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1.

Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection.

Wei, Jin; Alfajaro, Mia Madel; DeWeirdt, Peter C; Hanna, Ruth E; Lu-Culligan, William J; Cai, Wesley L; Strine, Madison S; Zhang, Shang-Min; Graziano, Vincent R; Schmitz, Cameron O; Chen, Jennifer S; Mankowski, Madeleine C; Filler, Renata B; Ravindra, Neal G; Gasque, Victor; de Miguel, Fernando J; Patil, Ajinkya; Chen, Huacui; Oguntuyo, Kasopefoluwa Y; Abriola, Laura; Surovtseva, Yulia V; Orchard, Robert C; Lee, Benhur; Lindenbach, Brett D; Politi, Katerina; van Dijk, David; Kadoch, Cigall; Simon, Matthew D; Yan, Qin; Doench, John G; Wilen, Craig B.

Cell; 184(1): 76-91.e13, 2021 01 07.

Artículo en Inglés | MEDLINE | ID: mdl-33147444

2.

YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics.

Fan, Pang-Dian; Narzisi, Giuseppe; Jayaprakash, Anitha D; Venturini, Elisa; Robine, Nicolas; Smibert, Peter; Germer, Soren; Yu, Helena A; Jordan, Emmet J; Paik, Paul K; Janjigian, Yelena Y; Chaft, Jamie E; Wang, Lu; Jungbluth, Achim A; Middha, Sumit; Spraggon, Lee; Qiao, Huan; Lovly, Christine M; Kris, Mark G; Riely, Gregory J; Politi, Katerina; Varmus, Harold; Ladanyi, Marc.

Proc Natl Acad Sci U S A; 115(26): E6030-E6038, 2018 06 26.

Artículo en Inglés | MEDLINE | ID: mdl-29875142

3.

Immunotherapy in Non-Small Cell Lung Cancer: Facts and Hopes.

Doroshow, Deborah B; Sanmamed, Miguel F; Hastings, Katherine; Politi, Katerina; Rimm, David L; Chen, Lieping; Melero, Ignacio; Schalper, Kurt A; Herbst, Roy S.

Clin Cancer Res; 25(15): 4592-4602, 2019 08 01.

Artículo en Inglés | MEDLINE | ID: mdl-30824587

4.

The EGFR Exon 19 Mutant L747-A750>P Exhibits Distinct Sensitivity to Tyrosine Kinase Inhibitors in Lung Adenocarcinoma.

Truini, Anna; Starrett, Jacqueline H; Stewart, Tyler; Ashtekar, Kumar; Walther, Zenta; Wurtz, Anna; Lu, David; Park, Jin H; DeVeaux, Michelle; Song, Xiaoling; Gettinger, Scott; Zelterman, Daniel; Lemmon, Mark A; Goldberg, Sarah B; Politi, Katerina.

Clin Cancer Res; 25(21): 6382-6391, 2019 11 01.

Artículo en Inglés | MEDLINE | ID: mdl-31182434

5.

Expression Analysis and Significance of PD-1, LAG-3, and TIM-3 in Human Non-Small Cell Lung Cancer Using Spatially Resolved and Multiparametric Single-Cell Analysis.

Datar, Ila; Sanmamed, Miguel F; Wang, Jun; Henick, Brian S; Choi, Jungmin; Badri, Ti; Dong, Weilai; Mani, Nikita; Toki, Maria; Mejías, Luis D; Lozano, Maria D; Perez-Gracia, Jose Luis; Velcheti, Vamsidhar; Hellmann, Matthew D; Gainor, Justin F; McEachern, Kristen; Jenkins, David; Syrigos, Konstantinos; Politi, Katerina; Gettinger, Scott; Rimm, David L; Herbst, Roy S; Melero, Ignacio; Chen, Lieping; Schalper, Kurt A.

Clin Cancer Res; 25(15): 4663-4673, 2019 08 01.

