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1.

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.

Hoffmann, Markus; Kleine-Weber, Hannah; Schroeder, Simon; Krüger, Nadine; Herrler, Tanja; Erichsen, Sandra; Schiergens, Tobias S; Herrler, Georg; Wu, Nai-Huei; Nitsche, Andreas; Müller, Marcel A; Drosten, Christian; Pöhlmann, Stefan.

Cell; 181(2): 271-280.e8, 2020 04 16.

Artículo en Inglés | MEDLINE | ID: mdl-32142651

2.

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.

Wrapp, Daniel; De Vlieger, Dorien; Corbett, Kizzmekia S; Torres, Gretel M; Wang, Nianshuang; Van Breedam, Wander; Roose, Kenny; van Schie, Loes; Hoffmann, Markus; Pöhlmann, Stefan; Graham, Barney S; Callewaert, Nico; Schepens, Bert; Saelens, Xavier; McLellan, Jason S.

Cell; 181(5): 1004-1015.e15, 2020 05 28.

Artículo en Inglés | MEDLINE | ID: mdl-32375025

3.

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.

Wrapp, Daniel; De Vlieger, Dorien; Corbett, Kizzmekia S; Torres, Gretel M; Wang, Nianshuang; Van Breedam, Wander; Roose, Kenny; van Schie, Loes; Hoffmann, Markus; Pöhlmann, Stefan; Graham, Barney S; Callewaert, Nico; Schepens, Bert; Saelens, Xavier; McLellan, Jason S.

Cell; 181(6): 1436-1441, 2020 Jun 11.

Artículo en Inglés | MEDLINE | ID: mdl-32531248

4.

Neutrophil Extracellular Traps Initiate Gallstone Formation.

Muñoz, Luis E; Boeltz, Sebastian; Bilyy, Rostyslav; Schauer, Christine; Mahajan, Aparna; Widulin, Navena; Grüneboom, Anika; Herrmann, Irmgard; Boada, Edgyda; Rauh, Manfred; Krenn, Veit; Biermann, Mona H C; Podolska, Malgorzata J; Hahn, Jonas; Knopf, Jasmin; Maueröder, Christian; Paryzhak, Solomiya; Dumych, Tetiana; Zhao, Yi; Neurath, Markus F; Hoffmann, Markus H; Fuchs, Tobias A; Leppkes, Moritz; Schett, Georg; Herrmann, Martin.

Immunity; 51(3): 443-450.e4, 2019 09 17.

Artículo en Inglés | MEDLINE | ID: mdl-31422870

5.

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells.

Hoffmann, Markus; Kleine-Weber, Hannah; Pöhlmann, Stefan.

Mol Cell; 78(4): 779-784.e5, 2020 05 21.

Artículo en Inglés | MEDLINE | ID: mdl-32362314

6.

Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo.

Ulges, Alexander; Klein, Matthias; Reuter, Sebastian; Gerlitzki, Bastian; Hoffmann, Markus; Grebe, Nadine; Staudt, Valérie; Stergiou, Natascha; Bohn, Toszka; Brühl, Till-Julius; Muth, Sabine; Yurugi, Hajime; Rajalingam, Krishnaraj; Bellinghausen, Iris; Tuettenberg, Andrea; Hahn, Susanne; Reißig, Sonja; Haben, Irma; Zipp, Frauke; Waisman, Ari; Probst, Hans-Christian; Beilhack, Andreas; Buchou, Thierry; Filhol-Cochet, Odile; Boldyreff, Brigitte; Breloer, Minka; Jonuleit, Helmut; Schild, Hansjörg; Schmitt, Edgar; Bopp, Tobias.

Nat Immunol; 16(3): 267-75, 2015 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-25599562

7.

Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2.

Hoffmann, Markus; Mösbauer, Kirstin; Hofmann-Winkler, Heike; Kaul, Artur; Kleine-Weber, Hannah; Krüger, Nadine; Gassen, Nils C; Müller, Marcel A; Drosten, Christian; Pöhlmann, Stefan.

Nature; 585(7826): 588-590, 2020 09.

Artículo en Inglés | MEDLINE | ID: mdl-32698190

8.

Quantum supremacy using a programmable superconducting processor.

