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1.

Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection.

Wei, Jin; Alfajaro, Mia Madel; DeWeirdt, Peter C; Hanna, Ruth E; Lu-Culligan, William J; Cai, Wesley L; Strine, Madison S; Zhang, Shang-Min; Graziano, Vincent R; Schmitz, Cameron O; Chen, Jennifer S; Mankowski, Madeleine C; Filler, Renata B; Ravindra, Neal G; Gasque, Victor; de Miguel, Fernando J; Patil, Ajinkya; Chen, Huacui; Oguntuyo, Kasopefoluwa Y; Abriola, Laura; Surovtseva, Yulia V; Orchard, Robert C; Lee, Benhur; Lindenbach, Brett D; Politi, Katerina; van Dijk, David; Kadoch, Cigall; Simon, Matthew D; Yan, Qin; Doench, John G; Wilen, Craig B.

Cell; 184(1): 76-91.e13, 2021 01 07.

Artículo en Inglés | MEDLINE | ID: mdl-33147444

2.

A Compendium of Genetic Modifiers of Mitochondrial Dysfunction Reveals Intra-organelle Buffering.

To, Tsz-Leung; Cuadros, Alejandro M; Shah, Hardik; Hung, Wendy H W; Li, Yang; Kim, Sharon H; Rubin, Daniel H F; Boe, Ryan H; Rath, Sneha; Eaton, John K; Piccioni, Federica; Goodale, Amy; Kalani, Zohra; Doench, John G; Root, David E; Schreiber, Stuart L; Vafai, Scott B; Mootha, Vamsi K.

Cell; 179(5): 1222-1238.e17, 2019 11 14.

Artículo en Inglés | MEDLINE | ID: mdl-31730859

3.

MYC Controls the Epstein-Barr Virus Lytic Switch.

Guo, Rui; Jiang, Chang; Zhang, Yuchen; Govande, Apurva; Trudeau, Stephen J; Chen, Fang; Fry, Christopher J; Puri, Rishi; Wolinsky, Emma; Schineller, Molly; Frost, Thomas C; Gebre, Makda; Zhao, Bo; Giulino-Roth, Lisa; Doench, John G; Teng, Mingxiang; Gewurz, Benjamin E.

Mol Cell; 78(4): 653-669.e8, 2020 05 21.

Artículo en Inglés | MEDLINE | ID: mdl-32315601

4.

Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach.

Lee, Mark N; Roy, Matthew; Ong, Shao-En; Mertins, Philipp; Villani, Alexandra-Chloé; Li, Weibo; Dotiwala, Farokh; Sen, Jayita; Doench, John G; Orzalli, Megan H; Kramnik, Igor; Knipe, David M; Lieberman, Judy; Carr, Steven A; Hacohen, Nir.

Nat Immunol; 14(2): 179-85, 2013 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-23263557

5.

Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy.

Wei, Jun; Long, Lingyun; Zheng, Wenting; Dhungana, Yogesh; Lim, Seon Ah; Guy, Cliff; Wang, Yanyan; Wang, Yong-Dong; Qian, Chenxi; Xu, Beisi; Kc, Anil; Saravia, Jordy; Huang, Hongling; Yu, Jiyang; Doench, John G; Geiger, Terrence L; Chi, Hongbo.

Nature; 576(7787): 471-476, 2019 12.

Artículo en Inglés | MEDLINE | ID: mdl-31827283

6.

Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade.

Ishizuka, Jeffrey J; Manguso, Robert T; Cheruiyot, Collins K; Bi, Kevin; Panda, Arpit; Iracheta-Vellve, Arvin; Miller, Brian C; Du, Peter P; Yates, Kathleen B; Dubrot, Juan; Buchumenski, Ilana; Comstock, Dawn E; Brown, Flavian D; Ayer, Austin; Kohnle, Ian C; Pope, Hans W; Zimmer, Margaret D; Sen, Debattama R; Lane-Reticker, Sarah K; Robitschek, Emily J; Griffin, Gabriel K; Collins, Natalie B; Long, Adrienne H; Doench, John G; Kozono, David; Levanon, Erez Y; Haining, W Nicholas.

