoplasias Neuroepiteliales/diagnóstico por imagen , Neoplasias Neuroepiteliales/cirugía , Neoplasias Neuroepiteliales/genética , Protocolos de Quimioterapia Combinada Antineoplásica
8.
Childs Nerv Syst ; 34(5): 933-938, 2018 05.
Artículo en Inglés | MEDLINE | ID: mdl-29392421

RESUMEN

PURPOSE: We aimed to determine whether varying the magnetic field during magnetic resonance imaging would affect the development of chicken embryos and neural tube defects. METHODS: Following incubation for 24 h, we exposed chicken embryos to varying magnetic fields for 10 min to assess the impact on development. Three magnetic resonance imaging devices were used, and the eggs were divided into four groups: group 1 is exposed to 1 T, group 2 is exposed to 1.5 T, group 3 is exposed to 3 T, and group 4, control group, was not exposed to magnetic field. After MRI exposure, all embryos were again put inside incubator to complete 48 h. "The new technique" was used to open eggs, a stereomicroscope was used for the examination of magnified external morphology, and each embryo was examined according to the Hamburger and Hamilton chicken embryo stages. Embryos who had delayed stages of development are considered growth retarded. Growth retardation criteria do not include small for stage. RESULTS: Compared with embryos not exposed to a magnetic field, there was a statistically significant increase in the incidence of neural tube closure defects and growth retardation in the embryos exposed to magnetic fields (p < 0.05). However, although the incidence of neural tube closure defects was expected to increase as exposure (tesla level) increased, we found a higher rate of defects in the 1.5-T group compared with the 3-T group. By contrast, the highest incidence of growth retardation was in the 3-T group, which was consistent with our expectation that growth retardation would be more likely as tesla level increased. CONCLUSIONS: We therefore conclude that the use of magnetic resonance imaging as a diagnostic tool can result in midline closure defects and growth retardation in chicken embryos. We hypothesize that this may also be true for human embryos exposed to MRI. If a pregnant individual is to take an MRI scan, as for lumbar disc disease or any other any other reason, our results indicate that consideration should be given to an avoidance of MRI during pregnancy.


Asunto(s)
Embrión de Pollo/efectos de la radiación , Desarrollo Embrionario/efectos de la radiación , Campos Magnéticos/efectos adversos , Imagen por Resonancia Magnética/efectos adversos , Defectos del Tubo Neural/etiología , Tubo Neural/efectos de la radiación , Animales , Modelos Animales de Enfermedad , Relación Dosis-Respuesta en la Radiación , Tubo Neural/diagnóstico por imagen , Tubo Neural/embriología , Defectos del Tubo Neural/diagnóstico por imagen
9.
Childs Nerv Syst ; 31(9): 1595-9, 2015 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-25953097

RESUMEN

INTRODUCTION: Postoperative pneumocephalus is an unexpected condition after endoscopic odontoidectomy surgery. CASE: We present the first case of pneumocephalus after odontoidectomy in a pediatric patient. The clinical presentation, radiological findings, and surgical procedures are described with related pathophysiology. CONCLUSION: We outline the key for management of a rare intracranial air entrapment case after an endoscopic odontoidectomy surgery in a pediatric patient and the measures taken to prevent its occurrence in the future.


Asunto(s)
Endoscopios/efectos adversos , Procedimientos Neuroquirúrgicos/efectos adversos , Neumocéfalo/etiología , Complicaciones Posoperatorias/fisiopatología , Adolescente , Humanos , Imagen por Resonancia Magnética , Masculino , Paresia/cirugía , Neumocéfalo/diagnóstico , Tomografía Computarizada por Rayos X
10.
Turk Neurosurg ; 34(5): 926-938, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-39087287

