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1.

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.

Wrapp, Daniel; De Vlieger, Dorien; Corbett, Kizzmekia S; Torres, Gretel M; Wang, Nianshuang; Van Breedam, Wander; Roose, Kenny; van Schie, Loes; Hoffmann, Markus; Pöhlmann, Stefan; Graham, Barney S; Callewaert, Nico; Schepens, Bert; Saelens, Xavier; McLellan, Jason S.

Cell; 181(5): 1004-1015.e15, 2020 05 28.

Artículo en Inglés | MEDLINE | ID: covidwho-88549

2.

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.

Wrapp, Daniel; De Vlieger, Dorien; Corbett, Kizzmekia S; Torres, Gretel M; Wang, Nianshuang; Van Breedam, Wander; Roose, Kenny; van Schie, Loes; Hoffmann, Markus; Pöhlmann, Stefan; Graham, Barney S; Callewaert, Nico; Schepens, Bert; Saelens, Xavier; McLellan, Jason S.

Cell; 181(5): 1004-1015.e15, 2020 05 28.

Artículo en Inglés | MEDLINE | ID: mdl-32375025

3.

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.

Wrapp, Daniel; De Vlieger, Dorien; Corbett, Kizzmekia S; Torres, Gretel M; Wang, Nianshuang; Van Breedam, Wander; Roose, Kenny; van Schie, Loes; Hoffmann, Markus; Pöhlmann, Stefan; Graham, Barney S; Callewaert, Nico; Schepens, Bert; Saelens, Xavier; McLellan, Jason S.

Cell; 181(6): 1436-1441, 2020 Jun 11.

Artículo en Inglés | MEDLINE | ID: covidwho-598186

4.

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.

Wrapp, Daniel; De Vlieger, Dorien; Corbett, Kizzmekia S; Torres, Gretel M; Wang, Nianshuang; Van Breedam, Wander; Roose, Kenny; van Schie, Loes; Hoffmann, Markus; Pöhlmann, Stefan; Graham, Barney S; Callewaert, Nico; Schepens, Bert; Saelens, Xavier; McLellan, Jason S.

Cell; 181(6): 1436-1441, 2020 Jun 11.

Artículo en Inglés | MEDLINE | ID: mdl-32531248

5.

Mx1 in Hematopoietic Cells Protects against Thogoto Virus Infection.

Spitaels, Jan; Van Hoecke, Lien; Roose, Kenny; Kochs, Georg; Saelens, Xavier.

J Virol; 93(15)2019 08 01.

Artículo en Inglés | MEDLINE | ID: mdl-31092574

6.

How mRNA therapeutics are entering the monoclonal antibody field.

Van Hoecke, Lien; Roose, Kenny.

J Transl Med; 17(1): 54, 2019 02 22.

Artículo en Inglés | MEDLINE | ID: mdl-30795778

7.

Hierarchical and Redundant Roles of Activating FcÎ³Rs in Protection against Influenza Disease by M2e-Specific IgG1 and IgG2a Antibodies.

Van den Hoecke, Silvie; Ehrhardt, Katrin; Kolpe, Annasaheb; El Bakkouri, Karim; Deng, Lei; Grootaert, Hendrik; Schoonooghe, Steve; Smet, Anouk; Bentahir, Mostafa; Roose, Kenny; Schotsaert, Michael; Schepens, Bert; Callewaert, Nico; Nimmerjahn, Falk; Staeheli, Peter; Hengel, Hartmut; Saelens, Xavier.

J Virol; 91(7)2017 04 01.

Artículo en Inglés | MEDLINE | ID: mdl-28077656

8.

A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection.

Maelfait, Jonathan; Roose, Kenny; Vereecke, Lars; Mc Guire, Conor; Sze, Mozes; Schuijs, Martijn J; Willart, Monique; Ibañez, Lorena Itati; Hammad, Hamida; Lambrecht, Bart N; Beyaert, Rudi; Saelens, Xavier; van Loo, Geert.

PLoS Pathog; 12(1): e1005410, 2016 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-26815999

9.

Increased Protein Degradation Improves Influenza Virus Nucleoprotein-Specific CD8+ T Cell Activation In Vitro but Not in C57BL/6 Mice.

