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1.

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.

Hoffmann, Markus; Kleine-Weber, Hannah; Schroeder, Simon; Krüger, Nadine; Herrler, Tanja; Erichsen, Sandra; Schiergens, Tobias S; Herrler, Georg; Wu, Nai-Huei; Nitsche, Andreas; Müller, Marcel A; Drosten, Christian; Pöhlmann, Stefan.

Cell; 181(2): 271-280.e8, 2020 04 16.

Artículo en Inglés | MEDLINE | ID: mdl-32142651

2.

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.

Wrapp, Daniel; De Vlieger, Dorien; Corbett, Kizzmekia S; Torres, Gretel M; Wang, Nianshuang; Van Breedam, Wander; Roose, Kenny; van Schie, Loes; Hoffmann, Markus; Pöhlmann, Stefan; Graham, Barney S; Callewaert, Nico; Schepens, Bert; Saelens, Xavier; McLellan, Jason S.

Cell; 181(5): 1004-1015.e15, 2020 05 28.

Artículo en Inglés | MEDLINE | ID: mdl-32375025

3.

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.

Wrapp, Daniel; De Vlieger, Dorien; Corbett, Kizzmekia S; Torres, Gretel M; Wang, Nianshuang; Van Breedam, Wander; Roose, Kenny; van Schie, Loes; Hoffmann, Markus; Pöhlmann, Stefan; Graham, Barney S; Callewaert, Nico; Schepens, Bert; Saelens, Xavier; McLellan, Jason S.

Cell; 181(6): 1436-1441, 2020 Jun 11.

Artículo en Inglés | MEDLINE | ID: mdl-32531248

4.

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells.

Hoffmann, Markus; Kleine-Weber, Hannah; Pöhlmann, Stefan.

Mol Cell; 78(4): 779-784.e5, 2020 05 21.

Artículo en Inglés | MEDLINE | ID: mdl-32362314

5.

Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2.

Hoffmann, Markus; Mösbauer, Kirstin; Hofmann-Winkler, Heike; Kaul, Artur; Kleine-Weber, Hannah; Krüger, Nadine; Gassen, Nils C; Müller, Marcel A; Drosten, Christian; Pöhlmann, Stefan.

Nature; 585(7826): 588-590, 2020 09.

Artículo en Inglés | MEDLINE | ID: mdl-32698190

6.

Natural cystatin C fragments inhibit GPR15-mediated HIV and SIV infection without interfering with GPR15L signaling.

Hayn, Manuel; Blötz, Andrea; Rodríguez, Armando; Vidal, Solange; Preising, Nico; Ständker, Ludger; Wiese, Sebastian; Stürzel, Christina M; Harms, Mirja; Gross, Rüdiger; Jung, Christoph; Kiene, Miriam; Jacob, Timo; Pöhlmann, Stefan; Forssmann, Wolf-Georg; Münch, Jan; Sparrer, Konstantin M J; Seuwen, Klaus; Hahn, Beatrice H; Kirchhoff, Frank.

Proc Natl Acad Sci U S A; 118(3)2021 Jan 19.

Artículo en Inglés | MEDLINE | ID: mdl-33431697

7.

Sphingosine prevents binding of SARS-CoV-2 spike to its cellular receptor ACE2.

Edwards, Michael J; Becker, Katrin Anne; Gripp, Barbara; Hoffmann, Markus; Keitsch, Simone; Wilker, Barbara; Soddemann, Matthias; Gulbins, Anne; Carpinteiro, Elisa; Patel, Sameer H; Wilson, Gregory C; Pöhlmann, Stefan; Walter, Silke; Fassbender, Klaus; Ahmad, Syed A; Carpinteiro, Alexander; Gulbins, Erich.

J Biol Chem; 295(45): 15174-15182, 2020 11 06.

Artículo en Inglés | MEDLINE | ID: mdl-32917722

8.

Modulation of HIV-1 Gag/Gag-Pol frameshifting by tRNA abundance.

Korniy, Natalia; Goyal, Akanksha; Hoffmann, Markus; Samatova, Ekaterina; Peske, Frank; Pöhlmann, Stefan; Rodnina, Marina V.