RESUMEN

AIM: To demonstrate the possible use of mixed reality (MR) technology in neurosurgery for multiple purposes, including preoperative planning, training, and three-dimensional (3D) navigation. MATERIAL AND METHODS: Using magnetic resonance imaging (MRI) and computed tomography (CT), 3D holographic images of three patients were created and inspected using a remote control. Preoperative planning was performed in a conference room using holographic images. Intraoperatively, the 3D images were matched and the adjacent structures were examined. RESULTS: The MR System (MRS) was a useful tool for preoperative planning and intraoperative navigation during the cranial intervention. It reduces operative time, decreases complication rates, increases surgical success, and enhances surgical outcomes. Eventually, MRS may be more economical. CONCLUSION: The MRS can be used for intraoperative navigation by displaying a 3D hologram at the surgeon's fingertips and for preoperative 3D examination of the lesions and its surrounding structures. The MRS enhances surgical efficacy, reduces healthcare costs, and has a shorter learning curve than the conventional methods. It also enables customized patient-specific surgery.


Asunto(s)
Imagenología Tridimensional , Imagen por Resonancia Magnética , Microcirugia , Neuronavegación , Procedimientos Neuroquirúrgicos , Tomografía Computarizada por Rayos X , Humanos , Microcirugia/métodos , Imagenología Tridimensional/métodos , Procedimientos Neuroquirúrgicos/métodos , Neuronavegación/métodos , Cirugía Asistida por Computador/métodos , Masculino , Femenino , Realidad Aumentada , Neoplasias Encefálicas/cirugía , Neoplasias Encefálicas/diagnóstico por imagen , Holografía/métodos , Adulto , Persona de Mediana Edad
11.
World Neurosurg ; 183: e540-e548, 2024 03.
Artículo en Inglés | MEDLINE | ID: mdl-38163584

RESUMEN

BACKGROUND: For surgical interventions, a precise understanding of the anatomical variations of the brain and defined anatomical landmarks to demarcate the regions of the temporal lobe is essential. Many anatomical studies have facilitated important surgical approaches to the temporobasal region. Because there is considerable sulcal variability, morphological analysis of the brain is imperative. The aim of this study was to define the boundaries of the temporal and occipital lobes and to define the variations in sulci and gyri in the inferior aspect. METHODS: In 110 cerebral hemispheres variations were identified and the major landmarks of the gyral-sulcal pattern at the inferior aspect of the brain were defined. RESULTS: The anatomy of the inferior aspect of the brain is defined in detail by morphological analysis of formalin-fixed hemispheres with a view to informing important surgical approaches. CONCLUSIONS: Since the literature defines no clear separation between the temporal and occipital lobes, certain landmarks such as the preoccipital notch and a basal temporo-occipital line were suggested as ways of making the distinction. The parahippocampal ramus is a constant structure that can be used as a reliable landmark for the posterior end of the hippocampus.


Asunto(s)
Neurocirugia , Humanos , Lóbulo Occipital/cirugía , Lóbulo Occipital/anatomía & histología , Lóbulo Temporal/cirugía , Lóbulo Temporal/anatomía & histología , Encéfalo , Cadáver
12.
World Neurosurg ; 185: e767-e773, 2024 05.
Artículo en Inglés | MEDLINE | ID: mdl-38431212

RESUMEN

OBJECTIVE: This study aimed to examine pneumatization and topographic location of the posterior clinoid process (PCP) in Chiari type I malformation (CIM) for skull base approaches. METHODS: Computed tomography images of 52 (23 males/29 females) CIM subjects aged 23.87 ± 16.09 years and 71 (26 males/45 females) healthy subjects aged 42.48 ± 21.48 years constituted the study universe. RESULTS: The distances of PCP to the foramen magnum (P = 0.037), superior orbital fissure (P < 0.001), foramen rotundum (P < 0.001), and foramen ovale (P < 0.001) were smaller, but the distance of PCP to the crista galli (P = 0.038) was greater in CIM patients, compared with normal subjects. In CIM, the fusion between PCP and the anterior clinoid process was observed in 9 sides (8.70%), while in controls it was observed in 12 sides (8.50%). PCP pneumatization was observed in 40 sides (38.50%) in CIM patients, while it was observed in 28 sides (19.70%) in normal subjects. These data displayed that PCP pneumatization was affected by CIM (P < 0.001). CONCLUSIONS: The distances of PCP to the crista galli and foramen magnum indicate the anterior fossa length and the posterior fossa depth, respectively; thus CIM patients have a longer anterior fossa and a shallow posterior fossa. In addition, the distances of PCP to the superior orbital fissure, foramen rotundum, and foramen ovale indicate the middle fossa width; hence CIM patients have less middle fossa width than normal individuals. CIM patients have an approximately 50% higher PCP pneumatization rate, and this may increase the risk of complications such as cerebrospinal fluid fistula during the application of posterior clinoidectomy.


