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1.

Investigating CNS distribution of PF-05212377, a P-glycoprotein substrate, by translation of 5-HT₆ receptor occupancy from non-human primates to humans.

Sawant-Basak, Aarti; Chen, Laigao; Lockwood, Peter; Boyden, Tracey; Doran, Angela C; Mancuso, Jessica; Zasadny, Kenneth; McCarthy, Timothy; Morris, Evan D; Carson, Richard E; Esterlis, Irina; Huang, Yiyun; Nabulsi, Nabeel; Planeta, Beata; Fullerton, Terence.

Biopharm Drug Dispos; 44(1): 48-59, 2023 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-36825693

2.

Brain pharmacology of intrathecal antisense oligonucleotides revealed through multimodal imaging.

Mazur, Curt; Powers, Berit; Zasadny, Kenneth; Sullivan, Jenna M; Dimant, Hemi; Kamme, Fredrik; Hesterman, Jacob; Matson, John; Oestergaard, Michael; Seaman, Marc; Holt, Robert W; Qutaish, Mohammed; Polyak, Ildiko; Coelho, Richard; Gottumukkala, Vijay; Gaut, Carolynn M; Berridge, Marc; Albargothy, Nazira J; Kelly, Louise; Carare, Roxana O; Hoppin, Jack; Kordasiewicz, Holly; Swayze, Eric E; Verma, Ajay.

JCI Insight; 4(20)2019 10 17.

Artículo en Inglés | MEDLINE | ID: mdl-31619586

3.

131I-tositumomab therapy as initial treatment for follicular lymphoma.

Kaminski, Mark S; Tuck, Melissa; Estes, Judith; Kolstad, Arne; Ross, Charles W; Zasadny, Kenneth; Regan, Denise; Kison, Paul; Fisher, Susan; Kroll, Stewart; Wahl, Richard L.

N Engl J Med; 352(5): 441-9, 2005 Feb 03.

Artículo en Inglés | MEDLINE | ID: mdl-15689582

4.

MicroPET detection of regional brain activation induced by colonic distention in a rat model of visceral hypersensitivity.

Ohashi, Katsuyo; Ichikawa, Katsuomi; Chen, Laigao; Callahan, Michael; Zasadny, Kenneth; Kurebayashi, Yoichi.

J Vet Med Sci; 70(1): 43-9, 2008 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-18250571

5.

The Discovery of a Novel Phosphodiesterase (PDE) 4B-Preferring Radioligand for Positron Emission Tomography (PET) Imaging.

Zhang, Lei; Chen, Laigao; Beck, Elizabeth M; Chappie, Thomas A; Coelho, Richard V; Doran, Shawn D; Fan, Kuo-Hsien; Helal, Christopher J; Humphrey, John M; Hughes, Zoe; Kuszpit, Kyle; Lachapelle, Erik A; Lazzaro, John T; Lee, Chewah; Mather, Robert J; Patel, Nandini C; Skaddan, Marc B; Sciabola, Simone; Verhoest, Patrick R; Young, Joseph M; Zasadny, Kenneth; Villalobos, Anabella.

J Med Chem; 60(20): 8538-8551, 2017 10 26.

Artículo en Inglés | MEDLINE | ID: mdl-28957634

6.

Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates.

Stepan, Antonia F; Claffey, Michelle M; Reese, Matthew R; Balan, Gayatri; Barreiro, Gabriela; Barricklow, Jason; Bohanon, Michael J; Boscoe, Brian P; Cappon, Gregg D; Chenard, Lois K; Cianfrogna, Julie; Chen, Laigao; Coffman, Karen J; Drozda, Susan E; Dunetz, Joshua R; Ghosh, Somraj; Hou, Xinjun; Houle, Christopher; Karki, Kapil; Lazzaro, John T; Mancuso, Jessica Y; Marcek, John M; Miller, Emily L; Moen, Mark A; O'Neil, Steven; Sakurada, Isao; Skaddan, Marc; Parikh, Vinod; Smith, Deborah L; Trapa, Patrick; Tuttle, Jamison B; Verhoest, Patrick R; Walker, Daniel P; Won, Annie; Wright, Ann S; Whritenour, Jessica; Zasadny, Kenneth; Zaleska, Margaret M; Zhang, Lei; Shaffer, Christopher L.

