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1.

SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses.

Banerjee, Abhik K; Blanco, Mario R; Bruce, Emily A; Honson, Drew D; Chen, Linlin M; Chow, Amy; Bhat, Prashant; Ollikainen, Noah; Quinodoz, Sofia A; Loney, Colin; Thai, Jasmine; Miller, Zachary D; Lin, Aaron E; Schmidt, Madaline M; Stewart, Douglas G; Goldfarb, Daniel; De Lorenzo, Giuditta; Rihn, Suzannah J; Voorhees, Rebecca M; Botten, Jason W; Majumdar, Devdoot; Guttman, Mitchell.

Cell; 183(5): 1325-1339.e21, 2020 11 25.

Artículo en Inglés | MEDLINE | ID: mdl-33080218

2.

Direct RT-qPCR detection of SARS-CoV-2 RNA from patient nasopharyngeal swabs without an RNA extraction step.

Bruce, Emily A; Huang, Meei-Li; Perchetti, Garrett A; Tighe, Scott; Laaguiby, Pheobe; Hoffman, Jessica J; Gerrard, Diana L; Nalla, Arun K; Wei, Yulun; Greninger, Alexander L; Diehl, Sean A; Shirley, David J; Leonard, Debra G B; Huston, Christopher D; Kirkpatrick, Beth D; Dragon, Julie A; Crothers, Jessica W; Jerome, Keith R; Botten, Jason W.

PLoS Biol; 18(10): e3000896, 2020 10.

Artículo en Inglés | MEDLINE | ID: mdl-33006983

3.

NEDD4 family ubiquitin ligases associate with LCMV Z's PPXY domain and are required for virus budding, but not via direct ubiquitination of Z.

Ziegler, Christopher M; Dang, Loan; Eisenhauer, Philip; Kelly, Jamie A; King, Benjamin R; Klaus, Joseph P; Manuelyan, Inessa; Mattice, Ethan B; Shirley, David J; Weir, Marion E; Bruce, Emily A; Ballif, Bryan A; Botten, Jason.

PLoS Pathog; 15(11): e1008100, 2019 11.

Artículo en Inglés | MEDLINE | ID: mdl-31710650

4.

Visualization of Arenavirus RNA Species in Individual Cells by Single-Molecule Fluorescence In Situ Hybridization Suggests a Model of Cyclical Infection and Clearance during Persistence.

King, Benjamin R; Samacoits, Aubin; Eisenhauer, Philip L; Ziegler, Christopher M; Bruce, Emily A; Zenklusen, Daniel; Zimmer, Christophe; Mueller, Florian; Botten, Jason.

J Virol; 92(12)2018 06 15.

Artículo en Inglés | MEDLINE | ID: mdl-29643234

5.

A Proteomics Survey of Junín Virus Interactions with Human Proteins Reveals Host Factors Required for Arenavirus Replication.

Ziegler, Christopher M; Eisenhauer, Philip; Kelly, Jamie A; Dang, Loan N; Beganovic, Vedran; Bruce, Emily A; King, Benjamin R; Shirley, David J; Weir, Marion E; Ballif, Bryan A; Botten, Jason.

J Virol; 92(4)2018 02 15.

Artículo en Inglés | MEDLINE | ID: mdl-29187543

6.

The use of novel epitope-tagged arenaviruses reveals that Rab5c-positive endosomal membranes are targeted by the LCMV matrix protein.

Ziegler, Christopher M; Bruce, Emily A; Kelly, Jamie A; King, Benjamin R; Botten, Jason W.

J Gen Virol; 99(2): 187-193, 2018 02.

Artículo en Inglés | MEDLINE | ID: mdl-29393022

7.

A Map of the Arenavirus Nucleoprotein-Host Protein Interactome Reveals that Junín Virus Selectively Impairs the Antiviral Activity of Double-Stranded RNA-Activated Protein Kinase (PKR).

King, Benjamin R; Hershkowitz, Dylan; Eisenhauer, Philip L; Weir, Marion E; Ziegler, Christopher M; Russo, Joanne; Bruce, Emily A; Ballif, Bryan A; Botten, Jason.

J Virol; 91(15)2017 08 01.

Artículo en Inglés | MEDLINE | ID: mdl-28539447

8.

The Lymphocytic Choriomeningitis Virus Matrix Protein PPXY Late Domain Drives the Production of Defective Interfering Particles.

Ziegler, Christopher M; Eisenhauer, Philip; Bruce, Emily A; Weir, Marion E; King, Benjamin R; Klaus, Joseph P; Krementsov, Dimitry N; Shirley, David J; Ballif, Bryan A; Botten, Jason.

PLoS Pathog; 12(3): e1005501, 2016 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-27010636

9.

Visualization of the lymphocytic choriomeningitis mammarenavirus (LCMV) genome reveals the early endosome as a possible site for genome replication and viral particle pre-assembly.

King, Benjamin R; Kellner, Samuel; Eisenhauer, Philip L; Bruce, Emily A; Ziegler, Christopher M; Zenklusen, Daniel; Botten, Jason William.

J Gen Virol; 98(10): 2454-2460, 2017 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-28949905

10.

A novel phosphoserine motif in the LCMV matrix protein Z regulates the release of infectious virus and defective interfering particles.

Ziegler, Christopher M; Eisenhauer, Philip; Bruce, Emily A; Beganovic, Vedran; King, Benjamin R; Weir, Marion E; Ballif, Bryan A; Botten, Jason.

J Gen Virol; 97(9): 2084-2089, 2016 09.

Artículo en Inglés | MEDLINE | ID: mdl-27421645

11.

