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Nano Lett ; 14(9): 5458-70, 2014 Sep 10.
Artículo en Inglés | MEDLINE | ID: mdl-25115645

RESUMEN

Properties like high interfacial area with cellular membranes, unique ability to incorporate multiple functionalization, as well as compatibility and transport in biological fluids make carbon nanotubes (CNTs) useful for a variety of therapeutic and drug-delivery applications. Here we used a totally synthetic hybrid supramolecule as an anticancer vaccine formulation. This complex structure comprises CNTs as delivery system for the Cancer Testis Antigen named NY-ESO-1, allied to a synthetic Toll-Like Receptor agonist. The CNT constructs were rapidly internalized into dendritic cells, both in vitro and in vivo, and served as an intracellular antigen depot. This property favored the induction of strong CD4(+) T as well as CD8(+) T cell-mediated immune responses against the NY-ESO-1. Importantly, the vaccination significantly delayed the tumor development and prolonged the mice survival, highlighting the potential application of CNTs as a vaccine delivery system to provide superior immunogenicity and strong protection against cancer.


Asunto(s)
Linfocitos T CD8-positivos/citología , Vacunas contra el Cáncer/química , Nanotecnología/métodos , Nanotubos de Carbono/química , Neoplasias/prevención & control , Neoplasias/terapia , Animales , Anticarcinógenos/química , Antígenos/química , Antígenos de Neoplasias/química , Linfocitos T CD4-Positivos/citología , Calibración , Proliferación Celular , Islas de CpG , Células Dendríticas/efectos de los fármacos , Femenino , Citometría de Flujo , Humanos , Linfocitos/citología , Proteínas de la Membrana/química , Ratones , Ratones Endogámicos BALB C , Ratones Endogámicos C57BL , Microscopía Electrónica de Transmisión , Neoplasias/metabolismo , Oxígeno/química , Péptidos/química , Espectrometría Raman
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