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1.

A Call for Systematic Research on Solute Carriers.

César-Razquin, Adrián; Snijder, Berend; Frappier-Brinton, Tristan; Isserlin, Ruth; Gyimesi, Gergely; Bai, Xiaoyun; Reithmeier, Reinhart A; Hepworth, David; Hediger, Matthias A; Edwards, Aled M; Superti-Furga, Giulio.

Cell; 162(3): 478-87, 2015 Jul 30.

Artículo en Inglés | MEDLINE | ID: mdl-26232220

2.

Assessment of a method to characterize antibody selectivity and specificity for use in immunoprecipitation.

Marcon, Edyta; Jain, Harshika; Bhattacharya, Anandi; Guo, Hongbo; Phanse, Sadhna; Pu, Shuye; Byram, Gregory; Collins, Ben C; Dowdell, Evan; Fenner, Maria; Guo, Xinghua; Hutchinson, Ashley; Kennedy, Jacob J; Krastins, Bryan; Larsen, Brett; Lin, Zhen-Yuan; Lopez, Mary F; Loppnau, Peter; Miersch, Shane; Nguyen, Tin; Olsen, Jonathan B; Paduch, Marcin; Ravichandran, Mani; Seitova, Alma; Vadali, Gouri; Vogelsang, Maryann S; Whiteaker, Jeffrey R; Zhong, Guoqing; Zhong, Nan; Zhao, Lei; Aebersold, Ruedi; Arrowsmith, Cheryl H; Emili, Andrew; Frappier, Lori; Gingras, Anne-Claude; Gstaiger, Matthias; Paulovich, Amanda G; Koide, Shohei; Kossiakoff, Anthony A; Sidhu, Sachdev S; Wodak, Shoshana J; Gräslund, Susanne; Greenblatt, Jack F; Edwards, Aled M.

Nat Methods; 12(8): 725-31, 2015 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-26121405

3.

Discovery and structure activity relationship of the first potent cryptosporidium FIKK kinase inhibitor.

Osman, Khan T; Ye, Juntao; Shi, Zhihao; Toker, Christina; Lovato, Diogo; Jumani, Rajiv S; Zuercher, William; Huston, Christopher D; Edwards, Aled M; Lautens, Mark; Santhakumar, Vijayaratnam; Hui, Raymond.

Bioorg Med Chem; 25(5): 1672-1680, 2017 03 01.

Artículo en Inglés | MEDLINE | ID: mdl-28162900

4.

Functional Diversity of Haloacid Dehalogenase Superfamily Phosphatases from Saccharomyces cerevisiae: BIOCHEMICAL, STRUCTURAL, AND EVOLUTIONARY INSIGHTS.

Kuznetsova, Ekaterina; Nocek, Boguslaw; Brown, Greg; Makarova, Kira S; Flick, Robert; Wolf, Yuri I; Khusnutdinova, Anna; Evdokimova, Elena; Jin, Ke; Tan, Kemin; Hanson, Andrew D; Hasnain, Ghulam; Zallot, Rémi; de Crécy-Lagard, Valérie; Babu, Mohan; Savchenko, Alexei; Joachimiak, Andrzej; Edwards, Aled M; Koonin, Eugene V; Yakunin, Alexander F.

J Biol Chem; 290(30): 18678-98, 2015 Jul 24.

Artículo en Inglés | MEDLINE | ID: mdl-26071590

5.

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states.

Shintre, Chitra A; Pike, Ashley C W; Li, Qiuhong; Kim, Jung-In; Barr, Alastair J; Goubin, Solenne; Shrestha, Leela; Yang, Jing; Berridge, Georgina; Ross, Jonathan; Stansfeld, Phillip J; Sansom, Mark S P; Edwards, Aled M; Bountra, Chas; Marsden, Brian D; von Delft, Frank; Bullock, Alex N; Gileadi, Opher; Burgess-Brown, Nicola A; Carpenter, Elisabeth P.

Proc Natl Acad Sci U S A; 110(24): 9710-5, 2013 Jun 11.

Artículo en Inglés | MEDLINE | ID: mdl-23716676

6.

Highlights of B/D-HPP and HPP Resource Pillar Workshops at 12th Annual HUPO World Congress of Proteomics: September 14-18, 2013, Yokohama, Japan.

