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1.

Shared Immunogenic Poly-Epitope Frameshift Mutations in Microsatellite Unstable Tumors.

Roudko, Vladimir; Bozkus, Cansu Cimen; Orfanelli, Theofano; McClain, Christopher B; Carr, Caitlin; O'Donnell, Timothy; Chakraborty, Lauren; Samstein, Robert; Huang, Kuan-Lin; Blank, Stephanie V; Greenbaum, Benjamin; Bhardwaj, Nina.

Cell; 183(6): 1634-1649.e17, 2020 Dec 10.

Artículo en Inglés | MEDLINE | ID: mdl-33259803

2.

Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction.

Wells, Daniel K; van Buuren, Marit M; Dang, Kristen K; Hubbard-Lucey, Vanessa M; Sheehan, Kathleen C F; Campbell, Katie M; Lamb, Andrew; Ward, Jeffrey P; Sidney, John; Blazquez, Ana B; Rech, Andrew J; Zaretsky, Jesse M; Comin-Anduix, Begonya; Ng, Alphonsus H C; Chour, William; Yu, Thomas V; Rizvi, Hira; Chen, Jia M; Manning, Patrice; Steiner, Gabriela M; Doan, Xengie C; Merghoub, Taha; Guinney, Justin; Kolom, Adam; Selinsky, Cheryl; Ribas, Antoni; Hellmann, Matthew D; Hacohen, Nir; Sette, Alessandro; Heath, James R; Bhardwaj, Nina; Ramsdell, Fred; Schreiber, Robert D; Schumacher, Ton N; Kvistborg, Pia; Defranoux, Nadine A.

Cell; 183(3): 818-834.e13, 2020 Oct 29.

Artículo en Inglés | MEDLINE | ID: mdl-33038342

3.

A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer.

Ott, Patrick A; Hu-Lieskovan, Siwen; Chmielowski, Bartosz; Govindan, Ramaswamy; Naing, Aung; Bhardwaj, Nina; Margolin, Kim; Awad, Mark M; Hellmann, Matthew D; Lin, Jessica J; Friedlander, Terence; Bushway, Meghan E; Balogh, Kristen N; Sciuto, Tracey E; Kohler, Victoria; Turnbull, Samantha J; Besada, Rana; Curran, Riley R; Trapp, Benjamin; Scherer, Julian; Poran, Asaf; Harjanto, Dewi; Barthelme, Dominik; Ting, Ying Sonia; Dong, Jesse Z; Ware, Yvonne; Huang, Yuting; Huang, Zhengping; Wanamaker, Amy; Cleary, Lisa D; Moles, Melissa A; Manson, Kelledy; Greshock, Joel; Khondker, Zakaria S; Fritsch, Ed; Rooney, Michael S; DeMario, Mark; Gaynor, Richard B; Srinivasan, Lakshmi.

Cell; 183(2): 347-362.e24, 2020 Oct 15.

Artículo en Inglés | MEDLINE | ID: mdl-33064988

4.

Intravenous nanoparticle vaccination generates stem-like TCF1⁺ neoantigen-specific CD8⁺ T cells.

Baharom, Faezzah; Ramirez-Valdez, Ramiro A; Tobin, Kennedy K S; Yamane, Hidehiro; Dutertre, Charles-Antoine; Khalilnezhad, Ahad; Reynoso, Glennys V; Coble, Vincent L; Lynn, Geoffrey M; Mulè, Matthew P; Martins, Andrew J; Finnigan, John P; Zhang, Xiao Meng; Hamerman, Jessica A; Bhardwaj, Nina; Tsang, John S; Hickman, Heather D; Ginhoux, Florent; Ishizuka, Andrew S; Seder, Robert A.

Nat Immunol; 2020 Nov 02.

Artículo en Inglés | MEDLINE | ID: mdl-33139915

5.

Immunology of COVID-19: Current State of the Science.

