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1.

Gut Microbiota Regulation of T Cells During Inflammation and Autoimmunity.

Brown, Eric M; Kenny, Douglas J; Xavier, Ramnik J.

Annu Rev Immunol; 37: 599-624, 2019 04 26.

Artículo en Inglés | MEDLINE | ID: mdl-31026411

2.

NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion.

Wlodarska, Marta; Thaiss, Christoph A; Nowarski, Roni; Henao-Mejia, Jorge; Zhang, Jian-Ping; Brown, Eric M; Frankel, Gad; Levy, Maayan; Katz, Meirav N; Philbrick, William M; Elinav, Eran; Finlay, B Brett; Flavell, Richard A.

Cell; 156(5): 1045-59, 2014 Feb 27.

Artículo en Inglés | MEDLINE | ID: mdl-24581500

3.

A Deep Learning Approach to Antibiotic Discovery.

Stokes, Jonathan M; Yang, Kevin; Swanson, Kyle; Jin, Wengong; Cubillos-Ruiz, Andres; Donghia, Nina M; MacNair, Craig R; French, Shawn; Carfrae, Lindsey A; Bloom-Ackermann, Zohar; Tran, Victoria M; Chiappino-Pepe, Anush; Badran, Ahmed H; Andrews, Ian W; Chory, Emma J; Church, George M; Brown, Eric D; Jaakkola, Tommi S; Barzilay, Regina; Collins, James J.

Cell; 180(4): 688-702.e13, 2020 02 20.

Artículo en Inglés | MEDLINE | ID: mdl-32084340

4.

A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria.

Peters, Jason M; Colavin, Alexandre; Shi, Handuo; Czarny, Tomasz L; Larson, Matthew H; Wong, Spencer; Hawkins, John S; Lu, Candy H S; Koo, Byoung-Mo; Marta, Elizabeth; Shiver, Anthony L; Whitehead, Evan H; Weissman, Jonathan S; Brown, Eric D; Qi, Lei S; Huang, Kerwyn Casey; Gross, Carol A.

Cell; 165(6): 1493-1506, 2016 Jun 02.

Artículo en Inglés | MEDLINE | ID: mdl-27238023

5.

A Deep Learning Approach to Antibiotic Discovery.

Stokes, Jonathan M; Yang, Kevin; Swanson, Kyle; Jin, Wengong; Cubillos-Ruiz, Andres; Donghia, Nina M; MacNair, Craig R; French, Shawn; Carfrae, Lindsey A; Bloom-Ackermann, Zohar; Tran, Victoria M; Chiappino-Pepe, Anush; Badran, Ahmed H; Andrews, Ian W; Chory, Emma J; Church, George M; Brown, Eric D; Jaakkola, Tommi S; Barzilay, Regina; Collins, James J.

Cell; 181(2): 475-483, 2020 Apr 16.

Artículo en Inglés | MEDLINE | ID: mdl-32302574

6.

Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells.

Sachlos, Eleftherios; Risueño, Ruth M; Laronde, Sarah; Shapovalova, Zoya; Lee, Jong-Hee; Russell, Jennifer; Malig, Monika; McNicol, Jamie D; Fiebig-Comyn, Aline; Graham, Monica; Levadoux-Martin, Marilyne; Lee, Jung Bok; Giacomelli, Andrew O; Hassell, John A; Fischer-Russell, Daniela; Trus, Michael R; Foley, Ronan; Leber, Brian; Xenocostas, Anargyros; Brown, Eric D; Collins, Tony J; Bhatia, Mickie.

Cell; 149(6): 1284-97, 2012 Jun 08.

Artículo en Inglés | MEDLINE | ID: mdl-22632761

7.

Genome-wide Identification of Structure-Forming Repeats as Principal Sites of Fork Collapse upon ATR Inhibition.

Shastri, Nishita; Tsai, Yu-Chen; Hile, Suzanne; Jordan, Deondre; Powell, Barrett; Chen, Jessica; Maloney, Dillon; Dose, Marei; Lo, Yancy; Anastassiadis, Theonie; Rivera, Osvaldo; Kim, Taehyong; Shah, Sharvin; Borole, Piyush; Asija, Kanika; Wang, Xiang; Smith, Kevin D; Finn, Darren; Schug, Jonathan; Casellas, Rafael; Yatsunyk, Liliya A; Eckert, Kristin A; Brown, Eric J.

