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1.

SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract.

Hou, Yixuan J; Okuda, Kenichi; Edwards, Caitlin E; Martinez, David R; Asakura, Takanori; Dinnon, Kenneth H; Kato, Takafumi; Lee, Rhianna E; Yount, Boyd L; Mascenik, Teresa M; Chen, Gang; Olivier, Kenneth N; Ghio, Andrew; Tse, Longping V; Leist, Sarah R; Gralinski, Lisa E; Schäfer, Alexandra; Dang, Hong; Gilmore, Rodney; Nakano, Satoko; Sun, Ling; Fulcher, M Leslie; Livraghi-Butrico, Alessandra; Nicely, Nathan I; Cameron, Mark; Cameron, Cheryl; Kelvin, David J; de Silva, Aravinda; Margolis, David M; Markmann, Alena; Bartelt, Luther; Zumwalt, Ross; Martinez, Fernando J; Salvatore, Steven P; Borczuk, Alain; Tata, Purushothama R; Sontake, Vishwaraj; Kimple, Adam; Jaspers, Ilona; O'Neal, Wanda K; Randell, Scott H; Boucher, Richard C; Baric, Ralph S.

Cell; 2020 May 27.

Artículo en Inglés | MEDLINE | ID: covidwho-381993

2.

A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice.

Leist, Sarah R; Dinnon, Kenneth H; Schäfer, Alexandra; Tse, Longping V; Okuda, Kenichi; Hou, Yixuan J; West, Ande; Edwards, Caitlin E; Sanders, Wes; Fritch, Ethan J; Gully, Kendra L; Scobey, Trevor; Brown, Ariane J; Sheahan, Timothy P; Moorman, Nathaniel J; Boucher, Richard C; Gralinski, Lisa E; Montgomery, Stephanie A; Baric, Ralph S.

Cell; 183(4): 1070-1085.e12, 2020 11 12.

Artículo en Inglés | MEDLINE | ID: mdl-33031744

3.

Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2.

Walls, Alexandra C; Fiala, Brooke; Schäfer, Alexandra; Wrenn, Samuel; Pham, Minh N; Murphy, Michael; Tse, Longping V; Shehata, Laila; O'Connor, Megan A; Chen, Chengbo; Navarro, Mary Jane; Miranda, Marcos C; Pettie, Deleah; Ravichandran, Rashmi; Kraft, John C; Ogohara, Cassandra; Palser, Anne; Chalk, Sara; Lee, E-Chiang; Guerriero, Kathryn; Kepl, Elizabeth; Chow, Cameron M; Sydeman, Claire; Hodge, Edgar A; Brown, Brieann; Fuller, Jim T; Dinnon, Kenneth H; Gralinski, Lisa E; Leist, Sarah R; Gully, Kendra L; Lewis, Thomas B; Guttman, Miklos; Chu, Helen Y; Lee, Kelly K; Fuller, Deborah H; Baric, Ralph S; Kellam, Paul; Carter, Lauren; Pepper, Marion; Sheahan, Timothy P; Veesler, David; King, Neil P.

Cell; 183(5): 1367-1382.e17, 2020 11 25.

Artículo en Inglés | MEDLINE | ID: mdl-33160446

4.

A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2.

Hassan, Ahmed O; Kafai, Natasha M; Dmitriev, Igor P; Fox, Julie M; Smith, Brittany K; Harvey, Ian B; Chen, Rita E; Winkler, Emma S; Wessel, Alex W; Case, James Brett; Kashentseva, Elena; McCune, Broc T; Bailey, Adam L; Zhao, Haiyan; VanBlargan, Laura A; Dai, Ya-Nan; Ma, Meisheng; Adams, Lucas J; Shrihari, Swathi; Danis, Jonathan E; Gralinski, Lisa E; Hou, Yixuan J; Schäfer, Alexandra; Kim, Arthur S; Keeler, Shamus P; Weiskopf, Daniela; Baric, Ralph S; Holtzman, Michael J; Fremont, Daved H; Curiel, David T; Diamond, Michael S.

Cell; 183(1): 169-184.e13, 2020 10 01.

Artículo en Inglés | MEDLINE | ID: mdl-32931734

5.

SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract.