Altenburg, Arwen F; van de Sandt, Carolien E; van Trierum, Stella E; De Gruyter, Heidi L M; van Run, Peter R W A; Fouchier, Ron A M; Roose, Kenny; Saelens, Xavier; Volz, Asisa; Sutter, Gerd; de Vries, Rory D; Rimmelzwaan, Guus F.

J Virol; 90(22): 10209-10219, 2016 Nov 15.

Artículo en Inglés | MEDLINE | ID: mdl-27581985

10.

Type I Interferons Interfere with the Capacity of mRNA Lipoplex Vaccines to Elicit Cytolytic T Cell Responses.

De Beuckelaer, Ans; Pollard, Charlotte; Van Lint, Sandra; Roose, Kenny; Van Hoecke, Lien; Naessens, Thomas; Udhayakumar, Vimal Kumar; Smet, Muriel; Sanders, Niek; Lienenklaus, Stefan; Saelens, Xavier; Weiss, Siegfried; Vanham, Guido; Grooten, Johan; De Koker, Stefaan.

Mol Ther; 24(11): 2012-2020, 2016 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-27506450

11.

Sequence-dependent internalization of aggregating peptides.

Couceiro, José R; Gallardo, Rodrigo; De Smet, Frederik; De Baets, Greet; Baatsen, Pieter; Annaert, Wim; Roose, Kenny; Saelens, Xavier; Schymkowitz, Joost; Rousseau, Frederic.

J Biol Chem; 290(1): 242-58, 2015 Jan 02.

Artículo en Inglés | MEDLINE | ID: mdl-25391649

12.

Structure of the extracellular domain of matrix protein 2 of influenza A virus in complex with a protective monoclonal antibody.

Cho, Ki Joon; Schepens, Bert; Seok, Jong Hyeon; Kim, Sella; Roose, Kenny; Lee, Ji-Hye; Gallardo, Rodrigo; Van Hamme, Evelien; Schymkowitz, Joost; Rousseau, Frederic; Fiers, Walter; Saelens, Xavier; Kim, Kyung Hyun.

J Virol; 89(7): 3700-11, 2015 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-25609808

13.

Single-domain antibodies targeting neuraminidase protect against an H5N1 influenza virus challenge.

Cardoso, Francisco Miguel; Ibañez, Lorena Itatí; Van den Hoecke, Silvie; De Baets, Sarah; Smet, Anouk; Roose, Kenny; Schepens, Bert; Descamps, Francis J; Fiers, Walter; Muyldermans, Serge; Depicker, Ann; Saelens, Xavier.

J Virol; 88(15): 8278-96, 2014 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-24829341

14.

Recombinant influenza virus carrying the respiratory syncytial virus (RSV) F85-93 CTL epitope reduces RSV replication in mice.

De Baets, Sarah; Schepens, Bert; Sedeyn, Koen; Schotsaert, Michael; Roose, Kenny; Bogaert, Pieter; Fiers, Walter; Saelens, Xavier.

J Virol; 87(6): 3314-23, 2013 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-23302879

15.

A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection.

Maelfait, Jonathan; Roose, Kenny; Bogaert, Pieter; Sze, Mozes; Saelens, Xavier; Pasparakis, Manolis; Carpentier, Isabelle; van Loo, Geert; Beyaert, Rudi.

PLoS Pathog; 8(3): e1002570, 2012.

Artículo en Inglés | MEDLINE | ID: mdl-22396652

16.

Antiserum against the conserved nine amino acid N-terminal peptide of influenza A virus matrix protein 2 is not immunoprotective.

De Filette, Marina; Ysenbaert, Tine; Roose, Kenny; Schotsaert, Michael; Roels, Stefan; Goossens, Els; Schepens, Bert; Fiers, Walter; Saelens, Xavier.

J Gen Virol; 92(Pt 2): 301-6, 2011 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-20965983

17.

Pandemic preparedness: toward a universal influenza vaccine.

Roose, Kenny; Fiers, Walter; Saelens, Xavier.

Drug News Perspect; 22(2): 80-92, 2009 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-19330167

18.

mRNA Encoding a Bispecific Single Domain Antibody Construct Protects against Influenza A Virus Infection in Mice.

