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1.

Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing.

Riva, Laura; Yuan, Shuofeng; Yin, Xin; Martin-Sancho, Laura; Matsunaga, Naoko; Pache, Lars; Burgstaller-Muehlbacher, Sebastian; De Jesus, Paul D; Teriete, Peter; Hull, Mitchell V; Chang, Max W; Chan, Jasper Fuk-Woo; Cao, Jianli; Poon, Vincent Kwok-Man; Herbert, Kristina M; Cheng, Kuoyuan; Nguyen, Tu-Trinh H; Rubanov, Andrey; Pu, Yuan; Nguyen, Courtney; Choi, Angela; Rathnasinghe, Raveen; Schotsaert, Michael; Miorin, Lisa; Dejosez, Marion; Zwaka, Thomas P; Sit, Ko-Yung; Martinez-Sobrido, Luis; Liu, Wen-Chun; White, Kris M; Chapman, Mackenzie E; Lendy, Emma K; Glynne, Richard J; Albrecht, Randy; Ruppin, Eytan; Mesecar, Andrew D; Johnson, Jeffrey R; Benner, Christopher; Sun, Ren; Schultz, Peter G; Su, Andrew I; García-Sastre, Adolfo; Chatterjee, Arnab K; Yuen, Kwok-Yung; Chanda, Sumit K.

Nature; 586(7827): 113-119, 2020 10.

Artículo en Inglés | MEDLINE | ID: mdl-32707573

2.

Absence of vaccine-enhanced disease with unexpected positive protection against SARS-CoV-2 by inactivated vaccine given within three days of virus challenge in Syrian hamster model.

Li, Can; Chen, Yan-Xia; Liu, Fei-Fei; Lee, Andrew Chak-Yiu; Zhao, Yan; Ye, Zhan-Hong; Cai, Jian-Piao; Chu, Hin; Zhang, Rui-Qi; Chan, Kwok-Hung; Chiu, Kelvin Hei-Yeung; Lung, David Christopher; Sridhar, Siddharth; Hung, Ivan Fan-Ngai; To, Kelvin Kai-Wang; Zhang, Anna Jin-Xia; Chan, Jasper Fuk-Woo; Yuen, Kwok-Yung.

Clin Infect Dis; 2021 Jan 30.

Artículo en Inglés | MEDLINE | ID: mdl-33515458

3.

A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster.

Chan, Jasper Fuk-Woo; Yuan, Shuofeng; Kok, Kin-Hang; To, Kelvin Kai-Wang; Chu, Hin; Yang, Jin; Xing, Fanfan; Liu, Jieling; Yip, Cyril Chik-Yan; Poon, Rosana Wing-Shan; Tsoi, Hoi-Wah; Lo, Simon Kam-Fai; Chan, Kwok-Hung; Poon, Vincent Kwok-Man; Chan, Wan-Mui; Ip, Jonathan Daniel; Cai, Jian-Piao; Cheng, Vincent Chi-Chung; Chen, Honglin; Hui, Christopher Kim-Ming; Yuen, Kwok-Yung.

Lancet; 395(10223): 514-523, 2020 02 15.

Artículo en Inglés | MEDLINE | ID: mdl-31986261

4.

Triple combination of interferon beta-1b, lopinavir-ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial.

Hung, Ivan Fan-Ngai; Lung, Kwok-Cheung; Tso, Eugene Yuk-Keung; Liu, Raymond; Chung, Tom Wai-Hin; Chu, Man-Yee; Ng, Yuk-Yung; Lo, Jenny; Chan, Jacky; Tam, Anthony Raymond; Shum, Hoi-Ping; Chan, Veronica; Wu, Alan Ka-Lun; Sin, Kit-Man; Leung, Wai-Shing; Law, Wai-Lam; Lung, David Christopher; Sin, Simon; Yeung, Pauline; Yip, Cyril Chik-Yan; Zhang, Ricky Ruiqi; Fung, Agnes Yim-Fong; Yan, Erica Yuen-Wing; Leung, Kit-Hang; Ip, Jonathan Daniel; Chu, Allen Wing-Ho; Chan, Wan-Mui; Ng, Anthony Chin-Ki; Lee, Rodney; Fung, Kitty; Yeung, Alwin; Wu, Tak-Chiu; Chan, Johnny Wai-Man; Yan, Wing-Wah; Chan, Wai-Ming; Chan, Jasper Fuk-Woo; Lie, Albert Kwok-Wai; Tsang, Owen Tak-Yin; Cheng, Vincent Chi-Chung; Que, Tak-Lun; Lau, Chak-Sing; Chan, Kwok-Hung; To, Kelvin Kai-Wang; Yuen, Kwok-Yung.

