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1.

Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates.

Goubau, Delphine; Schlee, Martin; Deddouche, Safia; Pruijssers, Andrea J; Zillinger, Thomas; Goldeck, Marion; Schuberth, Christine; Van der Veen, Annemarthe G; Fujimura, Tsutomu; Rehwinkel, Jan; Iskarpatyoti, Jason A; Barchet, Winfried; Ludwig, Janos; Dermody, Terence S; Hartmann, Gunther; Reis e Sousa, Caetano.

Nature; 514(7522): 372-375, 2014 10 16.

Artículo en Inglés | MEDLINE | ID: mdl-25119032

2.

Immune Sensing Mechanisms that Discriminate Self from Altered Self and Foreign Nucleic Acids.

Bartok, Eva; Hartmann, Gunther.

Immunity; 53(1): 54-77, 2020 Jul 14.

Artículo en Inglés | MEDLINE | ID: mdl-32668228

3.

Immune Sensing of Synthetic, Bacterial, and Protozoan RNA by Toll-like Receptor 8 Requires Coordinated Processing by RNase T2 and RNase 2.

Ostendorf, Thomas; Zillinger, Thomas; Andryka, Katarzyna; Schlee-Guimaraes, Thais Marina; Schmitz, Saskia; Marx, Samira; Bayrak, Kübra; Linke, Rebecca; Salgert, Sarah; Wegner, Julia; Grasser, Tatjana; Bauersachs, Sonja; Soltesz, Leon; Hübner, Marc P; Nastaly, Maximilian; Coch, Christoph; Kettwig, Matthias; Roehl, Ingo; Henneke, Marco; Hoerauf, Achim; Barchet, Winfried; Gärtner, Jutta; Schlee, Martin; Hartmann, Gunther; Bartok, Eva.

Immunity; 52(4): 591-605.e6, 2020 04 14.

Artículo en Inglés | MEDLINE | ID: mdl-32294405

4.

Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA.

Gao, Pu; Ascano, Manuel; Zillinger, Thomas; Wang, Weiyi; Dai, Peihong; Serganov, Artem A; Gaffney, Barbara L; Shuman, Stewart; Jones, Roger A; Deng, Liang; Hartmann, Gunther; Barchet, Winfried; Tuschl, Thomas; Patel, Dinshaw J.

Cell; 154(4): 748-62, 2013 Aug 15.

Artículo en Inglés | MEDLINE | ID: mdl-23910378

5.

Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.

Gao, Pu; Ascano, Manuel; Wu, Yang; Barchet, Winfried; Gaffney, Barbara L; Zillinger, Thomas; Serganov, Artem A; Liu, Yizhou; Jones, Roger A; Hartmann, Gunther; Tuschl, Thomas; Patel, Dinshaw J.

Cell; 153(5): 1094-107, 2013 May 23.

Artículo en Inglés | MEDLINE | ID: mdl-23647843

6.

Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA.

Herzner, Anna-Maria; Hagmann, Cristina Amparo; Goldeck, Marion; Wolter, Steven; Kübler, Kirsten; Wittmann, Sabine; Gramberg, Thomas; Andreeva, Liudmila; Hopfner, Karl-Peter; Mertens, Christina; Zillinger, Thomas; Jin, Tengchuan; Xiao, Tsan Sam; Bartok, Eva; Coch, Christoph; Ackermann, Damian; Hornung, Veit; Ludwig, Janos; Barchet, Winfried; Hartmann, Gunther; Schlee, Martin.

Nat Immunol; 16(10): 1025-33, 2015 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-26343537

7.

Self-priming determines high type I IFN production by plasmacytoid dendritic cells.

Kim, Sarah; Kaiser, Vera; Beier, Esther; Bechheim, Matthias; Guenthner-Biller, Margit; Ablasser, Andrea; Berger, Michael; Endres, Stefan; Hartmann, Gunther; Hornung, Veit.

Eur J Immunol; 44(3): 807-818, 2014 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-24338737

8.

Inflammasome-Dependent Induction of Adaptive NK Cell Memory.

van den Boorn, Jasper G; Jakobs, Christopher; Hagen, Christian; Renn, Marcel; Luiten, Rosalie M; Melief, Cornelis J M; Tüting, Thomas; Garbi, Natalio; Hartmann, Gunther; Hornung, Veit.

Immunity; 44(6): 1406-21, 2016 06 21.

Artículo en Inglés | MEDLINE | ID: mdl-27287410

9.

A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2'O-Methylated Self RNA.

Schuberth-Wagner, Christine; Ludwig, Janos; Bruder, Ann Kristin; Herzner, Anna-Maria; Zillinger, Thomas; Goldeck, Marion; Schmidt, Tobias; Schmid-Burgk, Jonathan L; Kerber, Romy; Wolter, Steven; Stümpel, Jan-Philip; Roth, Andreas; Bartok, Eva; Drosten, Christian; Coch, Christoph; Hornung, Veit; Barchet, Winfried; Kümmerer, Beate M; Hartmann, Gunther; Schlee, Martin.

Immunity; 43(1): 41-51, 2015 Jul 21.

Artículo en Inglés | MEDLINE | ID: mdl-26187414

10.

Absence of cGAS-mediated type I IFN responses in HIV-1-infected T cells.

Elsner, Carina; Ponnurangam, Aparna; Kazmierski, Julia; Zillinger, Thomas; Jansen, Jenny; Todt, Daniel; Döhner, Katinka; Xu, Shuting; Ducroux, Aurélie; Kriedemann, Nils; Malassa, Angelina; Larsen, Pia-Katharina; Hartmann, Gunther; Barchet, Winfried; Steinmann, Eike; Kalinke, Ulrich; Sodeik, Beate; Goffinet, Christine.