Nucleic Acids Res; 47(10): 5210-5222, 2019 06 04.

Artículo en Inglés | MEDLINE | ID: mdl-30968122

9.

Glycan-Gold Nanoparticles as Multifunctional Probes for Multivalent Lectin-Carbohydrate Binding: Implications for Blocking Virus Infection and Nanoparticle Assembly.

Budhadev, Darshita; Poole, Emma; Nehlmeier, Inga; Liu, Yuanyuan; Hooper, James; Kalverda, Elizabeth; Akshath, Uchangi Satyaprasad; Hondow, Nicole; Turnbull, W Bruce; Pöhlmann, Stefan; Guo, Yuan; Zhou, Dejian.

J Am Chem Soc; 142(42): 18022-18034, 2020 Oct 21.

Artículo en Inglés | MEDLINE | ID: mdl-32935985

10.

Hemagglutinin Cleavability, Acid Stability, and Temperature Dependence Optimize Influenza B Virus for Replication in Human Airways.

Laporte, Manon; Stevaert, Annelies; Raeymaekers, Valerie; Boogaerts, Talitha; Nehlmeier, Inga; Chiu, Winston; Benkheil, Mohammed; Vanaudenaerde, Bart; Pöhlmann, Stefan; Naesens, Lieve.

J Virol; 94(1)2019 12 12.

Artículo en Inglés | MEDLINE | ID: mdl-31597759

11.

Mutations in the Spike Protein of Middle East Respiratory Syndrome Coronavirus Transmitted in Korea Increase Resistance to Antibody-Mediated Neutralization.

Kleine-Weber, Hannah; Elzayat, Mahmoud Tarek; Wang, Lingshu; Graham, Barney S; Müller, Marcel A; Drosten, Christian; Pöhlmann, Stefan; Hoffmann, Markus.

J Virol; 93(2)2019 01 15.

Artículo en Inglés | MEDLINE | ID: mdl-30404801

12.

Tetherin Inhibits Nipah Virus but Not Ebola Virus Replication in Fruit Bat Cells.

Hoffmann, Markus; Nehlmeier, Inga; Brinkmann, Constantin; Krähling, Verena; Behner, Laura; Moldenhauer, Anna-Sophie; Krüger, Nadine; Nehls, Julia; Schindler, Michael; Hoenen, Thomas; Maisner, Andrea; Becker, Stephan; Pöhlmann, Stefan.

J Virol; 93(3)2019 02 01.

Artículo en Inglés | MEDLINE | ID: mdl-30429347

13.

Interferon-Induced Transmembrane Proteins Mediate Viral Evasion in Acute and Chronic Hepatitis C Virus Infection.

Wrensch, Florian; Ligat, Gaëtan; Heydmann, Laura; Schuster, Catherine; Zeisel, Mirjam B; Pessaux, Patrick; Habersetzer, François; King, Barnabas J; Tarr, Alexander W; Ball, Jonathan K; Winkler, Michael; Pöhlmann, Stefan; Keck, Zhen-Yong; Foung, Steven K H; Baumert, Thomas F.

Hepatology; 70(5): 1506-1520, 2019 11.

Artículo en Inglés | MEDLINE | ID: mdl-31062385

14.

H2 influenza A virus is not pathogenic in Tmprss2 knock-out mice.

Lambertz, Ruth Lydia Olga; Gerhauser, Ingo; Nehlmeier, Inga; Gärtner, Sabine; Winkler, Michael; Leist, Sarah Rebecca; Kollmus, Heike; Pöhlmann, Stefan; Schughart, Klaus.

Virol J; 17(1): 56, 2020 04 22.

Artículo en Inglés | MEDLINE | ID: mdl-32321537

15.

TMPRSS11A activates the influenza A virus hemagglutinin and the MERS coronavirus spike protein and is insensitive against blockade by HAI-1.

Zmora, Pawel; Hoffmann, Markus; Kollmus, Heike; Moldenhauer, Anna-Sophie; Danov, Olga; Braun, Armin; Winkler, Michael; Schughart, Klaus; Pöhlmann, Stefan.

J Biol Chem; 293(36): 13863-13873, 2018 09 07.

