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1.

Clofazimine broadly inhibits coronaviruses including SARS-CoV-2.

Yuan, Shuofeng; Yin, Xin; Meng, Xiangzhi; Chan, Jasper Fuk-Woo; Ye, Zi-Wei; Riva, Laura; Pache, Lars; Chan, Chris Chun-Yiu; Lai, Pok-Man; Chan, Chris Chung-Sing; Poon, Vincent Kwok-Man; Lee, Andrew Chak-Yiu; Matsunaga, Naoko; Pu, Yuan; Yuen, Chun-Kit; Cao, Jianli; Liang, Ronghui; Tang, Kaiming; Sheng, Li; Du, Yushen; Xu, Wan; Lau, Chit-Ying; Sit, Ko-Yung; Au, Wing-Kuk; Wang, Runming; Zhang, Yu-Yuan; Tang, Yan-Dong; Clausen, Thomas Mandel; Pihl, Jessica; Oh, Juntaek; Sze, Kong-Hung; Zhang, Anna Jinxia; Chu, Hin; Kok, Kin-Hang; Wang, Dong; Cai, Xue-Hui; Esko, Jeffrey D; Hung, Ivan Fan-Ngai; Li, Ronald Adolphus; Chen, Honglin; Sun, Hongzhe; Jin, Dong-Yan; Sun, Ren; Chanda, Sumit K; Yuen, Kwok-Yung.

Nature; 2021 Mar 16.

Artículo en Inglés | MEDLINE | ID: mdl-33727703

2.

Co-infection by severe acute respiratory syndrome coronavirus 2 and influenza A(H1N1)pdm09 virus enhances the severity of pneumonia in golden Syrian hamsters.

Zhang, Anna Jinxia; Lee, Andrew Chak-Yiu; Chan, Jasper Fuk-Woo; Liu, Feifei; Li, Can; Chen, Yanxia; Chu, Hin; Lau, Siu-Ying; Wang, Pui; Chan, Chris Chung-Sing; Poon, Vincent Kwok-Man; Yuan, Shuofeng; To, Kelvin Kai-Wang; Chen, Honglin; Yuen, Kwok-Yung.

Clin Infect Dis; 2020 Nov 20.

Artículo en Inglés | MEDLINE | ID: mdl-33216851

3.

SARS-CoV-2 infects and damages the mature and immature olfactory sensory neurons of hamsters.

Zhang, Anna Jinxia; Lee, Andrew Chak-Yiu; Chu, Hin; Chan, Jasper Fuk-Woo; Fan, Zhimeng; Li, Can; Liu, Feifei; Chen, Yanxia; Yuan, Shuofeng; Poon, Vincent Kwok-Man; Chan, Chris Chung-Sing; Cai, Jian-Piao; Wu, Kenneth Lap-Kei; Sridhar, Siddharth; Chan, Ying-Shing; Yuen, Kwok-Yung.

Clin Infect Dis; 2020 Jul 15.

Artículo en Inglés | MEDLINE | ID: mdl-32667973

4.

Simulation of the Clinical and Pathological Manifestations of Coronavirus Disease 2019 (COVID-19) in a Golden Syrian Hamster Model: Implications for Disease Pathogenesis and Transmissibility.

Chan, Jasper Fuk-Woo; Zhang, Anna Jinxia; Yuan, Shuofeng; Poon, Vincent Kwok-Man; Chan, Chris Chung-Sing; Lee, Andrew Chak-Yiu; Chan, Wan-Mui; Fan, Zhimeng; Tsoi, Hoi-Wah; Wen, Lei; Liang, Ronghui; Cao, Jianli; Chen, Yanxia; Tang, Kaiming; Luo, Cuiting; Cai, Jian-Piao; Kok, Kin-Hang; Chu, Hin; Chan, Kwok-Hung; Sridhar, Siddharth; Chen, Zhiwei; Chen, Honglin; To, Kelvin Kai-Wang; Yuen, Kwok-Yung.

Clin Infect Dis; 71(9): 2428-2446, 2020 12 03.

Artículo en Inglés | MEDLINE | ID: mdl-32215622

5.

Surgical Mask Partition Reduces the Risk of Noncontact Transmission in a Golden Syrian Hamster Model for Coronavirus Disease 2019 (COVID-19).