Asunto(s)
Malformación de Arnold-Chiari , Tomografía Computarizada por Rayos X , Humanos , Malformación de Arnold-Chiari/diagnóstico por imagen , Masculino , Femenino , Adulto , Adulto Joven , Adolescente , Persona de Mediana Edad , Base del Cráneo/diagnóstico por imagen , Base del Cráneo/anatomía & histología , Foramen Magno/diagnóstico por imagen , Foramen Magno/anatomía & histología , Hueso Esfenoides/diagnóstico por imagen , Hueso Esfenoides/anatomía & histología
13.
World Neurosurg ; 185: e1030-e1039, 2024 05.
Artículo en Inglés | MEDLINE | ID: mdl-38479640

RESUMEN

BACKGROUND: Management of interhemispheric pathologies requires surgical intervention through a restricted anatomical corridor ensconced within critical cerebral structures. The use of retractors to facilitate operative access may cause damage to cerebral tissue. The development of an innovative retraction technique designed to alleviate cerebral damage in such cases is imperative. In this study, we present a novel and gentle retraction method to facilitate the interhemisferic approach. METHODS: We retrospectively examined data of 9 right-handed patients who underwent surgical resection of interhemispheric lesions between 2021 and 2022. All patients underwent surgery for the first time because of this pathology. All operative specimens were histologically confirmed. Clinical characteristics, operative details, and follow-up data were retrospectively analyzed. RESULTS: The new retraction technique was successfully applied to 8 tumor patients and 1 patient with an aneurysm. Eight patients had an anterior interhemispheric approach, and 1 patient had a posterior interhemispheric approach. Complete surgical excision was achieved in all patients with no postoperative complications. Postoperative Gadolinium (Gd)-enhanced magnetic resonance imaging (MRI) showed no signs of ischemia or contusion. All patients exhibited significant improvements in their symptoms. An illustrative video that elucidates the removal of an interhemispheric epidermoid tumor, employing the anterior ipsilateral interhemispheric approach, featuring the novel retraction method. CONCLUSIONS: The ideal retraction technique during the interhemispheric approach is still a challenge. Our novel retraction technique may help minimize brain parenchymal damage during surgical resection of interhemispheric lesions.


Asunto(s)
Neoplasias Encefálicas , Procedimientos Neuroquirúrgicos , Humanos , Femenino , Masculino , Persona de Mediana Edad , Adulto , Estudios Retrospectivos , Neoplasias Encefálicas/cirugía , Neoplasias Encefálicas/diagnóstico por imagen , Procedimientos Neuroquirúrgicos/métodos , Anciano , Aneurisma Intracraneal/cirugía , Aneurisma Intracraneal/diagnóstico por imagen , Catéteres , Adulto Joven , Quiste Epidérmico/cirugía , Quiste Epidérmico/diagnóstico por imagen
14.
World Neurosurg ; 182: e57-e61, 2024 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-37979686

