Omega-3 fatty acids in the treatment of spinal cord injury: untapped potential for therapeutic intervention?

Omega-3 fatty acids constitute a group of fatty acids with anti-inflammatory and preventive effects against various diseases. Studies in animal models have demonstrated the preventive and therapeutic effects of omega-3 fatty acids after spinal cord injury (SCI) in reducing inflammatory reactions and promoting neuroregeneration. However, studies on the efficacy of omega-3 fatty acids in treatment and prevention after SCI seem to be questionable. This study evaluates potential reasons for omega-3 fatty acid therapy oversight in populations after SCI. Therefore, some of the reasons could cover heterogeneous patient groups in size, level of injury, quality of life assessment, time since injury, no single standardised dose, various follow-up durations and metabolic changes, often insufficient to record. Due to the difficulty of collecting cases for the study, especially in the acute phase after SCI, multicenter, coordinated studies are needed to establish the effects of omega-3 fatty acids on treatment, recovery, and disease prevention in patients after SCI. Although the present results of such studies are still inconclusive, the failure to exploit the potential properties of omega-3 fatty acids in the treatment of patients with SCI solely due to methodological difficulties should be considered a potential waste.

Are Beards Honest Signals of Male Dominance and Testosterone?

The male beard is one of the most visually salient and sexually dimorphic traits and a hypothesized potential marker of other traits, such as dominance, masculinity, social status, and self-confidence. However, as men can easily alter their facial hair, beards may provide unreliable information about the beard owner's characteristics. Here, we examined whether beards are honest signals of biological (testosterone levels) and psychological (self-reported dominance) traits. Young (M = 21.29, SD = 1.54) and healthy men (N = 97) participated in the study. Their beards were measured directly (using digital calipers) and by self-report. Participants provided saliva samples before and after acute exercise (to assess their testosterone and cortisol levels) and reported their dominance on a 5-item scale. The results showed that beard length (directly measured and self-reported) was not related to testosterone levels or dominance; thus, no evidence was found to support the hypothesis that beards are honest (or dishonest) signals of the beard owners' testosterone levels and dominance.

Association of physical fitness with quality of life in community-dwelling older adults aged 80 and over in Poland: a cross-sectional study.

BACKGROUND: Aging is a progressive and irreversible process that negatively affects the quality of life (QOL). Older adults face difficulties related to worsening health, lowering the level of physical and mental efficiency. We aimed to analyze the associations between physical fitness and QOL in Polish older adults considering sex differences. METHODS: This cross-sectional study was performed from March to August 2015. The sample consisted of 100 community-dwelling adults (67 women, 33 men) with a mean age of 82.94 ± 2.67 years. The World Health Organization QOL, Short Form questionnaire (WHOQOL-BREF), and the Fullerton Functional Fitness Test (FFFT) were used. Biometric data, social and environmental situation, nutritional and lifestyle behaviors have been also collected using a questionnaire designed by the authors. RESULTS: The results obtained in individual domains of WHOWOL-BREF indicate a good level of QOL in all the examined domains. Statistically significant sex differences were obtained in physical (p = 0.01), psychological (p = 0.04) and environmental (p = 0.02) domains in WHOQOL-BREF. It was noted that men perform better in terms of the upper (arm curl, p < 0.001) and lower body strength (chair stand, p = 0.01), aerobic endurance (two-minute step test, p < 0.001), agility and dynamic balance (up and go test, p < 0.001) in FFFT. CONCLUSIONS: Community-dwelling older adults aged 80-93 years in Poland present a good level of QOL, and the higher score was obtained in men. Also, men presented better physical fitness, showed a higher level of independence in daily activities, and assessed better their own QOL than women.

The relationship between the level of physical activity, independence in daily activities, and life quality and satisfaction in women over 80 living in rural areas - a pilot study.