Lancet; 395(10238): 1695-1704, 2020 05 30.

Artículo en Inglés | MEDLINE | ID: mdl-32401715

5.

Transmission of Rat Hepatitis E Virus Infection to Humans in Hong Kong: A Clinical and Epidemiological Analysis.

Sridhar, Siddharth; Yip, Cyril Chik-Yan; Wu, Shusheng; Chew, Nicholas Foo-Siong; Leung, Kit-Hang; Chan, Jasper Fuk-Woo; Zhao, Pyrear Suhui; Chan, Wan-Mui; Poon, Rosana Wing-Shan; Tsoi, Hoi-Wah; Cai, Jian-Piao; Chan, Helen Shuk-Ying; Leung, Anthony Wai-Shing; Tse, Cindy Wing-Sze; Zee, Jonpaul Sze-Tsing; Tsang, Owen Tak-Yin; Cheng, Vincent Chi-Chung; Lau, Susanna Kar-Pui; Woo, Patrick Chiu-Yat; Tsang, Dominic Ngai-Chong; Yuen, Kwok-Yung.

Hepatology; 2020 Jan 20.

Artículo en Inglés | MEDLINE | ID: mdl-31960460

6.

Differentiated human airway organoids to assess infectivity of emerging influenza virus.

Zhou, Jie; Li, Cun; Sachs, Norman; Chiu, Man Chun; Wong, Bosco Ho-Yin; Chu, Hin; Poon, Vincent Kwok-Man; Wang, Dong; Zhao, Xiaoyu; Wen, Lei; Song, Wenjun; Yuan, Shuofeng; Wong, Kenneth Kak-Yuen; Chan, Jasper Fuk-Woo; To, Kelvin Kai-Wang; Chen, Honglin; Clevers, Hans; Yuen, Kwok-Yung.

Proc Natl Acad Sci U S A; 115(26): 6822-6827, 2018 06 26.

Artículo en Inglés | MEDLINE | ID: mdl-29891677

7.

Activation of C-Type Lectin Receptor and (RIG)-I-Like Receptors Contributes to Proinflammatory Response in Middle East Respiratory Syndrome Coronavirus-Infected Macrophages.

Zhao, Xiaoyu; Chu, Hin; Wong, Bosco Ho-Yin; Chiu, Man Chun; Wang, Dong; Li, Cun; Liu, Xiaojuan; Yang, Dong; Poon, Vincent Kwok-Man; Cai, Jianpiao; Chan, Jasper Fuk-Woo; To, Kelvin Kai-Wang; Zhou, Jie; Yuen, Kwok-Yung.

J Infect Dis; 221(4): 647-659, 2020 02 03.

Artículo en Inglés | MEDLINE | ID: mdl-31562757

8.

Attenuated Interferon and Proinflammatory Response in SARS-CoV-2-Infected Human Dendritic Cells Is Associated With Viral Antagonism of STAT1 Phosphorylation.

Yang, Dong; Chu, Hin; Hou, Yuxin; Chai, Yue; Shuai, Huiping; Lee, Andrew Chak-Yiu; Zhang, Xi; Wang, Yixin; Hu, Bingjie; Huang, Xiner; Yuen, Terrence Tsz-Tai; Cai, Jian-Piao; Zhou, Jie; Yuan, Shuofeng; Zhang, Anna Jinxia; Chan, Jasper Fuk-Woo; Yuen, Kwok-Yung.

J Infect Dis; 222(5): 734-745, 2020 08 04.

Artículo en Inglés | MEDLINE | ID: mdl-32563187

9.

Co-infection by severe acute respiratory syndrome coronavirus 2 and influenza A(H1N1)pdm09 virus enhances the severity of pneumonia in golden Syrian hamsters.

Zhang, Anna Jinxia; Lee, Andrew Chak-Yiu; Chan, Jasper Fuk-Woo; Liu, Feifei; Li, Can; Chen, Yanxia; Chu, Hin; Lau, Siu-Ying; Wang, Pui; Chan, Chris Chung-Sing; Poon, Vincent Kwok-Man; Yuan, Shuofeng; To, Kelvin Kai-Wang; Chen, Honglin; Yuen, Kwok-Yung.

Clin Infect Dis; 2020 Nov 20.

Artículo en Inglés | MEDLINE | ID: mdl-33216851

10.

SARS-CoV-2 infects and damages the mature and immature olfactory sensory neurons of hamsters.

Zhang, Anna Jinxia; Lee, Andrew Chak-Yiu; Chu, Hin; Chan, Jasper Fuk-Woo; Fan, Zhimeng; Li, Can; Liu, Feifei; Chen, Yanxia; Yuan, Shuofeng; Poon, Vincent Kwok-Man; Chan, Chris Chung-Sing; Cai, Jian-Piao; Wu, Kenneth Lap-Kei; Sridhar, Siddharth; Chan, Ying-Shing; Yuen, Kwok-Yung.