Arute, Frank; Arya, Kunal; Babbush, Ryan; Bacon, Dave; Bardin, Joseph C; Barends, Rami; Biswas, Rupak; Boixo, Sergio; Brandao, Fernando G S L; Buell, David A; Burkett, Brian; Chen, Yu; Chen, Zijun; Chiaro, Ben; Collins, Roberto; Courtney, William; Dunsworth, Andrew; Farhi, Edward; Foxen, Brooks; Fowler, Austin; Gidney, Craig; Giustina, Marissa; Graff, Rob; Guerin, Keith; Habegger, Steve; Harrigan, Matthew P; Hartmann, Michael J; Ho, Alan; Hoffmann, Markus; Huang, Trent; Humble, Travis S; Isakov, Sergei V; Jeffrey, Evan; Jiang, Zhang; Kafri, Dvir; Kechedzhi, Kostyantyn; Kelly, Julian; Klimov, Paul V; Knysh, Sergey; Korotkov, Alexander; Kostritsa, Fedor; Landhuis, David; Lindmark, Mike; Lucero, Erik; Lyakh, Dmitry; Mandrà, Salvatore; McClean, Jarrod R; McEwen, Matthew; Megrant, Anthony; Mi, Xiao.

Nature; 574(7779): 505-510, 2019 10.

Artículo en Inglés | MEDLINE | ID: mdl-31645734

9.

Myeloperoxidase Modulates Inflammation in Generalized Pustular Psoriasis and Additional Rare Pustular Skin Diseases.

Haskamp, Stefan; Bruns, Heiko; Hahn, Madelaine; Hoffmann, Markus; Gregor, Anne; Löhr, Sabine; Hahn, Jonas; Schauer, Christine; Ringer, Mark; Flamann, Cindy; Frey, Benjamin; Lesner, Adam; Thiel, Christian T; Ekici, Arif B; von Hörsten, Stephan; Aßmann, Gunter; Riepe, Claudia; Euler, Maximilien; Schäkel, Knut; Philipp, Sandra; Prinz, Jörg C; Mößner, Rotraut; Kersting, Florina; Sticherling, Michael; Sefiani, Abdelaziz; Lyahyai, Jaber; Sondermann, Wiebke; Oji, Vinzenz; Schulz, Peter; Wilsmann-Theis, Dagmar; Sticht, Heinrich; Schett, Georg; Reis, André; Uebe, Steffen; Frey, Silke; Hüffmeier, Ulrike.

Am J Hum Genet; 107(3): 527-538, 2020 09 03.

Artículo en Inglés | MEDLINE | ID: mdl-32758447

10.

Sphingosine prevents binding of SARS-CoV-2 spike to its cellular receptor ACE2.

Edwards, Michael J; Becker, Katrin Anne; Gripp, Barbara; Hoffmann, Markus; Keitsch, Simone; Wilker, Barbara; Soddemann, Matthias; Gulbins, Anne; Carpinteiro, Elisa; Patel, Sameer H; Wilson, Gregory C; Pöhlmann, Stefan; Walter, Silke; Fassbender, Klaus; Ahmad, Syed A; Carpinteiro, Alexander; Gulbins, Erich.

J Biol Chem; 295(45): 15174-15182, 2020 11 06.

Artículo en Inglés | MEDLINE | ID: mdl-32917722

11.

The Amino Acid at Position 8 of the Proteolytic Cleavage Site of the Mumps Virus Fusion Protein Affects Viral Proteolysis and Fusogenicity.

Hüttl, Sarah; Hoffmann, Markus; Steinmetzer, Torsten; Sauder, Christian; Krüger, Nadine.

J Virol; 94(22)2020 Oct 27.

Artículo en Inglés | MEDLINE | ID: mdl-32907974

12.

A framework for modeling epistatic interaction.

Blumenthal, David B; Baumbach, Jan; Hoffmann, Markus; Kacprowski, Tim; List, Markus.

Bioinformatics; 2020 Nov 30.

Artículo en Inglés | MEDLINE | ID: mdl-33252645

13.

Modulation of HIV-1 Gag/Gag-Pol frameshifting by tRNA abundance.

Korniy, Natalia; Goyal, Akanksha; Hoffmann, Markus; Samatova, Ekaterina; Peske, Frank; Pöhlmann, Stefan; Rodnina, Marina V.

Nucleic Acids Res; 47(10): 5210-5222, 2019 06 04.

Artículo en Inglés | MEDLINE | ID: mdl-30968122

14.

Missing in action-The meaning of cell death in tissue damage and inflammation.

Muñoz, Luis E; Leppkes, Moritz; Fuchs, Tobias A; Hoffmann, Markus; Herrmann, Martin.

Immunol Rev; 280(1): 26-40, 2017 11.

Artículo en Inglés | MEDLINE | ID: mdl-29027227

15.

Mutations in the Spike Protein of Middle East Respiratory Syndrome Coronavirus Transmitted in Korea Increase Resistance to Antibody-Mediated Neutralization.