Van Hoecke, Lien; Verbeke, Rein; De Vlieger, Dorien; Dewitte, Heleen; Roose, Kenny; Van Nevel, Sharon; Krysko, Olga; Bachert, Claus; Schepens, Bert; Lentacker, Ine; Saelens, Xavier.

Mol Ther Nucleic Acids; 20: 777-787, 2020 May 01.

Artículo en Inglés | MEDLINE | ID: mdl-32438313

19.

Reverse engineering synthetic antiviral amyloids.

Michiels, Emiel; Roose, Kenny; Gallardo, Rodrigo; Khodaparast, Ladan; Khodaparast, Laleh; van der Kant, Rob; Siemons, Maxime; Houben, Bert; Ramakers, Meine; Wilkinson, Hannah; Guerreiro, Patricia; Louros, Nikolaos; Kaptein, Suzanne J F; Ibañez, Lorena Itatí; Smet, Anouk; Baatsen, Pieter; Liu, Shu; Vorberg, Ina; Bormans, Guy; Neyts, Johan; Saelens, Xavier; Rousseau, Frederic; Schymkowitz, Joost.

Nat Commun; 11(1): 2832, 2020 06 05.

Artículo en Inglés | MEDLINE | ID: mdl-32504029

20.

STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters.

Boudewijns, Robbert; Thibaut, Hendrik Jan; Kaptein, Suzanne J F; Li, Rong; Vergote, Valentijn; Seldeslachts, Laura; Van Weyenbergh, Johan; De Keyzer, Carolien; Bervoets, Lindsey; Sharma, Sapna; Liesenborghs, Laurens; Ma, Ji; Jansen, Sander; Van Looveren, Dominique; Vercruysse, Thomas; Wang, Xinyu; Jochmans, Dirk; Martens, Erik; Roose, Kenny; De Vlieger, Dorien; Schepens, Bert; Van Buyten, Tina; Jacobs, Sofie; Liu, Yanan; Martí-Carreras, Joan; Vanmechelen, Bert; Wawina-Bokalanga, Tony; Delang, Leen; Rocha-Pereira, Joana; Coelmont, Lotte; Chiu, Winston; Leyssen, Pieter; Heylen, Elisabeth; Schols, Dominique; Wang, Lanjiao; Close, Lila; Matthijnssens, Jelle; Van Ranst, Marc; Compernolle, Veerle; Schramm, Georg; Van Laere, Koen; Saelens, Xavier; Callewaert, Nico; Opdenakker, Ghislain; Maes, Piet; Weynand, Birgit; Cawthorne, Christopher; Vande Velde, Greetje; Wang, Zhongde; Neyts, Johan.

Nat Commun; 11(1): 5838, 2020 11 17.

Artículo en Inglés | MEDLINE | ID: mdl-33203860

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Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.

Mx1 in Hematopoietic Cells Protects against Thogoto Virus Infection.

How mRNA therapeutics are entering the monoclonal antibody field.

Hierarchical and Redundant Roles of Activating FcÎ³Rs in Protection against Influenza Disease by M2e-Specific IgG1 and IgG2a Antibodies.

A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection.

Increased Protein Degradation Improves Influenza Virus Nucleoprotein-Specific CD8+ T Cell Activation In Vitro but Not in C57BL/6 Mice.

Type I Interferons Interfere with the Capacity of mRNA Lipoplex Vaccines to Elicit Cytolytic T Cell Responses.

Sequence-dependent internalization of aggregating peptides.

Structure of the extracellular domain of matrix protein 2 of influenza A virus in complex with a protective monoclonal antibody.

Single-domain antibodies targeting neuraminidase protect against an H5N1 influenza virus challenge.

Recombinant influenza virus carrying the respiratory syncytial virus (RSV) F85-93 CTL epitope reduces RSV replication in mice.

A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection.

Antiserum against the conserved nine amino acid N-terminal peptide of influenza A virus matrix protein 2 is not immunoprotective.

Pandemic preparedness: toward a universal influenza vaccine.

mRNA Encoding a Bispecific Single Domain Antibody Construct Protects against Influenza A Virus Infection in Mice.

Reverse engineering synthetic antiviral amyloids.

STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters.