Characterization of pathogenic synovial IL-17A-producing CD8+ T cell subsets in collagen-induced arthritis.

Using a murine collagen-induced arthritis model, we characterized the heterogeneity of synovial CD8+ T cells based on the expression of chemokine receptors, cytokines, and nuclear transcription factors. Four subsets, i.e. CXCR3-CCR4- cells, CXCR3+CCR4- cells, CXCR3+CCR4+ cells, and CXCR3-CCR4+ cells, were present in synovial CD8+CD62L-CCR6+IL-23R+CCR10- T cells. CXCR3-CCR4- cells belonged to exhausted CD8+ T cells. CXCR3+CCR4- cells were Tc17.1 cells expressing both IL-17A and IFN-γ. CXCR3+CCR4+ cells were transitional Tc17.1 cells expressing IL-17A but lower IFN-γ, and CXCR3-CCR4+ cells were Tc17 cells expressing IL-17A but no IFN-γ. Transitional Tc17.1 cells can differentiate into Tc17.1 cells in vitro under the instruction of IL-12. Tc17.1 cells and transitional Tc17.1 cells strongly induced the expression of pro-inflammatory mediators in synovial fibroblasts, whereas Tc17 cells were less potent in doing so. IFN-γ was involved in the higher pathogenicity of Tc17.1 cells and transitional Tc17.1 cells on synovial fibroblasts. This study expands the understanding of Tc17 biology by unveiling the phenotypic and functional heterogeneity of synovial IL-17A-expressing CD8+ T cells. These heterogeneous IL-17A-expressing CD8+ T cells could be novel therapeutic targets in future arthritis treatment.

Enhanced activation of PMS by a novel Fenton-like composite Fe3O4/S-WO3 for rapid chloroxylenol degradation.

Chloroxylenol (PCMX) is widely used as disinfectant since the epidemic outbreak due to its effective killing of Covid-19 virus. Its stable chemical properties make it frequently detected in surface water. Herein, we successfully modified Fe3O4 nanoparticles with S-WO3 (X-Fe3O4/S-WO3) to accelerate the Fe2+/Fe3+ cycle. The composite has outstanding PCMX degradation and peroxymonosulfate (PMS) decomposition efficiency over a wide pH range (3.0 âˆ¼ 9.0). 80-Fe3O4/S-WO3/PMS system not only increased PMS decomposition efficiency from 27.7% to 100.0%, but also realized an enhancement of PCMX degradation efficiency by 16 times in comparison with that of Fe3O4 alone. The catalyst utilization efficiency reached 0.3506 mmol∙g-1∙min-1 which stands out among most Fenton-like catalysts. The composite has excellent degradation ability to a variety of emerging pollutants, such as antibiotics, drugs, phenols and endocrine disrupters, and at least a 90% removal efficiency reached in 10 min. The degradation of PCMX was dominated by HO•, SO4 •- and 1O2. The degradation pathways of PCMX were analyzed in detail. The component WS2 in S-WO3 plays a co-catalytic role instead of WO3. And the exposed active W4+ surf. efficiently enhanced the Fe3+/Fe2+ cycle, thereby complete PMS decomposition and high catalytic efficiency were achieved. Our findings clarify that applying two-dimensional transition metal sulfide WS2 to modify heterogeneous Fe3O4 is a feasible strategy to improve Fenton-like reaction and provide a promising catalyst for PCMX degradation.

PDA-cross-linked beta-cyclodextrin: a novel adsorbent for the removal of BPA and cationic dyes.

In this study, 4,4'-(hexafluoroisopropene) diphthalic acid (PDA)-CD polymers containing ß-cyclodextrin (CD) were synthesized for the adsorption of endocrine disrupting chemicals (EDCs) and dyes. It features great adsorption of bisphenol A (BPA), methylene blue (MB) and neutral red (NR). The maximum adsorption capacities of MB, NR and BPA can reach 113.06, 106.8 and 51.74 mg/g, respectively. The tandem adsorption results revealed that adsorptions of dyes and BPA onto PDA-CD polymer were two independent processes: non-polar BPA entrapment by cyclodextrin cavities while dyes were captured by the carboxyl groups and π-π stacking interactions. The adsorption processes performed well in a wide range of pH (4.0-10.0) and were not affected by fulvic acid (FA) and inorganic ions.

Degradation of sulfanilamide by Fenton-like reaction and optimization using response surface methodology.

Excess sulfonamides are discharged into the environmental system due to the abuse of antibiotics, which threatens the ecological environment and human health. In this study, the ferric and ferrous as well as calcium peroxide (CP), sodium percarbonate (SPC) and sodium persulfate (SPS) have been used to build Fenton-like system for the sulfanilamide (SA) removal. Compared with other Fenton-like system, the Fe3+/CP system exhibited better degradation capacity and 94.65% SA was removed with 3.0 mM CP and 3.0 mM Fe3+. A response surface and corresponding quadratic regression equation were obtained by using a three-level Box-Behnken factorial design with the initial pH value and the dosage of Fe3+ and CP as the model parameters. Depended on the result of the response surface, the optimum conditions of the removal of SA in Fe3+/CP system could be obtained: [Fe3+] = 2.96 mM, [CaO2] = 2.33 mM and [pH] = 6.45. Besides that, the influences of Na+, Mg2+, Cl-, HCO3-, NO3- and HA on SA removal were also investigated under the optimum condition. The results revealed that the high concentration of HCO3- was able to inhibit degradation of SA while other ions and HA have little effect on SA degradation. These results provided a novel strategy to evaluate the catalyst/oxidant system by combining experiment and computer simulation in wastewater treatment.

Adsorptive removal of bisphenol A, chloroxylenol, and carbamazepine from water using a novel ß-cyclodextrin polymer.

The emerging organic micro-pollutants, such as bisphenol A (BPA), chloroxylenol (PCMX) and carbamazepine (CBZ), have raised concerns owing to their adverse impact on human health and ecological security. In this study, a novel cyclodextrin polymer (ß-CDP) has been successfully prepared by nucleophilic substitution of ß-cyclodextrin with tetrafluoroterephthalonitrile (TFP). The removal of three emerging organic micro-pollutants (BPA, CBZ and PCMX) by ß-CDP under a single or mixture adsorption system was examined, and the adsorption behavior was investigated by adsorption kinetics and isotherm study. The maximum adsorption capacity of ß-CDP for BPA, PCMX and CBZ according to Langmuir isotherm in single system was 164.4, 144.1 and 136.4 mg/g, respectively. Compared with single system, the competitive adsorption of each pollutant on ß-CDP in mixture system was only slightly inhibited. Changing the pH, raising the presence of fulvic acid (FA) or ionic strength had no significant influence on the adsorption of BPA, PCMX and CBZ onto ß-CDP. The removal of these three organic micro-pollutants was related to the value of logKow of the contaminants. These results demonstrated remarkable advantages of ß-CDP material relevant to organic micro-pollutants removal in wastewater treatment.

Identifying Ammonia Hotspots in China Using a National Observation Network.

The limited availability of ammonia (NH3) measurements is currently a barrier to understanding the vital role of NH3 in secondary aerosol formation during haze pollution events and prevents a full assessment of the atmospheric deposition of reactive nitrogen. The observational gaps motivated us to design this study to investigate the spatial distributions and seasonal variations in atmospheric NH3 on a national scale in China. On the basis of a 1-year observational campaign at 53 sites with uniform protocols, we confirm that abundant concentrations of NH3 [1 to 23.9 µg m-3] were identified in typical agricultural regions, especially over the North China Plain (NCP). The spatial pattern of the NH3 surface concentration was generally similar to those of the satellite column concentrations as well as a bottom-up agriculture NH3 emission inventory. However, the observed NH3 concentrations at urban and desert sites were comparable with those from agricultural sites and 2-3 times those of mountainous/forest/grassland/waterbody sites. We also found that NH3 deposition fluxes at urban sites account for only half of the emissions in the NCP, suggesting the transport of urban NH3 emissions to downwind areas. This finding provides policy makers with insights into the potential mitigation of nonagricultural NH3 sources in developed regions.

Cyclodextrin modified filter paper for removal of cationic dyes/Cu ions from aqueous solutions.

A filter paper was functionalized with ß-cyclodextrin and citric acid via esterification reaction for the removal of dyes and Cu ions from aqueous solutions. The adsorption capacity and removal performance of the modified filter paper (MFP) was investigated using static and dynamic adsorption experiments. The static adsorption data fit well the Langmuir and pseudo-second-order models, and the adsorption capacity of Methylene Blue (MB), Brilliant Green (BG), Rhodamine-B (RB) and Cu(II) over the MFP were 124.6 mg/g, 130.4 mg/g, 99.7 mg/g and 39.1 mg/g, respectively, which are much higher than the unmodified filter paper (below 2 mg/g). Even better, the decolorization performance and Cu(II) removal of MFP are remarkable in dynamic adsorption. The effluent can reach the National Standard for dyeing and finishing of textile industry of China after three cycles in a continuous filtration-adsorption system. This method provides a new pathway to achieve high efficiency removal of dyes and metal ions from wastewater.

Sorption characteristics of phenanthrene and pyrene to surfactant-modified peat from aqueous solution: the contribution of partition and adsorption.

In this paper, the sorption characteristics and mechanisms of phenanthrene and pyrene onto peat (PT) and surfactant-modified peat (MPT) were investigated. Sorption results fit closely to the Partition model and Freundlich model, the coefficient of determination (R²) were higher than 0.98 and 0.99, respectively. The contributions of partition and adsorption to the total sorption of phenanthrene and pyrene by PT and MPT were analyzed quantitatively. Results indicate that the sorption process is a combination of partition and adsorption, and partition plays a major role in the sorption process. The contribution of partition increased with the increasing of initial concentrations of polycyclic aromatic hydrocarbons. The sorption ability of phenanthrene and pyrene by PT and MPT followed the order of pyrene > phenanthrene. MPT has demonstrated potential as a promising new class of materials for environmental remediation of organic pollutants.

Effects of sustained-release composite on the oxygen levels and sediment phosphorus fractions of an urban river in Shanghai.

The eutrophication of many rivers and lakes is attributed to the anoxia and the increasing internal loading of nutrients from sediment. A novel sustained-release composite (SRC) synthesis of stearic acid and calcium peroxide (CaO2) was applied to supply a water body with oxygen endured in this study. The influences of SRC on the dissolved oxygen (DO) level, pH and total phosphorus (TP) of an urban river in Shanghai were studied. The results show that SRC has a longer oxygen-releasing cycle and a more tender effect on pH with the comparison of CaO2 powder. Reduction of 79.6% in the concentration of TP was observed in the water column. After 35 days of SRC addition, there was a significant positive correlation between TP and DO. As a consequence, the phosphorus fractions in sediment, including loosely sorbed P (NH4Cl-P), redox-sensitive P (Fe-P), calcium bound P (Ca-P), aluminium bound P (Al-P) and residual P (organic and refractory P) were affected by the addition of SRC. The NH4Cl-P and Fe-P fractions in the sediment that could release P easily were well constrained under the positive effect of SRC.

De Novo Assembly, Characterization, and Comparative Transcriptome Analysis of Mature Male and Female Gonads of Rabbitfish (Siganus oramin) (Bloch & Schneider, 1801).

The rabbitfish, Siganus oramin, is a commercially important table fish in southeastern China. However, there have been few studies on its gonad development and reproduction regulation. Comparative transcriptome analysis was first performed on adult male and female gonads of S. oramin. In total, 47,070 unigenes were successfully assembled and 22,737 unigenes were successfully annotated. Through comparative transcriptome analysis of male and female gonads, a total of 6722 differentially expressed genes were successfully identified, with 3528 upregulated genes and 3154 downregulated genes in the testes. In addition, 39 differentially expressed reproduction-related genes were identified. Finally, quantitative real-time PCR was used to validate the expression levels of several differentially expressed genes. These results provide important data for further studying the function of reproduction-related genes and the molecular mechanism regulating gonad development and reproduction in S. oramin.

Enhanced oil-mineral aggregation with modified bentonite.

The application of modified-bentonite-enhanced oil dispersion in water and oil-mineral aggregate (OMA) formation was studied in the laboratory. The effect of modification on the surface properties of bentonite was characterized. The hydrophobicity and surface electric properties of bentonite were significantly improved by attaching cetyltrimethyl ammonium bromide to its surface. The results showed that surface properties of bentonite played an important role in OMA formation. Spherical droplets of OMAs were formed with natural bentonite and elongated solid OMAs and flake OMAs were formed with modified bentonite as observed by fluorescence microscopy. The effects of shaking time, oil concentration and mineral content were also studied. It was suggested that oil concentration and mineral content were critical factors and OMA formed rapidly with both types of bentonite. Modified bentonite had better performance on OMA formation than hydrophilic natural bentonite.