BACKGROUND: Better medicine and health care steadily increases the human life expectancy. Growing number of elderly people and the imbalance of population structure will affect many fields of life, including social security system, joborientation and culture. Therefore it is crucial that the elderly maintain not only good physical health but keep the ability to self-care as long as possible, stay functionally fit and express satisfaction of life in all domains. OBJECTIVE: This study aims to analyse the factors that affect the quality of life in different domains (physical, psychological, social and environmental), like the independence in performing everyday life activities and the level of physical activity of women above 80 years old, living in own households. MATERIALS AND METHODS: The study was performed from March to August 2015 in Opole, Lower Silesia and Silesia voivodeship, mosty in rural areas, on 67 women, age above 80 (average 82.9), who filled the standarized questionnaires of life quality (WHOQOL-BREF), physical activity (IPAQ), and self-maintenance in daily living (IADL, Lawton scale). RESULTS: The results show that the life satisfaction of women above 80 years old living in own households in rural areas is highest in the social and environmental domains, while is the lowest in physical health domain. There is a strong positive correlation between the level of physical activity, the level of self-maintenance and the life quality in four of its domains. CONCLUSIONS: Self-maintenance and higher level of physical fitness, which are the components of functional fitness, positively correlate with self-assesed life-satisfaction in all domains. It is crucial to stress the importance of physical activity in seniors, preferably in way of dedicated exercising of moderate and high intensity, that will bring benefits not only in domain of physical health but in overall well-being and higher life-satisfaction, the significant factors in healthy ageing.

Changes in concentration performance and alternating attention after short-term virtual reality training in E-athletes: a pilot study.

In the dynamic landscape of e-sports, where intense competitive gaming demands high cognitive abilities, concentration performance and alternating attention play a pivotal role. E-sports encompass diverse genres, each requiring specific cognitive functions. Maintaining unwavering focus is crucial, as split-second decisions can determine victory. The study explores the potential of Virtual Reality (VR) training to enhance concentration performance and alternating attention, shedding light on the importance and possibilities of optimizing cognitive abilities for e-athletes. VR training emerges as a promising intervention, offering immersive environments for cognitive exercises. The study investigates the impact of VR training on concentration performance and alternating attention in amateur e-athletes, utilizing standardized tests. A randomized controlled trial with 66 participants reveals significant improvements in the VR training group, highlighting the adaptability and plasticity of cognitive processes. The findings suggest that VR training can enhance concentration abilities, providing valuable insights for e-sports and potentially extending to other fields requiring sustained attention and rapid task-switching. The study underscores the convergence of cognitive psychology, neuroscience, and VR technology, paving the way for innovative training methodologies and advancements in e-sports performance.

The Role of Progranulin (PGRN) in the Pathogenesis of Glioblastoma Multiforme.

Glioblastoma multiforme (GBM) represents the most common and aggressive malignant form of brain tumour in adults and is characterized by an extremely poor prognosis with dismal survival rates. Currently, expanding concepts concerning the pathophysiology of GBM are inextricably linked with neuroinflammatory phenomena. On account of this fact, the identification of novel pathomechanisms targeting neuroinflammation seems to be crucial in terms of yielding successful individual therapeutic strategies. In recent years, the pleiotropic growth factor progranulin (PGRN) has attracted significant attention in the neuroscience and oncological community regarding its neuroimmunomodulatory and oncogenic functions. This review of the literature summarizes and updates contemporary knowledge about PGRN, its associated receptors and signalling pathway involvement in GBM pathogenesis, indicating possible cellular and molecular mechanisms with potential diagnostic, prognostic and therapeutic targets in order to yield successful individual therapeutic strategies. After a review of the literature, we found that there are possible PGRN-targeted therapeutic approaches for implementation in GBM treatment algorithms both in preclinical and future clinical studies. Furthermore, PGRN-targeted therapies exerted their highest efficacy in combination with other established chemotherapeutic agents, such as temozolomide. The results of the analysis suggested that the possible implementation of routine determinations of PGRN and its associated receptors in tumour tissue and biofluids could serve as a diagnostic and prognostic biomarker of GBM. Furthermore, promising preclinical applications of PGRN-related findings should be investigated in clinical studies in order to create new diagnostic and therapeutic algorithms for GBM treatment.

Esports Players Are Less Extroverted and Conscientious than Athletes.

The worldwide status of esports as a sporting phenomenon has been developed in the past decade. However, as the esports industry has grown, it has remained an understudied scientific field. Esports is often contrasted with traditional sports regarding various aspects, including lack of physical activity and the online nature of social interactions. However, little is known whether individuals competing in esports-esports players-differ from individuals competing in traditional sports-athletes. To address this question, we examined the personality characteristics of both types of performers. We collected cross-sectional data on esports players' (n = 416) and athletes' (n = 452) personalities and performance characteristics. We found that esports players were less extroverted and conscientious than athletes. Furthermore, greater sports and esports experience was positively related to being more extroverted. Our findings contribute to the literature by documenting the preferences for competitive activities based on individuals' personality characteristics. We suggest that esports (rather than sports) might be a more suitable form of competition for less extroverted and conscientious individuals.

