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1.

Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks.

Schneider, William M; Luna, Joseph M; Hoffmann, H-Heinrich; Sánchez-Rivera, Francisco J; Leal, Andrew A; Ashbrook, Alison W; Le Pen, Jérémie; Ricardo-Lax, Inna; Michailidis, Eleftherios; Peace, Avery; Stenzel, Ansgar F; Lowe, Scott W; MacDonald, Margaret R; Rice, Charles M; Poirier, John T.

Cell; 184(1): 120-132.e14, 2021 01 07.

Artículo en Inglés | MEDLINE | ID: mdl-33382968

2.

Phase and context shape the function of composite oncogenic mutations.

Gorelick, Alexander N; Sánchez-Rivera, Francisco J; Cai, Yanyan; Bielski, Craig M; Biederstedt, Evan; Jonsson, Philip; Richards, Allison L; Vasan, Neil; Penson, Alexander V; Friedman, Noah D; Ho, Yu-Jui; Baslan, Timour; Bandlamudi, Chaitanya; Scaltriti, Maurizio; Schultz, Nikolaus; Lowe, Scott W; Reznik, Ed; Taylor, Barry S.

Nature; 582(7810): 100-103, 2020 06.

Artículo en Inglés | MEDLINE | ID: mdl-32461694

3.

α-Ketoglutarate links p53 to cell fate during tumour suppression.

Morris, John P; Yashinskie, Jossie J; Koche, Richard; Chandwani, Rohit; Tian, Sha; Chen, Chi-Chao; Baslan, Timour; Marinkovic, Zoran S; Sánchez-Rivera, Francisco J; Leach, Steven D; Carmona-Fontaine, Carlos; Thompson, Craig B; Finley, Lydia W S; Lowe, Scott W.

Nature; 573(7775): 595-599, 2019 09.

Artículo en Inglés | MEDLINE | ID: mdl-31534224

4.

PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes.

Soto-Feliciano, Yadira M; Bartlebaugh, Jordan M E; Liu, Yunpeng; Sánchez-Rivera, Francisco J; Bhutkar, Arjun; Weintraub, Abraham S; Buenrostro, Jason D; Cheng, Christine S; Regev, Aviv; Jacks, Tyler E; Young, Richard A; Hemann, Michael T.

Genes Dev; 31(10): 973-989, 2017 05 15.

Artículo en Inglés | MEDLINE | ID: mdl-28607179

5.

A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma.

Tammela, Tuomas; Sanchez-Rivera, Francisco J; Cetinbas, Naniye Malli; Wu, Katherine; Joshi, Nikhil S; Helenius, Katja; Park, Yoona; Azimi, Roxana; Kerper, Natanya R; Wesselhoeft, R Alexander; Gu, Xin; Schmidt, Leah; Cornwall-Brady, Milton; Yilmaz, Ömer H; Xue, Wen; Katajisto, Pekka; Bhutkar, Arjun; Jacks, Tyler.

Nature; 545(7654): 355-359, 2017 05 18.

Artículo en Inglés | MEDLINE | ID: mdl-28489818

6.

Targeting de novo purine synthesis pathway via ADSL depletion impairs liver cancer growth by perturbing mitochondrial function.

Jiang, Tingting; Sánchez-Rivera, Francisco J; Soto-Feliciano, Yadira M; Yang, Qiyuan; Song, Chun-Qing; Bhuatkar, Arjun; Haynes, Cole M; Hemann, Michael T; Xue, Wen.

Hepatology; 2020 Dec 17.

Artículo en Inglés | MEDLINE | ID: mdl-33336367

7.

Rapid modelling of cooperating genetic events in cancer through somatic genome editing.

Sánchez-Rivera, Francisco J; Papagiannakopoulos, Thales; Romero, Rodrigo; Tammela, Tuomas; Bauer, Matthew R; Bhutkar, Arjun; Joshi, Nikhil S; Subbaraj, Lakshmipriya; Bronson, Roderick T; Xue, Wen; Jacks, Tyler.

Nature; 516(7531): 428-31, 2014 Dec 18.

Artículo en Inglés | MEDLINE | ID: mdl-25337879

8.

Quantitative proteomics identify Tenascin-C as a promoter of lung cancer progression and contributor to a signature prognostic of patient survival.

Gocheva, Vasilena; Naba, Alexandra; Bhutkar, Arjun; Guardia, Talia; Miller, Kathryn M; Li, Carman Man-Chung; Dayton, Talya L; Sanchez-Rivera, Francisco J; Kim-Kiselak, Caroline; Jailkhani, Noor; Winslow, Monte M; Del Rosario, Amanda; Hynes, Richard O; Jacks, Tyler.

Proc Natl Acad Sci U S A; 114(28): E5625-E5634, 2017 07 11.

Artículo en Inglés | MEDLINE | ID: mdl-28652369

9.

Stage-specific sensitivity to p53 restoration during lung cancer progression.