J Med Chem; 60(18): 7764-7780, 2017 09 28.

Artículo en Inglés | MEDLINE | ID: mdl-28817277

7.

Preclinical Evaluation of 18F-PF-05270430, a Novel PET Radioligand for the Phosphodiesterase 2A Enzyme.

Chen, Laigao; Nabulsi, Nabeel; Naganawa, Mika; Zasadny, Kenneth; Skaddan, Marc B; Zhang, Lei; Najafzadeh, Soheila; Lin, Shu-Fei; Helal, Christopher J; Boyden, Tracey L; Chang, Cheng; Ropchan, Jim; Carson, Richard E; Villalobos, Anabella; Huang, Yiyun.

J Nucl Med; 57(9): 1448-53, 2016 09.

Artículo en Inglés | MEDLINE | ID: mdl-27199356

8.

Accurate dosimetry in 131I radionuclide therapy using patient-specific, 3-dimensional methods for SPECT reconstruction and absorbed dose calculation.

Dewaraja, Yuni K; Wilderman, Scott J; Ljungberg, Michael; Koral, Kenneth F; Zasadny, Kenneth; Kaminiski, Mark S.

J Nucl Med; 46(5): 840-9, 2005 May.

Artículo en Inglés | MEDLINE | ID: mdl-15872359

9.

The discovery and characterization of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor potentiator N-{(3S,4S)-4-[4-(5-cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242).

Shaffer, Christopher L; Patel, Nandini C; Schwarz, Jacob; Scialis, Renato J; Wei, Yunjing; Hou, Xinjun J; Xie, Longfei; Karki, Kapil; Bryce, Dianne K; Osgood, Sarah M; Hoffmann, William E; Lazzaro, John T; Chang, Cheng; McGinnis, Dina F; Lotarski, Susan M; Liu, JianHua; Obach, R Scott; Weber, Mark L; Chen, Laigao; Zasadny, Kenneth R; Seymour, Patricia A; Schmidt, Christopher J; Hajós, Mihály; Hurst, Raymond S; Pandit, Jayvardhan; O'Donnell, Christopher J.

J Med Chem; 58(10): 4291-308, 2015 May 28.

Artículo en Inglés | MEDLINE | ID: mdl-25905800

10.

Update on hybrid conjugate-view SPECT tumor dosimetry and response in 131I-tositumomab therapy of previously untreated lymphoma patients.

Koral, Kenneth F; Dewaraja, Yuni; Li, Jia; Lin, Qiang; Regan, Denise D; Zasadny, Kenneth R; Rommelfanger, Stephen G; Francis, Issac R; Kaminski, Mark S; Wahl, Richard L.

J Nucl Med; 44(3): 457-64, 2003 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-12621015

11.

Comparison of attenuation-corrected and non-corrected FDG-PET images for axillary nodal staging in newly diagnosed breast cancer.

Nakamoto, Yuji; Chang, Alfred E; Zasadny, Kenneth R; Wahl, Richard L.

Mol Imaging Biol; 4(2): 161-9, 2002 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-14537139

12.

Reproducibility of common semi-quantitative parameters for evaluating lung cancer glucose metabolism with positron emission tomography using 2-deoxy-2-[18F]fluoro-D-glucose.

Nakamoto, Yuji; Zasadny, Kenneth R; Minn, Heikki; Wahl, Richard L.

Mol Imaging Biol; 4(2): 171-8, 2002 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-14537140

13.

A positron-emitting internal marker for identification of normal tissue by positron emission tomography: phantom studies and validation in patients.

Thomas, Cherry T; Meyer, Charles R; Koeppe, Robert A; Kalemkerian, Gregory P; Fisher, Susan J; Dull, Terry L; Zasadny, Kenneth R; Wahl, Richard L.

Mol Imaging Biol; 5(2): 79-85, 2003.

Artículo en Inglés | MEDLINE | ID: mdl-14499148

14.

Expression of hexokinase II and Glut-1 in untreated human breast cancer.

Brown, Raya S; Goodman, Tonya M; Zasadny, Kenneth R; Greenson, Joel K; Wahl, Richard L.

Nucl Med Biol; 29(4): 443-53, 2002 May.

Artículo en Inglés | MEDLINE | ID: mdl-12031879

15.

