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1.

Impact of Menglà Virus Proteins on Human and Bat Innate Immune Pathways.

Williams, Caroline G; Gibbons, Joyce Sweeney; Keiffer, Timothy R; Luthra, Priya; Edwards, Megan R; Basler, Christopher F.

J Virol; 94(13)2020 06 16.

Artículo en Inglés | MEDLINE | ID: mdl-32295912

2.

Henipavirus W Proteins Interact with 14-3-3 To Modulate Host Gene Expression.

Edwards, Megan R; Hoad, Mikayla; Tsimbalyuk, Sofiya; Menicucci, Andrea R; Messaoudi, Ilhem; Forwood, Jade K; Basler, Christopher F.

J Virol; 94(14)2020 07 01.

Artículo en Inglés | MEDLINE | ID: mdl-32321809

3.

VP24-Karyopherin Alpha Binding Affinities Differ between Ebolavirus Species, Influencing Interferon Inhibition and VP24 Stability.

Schwarz, Toni M; Edwards, Megan R; Diederichs, Audrey; Alinger, Joshua B; Leung, Daisy W; Amarasinghe, Gaya K; Basler, Christopher F.

J Virol; 91(4)2017 02 15.

Artículo en Inglés | MEDLINE | ID: mdl-27974555

4.

Marburg Virus VP24 Protein Relieves Suppression of the NF-κB Pathway Through Interaction With Kelch-like ECH-Associated Protein 1.

Edwards, Megan R; Basler, Christopher F.

J Infect Dis; 212 Suppl 2: S154-9, 2015 Oct 01.

Artículo en Inglés | MEDLINE | ID: mdl-25926686

5.

Structural basis for Marburg virus VP35-mediated immune evasion mechanisms.

Ramanan, Parameshwaran; Edwards, Megan R; Shabman, Reed S; Leung, Daisy W; Endlich-Frazier, Ariel C; Borek, Dominika M; Otwinowski, Zbyszek; Liu, Gai; Huh, Juyoung; Basler, Christopher F; Amarasinghe, Gaya K.

Proc Natl Acad Sci U S A; 109(50): 20661-6, 2012 Dec 11.

Artículo en Inglés | MEDLINE | ID: mdl-23185024

6.

Interactions of the Nipah Virus P, V, and W Proteins across the STAT Family of Transcription Factors.

Keiffer, Timothy R; Ciancanelli, Michael J; Edwards, Megan R; Basler, Christopher F.

mSphere; 5(6)2020 12 16.

Artículo en Inglés | MEDLINE | ID: mdl-33328346

7.

Small Molecule Compounds That Inhibit Antioxidant Response Gene Expression in an Inducer-Dependent Manner.

Edwards, Megan R; Liu, Gai; De, Sampriti; Sourimant, Julien; Pietzsch, Colette; Johnson, Britney; Amarasinghe, Gaya K; Leung, Daisy W; Bukreyev, Alexander; Plemper, Richard K; Aron, Zachary; Bowlin, Terry L; Moir, Donald T; Basler, Christopher F.

ACS Infect Dis; 6(3): 489-502, 2020 03 13.

Artículo en Inglés | MEDLINE | ID: mdl-31899866

8.

Current status of small molecule drug development for Ebola virus and other filoviruses.

Edwards, Megan R; Basler, Christopher F.

Curr Opin Virol; 35: 42-56, 2019 04.

Artículo en Inglés | MEDLINE | ID: mdl-31003196

9.

A high throughput screen identifies benzoquinoline compounds as inhibitors of Ebola virus replication.

Luthra, Priya; Liang, Jue; Pietzsch, Colette A; Khadka, Sudip; Edwards, Megan R; Wei, Shuguang; De, Sampriti; Posner, Bruce; Bukreyev, Alexander; Ready, Joseph M; Basler, Christopher F.

Antiviral Res; 150: 193-201, 2018 02.

Artículo en Inglés | MEDLINE | ID: mdl-29294299

10.

Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses.

Smith, Kate M; Tsimbalyuk, Sofiya; Edwards, Megan R; Cross, Emily M; Batra, Jyoti; Soares da Costa, Tatiana P; Aragão, David; Basler, Christopher F; Forwood, Jade K.

Nat Commun; 9(1): 3703, 2018 09 12.

Artículo en Inglés | MEDLINE | ID: mdl-30209309

11.

