Analysis of signal detection configurations in optical time-stretch imaging.

Optical time-stretch (OTS) imaging is effective for observing ultra-fast dynamic events in real time by virtue of its capability of acquiring images with high spatial resolution at high speed. In different implementations of OTS imaging, different configurations of its signal detection, i.e. fiber-coupled and free-space detection schemes, are employed. In this research, we quantitatively analyze and compare the two detection configurations of OTS imaging in terms of sensitivity and image quality with the USAF-1951 resolution chart and diamond films, respectively, providing a valuable guidance for the system design of OTS imaging in diverse fields.

Optical and Electrical Investigation of ZnO Nano-Wire Array to Micro-Flower from Hierarchical Nano-Rose Structures.

We have demonstrated a simple solvo-chemical and solvo-thermal route to design various nano-structures growth of zinc oxide (ZnO). The shapes and morphologies can be easily controlled by using different ambient conditions. We successfully fabricated ZnO nano-wires array on ITO substrate. Those nano-wire array center gradually formed micro-flower like structure evolved in this solvo-chemical route. This novel synthesis happened under cationic surfactant CTAB in the solution helps to form hierarchical structures of ZnO. The length of nano-wire is around 2.0 µm, which formed micro-flower diameter 5.0 µm. Micro-flowers were scratched out from ITO substrate thin film and annealed at 650 °C in electric oven for 1 hour, eventually this micro-flower transformed to novel nano-rose structure confirmed by electron microscopic study. Synthesized nano-rose diameter was around 730 nm. Moreover, we found a drastic change of dielectric behavior and DC conductivity of ZnO nanostructures depending on geometry regulated by the duration of preparation. Interestingly enough, optical and electrical properties also changed due to different crystalline structure formation. The dielectric constant is higher at 7.5 also high threshold voltages at 4 V, corresponds to nano-wires array with micro-flower system. A detail dielectric analysis of one step behavior of broad single relaxation peak was obtained only shows the normal dispersion in this system from 1000 kHz to 10 MHz. While less dielectric constant 1.7 and low threshold voltage 1 V, investigated nano-wires with micro-flower, then nano-rose transition appeared in two step behaviors of double relaxations phenomenon appeared one at low frequency and other at higher frequency region. Besides, I~V response characteristics is new idea about different breakdown voltages and bi-stable DC switching capability. Our work demonstrates the possibility of a fast novel synthesis route using a Solvo-chemical process for this type of nanomaterials transition. This special structural character was able to tune band gap which has potential applications in semiconductor electronic devices.

Avatrombopag for the treatment of thrombocytopenia induced by chemotherapy in patients with solid tumors: A multicenter, open-label, single-arm trial.

Objective: To explore the effect and safety of avatrombopag for chemotherapy-induced thrombocytopenia (CIT). Methods: This multicenter, open-label, single-arm trial enrolled CIT patients in eight centers from October 2020 to April 2021. The participants received avatrombopag tablets 60 mg once a day for 5-10 days. The main endpoint was the proportion of patients with platelet count ≥100×109/L or increased by ≥ 50×109/L or increased by ≥ 100% in the cycle after the start of treatment. Results: Seventy-four participants were enrolled with a mean age of 59.8 ± 11.62.2% were males. The cumulative effective rate (any criteria) was 70.3% at 4 weeks. 42 (56.8%) achieved platelet count ≥100×109/L, 44 (59.5%) increased by ≥ 50×109/L, and 27 (36.5%) increase by ≥ 100% from baseline. The duration of grade III and IV platelet reduction was 4.2 ± 5.3 days. The time of PLT recovery to ≥75×109/L was 9.4 ± 6.6 days. The time of PLT recovery to ≥100×109/L was 10.2 ± 6.4 days. The platelet count nadir was 57.9 ± 45.3×109/L. The most common adverse events were nausea (8.1%), fatigue (5.4%), and abdominal pain (1.4%). There were no cases of fever, headache, or peripheral edema. Conclusion: Although it was a single-arm trial without a control group, the application of avatrombopag in patients with CIT can increase the platelet count of the patients compared with baseline. Avatrombopag is safe and tolerable. Clinical Trial Registration: https://clinicaltrials.gov/ct2/show/NCT04609891?term=04609891&draw=2&rank=1, identifier [NCT04609891].

Flexible Polymer Dispersed Liquid Crystal Module with Graphene Electrode.

Flexible polymer dispersed liquid crystal (PDLC) module based on graphene electrode was presented in this article. We also investigated electromechanical, as well as electro-optical properties of PDLC module with graphene electrodes. Compared to the ITO electrodes, graphene electrodes exhibits higher light transmittance and more stable electromechanical property of under bend test. Due to the excellent mechanical property of graphene electrodes, it is expected that the flexibility of PDLC module could be further enhanced. Meanwhile, with the integration of graphene as the driving electrodes, the threshold voltage V(th) and saturation voltage V(sat) of PDLC module have small change, while the on-state transmittance T(on) is increased by 5%, that may attribute to the high transmittance of the graphene.