Novel Approach for the Approximation of Vitamin D3 Pharmacokinetics from In Vivo Absorption Studies.

The changing environment and modified lifestyles have meant that many vitamins and minerals are deficient in a significant portion of the human population. Therefore, supplementation is a viable nutritional approach, which helps to maintain health and well-being. The supplementation efficiency of a highly hydrophobic compound such as cholecalciferol (logP > 7) depends predominantly on the formulation. To overcome difficulties associated with the evaluation of pharmacokinetics of cholecalciferol, a method based on the short time absorption data in the clinical study and physiologically based mathematical modeling is proposed. The method was used to compare pharmacokinetics of liposomal and oily formulations of vitamin D3. The liposomal formulation was more effective in elevating calcidiol concentration in serum. The determined AUC value for liposomal vitamin D3 formulation was four times bigger than that for the oily formulation.

Evaluating the Effectiveness of Visuospatial Memory Stimulation Using Virtual Reality in Head and Neck Cancer Patients-Pilot Study.

The prevalence of Cancer-related Cognitive Impairment (CRCI) in cancer patients necessitates the search for methods to help stimulate cognitive function. An innovative and repeatedly used method in oncology departments is virtual reality (VR). To date, no one has used VR for head and neck cancer patients in an attempt to stimulate their working memory. The goal of our research is to intervene with off-the-shelf VR applications in HNC patients to lower the risk of CRCI. Twenty-two patients with head and neck cancer were enrolled in this pilot study to characterize their visuospatial memory capacity, a form of working memory. During the oncological treatment, the patient had 30 min sessions, three times a week, using publicly available applications of VR. No significant changes were observed in the pre- and post-study. The individual patient results present a favorable trend of changes in their working memory after the intervention: despite oncological treatment, visual-spatial memory did not deteriorate in 88% of patients, including 28% of patients with higher scores than before the intervention. In this pilot study, VR was safely used in patients with head and neck cancer with no negative side effects. The use of VR may prevent CRCI in most HNC patients and, in some, VR may improve their cognitive functioning. A more rigorous study with larger numbers and controls is advised.

The impact of changing the funding model for genetic diagnostics and improved access to personalized medicine in oncology.

AIM: In January 2017, a new funding model for diagnostic genetic testing in cancer was introduced in Poland. OBJECTIVES: The aim of this study was to assess the impact of changing the funding model for genetic diagnosis in oncology on improving access to personalized medicine in Poland between 2017 and 2019. METHODS: The analysis included data on settlements with the National Health Fund for genetic tests in cancer under a contract of the hospital treatment type and under the contract in the type of separately contracted services between 2017 and 2019. RESULTS: The 150,647 diagnostic genetic tests were reported, which were billed to 111,872 patients. The average number of tests per patient was 1.35. One test was billed to 83.5% of patients, 11.2% of patients had two tests billed, and 5.3% had at least three tests billed. The number of services provided under the hospital treatment contract in 2018 doubled compared to the previous year. For separately contracted services, more than threefold increase in genetic testing performed in 2019 compared to 2018 was observed. CONCLUSION: our data show that the novel funding model for genetic services introduced in Poland has positive impact on the availability of genetic testing for patients.

School-Based Family-Oriented Health Interventions to Promote Physical Activity in Children and Adolescents: A Systematic Review.

OBJECTIVE: This study aimed to systematically review and analyse intervention programs in a school context centred on the family, focused on increasing youths' physical activity. DATA SOURCE: The research was carried out in the PubMed, Scopus and Web of Science databases. STUDY INCLUSION CRITERIA: Studies were included if participants were children or adolescents, focusing on school-based intervention studies with parental involvement and physical activity, sedentary behaviour or physical fitness outcomes. DATA EXTRACTION: The search was performed according to the PRISMA protocol. A total of 416 articles were identified. After being considered for eligibility and duplicates, 22 studies were identified as relevant for inclusion. DATA SYNTHESIS: Sample and intervention characteristics, objective, the role of the family, outcomes measures, main findings regarding the outcomes and risk of bias. RESULTS: Ten studies reported improvements in physical activity, 6 in sedentary behaviour and 9 in the components of physical fitness and/or skills related to healthy behaviours and lifestyles. Most of the interventions adopted a multidisciplinary and multi-component approach. CONCLUSIONS: Most interventions employed a school's multidisciplinary/multi-component approach to promoting physical activity, nutrition, and general education for healthier lifestyle behaviours. The impact of school-based interventions involving families on youth's physical activity levels is still a relatively emerging theme. Further research is needed given the diversity of the intervention's characteristics and the disparity in the results' efficacy.