Aebersold, Ruedi; Bader, Gary D; Edwards, Aled M; van Eyk, Jennifer; Kussman, Martin; Qin, Jun; Omenn, Gilbert S.

Proteomics; 14(9): 975-88, 2014 May.

Artículo en Inglés | MEDLINE | ID: mdl-24596128

7.

Structural and functional studies of gpX of Escherichia coli phage P2 reveal a widespread role for LysM domains in the baseplates of contractile-tailed phages.

Maxwell, Karen L; Fatehi Hassanabad, Mostafa; Chang, Tom; Paul, Vivek D; Pirani, Nawaz; Bona, Diane; Edwards, Aled M; Davidson, Alan R.

J Bacteriol; 195(24): 5461-8, 2013 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-24097944

8.

The biology/disease-driven human proteome project (B/D-HPP): enabling protein research for the life sciences community.

Aebersold, Ruedi; Bader, Gary D; Edwards, Aled M; van Eyk, Jennifer E; Kussmann, Martin; Qin, Jun; Omenn, Gilbert S.

J Proteome Res; 12(1): 23-7, 2013 Jan 04.

Artículo en Inglés | MEDLINE | ID: mdl-23259511

9.

Structural and biochemical characterization of phage λ FI protein (gpFI) reveals a novel mechanism of DNA packaging chaperone activity.

Popovic, Ana; Wu, Bin; Arrowsmith, Cheryl H; Edwards, Aled M; Davidson, Alan R; Maxwell, Karen L.

J Biol Chem; 287(38): 32085-95, 2012 Sep 14.

Artículo en Inglés | MEDLINE | ID: mdl-22801427

10.

The bacteriophage HK97 gp15 moron element encodes a novel superinfection exclusion protein.

Cumby, Nichole; Edwards, Aled M; Davidson, Alan R; Maxwell, Karen L.

J Bacteriol; 194(18): 5012-9, 2012 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-22797755

11.

Structure and biochemical functions of SIRT6.

Pan, Patricia W; Feldman, Jessica L; Devries, Mark K; Dong, Aiping; Edwards, Aled M; Denu, John M.

J Biol Chem; 286(16): 14575-87, 2011 Apr 22.

Artículo en Inglés | MEDLINE | ID: mdl-21362626

12.

A dual function of the CRISPR-Cas system in bacterial antivirus immunity and DNA repair.

Babu, Mohan; Beloglazova, Natalia; Flick, Robert; Graham, Chris; Skarina, Tatiana; Nocek, Boguslaw; Gagarinova, Alla; Pogoutse, Oxana; Brown, Greg; Binkowski, Andrew; Phanse, Sadhna; Joachimiak, Andrzej; Koonin, Eugene V; Savchenko, Alexei; Emili, Andrew; Greenblatt, Jack; Edwards, Aled M; Yakunin, Alexander F.

Mol Microbiol; 79(2): 484-502, 2011 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-21219465

13.

Corrigendum: The promise and peril of chemical probes.

Arrowsmith, Cheryl H; Audia, James E; Austin, Christopher; Baell, Jonathan; Bennett, Jonathan; Blagg, Julian; Bountra, Chas; Brennan, Paul E; Brown, Peter J; Bunnage, Mark E; Buser-Doepner, Carolyn; Campbell, Robert M; Carter, Adrian J; Cohen, Philip; Copeland, Robert A; Cravatt, Ben; Dahlin, Jayme L; Dhanak, Dashyant; Edwards, Aled M; Frederiksen, Mathias; Frye, Stephen V; Gray, Nathanael; Grimshaw, Charles E; Hepworth, David; Howe, Trevor; Huber, Kilian V M; Jin, Jian; Knapp, Stefan; Kotz, Joanne D; Kruger, Ryan G; Lowe, Derek; Mader, Mary M; Marsden, Brian; Mueller-Fahrnow, Anke; Müller, Susanne; O'Hagan, Ronan C; Overington, John P; Owen, Dafydd R; Rosenberg, Saul H; Ross, Ruth; Roth, Bryan; Schapira, Matthieu; Schreiber, Stuart L; Shoichet, Brian; Sundström, Michael; Superti-Furga, Giulio; Taunton, Jack; Toledo-Sherman, Leticia; Walpole, Chris; Walters, Michael A.