Mol Cell; 72(2): 222-238.e11, 2018 10 18.

Artículo en Inglés | MEDLINE | ID: mdl-30293786

8.

The role of the immune system in governing host-microbe interactions in the intestine.

Brown, Eric M; Sadarangani, Manish; Finlay, B Brett.

Nat Immunol; 14(7): 660-7, 2013 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-23778793

9.

Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation.

Zlitni, Soumaya; Ferruccio, Lauren F; Brown, Eric D.

Nat Chem Biol; 9(12): 796-804, 2013 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-24121552

10.

Chocolate habits of Nobel prizewinners.

Golomb, Beatrice A; Brenner, Sydney; Chalfie, Martin; Glashow, Sheldon Lee; Glauber, Roy J; Hubel, David Hunter; Maskin, Eric S; Greengard, Paul; Gross, David J; Roberts, Richard; Tonegawa, Susumu; Wilczek, Frank A; Brown, Eric Michael; Sejnowski, Terrence J.

Nature; 499(7459): 409, 2013 Jul 25.

Artículo en Inglés | MEDLINE | ID: mdl-23887421

11.

A multiplexable assay for screening antibiotic lethality against drug-tolerant bacteria.

Stokes, Jonathan M; Gutierrez, Arnaud; Lopatkin, Allison J; Andrews, Ian W; French, Shawn; Matic, Ivan; Brown, Eric D; Collins, James J.

Nat Methods; 16(4): 303-306, 2019 04.

Artículo en Inglés | MEDLINE | ID: mdl-30858599

12.

Discovery of an antivirulence compound that reverses ß-lactam resistance in MRSA.

El-Halfawy, Omar M; Czarny, Tomasz L; Flannagan, Ronald S; Day, Jonathan; Bozelli, José Carlos; Kuiack, Robert C; Salim, Ahmed; Eckert, Philip; Epand, Richard M; McGavin, Martin J; Organ, Michael G; Heinrichs, David E; Brown, Eric D.

Nat Chem Biol; 16(2): 143-149, 2020 02.

Artículo en Inglés | MEDLINE | ID: mdl-31768032

13.

Antibacterial drug discovery in the resistance era.

Brown, Eric D; Wright, Gerard D.

Nature; 529(7586): 336-43, 2016 Jan 21.

Artículo en Inglés | MEDLINE | ID: mdl-26791724

14.

Crystallographic analysis of Staphylococcus aureus LcpA, the primary wall teichoic acid ligase.

Li, Franco K K; Rosell, Federico I; Gale, Robert T; Simorre, Jean-Pierre; Brown, Eric D; Strynadka, Natalie C J.

J Biol Chem; 295(9): 2629-2639, 2020 02 28.

Artículo en Inglés | MEDLINE | ID: mdl-31969390

15.

Global proteomics of Ubqln2-based murine models of ALS.

Whiteley, Alexandra M; Prado, Miguel A; de Poot, Stefanie A H; Paulo, Joao A; Ashton, Marissa; Dominguez, Sara; Weber, Martin; Ngu, Hai; Szpyt, John; Jedrychowski, Mark P; Easton, Amy; Gygi, Steven P; Kurz, Thimo; Monteiro, Mervyn J; Brown, Eric J; Finley, Daniel.

J Biol Chem; 2020 Dec 04.

Artículo en Inglés | MEDLINE | ID: mdl-33277362

16.

Structure and mechanism of TagA, a novel membrane-associated glycosyltransferase that produces wall teichoic acids in pathogenic bacteria.

Kattke, Michele D; Gosschalk, Jason E; Martinez, Orlando E; Kumar, Garima; Gale, Robert T; Cascio, Duilio; Sawaya, Michael R; Philips, Martin; Brown, Eric D; Clubb, Robert T.

PLoS Pathog; 15(4): e1007723, 2019 04.

Artículo en Inglés | MEDLINE | ID: mdl-31002736

17.

RV144 HIV-1 vaccination impacts post-infection antibody responses.