Vabret, Nicolas; Britton, Graham J; Gruber, Conor; Hegde, Samarth; Kim, Joel; Kuksin, Maria; Levantovsky, Rachel; Malle, Louise; Moreira, Alvaro; Park, Matthew D; Pia, Luisanna; Risson, Emma; Saffern, Miriam; Salomé, Bérengère; Esai Selvan, Myvizhi; Spindler, Matthew P; Tan, Jessica; van der Heide, Verena; Gregory, Jill K; Alexandropoulos, Konstantina; Bhardwaj, Nina; Brown, Brian D; Greenbaum, Benjamin; Gümüs, Zeynep H; Homann, Dirk; Horowitz, Amir; Kamphorst, Alice O; Curotto de Lafaille, Maria A; Mehandru, Saurabh; Merad, Miriam; Samstein, Robert M.

Immunity; 52(6): 910-941, 2020 06 16.

Artículo en Inglés | MEDLINE | ID: mdl-32505227

6.

Author Correction: A conserved dendritic-cell regulatory program limits antitumour immunity.

Maier, Barbara; Leader, Andrew M; Chen, Steven T; Tung, Navpreet; Chang, Christie; LeBerichel, Jessica; Chudnovskiy, Aleksey; Maskey, Shrisha; Walker, Laura; Finnigan, John P; Kirkling, Margaret E; Reizis, Boris; Ghosh, Sourav; D'Amore, Natalie Roy; Bhardwaj, Nina; Rothlin, Carla V; Wolf, Andrea; Flores, Raja; Marron, Thomas; Rahman, Adeeb H; Kenigsberg, Ephraim; Brown, Brian D; Merad, Miriam.

Nature; 582(7813): E17, 2020 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-32499658

7.

A conserved dendritic-cell regulatory program limits antitumour immunity.

Maier, Barbara; Leader, Andrew M; Chen, Steven T; Tung, Navpreet; Chang, Christie; LeBerichel, Jessica; Chudnovskiy, Aleksey; Maskey, Shrisha; Walker, Laura; Finnigan, John P; Kirkling, Margaret E; Reizis, Boris; Ghosh, Sourav; D'Amore, Natalie Roy; Bhardwaj, Nina; Rothlin, Carla V; Wolf, Andrea; Flores, Raja; Marron, Thomas; Rahman, Adeeb H; Kenigsberg, Ephraim; Brown, Brian D; Merad, Miriam.

Nature; 580(7802): 257-262, 2020 04.

Artículo en Inglés | MEDLINE | ID: mdl-32269339

8.

Expansion and Activation of CD103(+) Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition.

Salmon, Hélène; Idoyaga, Juliana; Rahman, Adeeb; Leboeuf, Marylène; Remark, Romain; Jordan, Stefan; Casanova-Acebes, Maria; Khudoynazarova, Makhzuna; Agudo, Judith; Tung, Navpreet; Chakarov, Svetoslav; Rivera, Christina; Hogstad, Brandon; Bosenberg, Marcus; Hashimoto, Daigo; Gnjatic, Sacha; Bhardwaj, Nina; Palucka, Anna Karolina; Brown, Brian D; Brody, Joshua; Ginhoux, Florent; Merad, Miriam.

Immunity; 44(4): 924-38, 2016 Apr 19.

Artículo en Inglés | MEDLINE | ID: mdl-27096321

9.

A bloody mess: dendritic cells use hemophagocytosis to regulate viral inflammation.

Miller, Elizabeth; Bhardwaj, Nina.

Immunity; 39(3): 429-31, 2013 Sep 19.

Artículo en Inglés | MEDLINE | ID: mdl-24054326

10.

Mutation-derived Neoantigen-specific T-cell Responses in Multiple Myeloma.

Perumal, Deepak; Imai, Naoko; Laganà, Alessandro; Finnigan, John; Melnekoff, David; Leshchenko, Violetta V; Solovyov, Alexander; Madduri, Deepu; Chari, Ajai; Cho, Hearn Jay; Dudley, Joel T; Brody, Joshua D; Jagannath, Sundar; Greenbaum, Benjamin; Gnjatic, Sacha; Bhardwaj, Nina; Parekh, Samir.

Clin Cancer Res; 26(2): 450-464, 2020 01 15.