Hou, Yixuan J; Okuda, Kenichi; Edwards, Caitlin E; Martinez, David R; Asakura, Takanori; Dinnon, Kenneth H; Kato, Takafumi; Lee, Rhianna E; Yount, Boyd L; Mascenik, Teresa M; Chen, Gang; Olivier, Kenneth N; Ghio, Andrew; Tse, Longping V; Leist, Sarah R; Gralinski, Lisa E; Schäfer, Alexandra; Dang, Hong; Gilmore, Rodney; Nakano, Satoko; Sun, Ling; Fulcher, M Leslie; Livraghi-Butrico, Alessandra; Nicely, Nathan I; Cameron, Mark; Cameron, Cheryl; Kelvin, David J; de Silva, Aravinda; Margolis, David M; Markmann, Alena; Bartelt, Luther; Zumwalt, Ross; Martinez, Fernando J; Salvatore, Steven P; Borczuk, Alain; Tata, Purushothama R; Sontake, Vishwaraj; Kimple, Adam; Jaspers, Ilona; O'Neal, Wanda K; Randell, Scott H; Boucher, Richard C; Baric, Ralph S.

Cell; 182(2): 429-446.e14, 2020 07 23.

Artículo en Inglés | MEDLINE | ID: mdl-32526206

6.

A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures.

Dinnon, Kenneth H; Leist, Sarah R; Schäfer, Alexandra; Edwards, Caitlin E; Martinez, David R; Montgomery, Stephanie A; West, Ande; Yount, Boyd L; Hou, Yixuan J; Adams, Lily E; Gully, Kendra L; Brown, Ariane J; Huang, Emily; Bryant, Matthew D; Choong, Ingrid C; Glenn, Jeffrey S; Gralinski, Lisa E; Sheahan, Timothy P; Baric, Ralph S.

Nature; 586(7830): 560-566, 2020 10.

Artículo en Inglés | MEDLINE | ID: mdl-32854108

7.

Potently neutralizing and protective human antibodies against SARS-CoV-2.

Zost, Seth J; Gilchuk, Pavlo; Case, James Brett; Binshtein, Elad; Chen, Rita E; Nkolola, Joseph P; Schäfer, Alexandra; Reidy, Joseph X; Trivette, Andrew; Nargi, Rachel S; Sutton, Rachel E; Suryadevara, Naveenchandra; Martinez, David R; Williamson, Lauren E; Chen, Elaine C; Jones, Taylor; Day, Samuel; Myers, Luke; Hassan, Ahmed O; Kafai, Natasha M; Winkler, Emma S; Fox, Julie M; Shrihari, Swathi; Mueller, Benjamin K; Meiler, Jens; Chandrashekar, Abishek; Mercado, Noe B; Steinhardt, James J; Ren, Kuishu; Loo, Yueh-Ming; Kallewaard, Nicole L; McCune, Broc T; Keeler, Shamus P; Holtzman, Michael J; Barouch, Dan H; Gralinski, Lisa E; Baric, Ralph S; Thackray, Larissa B; Diamond, Michael S; Carnahan, Robert H; Crowe, James E.

Nature; 584(7821): 443-449, 2020 08.

Artículo en Inglés | MEDLINE | ID: mdl-32668443

8.

Animal models for COVID-19.

Muñoz-Fontela, César; Dowling, William E; Funnell, Simon G P; Gsell, Pierre-S; Riveros-Balta, A Ximena; Albrecht, Randy A; Andersen, Hanne; Baric, Ralph S; Carroll, Miles W; Cavaleri, Marco; Qin, Chuan; Crozier, Ian; Dallmeier, Kai; de Waal, Leon; de Wit, Emmie; Delang, Leen; Dohm, Erik; Duprex, W Paul; Falzarano, Darryl; Finch, Courtney L; Frieman, Matthew B; Graham, Barney S; Gralinski, Lisa E; Guilfoyle, Kate; Haagmans, Bart L; Hamilton, Geraldine A; Hartman, Amy L; Herfst, Sander; Kaptein, Suzanne J F; Klimstra, William B; Knezevic, Ivana; Krause, Philip R; Kuhn, Jens H; Le Grand, Roger; Lewis, Mark G; Liu, Wen-Chun; Maisonnasse, Pauline; McElroy, Anita K; Munster, Vincent; Oreshkova, Nadia; Rasmussen, Angela L; Rocha-Pereira, Joana; Rockx, Barry; Rodríguez, Estefanía; Rogers, Thomas F; Salguero, Francisco J; Schotsaert, Michael; Stittelaar, Koert J; Thibaut, Hendrik Jan; Tseng, Chien-Te.

Nature; 586(7830): 509-515, 2020 10.

Artículo en Inglés | MEDLINE | ID: mdl-32967005

9.

Rapid identification of a human antibody with high prophylactic and therapeutic efficacy in three animal models of SARS-CoV-2 infection.