Artículo en Inglés | MEDLINE | ID: mdl-31053602

6.

Early Assessment of Lung Cancer Immunotherapy Response via Circulating Tumor DNA.

Goldberg, Sarah B; Narayan, Azeet; Kole, Adam J; Decker, Roy H; Teysir, Jimmitti; Carriero, Nicholas J; Lee, Angela; Nemati, Roxanne; Nath, Sameer K; Mane, Shrikant M; Deng, Yanhong; Sukumar, Nitin; Zelterman, Daniel; Boffa, Daniel J; Politi, Katerina; Gettinger, Scott N; Wilson, Lynn D; Herbst, Roy S; Patel, Abhijit A.

Clin Cancer Res; 24(8): 1872-1880, 2018 04 15.

Artículo en Inglés | MEDLINE | ID: mdl-29330207

7.

The Impact of Smoking and TP53 Mutations in Lung Adenocarcinoma Patients with Targetable Mutations-The Lung Cancer Mutation Consortium (LCMC2).

Aisner, Dara L; Sholl, Lynette M; Berry, Lynne D; Rossi, Michael R; Chen, Heidi; Fujimoto, Junya; Moreira, Andre L; Ramalingam, Suresh S; Villaruz, Liza C; Otterson, Gregory A; Haura, Eric; Politi, Katerina; Glisson, Bonnie; Cetnar, Jeremy; Garon, Edward B; Schiller, Joan; Waqar, Saiama N; Sequist, Lecia V; Brahmer, Julie; Shyr, Yu; Kugler, Kelly; Wistuba, Ignacio I; Johnson, Bruce E; Minna, John D; Kris, Mark G; Bunn, Paul A; Kwiatkowski, David J.

Clin Cancer Res; 24(5): 1038-1047, 2018 03 01.

Artículo en Inglés | MEDLINE | ID: mdl-29217530

8.

Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma.

McFadden, David G; Politi, Katerina; Bhutkar, Arjun; Chen, Frances K; Song, Xiaoling; Pirun, Mono; Santiago, Philip M; Kim-Kiselak, Caroline; Platt, James T; Lee, Emily; Hodges, Emily; Rosebrock, Adam P; Bronson, Roderick T; Socci, Nicholas D; Hannon, Gregory J; Jacks, Tyler; Varmus, Harold.

Proc Natl Acad Sci U S A; 113(42): E6409-E6417, 2016 10 18.

Artículo en Inglés | MEDLINE | ID: mdl-27702896

9.

PD-1 Axis Inhibitors in EGFR- and ALK-Driven Lung Cancer: Lost Cause?

Gettinger, Scott; Politi, Katerina.

Clin Cancer Res; 22(18): 4539-41, 2016 Sep 15.

Artículo en Inglés | MEDLINE | ID: mdl-27470969

10.

Afatinib plus Cetuximab Delays Resistance Compared to Single-Agent Erlotinib or Afatinib in Mouse Models of TKI-Naïve EGFR L858R-Induced Lung Adenocarcinoma.

Pirazzoli, Valentina; Ayeni, Deborah; Meador, Catherine B; Sanganahalli, Basavaraju G; Hyder, Fahmeed; de Stanchina, Elisa; Goldberg, Sarah B; Pao, William; Politi, Katerina.

Clin Cancer Res; 22(2): 426-35, 2016 Jan 15.

Artículo en Inglés | MEDLINE | ID: mdl-26341921

11.

De novo selection of oncogenes.

Chacón, Kelly M; Petti, Lisa M; Scheideman, Elizabeth H; Pirazzoli, Valentina; Politi, Katerina; DiMaio, Daniel.

Proc Natl Acad Sci U S A; 111(1): E6-E14, 2014 Jan 07.

Artículo en Inglés | MEDLINE | ID: mdl-24344264

12.