Mdluli, Thembi; Jian, Ningbo; Slike, Bonnie; Paquin-Proulx, Dominic; Donofrio, Gina; Alrubayyi, Aljawharah; Gift, Syna; Grande, Rebecca; Bryson, Mary; Lee, Anna; Dussupt, Vincent; Mendez-Riveria, Letzibeth; Sanders-Buell, Eric; Chenine, Agnès-Laurence; Tran, Ursula; Li, Yifan; Brown, Eric; Edlefsen, Paul T; O'Connell, Robert; Gilbert, Peter; Nitayaphan, Sorachai; Pitisuttihum, Punnee; Rerks-Ngarm, Supachai; Robb, Merlin L; Gramzinski, Robert; Alter, Galit; Tovanabutra, Sodsai; Georgiev, Ivelin S; Ackerman, Margaret E; Polonis, Victoria R; Vasan, Sandhya; Michael, Nelson L; Kim, Jerome H; Eller, Michael A; Krebs, Shelly J; Rolland, Morgane.

PLoS Pathog; 16(12): e1009101, 2020 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-33290394

18.

PKCÎµ associates with the Kv3.4 channel to promote its expression in a kinase activity-dependent manner.

Zemel, Benjamin M; Zhi, Lianteng; Brown, Eric V; Tymanskyj, Stephen R; Liang, Qiansheng; Covarrubias, Manuel.

FASEB J; 35(1): e21241, 2021 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-33368632

19.

Hydroxylase Inhibition Selectively Induces Cell Death in Monocytes.

Crifo, Bianca; Schaible, Bettina; Brown, Eric; Halligan, Doug N; Scholz, Carsten C; Fitzpatrick, Susan F; Kirwan, Anna; Roche, Helen M; Criscuoli, Mattia; Naldini, Antonella; Giffney, Hugh; Crean, Daniel; Blanco, Alfonso; Cavadas, Miguel A; Cummins, Eoin P; Fabian, Zsolt; Taylor, Cormac T.

J Immunol; 202(5): 1521-1530, 2019 03 01.

Artículo en Inglés | MEDLINE | ID: mdl-30700584

20.

Novel antibody-antibiotic conjugate eliminates intracellular S. aureus.

Lehar, Sophie M; Pillow, Thomas; Xu, Min; Staben, Leanna; Kajihara, Kimberly K; Vandlen, Richard; DePalatis, Laura; Raab, Helga; Hazenbos, Wouter L; Morisaki, J Hiroshi; Kim, Janice; Park, Summer; Darwish, Martine; Lee, Byoung-Chul; Hernandez, Hilda; Loyet, Kelly M; Lupardus, Patrick; Fong, Rina; Yan, Donghong; Chalouni, Cecile; Luis, Elizabeth; Khalfin, Yana; Plise, Emile; Cheong, Jonathan; Lyssikatos, Joseph P; Strandh, Magnus; Koefoed, Klaus; Andersen, Peter S; Flygare, John A; Wah Tan, Man; Brown, Eric J; Mariathasan, Sanjeev.

Nature; 527(7578): 323-8, 2015 Nov 19.

Artículo en Inglés | MEDLINE | ID: mdl-26536114

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Gut Microbiota Regulation of T Cells During Inflammation and Autoimmunity.

NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion.

A Deep Learning Approach to Antibiotic Discovery.

A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria.

A Deep Learning Approach to Antibiotic Discovery.

Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells.

Genome-wide Identification of Structure-Forming Repeats as Principal Sites of Fork Collapse upon ATR Inhibition.

The role of the immune system in governing host-microbe interactions in the intestine.

Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation.

Chocolate habits of Nobel prizewinners.

A multiplexable assay for screening antibiotic lethality against drug-tolerant bacteria.

Discovery of an antivirulence compound that reverses ß-lactam resistance in MRSA.

Antibacterial drug discovery in the resistance era.

Crystallographic analysis of Staphylococcus aureus LcpA, the primary wall teichoic acid ligase.

Global proteomics of Ubqln2-based murine models of ALS.

Structure and mechanism of TagA, a novel membrane-associated glycosyltransferase that produces wall teichoic acids in pathogenic bacteria.

RV144 HIV-1 vaccination impacts post-infection antibody responses.

PKCÎµ associates with the Kv3.4 channel to promote its expression in a kinase activity-dependent manner.

Hydroxylase Inhibition Selectively Induces Cell Death in Monocytes.

Novel antibody-antibiotic conjugate eliminates intracellular S. aureus.