Chan, Jasper Fuk-Woo; Yuan, Shuofeng; Zhang, Anna Jinxia; Poon, Vincent Kwok-Man; Chan, Chris Chung-Sing; Lee, Andrew Chak-Yiu; Fan, Zhimeng; Li, Can; Liang, Ronghui; Cao, Jianli; Tang, Kaiming; Luo, Cuiting; Cheng, Vincent Chi-Chung; Cai, Jian-Piao; Chu, Hin; Chan, Kwok-Hung; To, Kelvin Kai-Wang; Sridhar, Siddharth; Yuen, Kwok-Yung.

Clin Infect Dis; 71(16): 2139-2149, 2020 11 19.

Artículo en Inglés | MEDLINE | ID: mdl-32472679

6.

Immunization With a Novel Human Type 5 Adenovirus-Vectored Vaccine Expressing the Premembrane and Envelope Proteins of Zika Virus Provides Consistent and Sterilizing Protection in Multiple Immunocompetent and Immunocompromised Animal Models.

Guo, Qiang; Chan, Jasper Fuk-Woo; Poon, Vincent Kwok-Man; Wu, Shipo; Chan, Chris Chung-Sing; Hou, Lihua; Yip, Cyril Chik-Yan; Ren, Changpeng; Cai, Jian-Piao; Zhao, Mengsu; Zhang, Anna Jinxia; Song, Xiaohong; Chan, Kwok-Hung; Wang, Busen; Kok, Kin-Hang; Wen, Yanbo; Yuen, Kwok-Yung; Chen, Wei.

J Infect Dis; 218(3): 365-377, 2018 07 02.

Artículo en Inglés | MEDLINE | ID: mdl-29617816

7.

Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5'-untranslated region of Zika virus.

Chan, Jasper Fuk-Woo; Yip, Cyril Chik-Yan; Tee, Kah-Meng; Zhu, Zheng; Tsang, Jessica Oi-Ling; Chik, Kenn Ka-Heng; Tsang, Terance Gi-Wai; Chan, Chris Chung-Sing; Poon, Vincent Kwok-Man; Sridhar, Siddharth; Yin, Feifei; Hung, Ivan Fan-Ngai; Chau, Sandy Ka-Yee; Zhang, Anna Jinxia; Chan, Kwok-Hung; Yuen, Kwok-Yung.

Trop Med Int Health; 22(5): 594-603, 2017 05.

Artículo en Inglés | MEDLINE | ID: mdl-28214373

8.

Beneficial effect of combinational methylprednisolone and remdesivir in hamster model of SARS-CoV-2 infection.

Ye, Zi-Wei; Yuan, Shuofeng; Chan, Jasper Fuk-Woo; Zhang, Anna Jinxia; Yu, Ching-Yun; Ong, Chon Phin; Yang, Dong; Chan, Chris Chun-Yiu; Tang, Kaiming; Cao, Jianli; Poon, Vincent Kwok-Man; Chan, Chris Chung-Sing; Cai, Jian-Piao; Chu, Hin; Yuen, Kwok-Yung; Jin, Dong-Yan.

Emerg Microbes Infect; 10(1): 291-304, 2021 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-33538646

9.

Cross-linking peptide and repurposed drugs inhibit both entry pathways of SARS-CoV-2.

Zhao, Hanjun; To, Kelvin K W; Lam, Hoiyan; Zhou, Xinxin; Chan, Jasper Fuk-Woo; Peng, Zheng; Lee, Andrew C Y; Cai, Jianpiao; Chan, Wan-Mui; Ip, Jonathan Daniel; Chan, Chris Chung-Sing; Yeung, Man Lung; Zhang, Anna Jinxia; Chu, Allen Wing Ho; Jiang, Shibo; Yuen, Kwok-Yung.

Nat Commun; 12(1): 1517, 2021 03 09.

Artículo en Inglés | MEDLINE | ID: mdl-33750821

10.

Robust SARS-CoV-2 infection in nasal turbinates after treatment with systemic neutralizing antibodies.