Application of High-Tech Solution for Memory Assessment in Patients With Disorders of Consciousness.

Testing cognitive function in patients after severe brain damage is a major clinical challenge. In the absence of both verbal and motor communication, tests commonly used to assess cognitive function are completely or partially undoable for disorders of consciousness patients. The study involved 12 patients with varying degrees of impaired consciousness due to brain damage, with no verbal and motor communication. Memory was assessed in study participants using oculography. Memory tasks were presented in four categories. The total percentage of correctly completed tasks obtained across the group was 39.58%. The most difficult tasks included category C.4 with tasks involving working memory. Regardless of the subjects' level of consciousness, there was no statistically significant difference in the percentage of correct responses obtained in subgroups distinguished by CRS-R score. Eye tracking technology can be successfully used in the assessment of cognitive function, particularly when eye movements are the only channel of communication in individuals after brain damage. We suggest that the cognitive functions of people after brain damage should be further analyzed using eye tracking.

Different response of perennial ryegrass-Epichloë endophyte symbiota to the elevated concentration of heavy metals in soil.

The phenomenon of plant mutualistic symbiosis with microbes may have a positive effect on the improvement of plant tolerance to environmental stresses as well as on the ability of plants to accumulate heavy metal (HM) ions from soil. The influence of Epichloë fungal endophyte (Ascomycota, Clavicipitaceae) on perennial ryegrass (Lolium perenne L.) plants grown in the presence of elevated concentrations of HM ions (Cd2+, Pb2+, and Cu2+) in soil was studied. The presence of Epichloë in the host grass tissues resulted in different accumulation of HM ions in the aboveground parts of the plants. In some cases, endophyte infection positively affected ryegrass ability to accumulate HM ions from soil. In plants with (E +) and without (E -) endophytes, the hormesis effect was induced by the elevated concentration of Cu2+ ions, resulting in better growth and photosynthesis, as examined by measurements of Chl a fluorescence. The obtained results indicate that based on the laboratory evaluation of the efficiency of HM accumulation, we were able to choose the best associations of perennial ryegrass with endophytes for HM phytoremediation.

Lignocellulosic Biomass of C3 and C4 Perennial Grasses as a Valuable Feedstock for Particleboard Manufacture.

Looking for new alternative raw materials is one of the key issues in line with a bioeconomy approach, particularly for particleboard manufacturing. In this framework, this paper presents a comparison of some physico-mechanical properties and the formaldehyde contents of particleboards made with 30% substitution of grass biomass from six perennial grass species. Our studies indicate relatively high values of mechanical properties for particleboards made with the addition of biomass from grasses with the C4 photosynthetic pathway: Miscanthus x giganteus and switchgrass (Panicum virgatum). Boards made with the addition of biomass from grasses with the C3 photosynthetic pathway-tall wheatgrass (Elymus elongatus), tall fescue (Festuca arundinacea), and perennial ryegrass (Lolium perenne)-gave lower values of mechanical properties. The opposite results were obtained in the case of the formaldehyde content: the lowest value was measured for particleboards made with the addition of tall fescue biomass (0.1% less than the control), and the highest for switchgrass (0.9% greater than the control) and cordgrass (3.2% greater than the control). Future research should address the optimization of the manufacturing process of particleboards from perennial grasses, taking into account the needs and technical possibilities of the wood industry sector.

Executive Function Level in Cadets' Shooting Performance.

Executive functions (EF) are crucial to a person's unique abilities, enabling one to achieve goals, adapt to new situations and manage social interactions. EF are also very important for the effective performance of military tasks including the shooting performance (SP) of soldiers. The aim of this study was to investigate the association of EF with SP and gender differences in the level of these traits among cadets of the General Tadeusz Kosciuszko Military University of Land Forces in Wroclaw i.e., 156 persons (19 females and 137 males). The level of EF and processes related to attention was measured with usage of the Color Trails Test (CTT-1 and CTT-2). SP was assessed on the basis of scores from four different small arms and rifle shootings at a fixed target and at emerging targets. The relations between explained and explanatory variables were assessed using Spearman correlation. The variation in the mean values of CTT scores and SP of men and women was compared using the Mann-Whitney U test for independent samples. The results of the present study did not reveal any significant differences between women and men in the level of EF and SP. The key finding of the present study is that the higher SP of males in all shooting events of the study and of females in pistol shooting were significantly correlated with higher executive functions.