Proc Natl Acad Sci U S A; 117(32): 19475-19486, 2020 08 11.

Artículo en Inglés | MEDLINE | ID: mdl-32709741

11.

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production.

Poeck, Hendrik; Bscheider, Michael; Gross, Olaf; Finger, Katrin; Roth, Susanne; Rebsamen, Manuele; Hannesschläger, Nicole; Schlee, Martin; Rothenfusser, Simon; Barchet, Winfried; Kato, Hiroki; Akira, Shizuo; Inoue, Satoshi; Endres, Stefan; Peschel, Christian; Hartmann, Gunther; Hornung, Veit; Ruland, Jürgen.

Nat Immunol; 11(1): 63-9, 2010 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-19915568

12.

Turning tumors into vaccines: co-opting the innate immune system.

van den Boorn, Jasper G; Hartmann, Gunther.

Immunity; 39(1): 27-37, 2013 Jul 25.

Artículo en Inglés | MEDLINE | ID: mdl-23890061

13.

Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing.

Gehrke, Nadine; Mertens, Christina; Zillinger, Thomas; Wenzel, Jörg; Bald, Tobias; Zahn, Sabine; Tüting, Thomas; Hartmann, Gunther; Barchet, Winfried.

Immunity; 39(3): 482-95, 2013 Sep 19.

Artículo en Inglés | MEDLINE | ID: mdl-23993650

14.

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate.

Ablasser, Andrea; Bauernfeind, Franz; Hartmann, Gunther; Latz, Eicke; Fitzgerald, Katherine A; Hornung, Veit.

Nat Immunol; 10(10): 1065-72, 2009 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-19609254

15.

High RIG-I expression in ovarian cancer associates with an immune-escape signature and poor clinical outcome.

Wolf, Dominik; Fiegl, Heidi; Zeimet, Alain G; Wieser, Verena; Marth, Christian; Sprung, Susanne; Sopper, Sieghart; Hartmann, Gunther; Reimer, Daniel; Boesch, Maximilian.

Int J Cancer; 146(7): 2007-2018, 2020 04 01.

Artículo en Inglés | MEDLINE | ID: mdl-31800094

16.

A continuous responder algorithm to optimize clinical management of small-cell lung cancer with progastrin-releasing peptide as a simple blood test.

Muley, Thomas; Zhang, Xiaotong; Holdenrieder, Stefan; Korse, Catharina M; Zhi, Xiu-Yi; Molina, Rafael; Liu, Zhongjuan; Hartmann, Gunther; van den Heuvel, Michel M; Qian, Kun; Marrades, Ramon; Engel, Christine; He, Ying; Wehnl, Birgit; Dayyani, Farshid; Herth, Felix.

Tumour Biol; 42(9): 1010428320958603, 2020 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-32964798

17.

Analysis of Serum miRNA in Glioblastoma Patients: CD44-Based Enrichment of Extracellular Vesicles Enhances Specificity for the Prognostic Signature.

Tzaridis, Theophilos; Reiners, Katrin S; Weller, Johannes; Bachurski, Daniel; Schäfer, Niklas; Schaub, Christina; Hallek, Michael; Scheffler, Björn; Glas, Martin; Herrlinger, Ulrich; Wild, Stefan; Coch, Christoph; Hartmann, Gunther.

Int J Mol Sci; 21(19)2020 Sep 29.

Artículo en Inglés | MEDLINE | ID: mdl-33003586

18.

Direct RIG-I activation in human NK cells induces TRAIL-dependent cytotoxicity toward autologous melanoma cells.

Daßler-Plenker, Juliane; Paschen, Annette; Putschli, Bastian; Rattay, Stephanie; Schmitz, Saskia; Goldeck, Marion; Bartok, Eva; Hartmann, Gunther; Coch, Christoph.

Int J Cancer; 144(7): 1645-1656, 2019 04 01.

Artículo en Inglés | MEDLINE | ID: mdl-30230526

19.

Structural Alterations of MET Trigger Response to MET Kinase Inhibition in Lung Adenocarcinoma Patients.

Plenker, Dennis; Bertrand, Miriam; de Langen, Adrianus J; Riedel, Richard; Lorenz, Carina; Scheel, Andreas H; Müller, Judith; Brägelmann, Johannes; Daßler-Plenker, Juliane; Kobe, Carsten; Persigehl, Thorsten; Kluge, Alexander; Wurdinger, Thomas; Schellen, Pepijn; Hartmann, Gunther; Zacherle, Tobias; Menon, Roopika; Thunnissen, Erik; Büttner, Reinhard; Griesinger, Frank; Wolf, Jürgen; Heukamp, Lukas; Sos, Martin L; Heuckmann, Johannes M.

Clin Cancer Res; 24(6): 1337-1343, 2018 03 15.

Artículo en Inglés | MEDLINE | ID: mdl-29284707

20.

Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus.

Schlee, Martin; Roth, Andreas; Hornung, Veit; Hagmann, Cristina Amparo; Wimmenauer, Vera; Barchet, Winfried; Coch, Christoph; Janke, Markus; Mihailovic, Aleksandra; Wardle, Greg; Juranek, Stefan; Kato, Hiroki; Kawai, Taro; Poeck, Hendrik; Fitzgerald, Katherine A; Takeuchi, Osamu; Akira, Shizuo; Tuschl, Thomas; Latz, Eicke; Ludwig, Janos; Hartmann, Gunther.

Immunity; 31(1): 25-34, 2009 Jul 17.

Artículo en Inglés | MEDLINE | ID: mdl-19576794

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