Nature; 565(7737): 43-48, 2019 01.

Artículo en Inglés | MEDLINE | ID: mdl-30559380

7.

Am I ready for CRISPR? A user's guide to genetic screens.

Doench, John G.

Nat Rev Genet; 19(2): 67-80, 2018 02.

Artículo en Inglés | MEDLINE | ID: mdl-29199283

8.

DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells.

He, Yizhou Joseph; Meghani, Khyati; Caron, Marie-Christine; Yang, Chunyu; Ronato, Daryl A; Bian, Jie; Sharma, Anchal; Moore, Jessica; Niraj, Joshi; Detappe, Alexandre; Doench, John G; Legube, Gaelle; Root, David E; D'Andrea, Alan D; Drané, Pascal; De, Subhajyoti; Konstantinopoulos, Panagiotis A; Masson, Jean-Yves; Chowdhury, Dipanjan.

Nature; 563(7732): 522-526, 2018 11.

Artículo en Inglés | MEDLINE | ID: mdl-30464262

9.

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target.

Manguso, Robert T; Pope, Hans W; Zimmer, Margaret D; Brown, Flavian D; Yates, Kathleen B; Miller, Brian C; Collins, Natalie B; Bi, Kevin; LaFleur, Martin W; Juneja, Vikram R; Weiss, Sarah A; Lo, Jennifer; Fisher, David E; Miao, Diana; Van Allen, Eliezer; Root, David E; Sharpe, Arlene H; Doench, John G; Haining, W Nicholas.

Nature; 547(7664): 413-418, 2017 07 27.

Artículo en Inglés | MEDLINE | ID: mdl-28723893

10.

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway.

Viswanathan, Vasanthi S; Ryan, Matthew J; Dhruv, Harshil D; Gill, Shubhroz; Eichhoff, Ossia M; Seashore-Ludlow, Brinton; Kaffenberger, Samuel D; Eaton, John K; Shimada, Kenichi; Aguirre, Andrew J; Viswanathan, Srinivas R; Chattopadhyay, Shrikanta; Tamayo, Pablo; Yang, Wan Seok; Rees, Matthew G; Chen, Sixun; Boskovic, Zarko V; Javaid, Sarah; Huang, Cherrie; Wu, Xiaoyun; Tseng, Yuen-Yi; Roider, Elisabeth M; Gao, Dong; Cleary, James M; Wolpin, Brian M; Mesirov, Jill P; Haber, Daniel A; Engelman, Jeffrey A; Boehm, Jesse S; Kotz, Joanne D; Hon, Cindy S; Chen, Yu; Hahn, William C; Levesque, Mitchell P; Doench, John G; Berens, Michael E; Shamji, Alykhan F; Clemons, Paul A; Stockwell, Brent R; Schreiber, Stuart L.

Nature; 547(7664): 453-457, 2017 07 27.

Artículo en Inglés | MEDLINE | ID: mdl-28678785

11.

UFMylation inhibits the proinflammatory capacity of interferon-Î³-activated macrophages.

Balce, Dale R; Wang, Ya-Ting; McAllaster, Michael R; Dunlap, Bria F; Orvedahl, Anthony; Hykes, Barry L; Droit, Lindsay; Handley, Scott A; Wilen, Craig B; Doench, John G; Orchard, Robert C; Stallings, Christina L; Virgin, Herbert W.

Proc Natl Acad Sci U S A; 118(1)2021 Jan 05.

Artículo en Inglés | MEDLINE | ID: mdl-33372156

12.

Autophagy genes in myeloid cells counteract IFNÎ³-induced TNF-mediated cell death and fatal TNF-induced shock.