Feldser, David M; Kostova, Kamena K; Winslow, Monte M; Taylor, Sarah E; Cashman, Chris; Whittaker, Charles A; Sanchez-Rivera, Francisco J; Resnick, Rebecca; Bronson, Roderick; Hemann, Michael T; Jacks, Tyler.

Nature; 468(7323): 572-5, 2010 Nov 25.

Artículo en Inglés | MEDLINE | ID: mdl-21107428

10.

Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors.

Hoffmann, H-Heinrich; Schneider, William M; Sánchez-Rivera, Francisco J; Luna, Joseph M; Ashbrook, Alison W; Soto-Feliciano, Yadira M; Leal, Andrew A; Le Pen, Jérémie; Ricardo-Lax, Inna; Michailidis, Eleftherios; Hao, Yuan; Stenzel, Ansgar F; Peace, Avery; Allis, C David; Lowe, Scott W; MacDonald, Margaret R; Poirier, John T; Rice, Charles M.

bioRxiv; 2020 Sep 11.

Artículo en Inglés | MEDLINE | ID: mdl-32935098

11.

Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors.

Hoffmann, H-Heinrich; Sánchez-Rivera, Francisco J; Schneider, William M; Luna, Joseph M; Soto-Feliciano, Yadira M; Ashbrook, Alison W; Le Pen, Jérémie; Leal, Andrew A; Ricardo-Lax, Inna; Michailidis, Eleftherios; Hao, Yuan; Stenzel, Ansgar F; Peace, Avery; Zuber, Johannes; Allis, C David; Lowe, Scott W; MacDonald, Margaret R; Poirier, John T; Rice, Charles M.

Cell Host Microbe; 2020 Dec 16.

Artículo en Inglés | MEDLINE | ID: mdl-33357464

12.

SOAT1 promotes mevalonate pathway dependency in pancreatic cancer.

Oni, Tobiloba E; Biffi, Giulia; Baker, Lindsey A; Hao, Yuan; Tonelli, Claudia; Somerville, Tim D D; Deschênes, Astrid; Belleau, Pascal; Hwang, Chang-Il; Sánchez-Rivera, Francisco J; Cox, Hilary; Brosnan, Erin; Doshi, Abhishek; Lumia, Rebecca P; Khaledi, Kimia; Park, Youngkyu; Trotman, Lloyd C; Lowe, Scott W; Krasnitz, Alexander; Vakoc, Christopher R; Tuveson, David A.

J Exp Med; 217(9)2020 Sep 07.

Artículo en Inglés | MEDLINE | ID: mdl-32633781

13.

Genome-scale identification of SARS-CoV-2 and pan-coronavirus host factor networks.

Schneider, William M; Luna, Joseph M; Hoffmann, H-Heinrich; Sánchez-Rivera, Francisco J; Leal, Andrew A; Ashbrook, Alison W; Le Pen, Jérémie; Michailidis, Eleftherios; Ricardo-Lax, Inna; Peace, Avery; Stenzel, Ansgar F; Lowe, Scott W; MacDonald, Margaret R; Rice, Charles M; Poirier, John T.

bioRxiv; 2020 Oct 08.

Artículo en Inglés | MEDLINE | ID: mdl-33052332

14.

Global Regulation of the Histone Mark H3K36me2 Underlies Epithelial Plasticity and Metastatic Progression.

Yuan, Salina; Natesan, Ramakrishnan; Sanchez-Rivera, Francisco J; Li, Jinyang; Bhanu, Natarajan V; Yamazoe, Taiji; Lin, Jeffrey H; Merrell, Allyson J; Sela, Yogev; Thomas, Stacy K; Jiang, Yanqing; Plesset, Jacqueline B; Miller, Emma M; Shi, Junwei; Garcia, Benjamin A; Lowe, Scott W; Asangani, Irfan A; Stanger, Ben Z.

Cancer Discov; 10(6): 854-871, 2020 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-32188706

15.

Somatic Tissue Engineering in Mouse Models Reveals an Actionable Role for WNT Pathway Alterations in Prostate Cancer Metastasis.

Leibold, Josef; Ruscetti, Marcus; Cao, Zhen; Ho, Yu-Jui; Baslan, Timour; Zou, Min; Abida, Wassim; Feucht, Judith; Han, Teng; Barriga, Francisco M; Tsanov, Kaloyan M; Zamechek, Leah; Kulick, Amanda; Amor, Corina; Tian, Sha; Rybczyk, Katarzyna; Salgado, Nelson R; Sánchez-Rivera, Francisco J; Watson, Philip A; de Stanchina, Elisa; Wilkinson, John E; Dow, Lukas E; Abate-Shen, Cory; Sawyers, Charles L; Lowe, Scott W.

Cancer Discov; 10(7): 1038-1057, 2020 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-32376773

16.

BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency.

