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1.

Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing.

Riva, Laura; Yuan, Shuofeng; Yin, Xin; Martin-Sancho, Laura; Matsunaga, Naoko; Pache, Lars; Burgstaller-Muehlbacher, Sebastian; De Jesus, Paul D; Teriete, Peter; Hull, Mitchell V; Chang, Max W; Chan, Jasper Fuk-Woo; Cao, Jianli; Poon, Vincent Kwok-Man; Herbert, Kristina M; Cheng, Kuoyuan; Nguyen, Tu-Trinh H; Rubanov, Andrey; Pu, Yuan; Nguyen, Courtney; Choi, Angela; Rathnasinghe, Raveen; Schotsaert, Michael; Miorin, Lisa; Dejosez, Marion; Zwaka, Thomas P; Sit, Ko-Yung; Martinez-Sobrido, Luis; Liu, Wen-Chun; White, Kris M; Chapman, Mackenzie E; Lendy, Emma K; Glynne, Richard J; Albrecht, Randy; Ruppin, Eytan; Mesecar, Andrew D; Johnson, Jeffrey R; Benner, Christopher; Sun, Ren; Schultz, Peter G; Su, Andrew I; García-Sastre, Adolfo; Chatterjee, Arnab K; Yuen, Kwok-Yung; Chanda, Sumit K.

Nature; 586(7827): 113-119, 2020 10.

Artículo en Inglés | MEDLINE | ID: mdl-32707573

2.

A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster.

Chan, Jasper Fuk-Woo; Yuan, Shuofeng; Kok, Kin-Hang; To, Kelvin Kai-Wang; Chu, Hin; Yang, Jin; Xing, Fanfan; Liu, Jieling; Yip, Cyril Chik-Yan; Poon, Rosana Wing-Shan; Tsoi, Hoi-Wah; Lo, Simon Kam-Fai; Chan, Kwok-Hung; Poon, Vincent Kwok-Man; Chan, Wan-Mui; Ip, Jonathan Daniel; Cai, Jian-Piao; Cheng, Vincent Chi-Chung; Chen, Honglin; Hui, Christopher Kim-Ming; Yuen, Kwok-Yung.

Lancet; 395(10223): 514-523, 2020 02 15.

Artículo en Inglés | MEDLINE | ID: mdl-31986261

3.

Differentiated human airway organoids to assess infectivity of emerging influenza virus.

Zhou, Jie; Li, Cun; Sachs, Norman; Chiu, Man Chun; Wong, Bosco Ho-Yin; Chu, Hin; Poon, Vincent Kwok-Man; Wang, Dong; Zhao, Xiaoyu; Wen, Lei; Song, Wenjun; Yuan, Shuofeng; Wong, Kenneth Kak-Yuen; Chan, Jasper Fuk-Woo; To, Kelvin Kai-Wang; Chen, Honglin; Clevers, Hans; Yuen, Kwok-Yung.

Proc Natl Acad Sci U S A; 115(26): 6822-6827, 2018 06 26.

Artículo en Inglés | MEDLINE | ID: mdl-29891677

4.

Activation of C-Type Lectin Receptor and (RIG)-I-Like Receptors Contributes to Proinflammatory Response in Middle East Respiratory Syndrome Coronavirus-Infected Macrophages.

Zhao, Xiaoyu; Chu, Hin; Wong, Bosco Ho-Yin; Chiu, Man Chun; Wang, Dong; Li, Cun; Liu, Xiaojuan; Yang, Dong; Poon, Vincent Kwok-Man; Cai, Jianpiao; Chan, Jasper Fuk-Woo; To, Kelvin Kai-Wang; Zhou, Jie; Yuen, Kwok-Yung.

J Infect Dis; 221(4): 647-659, 2020 02 03.

Artículo en Inglés | MEDLINE | ID: mdl-31562757

5.

Co-infection by severe acute respiratory syndrome coronavirus 2 and influenza A(H1N1)pdm09 virus enhances the severity of pneumonia in golden Syrian hamsters.