Artículo en Inglés | MEDLINE | ID: mdl-31857430

11.

P2X Antagonists Inhibit HIV-1 Productive Infection and Inflammatory Cytokines Interleukin-10 (IL-10) and IL-1ß in a Human Tonsil Explant Model.

Soare, Alexandra Y; Durham, Natasha D; Gopal, Ramya; Tweel, Benjamin; Hoffman, Kevin W; Brown, Julia A; O'Brien, Megan; Bhardwaj, Nina; Lim, Jean K; Chen, Benjamin K; Swartz, Talia H.

J Virol; 93(1)2019 01 01.

Artículo en Inglés | MEDLINE | ID: mdl-30305360

12.

Sequence-Specific Sensing of Nucleic Acids.

Vabret, Nicolas; Bhardwaj, Nina; Greenbaum, Benjamin D.

Trends Immunol; 38(1): 53-65, 2017 01.

Artículo en Inglés | MEDLINE | ID: mdl-27856145

13.

Therapeutic Immune Modulation against Solid Cancers with Intratumoral Poly-ICLC: A Pilot Trial.

Kyi, Chrisann; Roudko, Vladimir; Sabado, Rachel; Saenger, Yvonne; Loging, William; Mandeli, John; Thin, Tin Htwe; Lehrer, Deborah; Donovan, Michael; Posner, Marshall; Misiukiewicz, Krzysztof; Greenbaum, Benjamin; Salazar, Andres; Friedlander, Philip; Bhardwaj, Nina.

Clin Cancer Res; 24(20): 4937-4948, 2018 10 15.

Artículo en Inglés | MEDLINE | ID: mdl-29950349

14.

CD4 Receptor is a Key Determinant of Divergent HIV-1 Sensing by Plasmacytoid Dendritic Cells.

O'Brien, Meagan; Manches, Olivier; Wilen, Craig; Gopal, Ramya; Huq, Rumana; Wu, Vernon; Sunseri, Nicole; Bhardwaj, Nina.

PLoS Pathog; 12(4): e1005553, 2016 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-27082754

15.

Modulation of human Th17 cell responses through complement receptor 3 (CD11â¯b/CD18) ligation on monocyte-derived dendritic cells.

Nowatzky, Johannes; Manches, Olivier; Khan, Shaukat Ali; Godefroy, Emmanuelle; Bhardwaj, Nina.

J Autoimmun; 92: 57-66, 2018 08.

Artículo en Inglés | MEDLINE | ID: mdl-29908907

16.

Immune phenotype of peripheral blood mononuclear cells in patients with high-risk non-muscle invasive bladder cancer.

Audenet, François; Farkas, Adam M; Anastos, Harry; Galsky, Matthew D; Bhardwaj, Nina; Sfakianos, John P.

World J Urol; 36(11): 1741-1748, 2018 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-29860605

17.

Distinguishing the immunostimulatory properties of noncoding RNAs expressed in cancer cells.

Tanne, Antoine; Muniz, Luciana R; Puzio-Kuter, Anna; Leonova, Katerina I; Gudkov, Andrei V; Ting, David T; Monasson, Rémi; Cocco, Simona; Levine, Arnold J; Bhardwaj, Nina; Greenbaum, Benjamin D.

Proc Natl Acad Sci U S A; 112(49): 15154-9, 2015 Dec 08.

Artículo en Inglés | MEDLINE | ID: mdl-26575629

18.

Dendritic cells in progression and pathology of HIV infection.

Manches, Olivier; Frleta, Davor; Bhardwaj, Nina.

Trends Immunol; 35(3): 114-22, 2014 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-24246474

19.

Dendritic cell dysregulation during HIV-1 infection.

Miller, Elizabeth; Bhardwaj, Nina.

Immunol Rev; 254(1): 170-89, 2013 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-23772620

20.

Modulation of innate immunity in the tumor microenvironment.

Gonzalez-Gugel, Elena; Saxena, Mansi; Bhardwaj, Nina.

Cancer Immunol Immunother; 65(10): 1261-8, 2016 10.

Artículo en Inglés | MEDLINE | ID: mdl-27344341

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