Next-generation sequencing of paired tyrosine kinase inhibitor-sensitive and -resistant EGFR mutant lung cancer cell lines identifies spectrum of DNA changes associated with drug resistance.

Jia, Peilin; Jin, Hailing; Meador, Catherine B; Xia, Junfeng; Ohashi, Kadoaki; Liu, Lin; Pirazzoli, Valentina; Dahlman, Kimberly B; Politi, Katerina; Michor, Franziska; Zhao, Zhongming; Pao, William.

Genome Res; 23(9): 1434-45, 2013 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-23733853

13.

Lung cancer in the era of precision medicine.

Politi, Katerina; Herbst, Roy S.

Clin Cancer Res; 21(10): 2213-20, 2015 May 15.

Artículo en Inglés | MEDLINE | ID: mdl-25979927

14.

Emerging Agents and New Mutations in EGFR-Mutant Lung Cancer.

Ayeni, Deborah; Politi, Katerina; Goldberg, Sarah B.

Clin Cancer Res; 21(17): 3818-20, 2015 Sep 01.

Artículo en Inglés | MEDLINE | ID: mdl-26169963

15.

Isolation of epithelial, endothelial, and immune cells from lungs of transgenic mice with oncogene-induced lung adenocarcinomas.

Bantikassegn, Amlak; Song, Xiaoling; Politi, Katerina.

Am J Respir Cell Mol Biol; 52(4): 409-17, 2015 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-25347711

16.

Perfect ALKemy: optimizing the use of ALK-directed therapies in lung cancer.

Politi, Katerina; Gettinger, Scott.

Clin Cancer Res; 20(22): 5576-8, 2014 Nov 15.

Artículo en Inglés | MEDLINE | ID: mdl-25228532

17.

Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer.

de Bruin, Elza C; Cowell, Catherine; Warne, Patricia H; Jiang, Ming; Saunders, Rebecca E; Melnick, Mary Ann; Gettinger, Scott; Walther, Zenta; Wurtz, Anna; Heynen, Guus J; Heideman, Daniëlle A M; Gómez-Román, Javier; García-Castaño, Almudena; Gong, Yixuan; Ladanyi, Marc; Varmus, Harold; Bernards, René; Smit, Egbert F; Politi, Katerina; Downward, Julian.

Cancer Discov; 4(5): 606-19, 2014 May.

Artículo en Inglés | MEDLINE | ID: mdl-24535670

18.

Two sides of the same coin: EGFR exon 19 deletions and insertions in lung cancer.

Politi, Katerina; Lynch, Thomas J.

Clin Cancer Res; 18(6): 1490-2, 2012 Mar 15.

Artículo en Inglés | MEDLINE | ID: mdl-22317760

19.

Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer.

Sos, Martin L; Fischer, Stefanie; Ullrich, Roland; Peifer, Martin; Heuckmann, Johannes M; Koker, Mirjam; Heynck, Stefanie; Stückrath, Isabel; Weiss, Jonathan; Fischer, Florian; Michel, Kathrin; Goel, Aviva; Regales, Lucia; Politi, Katerina A; Perera, Samanthi; Getlik, Matthäus; Heukamp, Lukas C; Ansén, Sascha; Zander, Thomas; Beroukhim, Rameen; Kashkar, Hamid; Shokat, Kevan M; Sellers, William R; Rauh, Daniel; Orr, Christine; Hoeflich, Klaus P; Friedman, Lori; Wong, Kwok-Kin; Pao, William; Thomas, Roman K.

Proc Natl Acad Sci U S A; 106(43): 18351-6, 2009 Oct 27.

Artículo en Inglés | MEDLINE | ID: mdl-19805051

20.

Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras.

Podsypanina, Katrina; Politi, Katerina; Beverly, Levi J; Varmus, Harold E.

Proc Natl Acad Sci U S A; 105(13): 5242-7, 2008 Apr 01.

Artículo en Inglés | MEDLINE | ID: mdl-18356293

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