Clin Infect Dis; 2020 Jul 15.

Artículo en Inglés | MEDLINE | ID: mdl-32667973

11.

Consistent Detection of 2019 Novel Coronavirus in Saliva.

To, Kelvin Kai-Wang; Tsang, Owen Tak-Yin; Yip, Cyril Chik-Yan; Chan, Kwok-Hung; Wu, Tak-Chiu; Chan, Jacky Man-Chun; Leung, Wai-Shing; Chik, Thomas Shiu-Hong; Choi, Chris Yau-Chung; Kandamby, Darshana H; Lung, David Christopher; Tam, Anthony Raymond; Poon, Rosana Wing-Shan; Fung, Agnes Yim-Fong; Hung, Ivan Fan-Ngai; Cheng, Vincent Chi-Chung; Chan, Jasper Fuk-Woo; Yuen, Kwok-Yung.

Clin Infect Dis; 71(15): 841-843, 2020 07 28.

Artículo en Inglés | MEDLINE | ID: mdl-32047895

12.

Simulation of the Clinical and Pathological Manifestations of Coronavirus Disease 2019 (COVID-19) in a Golden Syrian Hamster Model: Implications for Disease Pathogenesis and Transmissibility.

Chan, Jasper Fuk-Woo; Zhang, Anna Jinxia; Yuan, Shuofeng; Poon, Vincent Kwok-Man; Chan, Chris Chung-Sing; Lee, Andrew Chak-Yiu; Chan, Wan-Mui; Fan, Zhimeng; Tsoi, Hoi-Wah; Wen, Lei; Liang, Ronghui; Cao, Jianli; Chen, Yanxia; Tang, Kaiming; Luo, Cuiting; Cai, Jian-Piao; Kok, Kin-Hang; Chu, Hin; Chan, Kwok-Hung; Sridhar, Siddharth; Chen, Zhiwei; Chen, Honglin; To, Kelvin Kai-Wang; Yuen, Kwok-Yung.

Clin Infect Dis; 71(9): 2428-2446, 2020 12 03.

Artículo en Inglés | MEDLINE | ID: mdl-32215622

13.

Surgical Mask Partition Reduces the Risk of Noncontact Transmission in a Golden Syrian Hamster Model for Coronavirus Disease 2019 (COVID-19).

Chan, Jasper Fuk-Woo; Yuan, Shuofeng; Zhang, Anna Jinxia; Poon, Vincent Kwok-Man; Chan, Chris Chung-Sing; Lee, Andrew Chak-Yiu; Fan, Zhimeng; Li, Can; Liang, Ronghui; Cao, Jianli; Tang, Kaiming; Luo, Cuiting; Cheng, Vincent Chi-Chung; Cai, Jian-Piao; Chu, Hin; Chan, Kwok-Hung; To, Kelvin Kai-Wang; Sridhar, Siddharth; Yuen, Kwok-Yung.

Clin Infect Dis; 71(16): 2139-2149, 2020 11 19.

Artículo en Inglés | MEDLINE | ID: mdl-32472679

14.

Comparative Replication and Immune Activation Profiles of SARS-CoV-2 and SARS-CoV in Human Lungs: An Ex Vivo Study With Implications for the Pathogenesis of COVID-19.

Chu, Hin; Chan, Jasper Fuk-Woo; Wang, Yixin; Yuen, Terrence Tsz-Tai; Chai, Yue; Hou, Yuxin; Shuai, Huiping; Yang, Dong; Hu, Bingjie; Huang, Xiner; Zhang, Xi; Cai, Jian-Piao; Zhou, Jie; Yuan, Shuofeng; Kok, Kin-Hang; To, Kelvin Kai-Wang; Chan, Ivy Hau-Yee; Zhang, Anna Jinxia; Sit, Ko-Yung; Au, Wing-Kuk; Yuen, Kwok-Yung.

Clin Infect Dis; 71(6): 1400-1409, 2020 09 12.

Artículo en Inglés | MEDLINE | ID: mdl-32270184

15.

Clinical Performance of the Luminex NxTAG CoV Extended Panel for SARS-CoV-2 Detection in Nasopharyngeal Specimens from COVID-19 Patients in Hong Kong.

Chen, Jonathan Hon-Kwan; Yip, Cyril Chik-Yan; Chan, Jasper Fuk-Woo; Poon, Rosana Wing-Shan; To, Kelvin Kai-Wang; Chan, Kwok-Hung; Cheng, Vincent Chi-Chung; Yuen, Kwok-Yung.