The major cellular sterol regulatory pathway is required for Andes virus infection.

Petersen, Josiah; Drake, Mary Jane; Bruce, Emily A; Riblett, Amber M; Didigu, Chukwuka A; Wilen, Craig B; Malani, Nirav; Male, Frances; Lee, Fang-Hua; Bushman, Frederic D; Cherry, Sara; Doms, Robert W; Bates, Paul; Briley, Kenneth.

PLoS Pathog; 10(2): e1003911, 2014 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-24516383

12.

Release of filamentous and spherical influenza A virus is not restricted by tetherin.

Bruce, Emily A; Abbink, Truus E; Wise, Helen M; Rollason, Ruth; Galao, Rui Pedro; Banting, George; Neil, Stuart J; Digard, Paul.

J Gen Virol; 93(Pt 5): 963-969, 2012 May.

Artículo en Inglés | MEDLINE | ID: mdl-22258861

13.

A Rab11- and microtubule-dependent mechanism for cytoplasmic transport of influenza A virus viral RNA.

Amorim, Maria Joao; Bruce, Emily A; Read, Eliot K C; Foeglein, Agnes; Mahen, Robert; Stuart, Amanda D; Digard, Paul.

J Virol; 85(9): 4143-56, 2011 May.

Artículo en Inglés | MEDLINE | ID: mdl-21307188

14.

Role of the Rab11 pathway in negative-strand virus assembly.

Bruce, Emily A; Stuart, Amanda; McCaffrey, Mary W; Digard, Paul.

Biochem Soc Trans; 40(6): 1409-15, 2012 Dec 01.

Artículo en Inglés | MEDLINE | ID: mdl-23176490

15.

The Rab11 pathway is required for influenza A virus budding and filament formation.

Bruce, Emily A; Digard, Paul; Stuart, Amanda D.

J Virol; 84(12): 5848-59, 2010 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-20357086

16.

'All In': a pragmatic framework for COVID-19 testing and action on a global scale.

Pettit, Syril D; Jerome, Keith R; Rouquié, David; Mari, Bernard; Barbry, Pascal; Kanda, Yasunari; Matsumoto, Mineo; Hester, Susan; Wehmas, Leah; Botten, Jason W; Bruce, Emily A.

EMBO Mol Med; 12(6): e12634, 2020 06 08.

Artículo en Inglés | MEDLINE | ID: mdl-32375201

17.

DIRECT RT-qPCR DETECTION OF SARS-CoV-2 RNA FROM PATIENT NASOPHARYNGEAL SWABS WITHOUT AN RNA EXTRACTION STEP.

Bruce, Emily A; Huang, Meei-Li; Perchetti, Garrett A; Tighe, Scott; Laaguiby, Pheobe; Hoffman, Jessica J; Gerrard, Diana L; Nalla, Arun K; Wei, Yulun; Greninger, Alexander L; Diehl, Sean A; Shirley, David J; Leonard, Debra G B; Huston, Christopher D; Kirkpatrick, Beth D; Dragon, Julie A; Crothers, Jessica W; Jerome, Keith R; Botten, Jason W.

bioRxiv; 2020 Apr 06.

Artículo en Inglés | MEDLINE | ID: mdl-32511328

18.

Kinetics and Isotype Assessment of Antibodies Targeting the Spike Protein Receptor Binding Domain of SARS-CoV-2 In COVID-19 Patients as a function of Age and Biological Sex.

Graham, Nancy R; Whitaker, Annalis N; Strother, Camilla A; Miles, Ashley K; Grier, Dore; McElvany, Benjamin D; Bruce, Emily A; Poynter, Matthew E; Pierce, Kristen K; Kirkpatrick, Beth D; Stapleton, Renee D; An, Gary; Botten, Jason W; Crothers, Jessica W; Diehl, Sean A.

medRxiv; 2020 Jul 16.

Artículo en Inglés | MEDLINE | ID: mdl-32743592

19.

Kinetics and isotype assessment of antibodies targeting the spike protein receptor-binding domain of severe acute respiratory syndrome-coronavirus-2 in COVID-19 patients as a function of age, biological sex and disease severity.

Graham, Nancy R; Whitaker, Annalis N; Strother, Camilla A; Miles, Ashley K; Grier, Dore; McElvany, Benjamin D; Bruce, Emily A; Poynter, Matthew E; Pierce, Kristen K; Kirkpatrick, Beth D; Stapleton, Renee D; An, Gary; van den Broek-Altenburg, Eline; Botten, Jason W; Crothers, Jessica W; Diehl, Sean A.

Clin Transl Immunology; 9(10): e1189, 2020.

Artículo en Inglés | MEDLINE | ID: mdl-33072323

20.

Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro.

Drayman, Nir; Jones, Krysten A; Azizi, Saara-Anne; Froggatt, Heather M; Tan, Kemin; Maltseva, Natalia Ivanovna; Chen, Siquan; Nicolaescu, Vlad; Dvorkin, Steve; Furlong, Kevin; Kathayat, Rahul S; Firpo, Mason R; Mastrodomenico, Vincent; Bruce, Emily A; Schmidt, Madaline M; Jedrzejczak, Robert; Muñoz-Alía, Miguel Á; Schuster, Brooke; Nair, Vishnu; Botten, Jason W; Brooke, Christopher B; Baker, Susan C; Mounce, Bryan C; Heaton, Nicholas S; Dickinson, Bryan C; Jaochimiak, Andrzej; Randall, Glenn; Tay, Savas.

bioRxiv; 2020 Sep 01.

Artículo en Inglés | MEDLINE | ID: mdl-32908976

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