Discovery and preclinical characterization of 1-methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo-[3,4-b]pyrazine (PF470): a highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator.

Zhang, Lei; Balan, Gayatri; Barreiro, Gabriela; Boscoe, Brian P; Chenard, Lois K; Cianfrogna, Julie; Claffey, Michelle M; Chen, Laigao; Coffman, Karen J; Drozda, Susan E; Dunetz, Joshua R; Fonseca, Kari R; Galatsis, Paul; Grimwood, Sarah; Lazzaro, John T; Mancuso, Jessica Y; Miller, Emily L; Reese, Matthew R; Rogers, Bruce N; Sakurada, Isao; Skaddan, Marc; Smith, Deborah L; Stepan, Antonia F; Trapa, Patrick; Tuttle, Jamison B; Verhoest, Patrick R; Walker, Daniel P; Wright, Ann S; Zaleska, Margaret M; Zasadny, Kenneth; Shaffer, Christopher L.

J Med Chem; 57(3): 861-77, 2014 Feb 13.

Artículo en Inglés | MEDLINE | ID: mdl-24392688

16.

Design and selection parameters to accelerate the discovery of novel central nervous system positron emission tomography (PET) ligands and their application in the development of a novel phosphodiesterase 2A PET ligand.

Zhang, Lei; Villalobos, Anabella; Beck, Elizabeth M; Bocan, Thomas; Chappie, Thomas A; Chen, Laigao; Grimwood, Sarah; Heck, Steven D; Helal, Christopher J; Hou, Xinjun; Humphrey, John M; Lu, Jiemin; Skaddan, Marc B; McCarthy, Timothy J; Verhoest, Patrick R; Wager, Travis T; Zasadny, Kenneth.

J Med Chem; 56(11): 4568-79, 2013 Jun 13.

Artículo en Inglés | MEDLINE | ID: mdl-23651455

17.

[(18)F]FLT-PET imaging does not always "light up" proliferating tumor cells.

Zhang, Cathy C; Yan, Zhengming; Li, Wenlin; Kuszpit, Kyle; Painter, Cory L; Zhang, Qin; Lappin, Patrick B; Nichols, Tim; Lira, Maruja E; Affolter, Timothy; Fahey, Neeta R; Cullinane, Carleen; Spilker, Mary; Zasadny, Kenneth; O'Brien, Peter; Buckman, Dana; Wong, Anthony; Christensen, James G.

Clin Cancer Res; 18(5): 1303-12, 2012 Mar 01.

Artículo en Inglés | MEDLINE | ID: mdl-22170262

18.

The synthesis and in vivo evaluation of [18F]PF-9811: a novel PET ligand for imaging brain fatty acid amide hydrolase (FAAH).

Skaddan, Marc B; Zhang, Lei; Johnson, Douglas S; Zhu, Aijun; Zasadny, Kenneth R; Coelho, Richard V; Kuszpit, Kyle; Currier, Gwen; Fan, Kuo-Hsien; Beck, Elizabeth M; Chen, Laigao; Drozda, Susan E; Balan, Gayatri; Niphakis, Micah; Cravatt, Benjamin F; Ahn, Kay; Bocan, Thomas; Villalobos, Anabella.

Nucl Med Biol; 39(7): 1058-67, 2012 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-22571907

19.

PF-03732010: a fully human monoclonal antibody against P-cadherin with antitumor and antimetastatic activity.

Zhang, Cathy C; Yan, Zhengming; Zhang, Qin; Kuszpit, Kyle; Zasadny, Kenneth; Qiu, Ming; Painter, Cory L; Wong, Anthony; Kraynov, Eugenia; Arango, Maria E; Mehta, Pramod P; Popoff, Ian; Casperson, Gerald F; Los, Gerrit; Bender, Steve; Anderes, Kenna; Christensen, James G; VanArsdale, Todd.

Clin Cancer Res; 16(21): 5177-88, 2010 Nov 01.

Artículo en Inglés | MEDLINE | ID: mdl-20829331

20.

Bias reduction in correlation of radiation-absorbed dose with response.

Koral, Kenneth F; Zasadny, Kenneth; Wahl, Richard L.

J Nucl Med; 45(7): 1271; author reply 1271-2, 2004 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-15235076

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