Gupta, Manav; Concepcion, Carla P; Fahey, Caroline G; Keshishian, Hasmik; Bhutkar, Arjun; Brainson, Christine F; Sanchez-Rivera, Francisco J; Pessina, Patrizia; Kim, Jonathan Y; Simoneau, Antoine; Paschini, Margherita; Beytagh, Mary C; Stanclift, Caroline R; Schenone, Monica; Mani, D R; Li, Chendi; Oh, Audris; Li, Fei; Hu, Hai; Karatza, Angeliki; Bronson, Roderick T; Shaw, Alice T; Hata, Aaron N; Wong, Kwok-Kin; Zou, Lee; Carr, Steven A; Jacks, Tyler; Kim, Carla F.

Cancer Res; 80(18): 3841-3854, 2020 Sep 15.

Artículo en Inglés | MEDLINE | ID: mdl-32690724

17.

A Gain-of-Function p53-Mutant Oncogene Promotes Cell Fate Plasticity and Myeloid Leukemia through the Pluripotency Factor FOXH1.

Loizou, Evangelia; Banito, Ana; Livshits, Geulah; Ho, Yu-Jui; Koche, Richard P; Sánchez-Rivera, Francisco J; Mayle, Allison; Chen, Chi-Chao; Kinalis, Savvas; Bagger, Frederik O; Kastenhuber, Edward R; Durham, Benjamin H; Lowe, Scott W.

Cancer Discov; 9(7): 962-979, 2019 07.

Artículo en Inglés | MEDLINE | ID: mdl-31068365

18.

Optimized base editors enable efficient editing in cells, organoids and mice.

Zafra, Maria Paz; Schatoff, Emma M; Katti, Alyna; Foronda, Miguel; Breinig, Marco; Schweitzer, Anabel Y; Simon, Amber; Han, Teng; Goswami, Sukanya; Montgomery, Emma; Thibado, Jordana; Kastenhuber, Edward R; Sánchez-Rivera, Francisco J; Shi, Junwei; Vakoc, Christopher R; Lowe, Scott W; Tschaharganeh, Darjus F; Dow, Lukas E.

Nat Biotechnol; 36(9): 888-893, 2018 10.

Artículo en Inglés | MEDLINE | ID: mdl-29969439

19.

NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination.

Ruscetti, Marcus; Leibold, Josef; Bott, Matthew J; Fennell, Myles; Kulick, Amanda; Salgado, Nelson R; Chen, Chi-Chao; Ho, Yu-Jui; Sanchez-Rivera, Francisco J; Feucht, Judith; Baslan, Timour; Tian, Sha; Chen, Hsuan-An; Romesser, Paul B; Poirier, John T; Rudin, Charles M; de Stanchina, Elisa; Manchado, Eusebio; Sherr, Charles J; Lowe, Scott W.

Science; 362(6421): 1416-1422, 2018 12 21.

Artículo en Inglés | MEDLINE | ID: mdl-30573629

20.

Epigenetically Regulated Chromosome 14q32 miRNA Cluster Induces Metastasis and Predicts Poor Prognosis in Lung Adenocarcinoma Patients.

González-Vallinas, Margarita; Rodríguez-Paredes, Manuel; Albrecht, Marco; Sticht, Carsten; Stichel, Damian; Gutekunst, Julian; Pitea, Adriana; Sass, Steffen; Sánchez-Rivera, Francisco J; Lorenzo-Bermejo, Justo; Schmitt, Jennifer; De La Torre, Carolina; Warth, Arne; Theis, Fabian J; Müller, Nikola S; Gretz, Norbert; Muley, Thomas; Meister, Michael; Tschaharganeh, Darjus F; Schirmacher, Peter; Matthäus, Franziska; Breuhahn, Kai.

Mol Cancer Res; 16(3): 390-402, 2018 03.

Artículo en Inglés | MEDLINE | ID: mdl-29330288

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Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks.

Phase and context shape the function of composite oncogenic mutations.

α-Ketoglutarate links p53 to cell fate during tumour suppression.

PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes.

A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma.

Targeting de novo purine synthesis pathway via ADSL depletion impairs liver cancer growth by perturbing mitochondrial function.

Rapid modelling of cooperating genetic events in cancer through somatic genome editing.

Quantitative proteomics identify Tenascin-C as a promoter of lung cancer progression and contributor to a signature prognostic of patient survival.

Stage-specific sensitivity to p53 restoration during lung cancer progression.

Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors.

Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors.

SOAT1 promotes mevalonate pathway dependency in pancreatic cancer.

Genome-scale identification of SARS-CoV-2 and pan-coronavirus host factor networks.

Global Regulation of the Histone Mark H3K36me2 Underlies Epithelial Plasticity and Metastatic Progression.

Somatic Tissue Engineering in Mouse Models Reveals an Actionable Role for WNT Pathway Alterations in Prostate Cancer Metastasis.

BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency.

A Gain-of-Function p53-Mutant Oncogene Promotes Cell Fate Plasticity and Myeloid Leukemia through the Pluripotency Factor FOXH1.

Optimized base editors enable efficient editing in cells, organoids and mice.

NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination.

Epigenetically Regulated Chromosome 14q32 miRNA Cluster Induces Metastasis and Predicts Poor Prognosis in Lung Adenocarcinoma Patients.