Zhang, Anna Jinxia; Lee, Andrew Chak-Yiu; Chan, Jasper Fuk-Woo; Liu, Feifei; Li, Can; Chen, Yanxia; Chu, Hin; Lau, Siu-Ying; Wang, Pui; Chan, Chris Chung-Sing; Poon, Vincent Kwok-Man; Yuan, Shuofeng; To, Kelvin Kai-Wang; Chen, Honglin; Yuen, Kwok-Yung.

Clin Infect Dis; 2020 Nov 20.

Artículo en Inglés | MEDLINE | ID: mdl-33216851

6.

SARS-CoV-2 infects and damages the mature and immature olfactory sensory neurons of hamsters.

Zhang, Anna Jinxia; Lee, Andrew Chak-Yiu; Chu, Hin; Chan, Jasper Fuk-Woo; Fan, Zhimeng; Li, Can; Liu, Feifei; Chen, Yanxia; Yuan, Shuofeng; Poon, Vincent Kwok-Man; Chan, Chris Chung-Sing; Cai, Jian-Piao; Wu, Kenneth Lap-Kei; Sridhar, Siddharth; Chan, Ying-Shing; Yuen, Kwok-Yung.

Clin Infect Dis; 2020 Jul 15.

Artículo en Inglés | MEDLINE | ID: mdl-32667973

7.

Simulation of the Clinical and Pathological Manifestations of Coronavirus Disease 2019 (COVID-19) in a Golden Syrian Hamster Model: Implications for Disease Pathogenesis and Transmissibility.

Chan, Jasper Fuk-Woo; Zhang, Anna Jinxia; Yuan, Shuofeng; Poon, Vincent Kwok-Man; Chan, Chris Chung-Sing; Lee, Andrew Chak-Yiu; Chan, Wan-Mui; Fan, Zhimeng; Tsoi, Hoi-Wah; Wen, Lei; Liang, Ronghui; Cao, Jianli; Chen, Yanxia; Tang, Kaiming; Luo, Cuiting; Cai, Jian-Piao; Kok, Kin-Hang; Chu, Hin; Chan, Kwok-Hung; Sridhar, Siddharth; Chen, Zhiwei; Chen, Honglin; To, Kelvin Kai-Wang; Yuen, Kwok-Yung.

Clin Infect Dis; 71(9): 2428-2446, 2020 12 03.

Artículo en Inglés | MEDLINE | ID: mdl-32215622

8.

Surgical Mask Partition Reduces the Risk of Noncontact Transmission in a Golden Syrian Hamster Model for Coronavirus Disease 2019 (COVID-19).

Chan, Jasper Fuk-Woo; Yuan, Shuofeng; Zhang, Anna Jinxia; Poon, Vincent Kwok-Man; Chan, Chris Chung-Sing; Lee, Andrew Chak-Yiu; Fan, Zhimeng; Li, Can; Liang, Ronghui; Cao, Jianli; Tang, Kaiming; Luo, Cuiting; Cheng, Vincent Chi-Chung; Cai, Jian-Piao; Chu, Hin; Chan, Kwok-Hung; To, Kelvin Kai-Wang; Sridhar, Siddharth; Yuen, Kwok-Yung.

Clin Infect Dis; 71(16): 2139-2149, 2020 11 19.

Artículo en Inglés | MEDLINE | ID: mdl-32472679

9.

Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells.

Chu, Hin; Chan, Che-Man; Zhang, Xi; Wang, Yixin; Yuan, Shuofeng; Zhou, Jie; Au-Yeung, Rex Kwok-Him; Sze, Kong-Hung; Yang, Dong; Shuai, Huiping; Hou, Yuxin; Li, Cun; Zhao, Xiaoyu; Poon, Vincent Kwok-Man; Leung, Sze Pui; Yeung, Man-Lung; Yan, Jinghua; Lu, Guangwen; Jin, Dong-Yan; Gao, George Fu; Chan, Jasper Fuk-Woo; Yuen, Kwok-Yung.

J Biol Chem; 293(30): 11709-11726, 2018 07 27.

Artículo en Inglés | MEDLINE | ID: mdl-29887526

10.

Immunization With a Novel Human Type 5 Adenovirus-Vectored Vaccine Expressing the Premembrane and Envelope Proteins of Zika Virus Provides Consistent and Sterilizing Protection in Multiple Immunocompetent and Immunocompromised Animal Models.