Zhou, Dongyan; Chan, Jasper Fuk-Woo; Zhou, Biao; Zhou, Runhong; Li, Shuang; Shan, Sisi; Liu, Li; Zhang, Anna Jinxia; Chen, Serena J; Chan, Chris Chung-Sing; Xu, Haoran; Poon, Vincent Kwok-Man; Yuan, Shuofeng; Li, Cun; Chik, Kenn Ka-Heng; Chan, Chris Chun-Yiu; Cao, Jianli; Chan, Chun-Yin; Kwan, Ka-Yi; Du, Zhenglong; Lau, Thomas Tsz-Kan; Zhang, Qi; Zhou, Jie; To, Kelvin Kai-Wang; Zhang, Linqi; Ho, David D; Yuen, Kwok-Yung; Chen, Zhiwei.

Cell Host Microbe; 29(4): 551-563.e5, 2021 04 14.

Artículo en Inglés | MEDLINE | ID: mdl-33657424

11.

Oral SARS-CoV-2 Inoculation Establishes Subclinical Respiratory Infection with Virus Shedding in Golden Syrian Hamsters.

Lee, Andrew Chak-Yiu; Zhang, Anna Jinxia; Chan, Jasper Fuk-Woo; Li, Can; Fan, Zhimeng; Liu, Feifei; Chen, Yanxia; Liang, Ronghui; Sridhar, Siddharth; Cai, Jian-Piao; Poon, Vincent Kwok-Man; Chan, Chris Chung-Sing; To, Kelvin Kai-Wang; Yuan, Shuofeng; Zhou, Jie; Chu, Hin; Yuen, Kwok-Yung.

Cell Rep Med; 1(7): 100121, 2020 Oct 20.

Artículo en Inglés | MEDLINE | ID: mdl-32984855

12.

SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target.

Yuan, Shuofeng; Chu, Hin; Chan, Jasper Fuk-Woo; Ye, Zi-Wei; Wen, Lei; Yan, Bingpeng; Lai, Pok-Man; Tee, Kah-Meng; Huang, Jingjing; Chen, Dongdong; Li, Cun; Zhao, Xiaoyu; Yang, Dong; Chiu, Man Chun; Yip, Cyril; Poon, Vincent Kwok-Man; Chan, Chris Chung-Sing; Sze, Kong-Hung; Zhou, Jie; Chan, Ivy Hau-Yee; Kok, Kin-Hang; To, Kelvin Kai-Wang; Kao, Richard Yi-Tsun; Lau, Johnson Yiu-Nam; Jin, Dong-Yan; Perlman, Stanley; Yuen, Kwok-Yung.

Nat Commun; 10(1): 120, 2019 01 10.

Artículo en Inglés | MEDLINE | ID: mdl-30631056

13.

The celecoxib derivative kinase inhibitor AR-12 (OSU-03012) inhibits Zika virus via down-regulation of the PI3K/Akt pathway and protects Zika virus-infected A129 mice: A host-targeting treatment strategy.

Chan, Jasper Fuk-Woo; Zhu, Zheng; Chu, Hin; Yuan, Shuofeng; Chik, Kenn Ka-Heng; Chan, Chris Chung-Sing; Poon, Vincent Kwok-Man; Yip, Cyril Chik-Yan; Zhang, Xi; Tsang, Jessica Oi-Ling; Zou, Zijiao; Tee, Kah-Meng; Shuai, Huiping; Lu, Gang; Yuen, Kwok-Yung.

Antiviral Res; 160: 38-47, 2018 12.

Artículo en Inglés | MEDLINE | ID: mdl-30326204

14.

Novel antiviral activity and mechanism of bromocriptine as a Zika virus NS2B-NS3 protease inhibitor.

Chan, Jasper Fuk-Woo; Chik, Kenn Ka-Heng; Yuan, Shuofeng; Yip, Cyril Chik-Yan; Zhu, Zheng; Tee, Kah-Meng; Tsang, Jessica Oi-Ling; Chan, Chris Chung-Sing; Poon, Vincent Kwok-Man; Lu, Gang; Zhang, Anna Jinxia; Lai, Kin-Kui; Chan, Kwok-Hung; Kao, Richard Yi-Tsun; Yuen, Kwok-Yung.

Antiviral Res; 141: 29-37, 2017 05.