RESUMEN

BACKGROUND: To evaluate any mismatch between rod bending and actual lordosis during posterior lumbar instrumentation and its effects on the quality of life (QOL) of patients. METHODS: Patient records for posterior lumbar fusion in 2018-2023 were retrospectively reviewed. The radiologic parameters consisted of pelvic incidence, sacral slope, L1S1 lumbar lordosis, lumbosacral angle, the distance between the posterior wall of the vertebra and the rod, lordosis of the rod. The postoperative QOL of patients was assessed using Oswestry Disability Index. The patients were grouped postoperative into Group-1 (minimal/moderate disability) and Group-2 (severe disability/crippled/bed bound). RESULTS: Total of 133 patients were included; 99 women, 34 men. The difference was significant for patients with diabetes to be presented in the more disabled Group-2. The distance between the posterior vertebral wall and the rod was found to be short in Group-2. Preoperative and postoperative sagittal lumbar Cobb angles were significantly higher in Group-2. The changing degree of pain was found to score high in Group-2. The postoperative visual analog scale was high in Group-2. The difference between the preoperative and postoperative lumbar sagittal Cobb and rod Cobb-angles was found to be high in Group-2. CONCLUSIONS: The results of our study confirm the importance of considering the preoperative actual lumbar lordosis during bending and maintaining it as much as possible. To our knowledge, this is the first study that evaluated the effect of rod bending on quality of life (QOL) and supports that this might be affected in case of any mismatches.


Asunto(s)
Lordosis , Fusión Vertebral , Masculino , Animales , Humanos , Femenino , Lordosis/diagnóstico por imagen , Lordosis/cirugía , Lordosis/etiología , Calidad de Vida , Estudios Retrospectivos , Resultado del Tratamiento , Vértebras Lumbares/diagnóstico por imagen , Vértebras Lumbares/cirugía , Fusión Vertebral/métodos
15.
World Neurosurg ; 185: e893-e899, 2024 05.
Artículo en Inglés | MEDLINE | ID: mdl-38453007

RESUMEN

OBJECTIVE: Predicting the aggressiveness of meningiomas may influence the surgical strategy timing. Because of the paucity of robust markers, the systemic immune-inflammation (SII) index is a novel biomarker to be an independent predictor of poor prognosis in various cancers including gliomas. We aimed to investigate the value of SII as well as neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) indices in predicting prognosis. METHODS: Records including demographic, clinical, and laboratory data of patients operated on due to intracranial meningioma in 2017-2023 were retrospectively reviewed. RESULTS: A total of 234 patients were included in this study. All of SII index, NLR, and PLR values at presentation were significantly higher in grade ≥2 meningiomas. A positive correlation was observed between SII index and Ki67 index (r=0.313; P<0.001); between NLR and Ki67 index (r=0.330; P<0.001); and between PLR and Ki67 index (r=0.223; P<0.01). SII index (optimal cutoff level >618), NLR (optimal cutoff level >3.53), and PLR (optimal cutoff level >121.2) showed significant predictive values. CONCLUSIONS: This is the first study to assess the prognostic value of the SII index in patients with intracranial meningiomas. Increased SII index, NLR and PLR were correlated with higher grade and higher Ki-67 index. They also harbor the potential to screen patients that may need more aggressive treatments or more frequent follow-up examinations.


Asunto(s)
Neoplasias Meníngeas , Meningioma , Clasificación del Tumor , Neutrófilos , Humanos , Meningioma/sangre , Meningioma/patología , Meningioma/cirugía , Femenino , Masculino , Persona de Mediana Edad , Neoplasias Meníngeas/sangre , Neoplasias Meníngeas/patología , Neoplasias Meníngeas/cirugía , Estudios Retrospectivos , Adulto , Anciano , Neutrófilos/patología , Pronóstico , Antígeno Ki-67/análisis , Antígeno Ki-67/metabolismo , Linfocitos/patología , Recuento de Plaquetas , Plaquetas/patología , Adulto Joven , Valor Predictivo de las Pruebas , Recuento de Linfocitos , Anciano de 80 o más Años
16.
Turk Neurosurg ; 33(3): 465-470, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37222014