Efficient photocatalytic remediation of typical antibiotics in water via Mn3O4 decorated carbon nitride nanotube.

Antibiotic abuse will seriously affect the ecology and environment. Photocatalytic oxidation technology based on carbon nitride (g-C3N4) has been widely adopted to treat wastewater containing antibiotics. Here, a novel composite photocatalyst MCNT was prepared by loading manganese oxide (Mn3O4) on the surface of g-C3N4 nanotubes (CNT). Three typical antibiotics, trimethoprim (TMP), norfloxacin (NOR), and tetracycline (TC) were used as model contaminants to evaluate the oxidative properties of prepared materials. Compared with bulk g-C3N4, the degradation rates of TMP, NOR, and TC catalyzed by MCNT-5 were increased by 2, 3, and 1.4 times, respectively, mainly due to 1) the larger specific surface area of the nanotube structure of CNT, which provides abundant active sites for antibiotic adsorption and catalytic oxidation, and 2) the loading of Mn3O4, which promotes the directional migration of photogenerated charges and improves the separation efficiency of photogenerated electrons and holes. The free radical capture and quenching experiments confirmed that MCNT degraded the target organic pollutants with hydroxyl radical (·OH) and singlet oxygen (1O2) as the main active oxidants. This catalyst maintained 80% photocatalytic oxidation performance after five cyclic experiments. This study provides new insights into developing efficient, stable, and environmentally-friendly photocatalysts and provides a new dimension to mitigate the antibiotic pollution problem.

Mechanism and characterization of microplastic aging process: A review.

With the increasing production of petroleum-based plastics, the problem of environmental pollution caused by plastics has aroused widespread concern. Microplastics, which are formed by the fragmentation of macro plastics, are bio-accumulate easily due to their small size and slow degradation under natural conditions. The aging of plastics is an inevitable process for their degradation and enhancement of adsorption performance toward pollutants due to a series of changes in their physiochemical properties, which significantly increase the toxicity and harm of plastics. Therefore, studies should focus on the aging process of microplastics through reasonable characterization methods to promote the aging process and prevent white pollution. This review summarizes the latest progress in natural aging process and characterization methods to determine the natural aging mechanism of microplastics. In addition, recent advances in the artificial aging of microplastic pollutants are reviewed. The degradation status and by-products of biodegradable plastics in the natural environment and whether they can truly solve the plastic pollution problem have been discussed. Findings from the literature pointed out that the aging process of microplastics lacks professional and exclusive characterization methods, which include qualitative and quantitative analyses. To lessen the toxicity of microplastics in the environment, future research directions have been suggested based on existing problems in the current research. This review could provide a systematic reference for in-depth exploration of the aging mechanism and behavior of microplastics in natural and artificial systems.

Graph neural networks for preference social recommendation.

Social recommendation aims to improve the performance of recommendation systems with additional social network information. In the state of art, there are two major problems in applying graph neural networks (GNNs) to social recommendation: (i) Social network is connected through social relationships, not item preferences, i.e., there may be connected users with completely different preferences, and (ii) the user representation of current graph neural network layer of social network and user-item interaction network is the output of the mixed user representation of the previous layer, which causes information redundancy. To address the above problems, we propose graph neural networks for preference social recommendation. First, a friend influence indicator is proposed to transform social networks into a new view for describing the similarity of friend preferences. We name the new view the Social Preference Network. Next, we use different GNNs to capture the respective information of the social preference network and the user-item interaction network, which effectively avoids information redundancy. Finally, we use two losses to penalize the unobserved user-item interaction and the unit space vector angle, respectively, to preserve the original connection relationship and widen the distance between positive and negative samples. Experiment results show that the proposed PSR is effective and lightweight for recommendation tasks, especially in dealing with cold-start problems.

Prenatal Sevoflurane Exposure Impairs the Learning and Memory of Rat Offspring via HMGB1-Induced NLRP3/ASC Inflammasome Activation.