Li, Wei; Chen, Chuan; Drelich, Aleksandra; Martinez, David R; Gralinski, Lisa E; Sun, Zehua; Schäfer, Alexandra; Kulkarni, Swarali S; Liu, Xianglei; Leist, Sarah R; Zhelev, Doncho V; Zhang, Liyong; Kim, Ye-Jin; Peterson, Eric C; Conard, Alex; Mellors, John W; Tseng, Chien-Te K; Falzarano, Darryl; Baric, Ralph S; Dimitrov, Dimiter S.

Proc Natl Acad Sci U S A; 117(47): 29832-29838, 2020 11 24.

Artículo en Inglés | MEDLINE | ID: mdl-33139569

10.

Trypsin Treatment Unlocks Barrier for Zoonotic Bat Coronavirus Infection.

Menachery, Vineet D; Dinnon, Kenneth H; Yount, Boyd L; McAnarney, Eileen T; Gralinski, Lisa E; Hale, Andrew; Graham, Rachel L; Scobey, Trevor; Anthony, Simon J; Wang, Lingshu; Graham, Barney; Randell, Scott H; Lipkin, W Ian; Baric, Ralph S.

J Virol; 94(5)2020 Feb 14.

Artículo en Inglés | MEDLINE | ID: mdl-31801868

11.

MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape.

Menachery, Vineet D; Schäfer, Alexandra; Burnum-Johnson, Kristin E; Mitchell, Hugh D; Eisfeld, Amie J; Walters, Kevin B; Nicora, Carrie D; Purvine, Samuel O; Casey, Cameron P; Monroe, Matthew E; Weitz, Karl K; Stratton, Kelly G; Webb-Robertson, Bobbie-Jo M; Gralinski, Lisa E; Metz, Thomas O; Smith, Richard D; Waters, Katrina M; Sims, Amy C; Kawaoka, Yoshihiro; Baric, Ralph S.

Proc Natl Acad Sci U S A; 115(5): E1012-E1021, 2018 01 30.

Artículo en Inglés | MEDLINE | ID: mdl-29339515

12.

Immune Predictors of Mortality After Ribonucleic Acid Virus Infection.

Graham, Jessica B; Swarts, Jessica L; Menachery, Vineet D; Gralinski, Lisa E; Schäfer, Alexandra; Plante, Kenneth S; Morrison, Clayton R; Voss, Kathleen M; Green, Richard; Choonoo, Gabrielle; Jeng, Sophia; Miller, Darla R; Mooney, Michael A; McWeeney, Shannon K; Ferris, Martin T; Pardo-Manuel de Villena, Fernando; Gale, Michael; Heise, Mark T; Baric, Ralph S; Lund, Jennifer M.

J Infect Dis; 221(6): 882-889, 2020 Mar 02.

Artículo en Inglés | MEDLINE | ID: mdl-31621854

13.

Combination Attenuation Offers Strategy for Live Attenuated Coronavirus Vaccines.

Menachery, Vineet D; Gralinski, Lisa E; Mitchell, Hugh D; Dinnon, Kenneth H; Leist, Sarah R; Yount, Boyd L; McAnarney, Eileen T; Graham, Rachel L; Waters, Katrina M; Baric, Ralph S.

J Virol; 92(17)2018 09 01.

Artículo en Inglés | MEDLINE | ID: mdl-29976657

14.

SARS-like WIV1-CoV poised for human emergence.

Menachery, Vineet D; Yount, Boyd L; Sims, Amy C; Debbink, Kari; Agnihothram, Sudhakar S; Gralinski, Lisa E; Graham, Rachel L; Scobey, Trevor; Plante, Jessica A; Royal, Scott R; Swanstrom, Jesica; Sheahan, Timothy P; Pickles, Raymond J; Corti, Davide; Randell, Scott H; Lanzavecchia, Antonio; Marasco, Wayne A; Baric, Ralph S.

Proc Natl Acad Sci U S A; 113(11): 3048-53, 2016 Mar 15.

Artículo en Inglés | MEDLINE | ID: mdl-26976607

15.

Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross.

Gralinski, Lisa E; Ferris, Martin T; Aylor, David L; Whitmore, Alan C; Green, Richard; Frieman, Matthew B; Deming, Damon; Menachery, Vineet D; Miller, Darla R; Buus, Ryan J; Bell, Timothy A; Churchill, Gary A; Threadgill, David W; Katze, Michael G; McMillan, Leonard; Valdar, William; Heise, Mark T; Pardo-Manuel de Villena, Fernando; Baric, Ralph S.