RESUMEN

AIM: To evaluate the impact of the post-master PhD degree on publication productivity in neurosurgery. MATERIAL AND METHODS: An online national electronic survey was designed based on the recent literature and factors related to publication productivity. The survey was conducted to simply evaluate main bibliometrics of the participants consisting of neurosurgeons in different stages of their career. The survey was distributed via email to all Turkish Neurosurgical Society members. RESULTS: A total of 220 neurosurgeons participated and answered the survey. Neurosurgeons that had published their Master's dissertation were found to have significantly higher number of published articles, citations and Hirsch (h)-index during their career (p < 0.001). Neurosurgeons with a PhD degree who have been involved in such program were found to have significantly higher number of published articles and h-index (p < 0.01). A majority of neurosurgeons who were involved in a PhD program were found to work in university hospitals (41.5%) and research and training hospitals (26.8%). Clinical anatomy, neuroscience, and molecular/ genetic biology were the most common PhD programs. CONCLUSION: Standardization in measurability of scientific productivity is mandatory to maintain stability and move further in academic activity. PhD programs have a significant contribution to academic performance and scientific productivity. Surgical residents and young neurosurgeons should be encouraged to be involved in such PhD training programs to promote success in both neurosurgery and scientific arenas.


Asunto(s)
Neurocirugia , Humanos , Procedimientos Neuroquirúrgicos , Neurocirujanos , Bibliometría , Hospitales Universitarios
17.
Turk Neurosurg ; 33(5): 847-854, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37309632

RESUMEN

AIM: To define whether characteristics of fluorescein staining help to distinguish low grade gliomas intraoperatively. MATERIAL AND METHODS: We studied 46 patients with supratentorial newly diagnosed noncontrast-enhancing LGGs removed by fluorescence guidance under the YELLOW 560 nm filter. Patients who were treated between July 2019 and 2022 were retrospectively analyzed. Clinical data were collected from patient records. Patients? intraoperative video recordings, pathological examination, and preoperative magnetic resonance imaging (MRI) were analyzed and compared for each patient after the operation. Histopathologically, patients were divided into WHO Grade 2 oligodendrogliomas, diffuse astrocytomas (IDH mutant, 1p19q negative tumors), and pre-glioblastomas (IDH wild type, 1p19q negative tumors). Resection margins were checked using controls contrastenhanced cranial MRI at the postoperative 24 and72 hours. RESULTS: Our observations indicate that fluorescein primarily stains diffuse astrocytomas (IDH mutant, 1p19q negative tumors) and pre-glioblastomas (IDH wild type, 1p19q negative tumors) rather than WHO Grade 2 oligodendrogliomas. CONCLUSION: Fluorescein staining might be an option to determine tumor borders in WHO Grade 2 glial tumors, particularly for those with a higher malignancy potential.


Asunto(s)
Astrocitoma , Neoplasias Encefálicas , Glioblastoma , Glioma , Oligodendroglioma , Humanos , Oligodendroglioma/diagnóstico por imagen , Oligodendroglioma/cirugía , Neoplasias Encefálicas/diagnóstico por imagen , Neoplasias Encefálicas/cirugía , Neoplasias Encefálicas/patología , Estudios Retrospectivos , Glioma/diagnóstico por imagen , Glioma/cirugía , Astrocitoma/diagnóstico por imagen , Astrocitoma/cirugía , Astrocitoma/patología , Fluoresceínas
18.
Turk Neurosurg ; 33(6): 1053-1057, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37846534

RESUMEN

AIM: To review the cases of craniosynostosis secondary to ventricular shunting procedure. MATERIAL AND METHODS: We retrospectively evaluated the medical records of all pediatric patients with hydrocephalus who were treated with ventriculoperitoneal shunt procedure between the years 2017 and 2021 at the Selcuk University, Ankara University, and Bursa Uludag University. RESULTS: Twenty-one patients were included in the study. The median age at the time of insertion of ventriculoperitoneal shunt for hydrocephalus was 8.1 (range, 1?22) months. Seven patients were shunted because of congenital hydrocephalus. The mean time to development of secondary synostosis was 8.8 (range, 1?36) months. Plagiocephaly was the most common type of secondary synostosis. While shunt revision was performed in 16 patients, cranial vault expansion surgery was performed in 5 patients. CONCLUSION: Slit ventricle syndrome is a frequent condition at shunted patients, but there is no consensus on identifying patients who require treatment. Using programmable or high-pressure valves, performing cranial vault modeling are possible treatment modalities. Increased awareness of this condition in follow-up may allow early diagnosis and intervention and prevent it from evolving into more serious deformities.