Nat Chem Biol; 11(11): 887, 2015 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-26485080

14.

The promise and peril of chemical probes.

Arrowsmith, Cheryl H; Audia, James E; Austin, Christopher; Baell, Jonathan; Bennett, Jonathan; Blagg, Julian; Bountra, Chas; Brennan, Paul E; Brown, Peter J; Bunnage, Mark E; Buser-Doepner, Carolyn; Campbell, Robert M; Carter, Adrian J; Cohen, Philip; Copeland, Robert A; Cravatt, Ben; Dahlin, Jayme L; Dhanak, Dashyant; Edwards, Aled M; Frederiksen, Mathias; Frye, Stephen V; Gray, Nathanael; Grimshaw, Charles E; Hepworth, David; Howe, Trevor; Huber, Kilian V M; Jin, Jian; Knapp, Stefan; Kotz, Joanne D; Kruger, Ryan G; Lowe, Derek; Mader, Mary M; Marsden, Brian; Mueller-Fahrnow, Anke; Müller, Susanne; O'Hagan, Ronan C; Overington, John P; Owen, Dafydd R; Rosenberg, Saul H; Roth, Bryan; Roth, Brian; Ross, Ruth; Schapira, Matthieu; Schreiber, Stuart L; Shoichet, Brian; Sundström, Michael; Superti-Furga, Giulio; Taunton, Jack; Toledo-Sherman, Leticia; Walpole, Chris.

Nat Chem Biol; 11(8): 536-41, 2015 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-26196764

15.

Too many roads not taken.

Edwards, Aled M; Isserlin, Ruth; Bader, Gary D; Frye, Stephen V; Willson, Timothy M; Yu, Frank H.

Nature; 470(7333): 163-5, 2011 Feb 10.

Artículo en Inglés | MEDLINE | ID: mdl-21307913

16.

Crystal structure of the CorA Mg2+ transporter.

Lunin, Vladimir V; Dobrovetsky, Elena; Khutoreskaya, Galina; Zhang, Rongguang; Joachimiak, Andrzej; Doyle, Declan A; Bochkarev, Alexey; Maguire, Michael E; Edwards, Aled M; Koth, Christopher M.

Nature; 440(7085): 833-7, 2006 Apr 06.

Artículo en Inglés | MEDLINE | ID: mdl-16598263

17.

Cell-type specific gene expression signature in liver underlies response to interferon therapy in chronic hepatitis C infection.

Chen, Limin; Borozan, Ivan; Sun, Jing; Guindi, Maha; Fischer, Sandra; Feld, Jordan; Anand, Nitasha; Heathcote, Jenny; Edwards, Aled M; McGilvray, Ian D.

Gastroenterology; 138(3): 1123-33.e1-3, 2010 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-19900446

18.

Open access chemical and clinical probes to support drug discovery.

Edwards, Aled M; Bountra, Chas; Kerr, David J; Willson, Timothy M.

Nat Chem Biol; 5(7): 436-40, 2009 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-19536100

19.

Polyphosphate-dependent synthesis of ATP and ADP by the family-2 polyphosphate kinases in bacteria.

Nocek, Boguslaw; Kochinyan, Samvel; Proudfoot, Michael; Brown, Greg; Evdokimova, Elena; Osipiuk, Jerzy; Edwards, Aled M; Savchenko, Alexei; Joachimiak, Andrzej; Yakunin, Alexander F.

Proc Natl Acad Sci U S A; 105(46): 17730-5, 2008 Nov 18.

Artículo en Inglés | MEDLINE | ID: mdl-19001261

20.

Crystal structure and molecular modeling study of N-carbamoylsarcosine amidase Ta0454 from Thermoplasma acidophilum.

Luo, Hai-Bin; Zheng, Heping; Zimmerman, Matthew D; Chruszcz, Maksymilian; Skarina, Tatiana; Egorova, Olga; Savchenko, Alexei; Edwards, Aled M; Minor, Wladek.

J Struct Biol; 169(3): 304-11, 2010 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-19932181

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