The neurotoxic effects of sevoflurane anesthesia on the immature nervous system have aroused public concern, but the specific effects and mechanism remain poorly understood. Pyroptosis caused by the activation of the NLRP3 inflammasome is pivotal for cell survival and acts as a key player in cognitive impairment. This study was carried out to determine the critical role of the NLRP3 inflammasome and high-mobility group box 1 (HMGB1) in sevoflurane-induced cognitive impairment. On gestational day 20 (G20), 3% sevoflurane was administered for 4 h to pregnant rats. The hippocampus and cerebral cortex of the offspring were harvested at postnatal day 1 (P1) for Western blotting and immunofluorescence staining. Pregnant rat sevoflurane exposure increased the protein levels of NLRP3, ASC, cleaved-caspase 1 (p20), mature-IL-1ß (m-IL-1ß), and HMGB1 in the cerebral cortex and hippocampus of offspring rats. More microglial cells of offspring were also observed after sevoflurane anesthesia. The Morris water maze (MWM) test was implemented to evaluate cognitive function from postnatal day 30 (P30) to postnatal 35 (P35) of offspring. The sevoflurane-treated offspring took longer than the control rats to find the MWM platform during the learning phase. Furthermore, they had a longer travel distance and less time in the target quadrant than the control rats in the probe trial. Maternal intraperitoneal injection of glycyrrhizin (an inhibitor of HMGB1) attenuated the sevoflurane-induced microglia and NLRP3/ASC inflammasome activation and cognitive impairment of offspring. Simultaneously, the sevoflurane-induced increase in Toll-like receptors (TLR4) and nuclear factor-κB (NF-κB) was significantly reduced by glycyrrhizin. We concluded that the HMGB1 inhibitor may repress the sevoflurane-induced activation of the NLRP3/ASC inflammasome and cognitive dysfunction and that TLR4/NF-κB signaling maybe the key pathway, at least in part.

Personal protective equipment (PPE) disposal during COVID-19: An emerging source of microplastic and microfiber pollution in the environment.

Waste generated by healthcare facilities during the COVID-19 pandemic has become a new source of pollution, particularly with the widespread use of single-use personal protective equipment (PPE). Releasing microplastics (MPs) and microfibers (MFs) from discarded PPE becomes an emerging threat to environmental sustainability. MPs/MFs have recently been reported in a variety of aquatic and terrestrial ecosystems, including water, deep-sea sediments, air, and soil. As COVID-19 spreads, the use of plastic-made PPE in healthcare facilities has increased significantly worldwide, resulting in massive amounts of plastic waste entering the terrestrial and marine environments. High loads of MPs/MFs emitted into the environment due to excessive PPE consumption are easily consumed by aquatic organisms, disrupting the food chain, and potentially causing chronic health problems in humans. Thus, proper management of PPE waste is critical for ensuring a post-COVID sustainable environment, which has recently attracted the attention of the scientific community. The current study aims to review the global consumption and sustainable management of discarded PPE in the context of COVID-19. The severe impacts of PPE-emitted MPs/MFs on human health and other environmental segments are briefly addressed. Despite extensive research progress in the area, many questions about MP/MF contamination in the context of COVID-19 remain unanswered. Therefore, in response to the post-COVID environmental remediation concerns, future research directions and recommendations are highlighted considering the current MP/MF research progress from COVID-related PPE waste.

Source apportionment of nitrate in the Pearl River Estuary using δ15N and δ18O values and isotope mixing model.

The mitigation of eutrophication in the Pearl River Estuary (PRE) has encountered numerous challenges in regards to source control. Herein, the isotope mixing model (SIAR) was used to quantify the primary nitrate sources in the PRE. The results showed that the nitrate levels were significantly higher in the high-flow season than in the low-flow season. Meanwhile, we found the most important nitrate sources were manure and sewage during the high-flow season, with a contribution ratio of 47 % in the low salt area (LSA) and 29 % in the high salt area (HSA). During the low-flow season, the primary nitrate sources were identified as reduced nitrogen fertilizer in the LSA and manure and sewage in the HSA, which accounted for 52 % and 44 %, respectively. Furthermore, we also suggest that a feasible measure might be to control the pollution caused in the PRE by manure and sewage as well as reduced nitrogen fertilizer.

An overview of the direct and indirect effects of acid rain on plants: Relationships among acid rain, soil, microorganisms, and plants.