Inhibiting pyrimidine biosynthesis impairs Ebola virus replication through depletion of nucleoside pools and activation of innate immune responses.

Luthra, Priya; Naidoo, Jacinth; Pietzsch, Colette A; De, Sampriti; Khadka, Sudip; Anantpadma, Manu; Williams, Caroline G; Edwards, Megan R; Davey, Robert A; Bukreyev, Alexander; Ready, Joseph M; Basler, Christopher F.

Antiviral Res; 158: 288-302, 2018 10.

Artículo en Inglés | MEDLINE | ID: mdl-30144461

12.

Conservation of Structure and Immune Antagonist Functions of Filoviral VP35 Homologs Present in Microbat Genomes.

Edwards, Megan R; Liu, Hejun; Shabman, Reed S; Ginell, Garrett M; Luthra, Priya; Ramanan, Parmeshwaran; Keefe, Lisa J; Köllner, Bernd; Amarasinghe, Gaya K; Taylor, Derek J; Leung, Daisy W; Basler, Christopher F.

Cell Rep; 24(4): 861-872.e6, 2018 07 24.

Artículo en Inglés | MEDLINE | ID: mdl-30044983

13.

Structural basis for human respiratory syncytial virus NS1-mediated modulation of host responses.

Chatterjee, Srirupa; Luthra, Priya; Esaulova, Ekaterina; Agapov, Eugene; Yen, Benjamin C; Borek, Dominika M; Edwards, Megan R; Mittal, Anuradha; Jordan, David S; Ramanan, Parameshwar; Moore, Martin L; Pappu, Rohit V; Holtzman, Michael J; Artyomov, Maxim N; Basler, Christopher F; Amarasinghe, Gaya K; Leung, Daisy W.

Nat Microbiol; 2: 17101, 2017 Jun 30.

Artículo en Inglés | MEDLINE | ID: mdl-28665409

14.

Dimerization Controls Marburg Virus VP24-dependent Modulation of Host Antioxidative Stress Responses.

Johnson, Britney; Li, Jing; Adhikari, Jagat; Edwards, Megan R; Zhang, Hao; Schwarz, Toni; Leung, Daisy W; Basler, Christopher F; Gross, Michael L; Amarasinghe, Gaya K.

J Mol Biol; 428(17): 3483-94, 2016 08 28.

Artículo en Inglés | MEDLINE | ID: mdl-27497688

15.

Differential Regulation of Interferon Responses by Ebola and Marburg Virus VP35 Proteins.

Edwards, Megan R; Liu, Gai; Mire, Chad E; Sureshchandra, Suhas; Luthra, Priya; Yen, Benjamin; Shabman, Reed S; Leung, Daisy W; Messaoudi, Ilhem; Geisbert, Thomas W; Amarasinghe, Gaya K; Basler, Christopher F.

Cell Rep; 14(7): 1632-1640, 2016 Feb 23.

Artículo en Inglés | MEDLINE | ID: mdl-26876165

16.

High-Throughput Minigenome System for Identifying Small-Molecule Inhibitors of Ebola Virus Replication.

Edwards, Megan R; Pietzsch, Colette; Vausselin, Thibaut; Shaw, Megan L; Bukreyev, Alexander; Basler, Christopher F.

ACS Infect Dis; 1(8): 380-7, 2015 Aug 14.

Artículo en Inglés | MEDLINE | ID: mdl-26284260

17.

The Marburg virus VP24 protein interacts with Keap1 to activate the cytoprotective antioxidant response pathway.

Edwards, Megan R; Johnson, Britney; Mire, Chad E; Xu, Wei; Shabman, Reed S; Speller, Lauren N; Leung, Daisy W; Geisbert, Thomas W; Amarasinghe, Gaya K; Basler, Christopher F.

Cell Rep; 6(6): 1017-1025, 2014 Mar 27.

Artículo en Inglés | MEDLINE | ID: mdl-24630991

18.

Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1.

Xu, Wei; Edwards, Megan R; Borek, Dominika M; Feagins, Alicia R; Mittal, Anuradha; Alinger, Joshua B; Berry, Kayla N; Yen, Benjamin; Hamilton, Jennifer; Brett, Tom J; Pappu, Rohit V; Leung, Daisy W; Basler, Christopher F; Amarasinghe, Gaya K.

Cell Host Microbe; 16(2): 187-200, 2014 Aug 13.

Artículo en Inglés | MEDLINE | ID: mdl-25121748

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