Guo, Qiang; Chan, Jasper Fuk-Woo; Poon, Vincent Kwok-Man; Wu, Shipo; Chan, Chris Chung-Sing; Hou, Lihua; Yip, Cyril Chik-Yan; Ren, Changpeng; Cai, Jian-Piao; Zhao, Mengsu; Zhang, Anna Jinxia; Song, Xiaohong; Chan, Kwok-Hung; Wang, Busen; Kok, Kin-Hang; Wen, Yanbo; Yuen, Kwok-Yung; Chen, Wei.

J Infect Dis; 218(3): 365-377, 2018 07 02.

Artículo en Inglés | MEDLINE | ID: mdl-29617816

11.

Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5'-untranslated region of Zika virus.

Chan, Jasper Fuk-Woo; Yip, Cyril Chik-Yan; Tee, Kah-Meng; Zhu, Zheng; Tsang, Jessica Oi-Ling; Chik, Kenn Ka-Heng; Tsang, Terance Gi-Wai; Chan, Chris Chung-Sing; Poon, Vincent Kwok-Man; Sridhar, Siddharth; Yin, Feifei; Hung, Ivan Fan-Ngai; Chau, Sandy Ka-Yee; Zhang, Anna Jinxia; Chan, Kwok-Hung; Yuen, Kwok-Yung.

Trop Med Int Health; 22(5): 594-603, 2017 05.

Artículo en Inglés | MEDLINE | ID: mdl-28214373

12.

Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis.

Zhou, Jie; Chu, Hin; Li, Cun; Wong, Bosco Ho-Yin; Cheng, Zhong-Shan; Poon, Vincent Kwok-Man; Sun, Tianhao; Lau, Candy Choi-Yi; Wong, Kenneth Kak-Yuen; Chan, Jimmy Yu-Wai; Chan, Jasper Fuk-Woo; To, Kelvin Kai-Wang; Chan, Kwok-Hung; Zheng, Bo-Jian; Yuen, Kwok-Yung.

J Infect Dis; 209(9): 1331-42, 2014 May 01.

Artículo en Inglés | MEDLINE | ID: mdl-24065148

13.

Translationally controlled tumor protein induces mitotic defects and chromosome missegregation in hepatocellular carcinoma development.

Chan, Tim Hon Man; Chen, Leilei; Liu, Ming; Hu, Liang; Zheng, Bo-jian; Poon, Vincent Kwok-Man; Huang, Pinzhu; Yuan, Yun-Fei; Huang, Jian-dong; Yang, Jie; Tsao, George Sai-wah; Guan, Xin-Yuan.

Hepatology; 55(2): 491-505, 2012 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-21953552

14.

Beneficial effect of combinational methylprednisolone and remdesivir in hamster model of SARS-CoV-2 infection.

Ye, Zi-Wei; Yuan, Shuofeng; Chan, Jasper Fuk-Woo; Zhang, Anna Jinxia; Yu, Ching-Yun; Ong, Chon Phin; Yang, Dong; Chan, Chris Chun-Yiu; Tang, Kaiming; Cao, Jianli; Poon, Vincent Kwok-Man; Chan, Chris Chung-Sing; Cai, Jian-Piao; Chu, Hin; Yuen, Kwok-Yung; Jin, Dong-Yan.

Emerg Microbes Infect; : 1-38, 2021 Feb 04.

Artículo en Inglés | MEDLINE | ID: mdl-33538646

15.

Oral SARS-CoV-2 Inoculation Establishes Subclinical Respiratory Infection with Virus Shedding in Golden Syrian Hamsters.

Lee, Andrew Chak-Yiu; Zhang, Anna Jinxia; Chan, Jasper Fuk-Woo; Li, Can; Fan, Zhimeng; Liu, Feifei; Chen, Yanxia; Liang, Ronghui; Sridhar, Siddharth; Cai, Jian-Piao; Poon, Vincent Kwok-Man; Chan, Chris Chung-Sing; To, Kelvin Kai-Wang; Yuan, Shuofeng; Zhou, Jie; Chu, Hin; Yuen, Kwok-Yung.

Cell Rep Med; 1(7): 100121, 2020 Oct 20.

Artículo en Inglés | MEDLINE | ID: mdl-32984855

16.

Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target.