Kleine-Weber, Hannah; Elzayat, Mahmoud Tarek; Wang, Lingshu; Graham, Barney S; Müller, Marcel A; Drosten, Christian; Pöhlmann, Stefan; Hoffmann, Markus.

J Virol; 93(2)2019 01 15.

Artículo en Inglés | MEDLINE | ID: mdl-30404801

16.

Tetherin Inhibits Nipah Virus but Not Ebola Virus Replication in Fruit Bat Cells.

Hoffmann, Markus; Nehlmeier, Inga; Brinkmann, Constantin; Krähling, Verena; Behner, Laura; Moldenhauer, Anna-Sophie; Krüger, Nadine; Nehls, Julia; Schindler, Michael; Hoenen, Thomas; Maisner, Andrea; Becker, Stephan; Pöhlmann, Stefan.

J Virol; 93(3)2019 02 01.

Artículo en Inglés | MEDLINE | ID: mdl-30429347

17.

Atomistic Perspective of Long Lifetimes of Small Skyrmions at Room Temperature.

Hoffmann, Markus; Müller, Gideon P; Blügel, Stefan.

Phys Rev Lett; 124(24): 247201, 2020 Jun 19.

Artículo en Inglés | MEDLINE | ID: mdl-32639835

18.

Aggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from antiproteases.

Hahn, Jonas; Schauer, Christine; Czegley, Christine; Kling, Lasse; Petru, Lenka; Schmid, Benjamin; Weidner, Daniela; Reinwald, Christiane; Biermann, Mona H C; Blunder, Stefan; Ernst, Jürgen; Lesner, Adam; Bäuerle, Tobias; Palmisano, Ralf; Christiansen, Silke; Herrmann, Martin; Bozec, Aline; Gruber, Robert; Schett, Georg; Hoffmann, Markus H.

FASEB J; 33(1): 1401-1414, 2019 01.

Artículo en Inglés | MEDLINE | ID: mdl-30130433

19.

Rapid response flow cytometric assay for the detection of antibody responses to SARS-CoV-2.

Lapuente, Dennis; Maier, Clara; Irrgang, Pascal; Hübner, Julian; Peter, Antonia Sophia; Hoffmann, Markus; Ensser, Armin; Ziegler, Katharina; Winkler, Thomas H; Birkholz, Torsten; Kremer, Andreas E; Steininger, Philipp; Korn, Klaus; Neipel, Frank; Überla, Klaus; Tenbusch, Matthias.

Eur J Clin Microbiol Infect Dis; 2020 Oct 20.

Artículo en Inglés | MEDLINE | ID: mdl-33078221

20.

TMPRSS11A activates the influenza A virus hemagglutinin and the MERS coronavirus spike protein and is insensitive against blockade by HAI-1.

Zmora, Pawel; Hoffmann, Markus; Kollmus, Heike; Moldenhauer, Anna-Sophie; Danov, Olga; Braun, Armin; Winkler, Michael; Schughart, Klaus; Pöhlmann, Stefan.

J Biol Chem; 293(36): 13863-13873, 2018 09 07.

Artículo en Inglés | MEDLINE | ID: mdl-29976755

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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.

Neutrophil Extracellular Traps Initiate Gallstone Formation.

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells.

Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo.

Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2.

Quantum supremacy using a programmable superconducting processor.

Myeloperoxidase Modulates Inflammation in Generalized Pustular Psoriasis and Additional Rare Pustular Skin Diseases.

Sphingosine prevents binding of SARS-CoV-2 spike to its cellular receptor ACE2.

The Amino Acid at Position 8 of the Proteolytic Cleavage Site of the Mumps Virus Fusion Protein Affects Viral Proteolysis and Fusogenicity.

A framework for modeling epistatic interaction.

Modulation of HIV-1 Gag/Gag-Pol frameshifting by tRNA abundance.

Missing in action-The meaning of cell death in tissue damage and inflammation.

Mutations in the Spike Protein of Middle East Respiratory Syndrome Coronavirus Transmitted in Korea Increase Resistance to Antibody-Mediated Neutralization.

Tetherin Inhibits Nipah Virus but Not Ebola Virus Replication in Fruit Bat Cells.

Atomistic Perspective of Long Lifetimes of Small Skyrmions at Room Temperature.

Aggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from antiproteases.

Rapid response flow cytometric assay for the detection of antibody responses to SARS-CoV-2.

TMPRSS11A activates the influenza A virus hemagglutinin and the MERS coronavirus spike protein and is insensitive against blockade by HAI-1.