Acid rain (AR) causes numerous environmental problems and complex negative effects on plants globally. Many studies have previously reported on direct effects of AR or its depositional substances on plant injury and performance. However, few studies have addressed the indirect effects of AR on plants as mediated by soil microorganisms and the abiotic environment of the soil rhizosphere. The indirect effects (e.g., AR â†’ soil microorganisms→plants) need greater attention, because acidic deposition not only affects the distribution, composition, abundance, function, and activity of plant-associated microorganisms, but also influences the dynamics of some substances in the soil in a way that may be harmful to plants. Therefore, this review not only focused on the direct effects of AR on plant performance, growth, and biomass allocations from a whole-plant perspective, but also addressed the pathway of AR-soil chemical characteristics-plants, which explains how soil solute leaching and acidification by AR will reduce the availability of essential nutrients and increase the availability of heavy metals for plants, affecting carbon and nitrogen cycles. Mainly, we evaluated the AR-soil microorganisms-plants pathway by: 1) synthesizing the potential roles of soil microbes in alleviating soil acidic stress on plants and the adverse effects of AR on plant-associated soil microorganisms; 2) exploring how plant mycorrhizal types affect the detection of AR effect on plants. The meta-analysis showed that the effects of AR-induced pH on leaf chlorophyll content, plant height, and plant root biomass were dependent on plant mycorrhizal types. Some possible reasons for different synergy between mycorrhizal symbiotic types and plants were discussed. Future research relating to the effects of AR on plants should focus on the combined direct and indirect effects to evaluate how AR affects plant performance comprehensively.

IL-18BP Alleviates Anxiety-Like Behavior Induced by Traumatic Stress via Inhibition of the IL-18R-NLRP3 Signaling Pathway in a Mouse Model of Hemorrhagic Shock and Resuscitation.

Psychological distress and posttraumatic stress, including anxiety, severely influence life quality. Previously, we reported that interleukin-18 (IL-18) was involved in pyroptosis-induced emotional changes in a rodent model of hemorrhagic shock and resuscitation (HSR). Here, we aimed to continue our investigation on the role of IL-18 binding protein (IL-18BP), which exhibits excellent anti-inflammatory effects as an IL-18 negative regulator. Mice were administered with an intraperitoneal injection of IL-18BP after HSR exposure and anxiety-like behavior was examined using the open-field test and elevated plus maze test. Moreover, the following variables post-HSR were measured: (1) the activation of astrocytes; (2) pyroptosis-associated factors including cleaved caspase-1, GSDMD, IL-18; (3) the roles of IL-18 receptor (IL-18R)-NOD-like receptor pyrin domain-containing-3 (NLRP3) signal with the application of the NLRP3 specific agonist or astrocyte-specific NLRP3 knockout mice. IL-18BP administration remarkably alleviated HSR-induced anxiety-like behavior, astrocytic activation, and increases in pyroptosis-associated factors, while NLRP3 agonist nigericin partially reversed IL-18BP-induced neuroprotective effects. Astrocyte-specific NLRP3 knockout mice exhibited relatively less anxiety-like behavior. Similarly, IL-18BP exhibited an anti-pyroptosis effect in astrocytes in an in vitro model of low oxygen-glucose deprivation. These findings offer unique perspectives on HSR-induced posttraumatic stress and indicate that inhibition of IL-18R-NLRP3 signal via IL-18BP can attenuate astrocytic activation and pyroptosis, broadening the therapeutic landscape for patients with psychological distress and posttraumatic stress.

Efficient Oxidation of Paracetamol Triggered by Molecular-Oxygen Activation at ß-Cyclodextrin-Modified Titanate Nanotubes.

Titanate nanotubes (TNTs) were coated with a cyclic oligosaccharide (carboxymethyl-ß-cyclodextrin, CM-ß-CD) to obtain a photocatalyst (CM-ß-CD-TNT) for efficiently activating molecular oxygen and removing the target contaminant. The hydrophobic cavity and the large specific surface area of the photocatalyst provide abundant active sites for activating molecular oxygen. The free radical capture experiment and quenching experiment showed that cyclodextrin could facilitate adsorption and activation of molecular oxygen to produce O2 .- . Therefore, compared with the pristine TNT, CM-ß-CD-TNT accelerated the oxidation efficiency of paracetamol (APAP) by 3.4 times. Moreover, the ring cleavage reaction induced by CM-ß-CD-TNT effectively reduced the acute toxicity of wastewater containing APAP. Furthermore, 100% of bisphenol A (BPA), bisphenol S (BPS), phenol, 2,4-dichlorophen (2,4-DCP), and carbamazepine (CBZ) were degraded by CM-ß-CD-TNT after 2.5 h ultraviolet (UV) light irradiation. This strategy provides a new dimension for the advanced treatment of organic wastewater by organic macrocyclic molecule-modified materials.