J Clin Microbiol; 58(8)2020 Jul 23.

Artículo en Inglés | MEDLINE | ID: mdl-32482633

16.

Improved Molecular Diagnosis of COVID-19 by the Novel, Highly Sensitive and Specific COVID-19-RdRp/Hel Real-Time Reverse Transcription-PCR Assay Validated In Vitro and with Clinical Specimens.

Chan, Jasper Fuk-Woo; Yip, Cyril Chik-Yan; To, Kelvin Kai-Wang; Tang, Tommy Hing-Cheung; Wong, Sally Cheuk-Ying; Leung, Kit-Hang; Fung, Agnes Yim-Fong; Ng, Anthony Chin-Ki; Zou, Zijiao; Tsoi, Hoi-Wah; Choi, Garnet Kwan-Yue; Tam, Anthony Raymond; Cheng, Vincent Chi-Chung; Chan, Kwok-Hung; Tsang, Owen Tak-Yin; Yuen, Kwok-Yung.

J Clin Microbiol; 58(5)2020 04 23.

Artículo en Inglés | MEDLINE | ID: mdl-32132196

17.

Identification of nsp1 gene as the target of SARS-CoV-2 real-time RT-PCR using nanopore whole-genome sequencing.

Chan, Wan-Mui; Ip, Jonathan Daniel; Chu, Allen Wing-Ho; Yip, Cyril Chik-Yan; Lo, Lap-Sum; Chan, Kwok-Hung; Ng, Anthony Chin-Ki; Poon, Rosana Wing-Shan; To, Wing-Kin; Tsang, Owen Tak-Yin; Leung, Wai-Shing; Kwan, Mike Yat-Wah; Chua, Gilbert T; Chung, Tom Wai-Hin; Hung, Ivan Fan-Ngai; Kok, Kin-Hang; Cheng, Vincent Chi-Chung; Chan, Jasper Fuk-Woo; Yuen, Kwok-Yung; To, Kelvin Kai-Wang.

J Med Virol; 92(11): 2725-2734, 2020 11.

Artículo en Inglés | MEDLINE | ID: mdl-32501535

18.

Detection of SARS-CoV-2 in conjunctival secretions from patients without ocular symptoms.

Li, Xin; Chan, Jasper Fuk-Woo; Li, Kenneth Kai-Wang; Tso, Eugene Yuk-Keung; Yip, Cyril Chik-Yan; Sridhar, Siddharth; Chung, Tom Wai-Hin; Chiu, Kelvin Hei-Yeung; Hung, Derek Ling-Lung; Wu, Alan Ka-Lun; Chau, Sandy Ka-Yee; Liu, Raymond; Lung, Kwok-Cheung; Tam, Anthony Raymond; Cheng, Vincent Chi-Chung; To, Kelvin Kai-Wang; Chan, Kwok-Hung; Hung, Ivan Fan-Ngai; Yuen, Kwok-Yung.

Infection; 2020 Sep 17.

Artículo en Inglés | MEDLINE | ID: mdl-32944840

19.

Development and Evaluation of Novel and Highly Sensitive Single-Tube Nested Real-Time RT-PCR Assays for SARS-CoV-2 Detection.

Yip, Cyril Chik-Yan; Sridhar, Siddharth; Leung, Kit-Hang; Ng, Anthony Chin-Ki; Chan, Kwok-Hung; Chan, Jasper Fuk-Woo; Tsang, Owen Tak-Yin; Hung, Ivan Fan-Ngai; Cheng, Vincent Chi-Chung; Yuen, Kwok-Yung; To, Kelvin Kai-Wang.

Int J Mol Sci; 21(16)2020 Aug 07.

Artículo en Inglés | MEDLINE | ID: mdl-32784770

20.

Development of a Novel, Genome Subtraction-Derived, SARS-CoV-2-Specific COVID-19-nsp2 Real-Time RT-PCR Assay and Its Evaluation Using Clinical Specimens.

Yip, Cyril Chik-Yan; Ho, Chi-Chun; Chan, Jasper Fuk-Woo; To, Kelvin Kai-Wang; Chan, Helen Shuk-Ying; Wong, Sally Cheuk-Ying; Leung, Kit-Hang; Fung, Agnes Yim-Fong; Ng, Anthony Chin-Ki; Zou, Zijiao; Tam, Anthony Raymond; Chung, Tom Wai-Hin; Chan, Kwok-Hung; Hung, Ivan Fan-Ngai; Cheng, Vincent Chi-Chung; Tsang, Owen Tak-Yin; Tsui, Stephen Kwok Wing; Yuen, Kwok-Yung.

Int J Mol Sci; 21(7)2020 Apr 08.

Artículo en Inglés | MEDLINE | ID: mdl-32276333

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