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1.
Br J Dermatol ; 167(2): 288-95, 2012 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-22458650

RESUMEN

BACKGROUND: Valrubicin is a cytostatic anthracycline analogue, lacking toxicity by skin and tissue contact, and represents a new drug with potential for topical treatment of psoriasis and nonmelanoma skin cancer (NMSC); the beneficial effects have been partly explained by its antiproliferative and proapoptotic characteristics. OBJECTIVES: To assess the effect of valrubicin on skin inflammation as inflammation also plays a key role in psoriasis and NMSC. METHODS: The effect of topical valrubicin treatment on skin inflammation in vivo was addressed in skin inflammation mouse models, where 12-O-tetradecanoylphorbol 13-acetate was used to induce irritant contact dermatitis. An acute and a chronic model were included, to investigate the effect of valrubicin in short-term inflammation and in more persistent inflammation. Inflammation-associated ear oedema was evaluated by measuring ear thickness, infiltration of neutrophil cells, and expression of inflammatory cytokines, interleukin (IL)-1ß and IL-6. RESULTS: Topical valrubicin treatment effectively reduced the inflammatory response in the acute and the chronic models. CONCLUSIONS: The present data document an anti-inflammatory effect of valrubicin, and may suggest an interesting new role for valrubicin in other debilitating skin diseases in which inflammation is a significant factor.


Asunto(s)
Antiinflamatorios/administración & dosificación , Dermatitis Irritante/tratamiento farmacológico , Doxorrubicina/análogos & derivados , Enfermedad Aguda , Administración Cutánea , Animales , Antiinflamatorios/farmacología , Enfermedad Crónica , Citocinas/metabolismo , Modelos Animales de Enfermedad , Doxorrubicina/administración & dosificación , Doxorrubicina/farmacología , Irritantes/toxicidad , Ratones , Ratones Endogámicos C57BL , Infiltración Neutrófila , Acetato de Tetradecanoilforbol/análogos & derivados , Acetato de Tetradecanoilforbol/toxicidad
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