Orvedahl, Anthony; McAllaster, Michael R; Sansone, Amy; Dunlap, Bria F; Desai, Chandni; Wang, Ya-Ting; Balce, Dale R; Luke, Cliff J; Lee, Sanghyun; Orchard, Robert C; Artyomov, Maxim N; Handley, Scott A; Doench, John G; Silverman, Gary A; Virgin, Herbert W.

Proc Natl Acad Sci U S A; 116(33): 16497-16506, 2019 08 13.

Artículo en Inglés | MEDLINE | ID: mdl-31346084

13.

CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML.

Vinyard, Michael E; Su, Cindy; Siegenfeld, Allison P; Waterbury, Amanda L; Freedy, Allyson M; Gosavi, Pallavi M; Park, Yongho; Kwan, Eugene E; Senzer, Benjamin D; Doench, John G; Bauer, Daniel E; Pinello, Luca; Liau, Brian B.

Nat Chem Biol; 15(5): 529-539, 2019 05.

Artículo en Inglés | MEDLINE | ID: mdl-30992567

14.

Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis.

Zou, Yilong; Li, Haoxin; Graham, Emily T; Deik, Amy A; Eaton, John K; Wang, Wenyu; Sandoval-Gomez, Gerardo; Clish, Clary B; Doench, John G; Schreiber, Stuart L.

Nat Chem Biol; 16(3): 302-309, 2020 03.

Artículo en Inglés | MEDLINE | ID: mdl-32080622

15.

Identification of Antinorovirus Genes in Human Cells Using Genome-Wide CRISPR Activation Screening.

Orchard, Robert C; Sullender, Meagan E; Dunlap, Bria F; Balce, Dale R; Doench, John G; Virgin, Herbert W.

J Virol; 93(1)2019 01 01.

Artículo en Inglés | MEDLINE | ID: mdl-30305350

16.

Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map.

Smith, Ian; Greenside, Peyton G; Natoli, Ted; Lahr, David L; Wadden, David; Tirosh, Itay; Narayan, Rajiv; Root, David E; Golub, Todd R; Subramanian, Aravind; Doench, John G.

PLoS Biol; 15(11): e2003213, 2017 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-29190685

17.

Reduced expression of ribosomal proteins relieves microRNA-mediated repression.

Janas, Maja M; Wang, Eric; Love, Tara; Harris, Abigail S; Stevenson, Kristen; Semmelmann, Karlheinz; Shaffer, Jonathan M; Chen, Po-Hao; Doench, John G; Yerramilli, Subrahmanyam V B K; Neuberg, Donna S; Iliopoulos, Dimitrios; Housman, David E; Burge, Christopher B; Novina, Carl D.

Mol Cell; 46(2): 171-86, 2012 Apr 27.

Artículo en Inglés | MEDLINE | ID: mdl-22541556

18.

Natural variation in a single amino acid substitution underlies physiological responses to topoisomerase II poisons.

Zdraljevic, Stefan; Strand, Christine; Seidel, Hannah S; Cook, Daniel E; Doench, John G; Andersen, Erik C.

PLoS Genet; 13(7): e1006891, 2017 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-28700616

19.

CRISPR-Cas9 Genome-Wide Knockout Screen Identifies Mechanism of Selective Activity of Dehydrofalcarinol in Mesenchymal Stem-like Triple-Negative Breast Cancer Cells.

Grant, Corena V; Cai, Shengxin; Risinger, April L; Liang, Huiyun; O'Keefe, Barry R; Doench, John G; Cichewicz, Robert H; Mooberry, Susan L.

J Nat Prod; 83(10): 3080-3092, 2020 10 23.

Artículo en Inglés | MEDLINE | ID: mdl-33021790

20.

Alternative to the soft-agar assay that permits high-throughput drug and genetic screens for cellular transformation.

Rotem, Asaf; Janzer, Andreas; Izar, Benjamin; Ji, Zhe; Doench, John G; Garraway, Levi A; Struhl, Kevin.

Proc Natl Acad Sci U S A; 112(18): 5708-13, 2015 May 05.

Artículo en Inglés | MEDLINE | ID: mdl-25902495

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