Asunto(s)
Craneosinostosis , Hidrocefalia , Humanos , Lactante , Craneosinostosis/cirugía , Hidrocefalia/cirugía , Hidrocefalia/complicaciones , Estudios Retrospectivos , Cráneo/cirugía , Derivación Ventriculoperitoneal/métodos
19.
World Neurosurg ; 180: e408-e414, 2023 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-37769844

RESUMEN

OBJECTIVE: This retrospective study aimed at determining the dimension of the interthalamic adhesion (ITA) in patients with the idiopathic intracranial hypertension (IIH) for assisting in preoperative radiologic diagnosis. METHODS: The study universe consisted of magnetic resonance images of 20 patients with IIH (age: 22.70 ± 4.04 years, sex: 14 females and 6 males) and 20 normal subjects (age 22.30± 2.94 years, sex: 14 females and 6 males). To determine the morphology of ITA, its height (vertical diameter) and width (horizontal diameter) were measured on the coronal and axial planes, respectively. RESULTS: The height and width of ITA in IIH were measured as 2.58 ± 0.71 mm (range: 1.40-4.20 mm) and 2.73 ± 0.77 mm (range: 1.70-4.40 mm), respectively. Its height and width in controls were measured as 4.99 ± 1.04 mm (range: 2.70-6.30 mm) and 4.92 ± 1.11 mm (range: 2.60-6.50 mm), respectively. ITA height and width in IIH was significantly smaller compared with controls (P < 0.001). For an arbitrary cutoff of 3.85 mm, the sensitivity of the height of ITA was 85% with 95% specificity. For an arbitrary cutoff of 4.45 mm, the sensitivity of the width of ITA was 75% with 100% specificity. CONCLUSIONS: The height and width of ITA are approximately 50% smaller in IIH than controls; therefore alterations in the dimension of ITA may be a valuable radiologic sign for the diagnosis of IIH.


Asunto(s)
Hipertensión Intracraneal , Seudotumor Cerebral , Radiología , Masculino , Femenino , Humanos , Adolescente , Adulto Joven , Adulto , Seudotumor Cerebral/diagnóstico por imagen , Estudios Retrospectivos , Imagen por Resonancia Magnética , Tálamo/patología
20.
Turk Neurosurg ; 2023 Jul 10.
Artículo en Inglés | MEDLINE | ID: mdl-37528724

RESUMEN

AIM: Thoracolumbar junction (TLJ) fractures are frequently encountered in spinal trauma occurring during earthquakes. This study aimed to assess the frequency of TLJ fractures (T10-L2) in survivors of the 2023 East Turkey earthquake. MATERIAL AND METHODS: Ten earthquake survivors, who were trapped under the rubble and rescued alive by rescue teams, were assessed for spinal trauma after the earthquake in Eastern Turkey on February 6, 2023. All patients underwent full spinal magnetic resonance imaging and computed tomography examinations to determine the level of spinal fracture and decide the treatment methods. RESULTS: All patients had sustained spinal fractures. Eight underwent surgery, while two were managed conservatively. Nine out of ten patients had TLJ fractures. Five patients had L1 fractures, four of them were treated surgically. Three patients had a T12 level fracture, two of whom were treated surgically. One patient with a T7-level fracture was treated surgically. Only one patient had multiple fractures (T12 and L2 levels) and was treated surgically. CONCLUSION: The TLJ was the commonest vertebral fracture level in the 2023 Turkey earthquake survivors. In the event of an earthquake, people tend to attain a fetal posture (fix and hyperflex the spine) when taking shelter in a narrow area (triangle of life). This position places an excessive load on the TLJ, predisposing it to injuries.

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