Implementing New Technologies to Improve Visual-Spatial Functions in Patients with Impaired Consciousness.

The quality of life of patients with severe brain damage is compromised by, e.g., impaired cognitive functions and ocular dysfunction. The paper contains research findings regarding participants of an oculomotor training course aimed at the therapy of visual-spatial functions. Five male patients with brain damage who did not communicate, verbally or motorically, participated in the study. Over a six-week period, the subjects solved tasks associated with recognising objects, size perception, colour perception, perception of object structures (letters), perception of object structures (objects), detecting differences between images and assembling image components into the complete image with the use of an eye tracker. The findings present evidence of oculomotor training effectiveness based on a longer duration of the work with the eye tracker and improved visual-spatial functions.

Monitoring Eye Movements Depending on the Type of Visual Stimulus in Patients with Impaired Consciousness Due to Brain Damage.

The eyeballs are often the only way to communicate messages as a result of brain damage. However, it is not uncommon for them to become dysfunctional, thus requiring the introduction of appropriate therapy. The trajectory of eye movements (saccadic movements and gaze fixation) during observation of a static and dynamic point presented with an eye tracker was analyzed in the present study. Twelve patients with brain injury of different etiology, with different degrees of consciousness disorders and not communicating through verbal and motor skills, qualified for the study. All participants demonstrated greater eye movement activity when presented with a dynamic task in which they observed a moving point. The findings suggest that effective eye movement therapy must incorporate dynamic stimuli.

Restored Life of Elite Athletes after Spinal Cord Injury.

Spinal cord injury (SCI) affects every aspect of human life: medical, psychological, social, material. People with SCI face a variety of secondary conditions (e.g., chronic pain, urinary tract infections, cognitive impairment) that place a significant emotional burden, resulting in an increased risk of depression and reduced quality of life. The purpose of this study was to better understand the coping strategies and to identify factors that promote or hinder the successful adjustment of elite athletes after SCI. Individual semi-structured interviews were conducted with eight top athletes after spinal cord injury. The interviews were recorded, transcribed, and then thematically analyzed using MAXQDA software. Thematic analysis identified the following categories: coping, athletic identity, and adjustment. The results of the study indicate that loss of functional ability does not cause loss of athlete identity. Elite athletes live a life consistent with this identity, attempting to maintain it despite the loss of physical fitness. Involvement in sports provides meaning and is a positive factor in the process of disability acceptance, which is essential in the process of adjustment to injury and also provides group belonging.

Alternating Attention and Physical Fitness in Relation to the Level of Combat Training.

The level of combat training (CT) of the future commander-leader is of critical importance to the armed forces in national defense. This study aimed to search for the relationship between the level of alternating attention, physical fitness and shooting accuracy (SA), and academic achievements in practical military subjects (PMS). The study group consisted of 137 cadets of the Military University of Land Forces. The measure of alternating attention in the study was the Color Trails Test results. Motor components were assessed by measuring hand static strength, endurance run, and time of a speed and agility run. SA and PMS were taken as measures of cadets' CT. Significantly higher PMS were associated with higher levels of strength and better endurance in cadets. The physical fitness of the cadets did not significantly affect the cadets' SA. The main result of the study is the revelation of the level of alternating attention as a strong determinant of cadets' SA. The authors suggest that the main emphasis should be put on the physical preparation of a modern soldier, focused on the development of strength and endurance skills. It is also reasonable to introduce cognitive stimulation exercises to shooting training.

The Relationship between Cognitive Performance and Quality of Life in Elite Athletes after Spinal Cord Injury.

BACKGROUND: The present investigation was designed to determine cognitive performance and quality of life (QoL) in a group of elite athletes who sustained spinal cord injury (SCI). METHODS: nine participants suffering a SCI participated in the study. Different cognitive functions were evaluated through the following tests: COWAT, Digit Span, Stroop color-word and QoL through the WHOQoL-BREF scale. RESULTS: Generally, participants positively assessed their overall quality of life and health status. Although the tests conducted indicate reduced cognitive function among the athletes, it did not affect the reduction in QoL. Single correlations between the results of cognitive tests and QoL could be treated as coincidental. CONCLUSIONS: Despite the observed decline in selected cognitive functions, the participants positively assessed their quality of life and physical health.Reduced cognitive functioning could be influenced by the impact of sleep-disordered breathing, pain, depressive disorders and medication. This indicates the need for an individualized approach to define the patient's deficits, needs and best care. Further studies with a larger group of participants are needed.