Artículo en Inglés | MEDLINE | ID: mdl-28185815

15.

Structure-based discovery of clinically approved drugs as Zika virus NS2B-NS3 protease inhibitors that potently inhibit Zika virus infection in vitro and in vivo.

Yuan, Shuofeng; Chan, Jasper Fuk-Woo; den-Haan, Helena; Chik, Kenn Ka-Heng; Zhang, Anna Jinxia; Chan, Chris Chung-Sing; Poon, Vincent Kwok-Man; Yip, Cyril Chik-Yan; Mak, Winger Wing-Nga; Zhu, Zheng; Zou, Zijiao; Tee, Kah-Meng; Cai, Jian-Piao; Chan, Kwok-Hung; de la Peña, Jorge; Pérez-Sánchez, Horacio; Cerón-Carrasco, José Pedro; Yuen, Kwok-Yung.

Antiviral Res; 145: 33-43, 2017 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-28712942

16.

A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses.

Zhao, Hanjun; Zhou, Jie; Zhang, Ke; Chu, Hin; Liu, Dabin; Poon, Vincent Kwok-Man; Chan, Chris Chung-Sing; Leung, Ho-Chuen; Fai, Ng; Lin, Yong-Ping; Zhang, Anna Jin-Xia; Jin, Dong-Yan; Yuen, Kwok-Yung; Zheng, Bo-Jian.

Sci Rep; 6: 22008, 2016 Feb 25.

Artículo en Inglés | MEDLINE | ID: mdl-26911565

17.

Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons.

Chan, Jasper Fuk-Woo; Zhang, Anna Jinxia; Chan, Chris Chung-Sing; Yip, Cyril Chik-Yan; Mak, Winger Wing-Nga; Zhu, Houshun; Poon, Vincent Kwok-Man; Tee, Kah-Meng; Zhu, Zheng; Cai, Jian-Piao; Tsang, Jessica Oi-Ling; Chik, Kenn Ka-Heng; Yin, Feifei; Chan, Kwok-Hung; Kok, Kin-Hang; Jin, Dong-Yan; Au-Yeung, Rex Kwok-Him; Yuen, Kwok-Yung.

EBioMedicine; 14: 112-122, 2016 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-27884655

18.

Differential cell line susceptibility to the emerging Zika virus: implications for disease pathogenesis, non-vector-borne human transmission and animal reservoirs.

Chan, Jasper Fuk-Woo; Yip, Cyril Chik-Yan; Tsang, Jessica Oi-Ling; Tee, Kah-Meng; Cai, Jian-Piao; Chik, Kenn Ka-Heng; Zhu, Zheng; Chan, Chris Chung-Sing; Choi, Garnet Kwan-Yue; Sridhar, Siddharth; Zhang, Anna Jinxia; Lu, Gang; Chiu, Kin; Lo, Amy Cheuk-Yin; Tsao, Sai-Wah; Kok, Kin-Hang; Jin, Dong-Yan; Chan, Kwok-Hung; Yuen, Kwok-Yung.

Emerg Microbes Infect; 5: e93, 2016 Aug 24.

Artículo en Inglés | MEDLINE | ID: mdl-27553173

19.

An H5N1-based matrix protein 2 ectodomain tetrameric peptide vaccine provides cross-protection against lethal infection with H7N9 influenza virus.

Leung, Ho-Chuen; Chan, Chris Chung-Sing; Poon, Vincent Kwok-Man; Zhao, Han-Jun; Cheung, Chung-Yan; Ng, Fai; Huang, Jian-Dong; Zheng, Bo-Jian.

Emerg Microbes Infect; 4(4): e22, 2015 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-26038770

20.

A novel CCR5 mutation selectively affects immunoreactivity and fusogenic property of the HIV co-receptor.

Zhao, Xiu-Ying; Lee, Shui-Shan; Wong, Ka-Hing; Chan, Kenny Chi-Wai; He, Zhi-Min; Ma, Selene; Ng, Fai; Chan, Chris Chung-Sing; Ho, Tina; Ng, Mun-Hon; Zheng, Bo-Jian.

AIDS; 18(12): 1729-32, 2004 Aug 20.

Artículo en Inglés | MEDLINE | ID: mdl-15280786

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