Artículo en Inglés | MEDLINE | ID: mdl-29976755

16.

Kaposi Sarcoma in Mantled Guereza.

Grewer, Anna; Bleyer, Martina; Mätz-Rensing, Kerstin; Hahn, Alexander S; Rüggeberg, Tim; Babaryka, Gregor; Zimmermann, Andre; Pöhlmann, Stefan; Kaul, Artur.

Emerg Infect Dis; 25(8): 1552-1555, 2019 08.

Artículo en Inglés | MEDLINE | ID: mdl-31310216

17.

Novel Virus Related to Kaposi's Sarcoma-Associated Herpesvirus from Colobus Monkey.

Dhingra, Akshay; Ganzenmueller, Tina; Hage, Elias; Suárez, Nicolás M; Mätz-Rensing, Kerstin; Widmer, Dimitri; Pöhlmann, Stefan; Davison, Andrew J; Schulz, Thomas F; Kaul, Artur.

Emerg Infect Dis; 25(8): 1548-1551, 2019 08.

Artículo en Inglés | MEDLINE | ID: mdl-31310220

18.

Tmprss2 knock-out mice are resistant to H10 influenza A virus pathogenesis.

Lambertz, Ruth L O; Gerhauser, Ingo; Nehlmeier, Inga; Leist, Sarah R; Kollmus, Heike; Pöhlmann, Stefan; Schughart, Klaus.

J Gen Virol; 100(7): 1073-1078, 2019 07.

Artículo en Inglés | MEDLINE | ID: mdl-31099738

19.

A GXXXA Motif in the Transmembrane Domain of the Ebola Virus Glycoprotein Is Required for Tetherin Antagonism.

González-Hernández, Mariana; Hoffmann, Markus; Brinkmann, Constantin; Nehls, Julia; Winkler, Michael; Schindler, Michael; Pöhlmann, Stefan.

J Virol; 92(13)2018 07 01.

Artículo en Inglés | MEDLINE | ID: mdl-29669839

20.

Analysis of IFITM-IFITM Interactions by a Flow Cytometry-Based FRET Assay.

Winkler, Michael; Wrensch, Florian; Bosch, Pascale; Knoth, Maike; Schindler, Michael; Gärtner, Sabine; Pöhlmann, Stefan.

Int J Mol Sci; 20(16)2019 Aug 08.

Artículo en Inglés | MEDLINE | ID: mdl-31398796

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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells.

Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2.

Natural cystatin C fragments inhibit GPR15-mediated HIV and SIV infection without interfering with GPR15L signaling.

Sphingosine prevents binding of SARS-CoV-2 spike to its cellular receptor ACE2.

Modulation of HIV-1 Gag/Gag-Pol frameshifting by tRNA abundance.

Glycan-Gold Nanoparticles as Multifunctional Probes for Multivalent Lectin-Carbohydrate Binding: Implications for Blocking Virus Infection and Nanoparticle Assembly.

Hemagglutinin Cleavability, Acid Stability, and Temperature Dependence Optimize Influenza B Virus for Replication in Human Airways.

Mutations in the Spike Protein of Middle East Respiratory Syndrome Coronavirus Transmitted in Korea Increase Resistance to Antibody-Mediated Neutralization.

Tetherin Inhibits Nipah Virus but Not Ebola Virus Replication in Fruit Bat Cells.

Interferon-Induced Transmembrane Proteins Mediate Viral Evasion in Acute and Chronic Hepatitis C Virus Infection.

H2 influenza A virus is not pathogenic in Tmprss2 knock-out mice.

TMPRSS11A activates the influenza A virus hemagglutinin and the MERS coronavirus spike protein and is insensitive against blockade by HAI-1.

Kaposi Sarcoma in Mantled Guereza.

Novel Virus Related to Kaposi's Sarcoma-Associated Herpesvirus from Colobus Monkey.

Tmprss2 knock-out mice are resistant to H10 influenza A virus pathogenesis.

A GXXXA Motif in the Transmembrane Domain of the Ebola Virus Glycoprotein Is Required for Tetherin Antagonism.

Analysis of IFITM-IFITM Interactions by a Flow Cytometry-Based FRET Assay.