Yuan, Shuofeng; Chu, Hin; Huang, Jingjing; Zhao, Xiaoyu; Ye, Zi-Wei; Lai, Pok-Man; Wen, Lei; Cai, Jian-Piao; Mo, Yufei; Cao, Jianli; Liang, Ronghui; Poon, Vincent Kwok-Man; Sze, Kong-Hung; Zhou, Jie; To, Kelvin Kai-Wang; Chen, Zhiwei; Chen, Honglin; Jin, Dong-Yan; Chan, Jasper Fuk-Woo; Yuen, Kwok-Yung.

Sci Adv; 6(35): eaba7910, 2020 08.

Artículo en Inglés | MEDLINE | ID: mdl-32923629

17.

A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals.

Riva, Laura; Yuan, Shuofeng; Yin, Xin; Martin-Sancho, Laura; Matsunaga, Naoko; Burgstaller-Muehlbacher, Sebastian; Pache, Lars; De Jesus, Paul P; Hull, Mitchell V; Chang, Max; Chan, Jasper Fuk-Woo; Cao, Jianli; Poon, Vincent Kwok-Man; Herbert, Kristina; Nguyen, Tu-Trinh; Pu, Yuan; Nguyen, Courtney; Rubanov, Andrey; Martinez-Sobrido, Luis; Liu, Wen-Chun; Miorin, Lisa; White, Kris M; Johnson, Jeffrey R; Benner, Christopher; Sun, Ren; Schultz, Peter G; Su, Andrew; Garcia-Sastre, Adolfo; Chatterjee, Arnab K; Yuen, Kwok-Yung; Chanda, Sumit K.

bioRxiv; 2020 Apr 17.

Artículo en Inglés | MEDLINE | ID: mdl-32511357

18.

Identification and characterization of GLDC as host susceptibility gene to severe influenza.

Zhou, Jie; Wang, Dong; Wong, Bosco Ho-Yin; Li, Cun; Poon, Vincent Kwok-Man; Wen, Lei; Zhao, Xiaoyu; Chiu, Man Chun; Liu, Xiaojuan; Ye, Ziwei; Yuan, Shuofeng; Sze, Kong-Hung; Chan, Jasper Fuk-Woo; Chu, Hin; To, Kelvin Kai-Wang; Yuen, Kwok Yung.

EMBO Mol Med; 11(1)2019 01.

Artículo en Inglés | MEDLINE | ID: mdl-30498026

19.

SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target.

Yuan, Shuofeng; Chu, Hin; Chan, Jasper Fuk-Woo; Ye, Zi-Wei; Wen, Lei; Yan, Bingpeng; Lai, Pok-Man; Tee, Kah-Meng; Huang, Jingjing; Chen, Dongdong; Li, Cun; Zhao, Xiaoyu; Yang, Dong; Chiu, Man Chun; Yip, Cyril; Poon, Vincent Kwok-Man; Chan, Chris Chung-Sing; Sze, Kong-Hung; Zhou, Jie; Chan, Ivy Hau-Yee; Kok, Kin-Hang; To, Kelvin Kai-Wang; Kao, Richard Yi-Tsun; Lau, Johnson Yiu-Nam; Jin, Dong-Yan; Perlman, Stanley; Yuen, Kwok-Yung.

Nat Commun; 10(1): 120, 2019 01 10.

Artículo en Inglés | MEDLINE | ID: mdl-30631056

20.

The celecoxib derivative kinase inhibitor AR-12 (OSU-03012) inhibits Zika virus via down-regulation of the PI3K/Akt pathway and protects Zika virus-infected A129 mice: A host-targeting treatment strategy.

Chan, Jasper Fuk-Woo; Zhu, Zheng; Chu, Hin; Yuan, Shuofeng; Chik, Kenn Ka-Heng; Chan, Chris Chung-Sing; Poon, Vincent Kwok-Man; Yip, Cyril Chik-Yan; Zhang, Xi; Tsang, Jessica Oi-Ling; Zou, Zijiao; Tee, Kah-Meng; Shuai, Huiping; Lu, Gang; Yuen, Kwok-Yung.

Antiviral Res; 160: 38-47, 2018 12.

Artículo en Inglés | MEDLINE | ID: mdl-30326204

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