PLoS Genet; 11(10): e1005504, 2015 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-26452100

16.

Molecular pathology of emerging coronavirus infections.

Gralinski, Lisa E; Baric, Ralph S.

J Pathol; 235(2): 185-95, 2015 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-25270030

17.

Attenuation and restoration of severe acute respiratory syndrome coronavirus mutant lacking 2'-o-methyltransferase activity.

Menachery, Vineet D; Yount, Boyd L; Josset, Laurence; Gralinski, Lisa E; Scobey, Trevor; Agnihothram, Sudhakar; Katze, Michael G; Baric, Ralph S.

J Virol; 88(8): 4251-64, 2014 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-24478444

18.

Modeling host genetic regulation of influenza pathogenesis in the collaborative cross.

Ferris, Martin T; Aylor, David L; Bottomly, Daniel; Whitmore, Alan C; Aicher, Lauri D; Bell, Timothy A; Bradel-Tretheway, Birgit; Bryan, Janine T; Buus, Ryan J; Gralinski, Lisa E; Haagmans, Bart L; McMillan, Leonard; Miller, Darla R; Rosenzweig, Elizabeth; Valdar, William; Wang, Jeremy; Churchill, Gary A; Threadgill, David W; McWeeney, Shannon K; Katze, Michael G; Pardo-Manuel de Villena, Fernando; Baric, Ralph S; Heise, Mark T.

PLoS Pathog; 9(2): e1003196, 2013 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-23468633

19.

Evaluation of serologic and antigenic relationships between middle eastern respiratory syndrome coronavirus and other coronaviruses to develop vaccine platforms for the rapid response to emerging coronaviruses.

Agnihothram, Sudhakar; Gopal, Robin; Yount, Boyd L; Donaldson, Eric F; Menachery, Vineet D; Graham, Rachel L; Scobey, Trevor D; Gralinski, Lisa E; Denison, Mark R; Zambon, Maria; Baric, Ralph S.

J Infect Dis; 209(7): 995-1006, 2014 Apr 01.

Artículo en Inglés | MEDLINE | ID: mdl-24253287

20.

Genetic analysis of complex traits in the emerging Collaborative Cross.

Aylor, David L; Valdar, William; Foulds-Mathes, Wendy; Buus, Ryan J; Verdugo, Ricardo A; Baric, Ralph S; Ferris, Martin T; Frelinger, Jeff A; Heise, Mark; Frieman, Matt B; Gralinski, Lisa E; Bell, Timothy A; Didion, John D; Hua, Kunjie; Nehrenberg, Derrick L; Powell, Christine L; Steigerwalt, Jill; Xie, Yuying; Kelada, Samir N P; Collins, Francis S; Yang, Ivana V; Schwartz, David A; Branstetter, Lisa A; Chesler, Elissa J; Miller, Darla R; Spence, Jason; Liu, Eric Yi; McMillan, Leonard; Sarkar, Abhishek; Wang, Jeremy; Wang, Wei; Zhang, Qi; Broman, Karl W; Korstanje, Ron; Durrant, Caroline; Mott, Richard; Iraqi, Fuad A; Pomp, Daniel; Threadgill, David; de Villena, Fernando Pardo-Manuel; Churchill, Gary A.

Genome Res; 21(8): 1213-22, 2011 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-21406540

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SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract.

A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice.

Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2.

A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2.

SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract.

A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures.

Potently neutralizing and protective human antibodies against SARS-CoV-2.

Animal models for COVID-19.

Rapid identification of a human antibody with high prophylactic and therapeutic efficacy in three animal models of SARS-CoV-2 infection.

Trypsin Treatment Unlocks Barrier for Zoonotic Bat Coronavirus Infection.

MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape.

Immune Predictors of Mortality After Ribonucleic Acid Virus Infection.

Combination Attenuation Offers Strategy for Live Attenuated Coronavirus Vaccines.

SARS-like WIV1-CoV poised for human emergence.

Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross.

Molecular pathology of emerging coronavirus infections.

Attenuation and restoration of severe acute respiratory syndrome coronavirus mutant lacking 2'-o-methyltransferase activity.

Modeling host genetic regulation of influenza pathogenesis in the collaborative cross.

Evaluation of serologic and antigenic relationships between middle eastern respiratory syndrome coronavirus and other coronaviruses to develop vaccine platforms for the rapid response to emerging coronaviruses.

Genetic analysis of complex traits in the emerging Collaborative Cross.